3.1.4.2	biotechnology	efficient selection system for the identification of phosphotriesterase mutants with enhanced catalytic properties for selected organophosphate substrates	678316	
3.1.4.2	diagnostics	increased enzyme activity due to altered phosphatidylcholine metabolism in epithelial ovarian cancer cells can serve as diagnostic marker, overview	714647	
3.1.4.2	drug development	possible vaccination, Protein D is immunogenic in human. Vaccine containing polysaccharides from 7 serotypes (each conjugated to CRM197, a nontoxic mutant of diphtheria toxin that is an immunogenically inactive carrier) shows high efficacy in young children. Experiments with rats: vaccination with Protein D induces high levels of serum IgG and IgA antibodies and significant bactericidal activity against homologous and heterologous strains (rat middle ear clearance model, rat pulmonary clearance model). Pronounced activity of Protein D antibodies is shown in the chinchilla acute otitis media model	697423	
3.1.4.2	medicine	enzyme inhibition represents a targeting strategy in the treatment of breast cancer	749764