1.1.1.88 (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ reaction mechanism purposal 287506 1.1.1.88 (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ There are two classes of enzyme, the third enzyme of the mevalonate pathway of isopentenyl diphosphate biosynthesis: the class I enzymes of eukaryotes and the class II enzymes of certain eubacteria 657303