5.6.1.1	ATP + H2O	-	
5.6.1.1	ATP + H2O + microtubule	-	
5.6.1.1	ATP + H2O + microtubule	assembly of female meiotic spindles requires MEI-1 and MEI-2, which constitute the microtubule-severing AAA+ ATPase Katanin	
5.6.1.1	ATP + H2O + microtubule	katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation	
5.6.1.1	ATP + H2O + microtubule	the enzyme plays important roles in various cellular events including axon regeneration, cytokinesis, and nuclear envelope sealing after mitosis	
5.6.1.1	GTP + H2O	-	
5.6.1.1	additional information	direct role of microtubule severing in translocation of the meiotic spindle to the cortex	
5.6.1.1	additional information	enzyme activity regulates the number of microtubule end in mitotic spindle, enzyme inhibition slows the rate of spindle microtubule disassembly	
5.6.1.1	additional information	enzyme acts on defects in microtubule lattice, promotes loss of tubulin at the defect site until the two microtubule segments are held together so weakly that mechanically unconstrained microtubules kink at the defect site	
5.6.1.1	additional information	katanin p60 destabilizes microtubules at the central spindle and the midbody