1.14.19.67 (R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 - 1.14.19.67 (R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 formation of salutaridine, a key intermediate in morphine biosynthesis 1.14.19.67 (R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 critical step in morphine biosynthesis