3.1.1.111 analysis immunoassay for determination of enzyme in blood serum samples. The mean standard deviation of the serum PS-PLA1 antigen concentration in 191 healthy subjects is 33.8 +- 16.6 microg/l. The concentration is significantly higher among men (13.8-80.6 microg/l) than among women (12.1-68.8 microg/l) 753301 3.1.1.111 medicine blood serum PS-PLA1 level is significantly higher in systemic lupus erythematosus (SLE) patients than in healthy controls, active rheumatoid arthritis and Sjoegren's syndrome patients. Although PS-PLA1 is significantly elevated in systemic sclerosis and Sjoegren's syndrome patients compared with healthy controls, PS-PLA1 is significantly higher in untreated SLE patients than in treated SLE patients and disease control patients. A cut-off value of 18.2 ng/ml distinguishes untreated SLE from disease control, with sensitivity and specificity of 71.4% and 57.5%, respectively. PS-PLA1 is significantly correlated with SLE Disease Activity Index (SLEDAI) and immunoglobulin G (IgG), and inversely correlated with white blood cell counts, lymphocyte counts, total complement hemolytic activity (CH50), complements C3, and C4 in SLE patients overall 753940 3.1.1.111 medicine during infection with hepatitis C virus, PLA1A plays an important role in bridging the membrane-associated NS2-E2 complex and the NS5A-associated replication complex via its interaction with E2, NS2, and NS5A 754543