3.4.22.38 aggrecan + H2O - 3.4.22.38 aggrecan + H2O degradation 3.4.22.38 alpha-isomerized C-telopeptide + H2O - 3.4.22.38 beta-endorphin + H2O - 3.4.22.38 beta-isomerized C-telopeptide + H2O - 3.4.22.38 bradykinin + H2O - 3.4.22.38 calf skin collagen type I + H2O - 3.4.22.38 chemo-attractant stromal-derived factor-1alpha + H2O the enzyme cleaves chemo-attractant stromal-derived factor-1alpha (SDF-1alpha) at 3 sites in the N-terminus, which is the region of SDF-1alpha that binds to its receptors 3.4.22.38 Collagen + H2O cathepsin K cleaves within the telo as well as triple helical domains of collagens 3.4.22.38 collagen I + H2O -