3.5.1.6 Co2+ - 685395, 695782 3.5.1.6 Mg2+ - 172061, 172065 3.5.1.6 Mn2+ - 695782 3.5.1.6 Ni2+ - 172065, 695782, 720104 3.5.1.6 Zn2+ - 172056, 172065, 685395 3.5.1.6 Zn2+ contains two tightly bound Zn2+, removal leads to loss of activity 656700 3.5.1.6 Zn2+ contains two Zn2+ per subunit, dizinc metal center in the catalytic domain of the subunit representing the active site of enzyme, binding mode 656188 3.5.1.6 Zn2+ two Zn2+ ions per subunit 685395 3.5.1.6 Zn2+ Zn2+-dependent enzyme, required as a catalytic cofactor 657030