3.4.22.40 bleomycin + H2O - 3.4.22.40 bleomycin + H2O bleomycin is a cytotoxic agent inducing pneumonitis, detoxification reaction 3.4.22.40 bleomycin + H2O detoxification reaction 3.4.22.40 bleomycin + H2O detoxification reaction, high enzyme expression level leads to resistance against the drug 3.4.22.40 bleomycin A2 + H2O the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins 3.4.22.40 bleomycin B2 + H2O the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins 3.4.22.40 deiminated filaggrin + H2O neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids 3.4.22.40 homocysteine-thiolactone + H2O - 3.4.22.40 huntingtin + H2O the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin 3.4.22.40 L-homocysteine-thiolactone + H2O -