1.13.11.40	Ca2+	Ca2+-regulated enzyme activity	
1.13.11.40	Ca2+	has three Ca2+ binding sites flanked by putative membrane insertion loops in the C2-like domain	
1.13.11.40	Fe2+	the catalytic iron in 8R-LOX is positioned by three invariant His384, His389, and His570 side chains and the terminal main chain. Fe2+ sits in the base of a large U-shaped cavity, positioned by invariant Leu385 on one side, and the iron and His384 and His389 on the other. Leu385 and the catalytic iron cradle the base of the U	
1.13.11.40	Iron	during the hydrogen abstraction step, the hydroxyl group bound to the metal center activates the C-H bond of the double-allylic carbon center of the substrate that leads to the formation of a radical center at the substrate