2.1.1.28	analysis	enzyme serves as a marker for tissues and cells producing epinephrine	639452	
2.1.1.28	analysis	method to measure tissue contents and activity of phenylethanolamine N-methyltransferase, utilizing double stable isotope ultra performance liquid chromatography-tandem mass spectrometry. The method is based on measurement of deuterium-labeled epinephrine produced from reaction of norepinephrine with deuterium-labeled S-adenosyl-Lmethionine as the methyl donor. In addition to enzyme activity the method allows for determination of tissue contents of PNMT using human recombinant enzyme for calibration. The calibration curve for epinephrine is linear over the range of 0.1 to 5000 pM, with 0.5 pM epinephrine representing the lower limit of quantification	733076	
2.1.1.28	medicine	strong relationship between PNMT gene expression and tissue epinephrine levels in human pheochromocytomas	733076	
2.1.1.28	additional information	a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits a minimal affinity for the alpha-adrenoceptor, would be a useful pharmacological tool for clearly defining the connection between central epinephrine concentrations and blood pressure.	675306	
2.1.1.28	additional information	a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits minimal affinity for the alpha2-adrenoceptor and is able to cross the brain-blood-barrier, would be a useful pharmacological tool for defining the role of epinephrine in the central nervous systhem.	672557	
2.1.1.28	additional information	selective inhibitors of phenylethanolamine N-methyltransferase would be useful pharmacological tools for clearly defining the connection between central epinephrine concentrations and peripheral blood pressure	675297