4.1.1.49	ADP + phosphoenolpyruvate + CO2	-	
4.1.1.49	ADP + phosphoenolpyruvate + CO2	synthesis of oxaloacetate is a key step in the formation of four-carbon compounds, such as malate, fumarate, and succinate	
4.1.1.49	ADP + phosphoenolpyruvate + CO2	in contrast to its normal role in gluconeogenesis, PEP carboxykinase can operate in the reverse direction from phosphoenolpyruvate to oxaloacetate, upon knockout of pyruvate kinase in a riboflavin-producing Bacillus subtilis strain and in wild-type 168	
4.1.1.49	ADP + phosphoenolpyruvate + CO2	the enzyme is responsible for the CO2 fixation	
4.1.1.49	ADP + phosphoenolpyruvate + CO2	catabolic CO2-fixing enzyme, important role in succinate formation	
4.1.1.49	ATP + oxaloacetate	-	
4.1.1.49	ATP + oxaloacetate	acts in the metabolic pathways at the intersection of the glycolysis, the gluconeogenesis and the Krebs cycle, enzyme activity increases when cells are submitted to hypothermic stress	
4.1.1.49	ATP + oxaloacetate	carbon and nitrogen metabolism	
4.1.1.49	ATP + oxaloacetate	critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates towards gluconeogenesis	
4.1.1.49	ATP + oxaloacetate	first commmitted step of gluconeogenesis	
4.1.1.49	ATP + oxaloacetate	gluconeogenesis and anaplerotic reactions	
4.1.1.49	ATP + oxaloacetate	key enzyme in the regulation of flux through the gluconeogenic pathway, gluconeogenic production of sugars from storage oil	
4.1.1.49	ATP + oxaloacetate	responsible for light-independent carbon fixation	
4.1.1.49	ATP + oxaloacetate	the enzyme is neither regulatory nor inducible, the main function is catalyzing the synthesis of phosphoenopyruvate as a part of the gluconeogenetic pathway	
4.1.1.49	ATP + phosphoenolpyruvate + CO2	-	
4.1.1.49	additional information	central role in energy metabolism	
4.1.1.49	additional information	under physiological conditions the enzyme is bidirectional and is regulated primarily by mass action	
4.1.1.49	additional information	important regulatory function of the enzyme in the amino-acid catabolism of Trypanosoma cruzi