2.7.11.11 ATP + a protein - 2.7.11.11 ATP + a protein regulation by reversible phosphorylation, overview 2.7.11.11 ATP + a protein regulation of the enzyme involves reversible phosphorylation at the activation loop, and associative or dissociative mechanisms 2.7.11.11 ATP + a protein the enzyme is a key player in cellular responses to the second messenger cAMP 2.7.11.11 ATP + A-kinase anchor protein phosphorylation at Ser1928 2.7.11.11 ATP + actin low activity 2.7.11.11 ATP + actin sperm protein substrate 2.7.11.11 ATP + adenylate kinase 1 sperm protein substrate 2.7.11.11 ATP + adenylate kinase 5 sperm protein substrate 2.7.11.11 ATP + AID protein - 2.7.11.11 ATP + alpha7 nicotinic acetylcholine receptor phosphorylation at Ser365 2.7.11.11 ATP + apical membrane antigen 1 - 2.7.11.11 ATP + autophagy-related protein kinase Atg1 initiating the degradative pathway, PKA regulates the association of Atg1 with the preautophagosomal structure PAS, overview 2.7.11.11 ATP + bAD protein - 2.7.11.11 ATP + beta-adrenergic receptor PKA phosphorylation mediates beta-1 adrenergic receptor endocytosis via the caveolae pathway 2.7.11.11 ATP + beta-catenin - 2.7.11.11 ATP + beta1-adrenergic receptor recombinant beta1-adrenergic receptor expressed in HEK-293 cell membranes, phosphorylation at Ser312 is essential for activation of endocytic recycling of the agonist-internalized beta1-adrenergic receptor, beta1-AR mutant S312A is not recycled, overview 2.7.11.11 ATP + BKCa channel ZERO recombinant murine HA-tagged tetrameric protein expressed in HEK-293 cells, activity with wild-type and mutant Y334V channel tetramers, but no activity with S899A mutant, phosphorylation at Ser899 activates the channels, overview 2.7.11.11 ATP + c-Myc protein - 2.7.11.11 ATP + calpain 2 - 2.7.11.11 ATP + cAMP-response element-binding protein phosphorylation at Ser133 2.7.11.11 ATP + cAMP-responsive element binding protein the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview 2.7.11.11 ATP + catchin low activity 2.7.11.11 ATP + Cav1.2 in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain 2.7.11.11 ATP + CaV1.2 protein phosphorylation at Ser1700 2.7.11.11 ATP + cellular nucleic acid binding protein CNBP performs a fine tune expression regulation of a group of target including c-myc, during vertebrate embryogenesis, different phosphorylation patterns at different development al stages, overview 2.7.11.11 ATP + CFTR protein - 2.7.11.11 ATP + claudin-3 high activity in ovarian cancer cells with recombinantly overexpressed claudin-3, phosphorylation of claudin-3 affecting the barrier function with extracellular Ca2+, overview 2.7.11.11 ATP + CRE-binding protein i.e. CREB, a transcription factor, activition by type I PKA 2.7.11.11 ATP + creatine kinase sperm protein substrate 2.7.11.11 ATP + CREB protein - 2.7.11.11 ATP + CREB protein in brain synapses 2.7.11.11 ATP + CREB-binding protein i.e. CBP, activition by type II PKA 2.7.11.11 ATP + Dot6 a protein implicated in telomere function 2.7.11.11 ATP + EPS8 protein sperm protein substrate 2.7.11.11 ATP + ezrin recombinant GST-tagged wild-type ezrin transiently expressed in primary gastric parietal cells from stomach, recombinant mutant S66A and S66D ezrin proteins are no substrates, phosphorylation of ezrin leads to activation of parietal cells required for dilation of apical vacuolar membrane and histamine-stimulated acid secretion in gastric mucosa, overview 2.7.11.11 ATP + G protein-coupled receptor GRK1 - 2.7.11.11 ATP + G protein-coupled receptor GRK1 recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation 2.7.11.11 ATP + G protein-coupled receptor GRK7 - 2.7.11.11 ATP + G protein-coupled receptor GRK7 recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation 2.7.11.11 ATP + GRK2 protein - 2.7.11.11 ATP + GSK3 protein - 2.7.11.11 ATP + histone deacetylase 8 FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme 2.7.11.11 ATP + HSL protein - 2.7.11.11 ATP + IP3R-2 phosphoregulation of the inositol 1,4,5-trisphosphate receptor subtype 2, PKA enhances inositol 1,4,5-trisphosphate-induced Ca2+ release in AR4-2J cells, regulation, overview 2.7.11.11 ATP + KCNN2 protein - 2.7.11.11 ATP + Kemptide - 2.7.11.11 ATP + lactate dehydrogenase subunit A mRNA the enzyme stabilizes lactate dehydrogenase LDH-A mRNA and increases intracellular LDH-A mRNA levels by phosphorylation of a cAMP-stabilizing region CSR on the 3'-untranslated region of the LDH-A