6.1.2.2 carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate (1a) - 6.1.2.2 carbamoyl phosphate + ATP + H2O = diphosphate + O-carbamoyladenylate + phosphate (2a) - 6.1.2.2 kanamycin A + carbamoyl phosphate + ATP + H2O = 6''-O-carbamoylkanamycin A + AMP + diphosphate + phosphate (2) overall reaction - 6.1.2.2 O-carbamoyladenylate + kanamycin A = AMP + 6''-O-carbamoylkanamycin A catalytic reaction mechanism, detailed overview - 6.1.2.2 O-carbamoyladenylate + tobramycin = AMP + nebramycin 5' (1b) - 6.1.2.2 tobramycin + carbamoyl phosphate + ATP + H2O = nebramycin 5' + AMP + diphosphate + phosphate (1) overall reaction -