1.14.15.30 Fe2+ a Rieske 2Fe-2S enzyme 743221 1.14.15.30 Fe2+ contains non-heme Fe2+ 744058 1.14.15.30 Fe2+ contains non-heme iron 718125 1.14.15.30 Fe2+ the enzyme contains a nonheme Fe2+ 717737 1.14.15.30 Fe2+ the oxygenase component, which performs the substrate hydroxylation, is an iron-sulfur protein and contains a non-heme iron situated at the active site. The iron is bidentate bound to the carboxyl group of the aspartate leaving two sites available for exogenous ligands. This metal centre is more labile compared to the covalently bound heme-iron. Non-heme iron is a highly catalytic platform able to bind O2 and steroid substrate simultaneously in different orientations 744058