mRNA, regulation, mechanism 2.7.11.11 ATP + merlin recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin 2.7.11.11 ATP + mitogen-activated protein kinase phosphatase-1 the enzyme enhances steroid hydroxylase CYP17 transcription via mitogen-activated protein kinase phosphatase-1 MKP-1 activation in H295R adrenocortical cells 2.7.11.11 ATP + MOS1 protein - 2.7.11.11 ATP + NDUFS4 subunit of complex I complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 2.7.11.11 ATP + NFAT2 protein - 2.7.11.11 ATP + paramyosin low activity 2.7.11.11 ATP + PDE11A protein sperm protein substrate 2.7.11.11 ATP + PDE5A protein sperm protein substrate 2.7.11.11 ATP + phosphofructokinase 2 - 2.7.11.11 ATP + Rap1a phosphorylation of Rap1a on serine 180. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. Because KSR can exist as a dimer with B-Raf, this provides Rap1 an indirect link to B-Raf and the MAP kinase cascade 2.7.11.11 ATP + Rap1b phosphorylation of Rap1b on serine 179. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR 2.7.11.11 ATP + RGS protein recombinant HA-tagged substrate expressed in B35 cells, phosphorylation of RGS14 by PKA potentiates its activity toward Galphai-GDP 2.7.11.11 ATP + ribosomal S6 protein - 2.7.11.11 ATP + SP20 protein i.e. TTYADFIASGRTGRRASIHD 2.7.11.11 ATP + stathmin phosphorylation at Ser63 2.7.11.11 ATP + twitchin - 2.7.11.11 ATP + type III inositol 1,4,5-trisphosphate receptor i.e. IP3 receptor, recombinantly expressed in HEK cells, forms tetrameric Ca2+ channels in the endoplasmic reticulum 2.7.11.11 ATP + tyrosine hydroxylase enzyme is involved in the signal transduction regulatory mechanism in the triiodothyronine T3-activation of forebrain tyrosine hydroxylase 2.7.11.11 ATP + ubiquinol-cytochrome c reductase complex core protein 2 sperm protein substrate 2.7.11.11 ATP + VASP protein - 2.7.11.11 ATP + [cystic fibrosis transmembrane conductance regulator protein] - 2.7.11.11 ATP + [tau-protein] - 2.7.11.11 ATP + [tau-protein] abnormal hyperphosphorylation of tau by PKA is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration 2.7.11.11 ATP + [Whi3 cell cycle regulator protein] phosphorylation of Ser568 leads to inhibition of Whi3 2.7.11.11 additional information enzyme plays an essential role during differentiation and fruit morphogenesis in Dictyostelium discoideum 2.7.11.11 additional information the enzyme plays a central role in the control of mammalian sperm capacitation and motility 2.7.11.11 additional information activated PKA catalytic subunit C with cAMP or 8-bromo-cAMP, stimulated by beta1-adrenoreceptor activity, inhibits store-operated channel current activity in vascular tissue 2.7.11.11 additional information cAMP concentration and PKA activity are increased and important in exocytotic acrosome reaction taking place in fertilization when sperm contacts the egg jelly layer EJ, EJ component fucose sulfate polymer triggers sperm PKA activation 2.7.11.11 additional information cAMP-dependent activation of BKCa channels in pulmonary arterial smooth muscle is not catalyzed by PKA but by cGMP-dependent protein kinase PKG, thus PKA is not involved in cAMP-induced signaling in pulmonary vasodilation 2.7.11.11 additional information enzyme regulation, overview 2.7.11.11 additional information induced by the pituitary follicle-stimulating hormone FSH PKA also catalyzes the dephosphorylation of residues T421 and S424 of the autoinhibitory domain of p70S6K, resulting in activation of p70S6K important for differentiation of Sertoli cells in male reproduction, regulation overview 2.7.11.11 additional information inositol 1,4,5-trisphosphate receptor-I is no substrate of PKA in vivo 2.7.11.11 additional information merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway 2.7.11.11 additional information no activity with claudin-4 2.7.11.11 additional information oestrogen-dependent increase in cAMP increases Ca2+-dependent exocytosis through protein kinase A-dependent pathway and through alternative cAMP-guanine nucleotide exchange factor GEF/Epac-dependent pathway in secretory cells 2.7.11.11 additional information PKA regulatory and catalytic subunits are bound in the CSR complex including the protein kinase A anchoring protein AKAP 95 and several CSR-binding proteins, the complex acts in stabilizing the LDH-A mRNA, overview 2.7.11.11 additional information PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview 2.7.11.11 