3.1.3.6	3'-AMP	processing of exogenously available 3'-nucleotides into a form suitable for transport across the surface membrane of the parasite, which is incapable of purine biosynthesis de novo	
3.1.3.6	3'-AMP + H2O	-	
3.1.3.6	a 3'-ribonucleotide + H2O	-	
3.1.3.6	additional information	the enzyme is involved in salvage of host-derived purines, which are essential for the survival of the parasite	
3.1.3.6	additional information	the enzyme is involved in the salvage of preformed purines via the hydrolysis of either 3'-nucleotides or nucleic acids	
3.1.3.6	additional information	the enzyme must play a critical role in purine salvage of the human pathogen	
3.1.3.6	additional information	the enzyme plays a critical role in purine salvage pathway during the rapid multiplicative expansion of the parasite population within its insect vector. Starvation of the parasite for purines results in the significant up-regulation of both the 3'-nucleotidase/nuclease mRNA and enzyme activity in promastigotes, but not in amastigotes	
3.1.3.6	additional information	the enzyme cleaves RNA and heat-denatured DNA endonucleolytically producing 5'-mononucleotides and shows 3'-nucleotidase activity