2.7.1.91	ATP + D-erythro-sphingosine	-	
2.7.1.91	ATP + D-erythro-sphingosine	major substrate of isozyme SPHK1, also active with isozyme SPHK2	
2.7.1.91	ATP + dihydrosphingosine	C14 and C16 dihydrosphingosine substrates	
2.7.1.91	ATP + phytosphingosine	-	
2.7.1.91	ATP + phytosphingosine	phytosphingosine 1-phosphate is capable of regulating the turgor in guard cells/stomatal aperture via G-proteins	
2.7.1.91	ATP + sphinganine	-	
2.7.1.91	ATP + sphinganine	D-erythro-sphinganine, sphingosine metabolism	
2.7.1.91	ATP + sphinganine	involved in regulation of GTP cyclohydrolase I and 6(r)-5,6,7,8-tetrahydrobiopterin	
2.7.1.91	ATP + sphinganine	calcium mobilization through antigen receptors utilizes enzyme	
2.7.1.91	ATP + sphinganine	overview on cellular functions	
2.7.1.91	ATP + sphinganine	involved in signal transduction in the nucleus	
2.7.1.91	ATP + sphinganine	the lipid phosphate acts as a pleiotropic agent in cell signalling pathways, acts often in concert with ceramide 1-phosphate, enzyme is involved in the sphingomyelid pathway, overview	
2.7.1.91	ATP + sphinganine	the lipid phosphate acts as a pleiotropic agent in cell signalling pathways, enzyme is involved in the sphingomyelid pathway, overview	
2.7.1.91	ATP + sphingosine	-	
2.7.1.91	ATP + sphingosine	C14 and C16 sphingosine substrates	
2.7.1.91	ATP + sphingosine	involved in diverse biological functions	
2.7.1.91	ATP + sphingosine	sphingosine 1-phosphate is capable of regulating the turgor in guard cells/stomatal aperture via G-proteins	
2.7.1.91	ATP + sphingosine	sphingosine is a modulator of membrane signal transduction systems and a regulatory element of cardiac and skeletal muscle physiology	
2.7.1.91	additional information	isozyme SPHK1 is involved in responses to macrophages, the enzyme is involved in mast cell signalling, in neutrophil priming, and in prostaglandin biosynthesis via arachidonic acid production, overview, sphinganine 1-phosphate acts as an extracellular mediator by binding to specific members of the EDG-family of G-protein coupled receptors, and intracellularly as a messenger	
2.7.1.91	additional information	requirement for Sk2 in normal reproductive function, product S1P signaling promotes cell proliferation, survival, and migration, enzyme reduces cellular levels of sphingosine and ceramide, sphingolipid metabolism, overview	
2.7.1.91	additional information	sphinganine 1-phosphate acts as an extracellular mediator by binding to specific members of the EDG-family of G-protein coupled receptors, and intracellularly as a messenger	
2.7.1.91	additional information	sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin	
2.7.1.91	additional information	sphingosine and sphingosine 1-phosphate activate phospholipase D in mouse myoblasts	
2.7.1.91	additional information	the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes	
2.7.1.91	additional information	the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis	
2.7.1.91	additional information	long-rSK1 is involved in cell signaling	
2.7.1.91	additional information	sphingosine kinase-mediated signalling plays a role in the innate and adaptive immune responses by altering migration of dendritic cells	
2.7.1.91	additional information	the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound