4.2.3.136	(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate	-	-	
4.2.3.136	(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate	reaction proceeds through caryophyllyl and presilphiperfolanyl cations and involves the protonation of a stable (-)-(E)-beta-caryophyllene intermediate	729600