2.3.1.133 agriculture downregulation of key genes involved in lignin biosynthesis, such as hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase (HCT), cinnamoyl-CoA reductase (CCR), and cinnamyl alcohol dehydrogenase (CAD), through terminator-less constructs to reduce lignin content. T1 transgenic rice plants show 36-86% transcript reduction in HCT lines. Down-regulated lines show significant reduction in total lignin content with lignin reduction ranging from 4.6 to 10.8% 757964 2.3.1.133 agriculture HCT is evaluated as a target for forage quality improvement 689416 2.3.1.133 agriculture reduction of content and improvement of biomass saccharification can be achieved by engineering transgenic lines that overproduce non-canonical substrates 3-hydroxybenzoate, gentisate, 2,3-dihydroxybenzoate, protocatechuate, 3-aminobenzoate, 3-hydroxyanthranilate, 5-hydroxyanthranilate, catechol or hydroquinone 736977 2.3.1.133 industry the global trend toward a biomaterials-based economy makes plant cell walls increasingly important as renewable resources, HCT is a metabolic entry point leading to the biosynthesis of G-lignin in coniferous gymnosperms 689750