4.2.3.104 synthesis chemolithoautotrophic production of a terpene from carbon dioxide, hydrogen, and oxygen, involving the engineered Cupriavidus necator cells and enzyme alpha-humulene synthase, is a promising starting point for the production of different high-value terpene compounds from abundant and simple raw materials. The production system is used to produce 17 mg alpha-humulene per gram cell dry mass (CDW) from CO2 and electrical energy in microbial electrosynthesis (MES) mode 746751