1.8.1.9 BrxA bacilliredoxin disulfide + NADPH + H+ - 1.8.1.9 BrxB bacilliredoxin disulfide + NADPH + H+ - 1.8.1.9 BrxC bacilliredoxin disulfide + NADPH + H+ - 1.8.1.9 additional information ribonucleotide reductase, thioredoxin and thioredoxin reductase constitute a system necessary for the biosynthesis of deesoxyribonucleotides 1.8.1.9 additional information HEK-293 cells overexpressing TrxR2 are more resistant to impairment of complex III bypassing function of TrxR2 1.8.1.9 additional information EhTRXR and EhTRX41 could be assayed as a functional redox pair that, together with peroxiredoxin, mediates the NADPH-dependent reduction of hydrogen peroxide and tert-butyl hydroperoxide. It is proposed that this detoxifying system could be operative in vivo 1.8.1.9 additional information function of TRXR1 in the self-defense mechanism against self-generated oxidative stress 1.8.1.9 additional information homozygous (-/-) knockout of Txnrd1 is embryonically lethal. No major effect of Txnrd1 hemizygosity and/or Se on male fertility and the viability of offspring 1.8.1.9 additional information homozygous (-/-) knockout of Txnrd2 is embryonically lethal. No major effect of Txnrd2 hemizygosity and/or Se on male fertility and the viability of offspring 1.8.1.9 additional information mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity