3.1.26.4	Ca2+	binding structure	664755	
3.1.26.4	Ca2+	strictly metal-dependent nuclease. It exhibits activity in the presence of Mg2+, Mn2+, Co2+ or Ni2+, whereas no activity is observed in the absence of these metal ions. Little activity is detected in the presence of other metals including Co3+, Cu2+, Zn2+, and Ca2+	721474	
3.1.26.4	Co2+	-	657287	
3.1.26.4	Co2+	10 mM Co2+ supports activity, with only minor inhibition observed at higher concentrations	729704	
3.1.26.4	Co2+	activates	664911	
3.1.26.4	Co2+	activates cleavage of only poly(A) hybrids	134369	
3.1.26.4	Co2+	activates, best at 0.5 mM	664911	
3.1.26.4	Co2+	cobalt hexaamine activates	134404	
3.1.26.4	Co2+	divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+	134409	
3.1.26.4	Co2+	divalent metal required, optimal concentration: 20 mM, 70% of the activity with Mg2+	134368