additional information PKA works coordinatedly with GSK3beta, EC 2.7.11.1, on tau phosphorylation 2.7.11.11 additional information regulation of GRK1 and GRK7 by cAMP level during light and dark phases 2.7.11.11 additional information tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory 2.7.11.11 additional information the enzyme activates NS1619-induced flavoprotein oxidation modulating mitochondrial Ca2+-activated K+ channels, mechanism of the cardioprotective effect and modulation by PKA, overview 2.7.11.11 additional information the enzyme interacts with the neuron cortex membrane protein gravin via Ca2+-independent binding to the regulatory RII enzyme subunit, gravin provides a platform to localize kinases, besides PKA also PKCalpha and PKCbetaII, in an isozyme-specific and activation-dependent manner at specific sites in neurons, gravin is strongly upregulated in cells during differentiation, overview 2.7.11.11 additional information the enzyme is not required for adenosine-induced dilation of intracerebral arterioles and regulation of cerebral blood flow 2.7.11.11 additional information the enzyme plays a central role in the adipokinetic signaling controling the mobilization of stored lipids in the fat body 2.7.11.11 additional information the enzyme plays a paradoxical role in cell motility facilitating and inhibiting actin cytoskeletal dynamics and cell migration, overview, the enzyme is regulated in a subcellular space during cell migration, regulatory subunits RII are enriched in protrusive cellular structures and pseudopodia formed during chemotaxis, anchoring of PKA inhibits pseudopod formation and cell migration, regulation of the process overview 2.7.11.11 additional information the enzyme regulates the G2/M transition in oocytes of Xenopus laevis, it also blocks progesterone-induced germinal vesicle envelope breakdown GVBD, Cdc-25-dependent dephosphorylation of Tyr15 in Cdc2, and synthesis of MEKK Mos 2.7.11.11 additional information cystic fibrosis results from mutations in the cystic fibrosis conductance regulator protein, CFTR, a cAMP/protein kinase A, PKA, and ATP-regulated Cl- channel, the formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein, CFTR, regulates CFTR channel function, overview, PKA regulates anx 2 and S100A10 cellular distribution in HNE cells, modulation of PKA activity alters localization and distribution of anx 2–S100A10 in HNE cells, overview 2.7.11.11 additional information inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients, overview 2.7.11.11 additional information PKA plays a crucial role in the release of the catch state of molluskan muscles, mechanism, overview 2.7.11.11 additional information redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview 2.7.11.11 additional information the enzyme is involved in cyclic nucleotide signaling, overview, individually phosphorylated PKA-R isozymes are differentially targeted to distinct cellular compartments by AKAP-isozymes, providing a multifaceted platform for the kinase 2.7.11.11 additional information the enzyme plays a central role in regulation of diverse aspects of cellular activity, especially in the controlling of maturation of spermatids 2.7.11.11 additional information cAMP elevation in the Schwann cell is sufficient to induce E-cadherin expression accompanied by suppression of N-cadherin expression 2.7.11.11 additional information cAMP-dependent neurite outgrowth is mediated by PKA 2.7.11.11 additional information cAMP-dependent PKA induces type I tumor necrosis factor receptor exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to A kinase-anchoring protein domains B and C of the guanine nucleotide exchange protein BIG2 2.7.11.11 additional information elevated PKA activity results in activation of stress-associated proteins and of enzymes involved in protein biosynthesis and glucose catabolism, in contrast, proteins which are involved in nucleotide and amino acid biosynthesis are downregulated 2.7.11.11 additional information exchange protein activated by cAMP acts synergistically with PKA in cAMP-mediated mitogenesis 2.7.11.11 additional information signaling by cAMP-dependent protein kinase plays an important role in the regulation of mammalian sperm motility 2.7.11.11 additional information the PKA catalytic subunit a serine/threonine kinase, that can phosphorylate many substrates, such as additional protein kinases and transcription factors