3.4.22.54	Ca2+	-	649012	
3.4.22.54	Ca2+	activated by Ca2+	731896	
3.4.22.54	Ca2+	activates	754170	
3.4.22.54	Ca2+	at less than 50 nM Ca2+ calpain-3 remains nonactivated, at 200 nM Ca2+ calpain-3 becomes active	698991	
3.4.22.54	Ca2+	autolysis of skeletal muscle-specific calpain does not require Ca2+, calpastatinolysis occurs in a Ca2+-dependent manner	665528	
3.4.22.54	Ca2+	Ca2+-regulated enzyme	752852	
3.4.22.54	Ca2+	calcium-dependent protease	670856	
3.4.22.54	Ca2+	calpain 3 is a calcium-dependent cysteine protease	709092	
3.4.22.54	Ca2+	calpain 3/p94 is activated by Ca2+ and undergoes very rapid autolytic degradation even in the absence of Ca2+	709121	
3.4.22.54	Ca2+	calpain-3 autolyzes (becoming proteolytically active) in a tightly calcium-dependent manner. It remains in its nonactivated full-length form if [Ca2+] is maintained at up to 50 nM, the normal resting level, even with brief increases to 0.002-0.02 mM during repeated tetanic contractions, but it becomes active (though still bound) if [Ca2+] is kept slightly elevated at 200 nM (about 20% autolysis in 1 h). Calpain-3 does not spontaneously autolyze even when free in solution with 200 nM Ca2+ for up to 60 min	698991