2.7.1.44 Co2+ divalent metal ion is required, lower activity than Mg2+ or Mn2+ 2.7.1.44 Mg2+ divalent metal ion is required, Zn2+ or Ni2+ are ineffective 2.7.1.44 Mg2+ Mn2+ (32% relative activity) and Ca2+ (61% relative activity) can substitute for Mg2+ 2.7.1.44 Mn2+ divalent metal ion is required, higher activity than Mg2+. Zn2+ or Ni2+ are ineffective