1.11.1.23 764973 Steric enforcement of cis-epoxide formation in the radical C-O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces fosfomycin J. Am. Chem. Soc. 141 20397-20406 2019 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769979&form=6&db=m 1.11.1.23 701777 A phosphonate-induced gene which promotes Penicillium-mediated bioconversion of cis-propenylphosphonic acid to fosfomycin Appl. Environ. Microbiol. 65 1036-1044 1999 Penicillium decumbens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10049860&form=6&db=m 1.11.1.23 702205 Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme Biochemistry 42 11577-11586 2003 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529267&form=6&db=m 1.11.1.23 702208 Biosynthesis of fosfomycin, re-examination and re-confirmation of a unique Fe(II)- and NAD(P)H-dependent epoxidation reaction Biochemistry 45 11473-11481 2006 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16981707&form=6&db=m 1.11.1.23 702728 Cloning and expression in Escherichia coli of 2-hydroxypropylphosphonic acid epoxidase from the fosfomycin-producing organism, Pseudomonas syringae PB-5123 Biosci. Biotechnol. Biochem. 63 2222-2224 1999 Pseudomonas syringae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10664856&form=6&db=m 1.11.1.23 702728 Cloning and expression in Escherichia coli of 2-hydroxypropylphosphonic acid epoxidase from the fosfomycin-producing organism, Pseudomonas syringae PB-5123 Biosci. Biotechnol. Biochem. 63 2222-2224 1999 Pseudomonas syringae PB-5123 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10664856&form=6&db=m 1.11.1.23 705742 Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis Mol. Gen. Genet. 249 274-280 1995 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7500951&form=6&db=m 1.11.1.23 705742 Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis Mol. Gen. Genet. 249 274-280 1995 Streptomyces wedmorensis 144-91 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7500951&form=6&db=m 1.11.1.23 702211 Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues Biochemistry 46 12628-12638 2007 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927218&form=6&db=m 1.11.1.23 727675 Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues J. Am. Chem. Soc. 134 16171-16174 2012 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23006053&form=6&db=m 1.11.1.23 730966 Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase Science 342 991-995 2013 Yersinia pseudotuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24114783&form=6&db=m 1.11.1.23 701481 Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis Acta Crystallogr. Sect. F 61 534-536 2005 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16511089&form=6&db=m 1.11.1.23 729898 Mechanistic consequences of chiral radical clock probes: analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates J. Am. Chem. Soc. 136 2944-2947 2014 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24512048&form=6&db=m 1.11.1.23 728377 Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction Nature 496 114-118 2013 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552950&form=6&db=m 1.11.1.23 701694 Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate Angew. Chem. Int. Ed. Engl. 41 4529-4532 2002 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12458528&form=6&db=m 1.11.1.23 727328 On the catalytic mechanism of (S)-2-hydroxypropylphosphonic acid epoxidase (HppE): a hybrid DFT study Chemistry 19 771-781 2013 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23150463&form=6&db=m 1.11.1.23 702547 On the conversion of structural analogues of (S)-2-hydroxypropylphosphonic acid to epoxides by the final enzyme of fosfomycin biosynthesis in S. fradiae Bioorg. Med. Chem. Lett. 18 3056-3059 2008 Streptomyces fradiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18155909&form=6&db=m 1.11.1.23 704157 Oxygenase activity in the self-hydroxylation of (S)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis J. Am. Chem. Soc. 126 10306-10312 2004 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15315444&form=6&db=m 1.11.1.23 704155 Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin J. Am. Chem. Soc. 123 4619-4620 2001 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457256&form=6&db=m 1.11.1.23 702244 Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae Biochemistry 47 8726-8735 2008 Pseudomonas syringae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18656958&form=6&db=m 1.11.1.23 727696 Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement J. Am. Chem. Soc. 135 8153-8156 2013 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23672451&form=6&db=m 1.11.1.23 701900 Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase Arch. Biochem. Biophys. 442 82-91 2005 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150418&form=6&db=m 1.11.1.23 705876 Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature 437 838-844 2005 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16015285&form=6&db=m 1.11.1.23 706480 Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism Proc. Natl. Acad. Sci. USA 102 14221-14226 2005 Streptomyces wedmorensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186494&form=6&db=m