3.2.2.20	alkylated DNA + H2O	-	
3.2.2.20	alkylated DNA + H2O	important role in preventing the mutagenic effects of deaminated purines and cyclic etheno adducts	
3.2.2.20	alkylated DNA + H2O	also removes 7-methylguanine	
3.2.2.20	alkylated DNA + H2O	smallest member of the helix-hairpin-helix HhH superfamily of DNA glycosylases	
3.2.2.20	alkylated DNA + H2O	double-stranded DNA is an effective substrate, enzyme is less efficient in excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication	
3.2.2.20	alkylated DNA + H2O	cellular repair of alkylated DNA base modifications	
3.2.2.20	alkylated DNA + H2O	reaction of the enzyme with alkylated DNA leads to introduction of apurinic sites but no chain breaks	
3.2.2.20	alkylated DNA + H2O	nuclear transcription factor estrogen receptor alpha interacts with 3-methyladenine DNA glycosylase to modulate transcription and DNA repair, enzyme catalyzes removal of hypoxanthine from DNA, estrogen receptor alpha stabilizes the interaction of the enzyme with hypoxanthine containing DNAand increases the catalytic removal of the modified base	
3.2.2.20	alkylated DNA + H2O	primarily removes N3-methyladenine but also N3-methylguanine from DNA by glycosylic cleavage in the first step of the base excision repair	
3.2.2.20	alkylated DNA + H2O	constitutive pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine