1.14.14.151	(+)-valencene + [reduced NADPH-hemoprotein reductase] + O2	enzyme HPO-mediated biohydroxylation of (+)-valencene	
1.14.14.151	additional information	HPO also catalyzes the equivalent regio-specific (C-2) hydroxylation of several eremophilane-type (decalin ring system) sesquiterpenes, such as with 5-epi-aristolochene	
1.14.14.151	additional information	co-expression of enzyme HPO and cytochrome P450 reductase (CPR) leads to the hydroxylation of externally added (+)-valencene to trans-nootkatol in Pichia pastoris cells