4.2.1.20	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine	-	
4.2.1.20	1-(indol-3-yl)glycerol 3-phosphate	alpha-subunit of the bienzyme complex, alpha-reaction	
4.2.1.20	1-(indol-3-yl)glycerol 3-phosphate + L-serine	-	
4.2.1.20	1-(indol-3-yl)glycerol 3-phosphate + L-serine	alpha-subunit of the bienzyme complex, alpha-reaction	
4.2.1.20	indoleglycerol phosphate	the reaction is catalyzed by the tryptophan synthase alpha-subunit TrpA	
4.2.1.20	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate	-	
4.2.1.20	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate	Trp is a precursor of several important signalling molecules in Pseudomonas spp., overview	
4.2.1.20	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate	overall reaction	
4.2.1.20	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate	the last two steps of L-tryptophan biosynthesis are catalyzed by Trp synthase, a heterotetramer composed of TrpA and TrpB. TrpB catalyzes the condensation of indole, synthesized by TrpA, and serine to Trp	
4.2.1.20	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate	the tryptophan synthase alpha2beta2 bi-enzyme complex catalyzes the last two steps in the synthesis of L-tryptophan (L-Trp). The alpha-subunit catalyzes cleavage of 3-indole-D-glycerol 3'-phosphate to give indole and D-glyceraldehyde 3'-phosphate. Indole is then transferred from the alpha-subunit to the beta-subunit where it reacts with L-Ser in a pyridoxal 5'-phosphate-dependent reaction to give L-Trp and a water molecule	
4.2.1.20	L-serine + indole	-	
4.2.1.20	L-serine + indole	beta-subunit of the bienzyme complex, beta-reaction	
4.2.1.20	L-serine + indole	the reaction is catalyzed by the tryptophan synthase beta-subunit paralogs TrpB1 and TrpB2	
4.2.1.20	additional information	last 2 steps of the tryptophan biosynthesis	
4.2.1.20	additional information	the enzyme is involved in regulation/inhibition of Pseudomonas aeruginosa type III secretion system, T3SS, by inhibition of T3SS expression through tryptophan catabolites, overview. The T3SS system consists of 43 coordinately regulated genes encoding type III secretion and translocation machinery, regulatory factors, type III effectors and effector-specific chaperones	
4.2.1.20	additional information	catalyzed reaction and structure of the tryptophan synthase complex, overview