2.4.2.9 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate recombinant bifunctional enzyme UK/UPRT 2.4.2.9 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate recombinant fusion enzyme in RM1 tumors of lung, spleen, heart, and prostate 2.4.2.9 UMP + diphosphate - 2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate - 2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate incorporation of uracil into nucleotides 2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate pyrimidine salvage enzyme, no de novo synthesis of pyrmidines 2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in the uracil salvage pathway, UPRT is a major cell supplier of UMP synthesized from uracil provided by preformed nucleic acid degradation, uracil salvage and pyrimidine biosynthetic pathways, overview 2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is specific for uracil 2.4.2.9 uridine + ATP the bifunctional enzyme UK/UPRT also performs the uridine kinase reaction, EC 2.7.1.48