1.1.1.1 alcohol dehydrogenase membrane - 16020 738721 1.1.1.1 alcohol dehydrogenase membrane 32% of total activity measured 16020 -, 678779 1.1.1.10 L-xylulose reductase membrane - 16020 654968, 655222 1.1.1.102 3-dehydrosphinganine reductase membrane of endoplasmic reticulum 16020 656256 1.1.1.102 3-dehydrosphinganine reductase membrane of endoplasmic reticulum, the large hydrophilic domain, which contains putative active site residues, faces the cytosol 16020 656256 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) membrane - 16020 690842 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) membrane associated with microsomal membrane 16020 285727 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) membrane behaves as an integral membrane protein, RoDH-4 contains four potential membrane-spanning domains 16020 691736 1.1.1.105 all-trans-retinol dehydrogenase (NAD+) membrane of endoplasmic reticulum 16020 691750 1.1.1.14 L-iditol 2-dehydrogenase membrane - 16020 740006 1.1.1.14 L-iditol 2-dehydrogenase membrane bound 16020 -, 655022, 655030, 655289 1.1.1.14 L-iditol 2-dehydrogenase membrane bound, 2 isozymes 16020 -, 654867 1.1.1.140 sorbitol-6-phosphate 2-dehydrogenase membrane GutM 16020 695750 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) membrane - 16020 690004 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) membrane fetal 16020 670524 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase membrane in amnion epithelium, chorion trophoblast and invasive trophoblast immunoreactive 3betaHSD is found from first to third trimester and term 16020 389388 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane - 16020 656356, 668424, 701324 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane anchored within the endoplasmic reticulum membrane with one single N-terminal hydrophobic domain 16020 654698 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane attached to the membrane facing the luminal compartment 16020 657253 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane membrane bound 16020 654637, 655216, 656356 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane membrane bound enzyme with the catalytic domain localized in the lumen of the ER 16020 655218 1.1.1.146 11beta-hydroxysteroid dehydrogenase membrane membrane bound, luminal orientation of 11beta-HSD1 is essential for efficient oxidation of cortisol 16020 656227 1.1.1.18 inositol 2-dehydrogenase membrane - 16020 389434 1.1.1.188 prostaglandin-F synthase membrane - 16020 654851 1.1.1.188 prostaglandin-F synthase membrane associated 16020 657211 1.1.1.188 prostaglandin-F synthase membrane inducible isozyme m-PGFS 16020 654851 1.1.1.189 prostaglandin-E2 9-reductase membrane - 16020 654851 1.1.1.189 prostaglandin-E2 9-reductase membrane fetal 16020 670733 1.1.1.2 alcohol dehydrogenase (NADP+) membrane proximal tubules 16020 -, 667168 1.1.1.201 7beta-hydroxysteroid dehydrogenase (NADP+) membrane - 16020 -, 286228 1.1.1.215 gluconate 2-dehydrogenase membrane - 16020 -, 739910, 760370, 762309 1.1.1.215 gluconate 2-dehydrogenase membrane bound 16020 -, 684567 1.1.1.215 gluconate 2-dehydrogenase membrane membrane-bound 16020 -, 740963 1.1.1.215 gluconate 2-dehydrogenase membrane the enzyme is located on the periplasmic side of the cytoplasmic membrane 16020 -, 685666 1.1.1.219 dihydroflavonol 4-reductase membrane - 16020 -, 706155 1.1.1.22 UDP-glucose 6-dehydrogenase membrane - 16020 761138 1.1.1.238 12beta-hydroxysteroid dehydrogenase membrane - 16020 286353 1.1.1.27 L-lactate dehydrogenase membrane embryonic membrane of oncosphere 16020 700558 1.1.1.27 L-lactate dehydrogenase membrane of infected erythrocytes 16020 656752 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase membrane - 16020 286474 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase membrane membrane-bound 16020 286472, 286473 1.1.1.287 D-arabinitol dehydrogenase (NADP+) membrane bound 16020 -, 658781 1.1.1.289 sorbose reductase membrane - 16020 -, 687381 1.1.1.294 chlorophyll(ide) b reductase membrane NYC1 isoform has three putative membrane-spanning domains, while NOL does not contain any predictable membrane-spanning domains 16020 714334 1.1.1.30 3-hydroxybutyrate dehydrogenase membrane - 16020 655126, 655261 1.1.1.300 NADP-retinol dehydrogenase membrane - 16020 740107 1.1.1.300 NADP-retinol dehydrogenase membrane associated with microsomal membranes 16020 691107 1.1.1.300 NADP-retinol dehydrogenase membrane microsomal membrane 16020 667537 1.1.1.300 NADP-retinol dehydrogenase membrane model of enzyme insertion into the membrane 16020 654687 1.1.1.315 11-cis-retinol dehydrogenase membrane - 16020 690842 1.1.1.315 11-cis-retinol dehydrogenase membrane associated to membrane, and ssequence displays several potential membrane-spanning segments 16020 715421 1.1.1.315 11-cis-retinol dehydrogenase membrane pronounced 11-cis-retinol dehydrogenase activity is associated with both endoplasmic reticulum- and plasma membrane-enriched membrane fractions. In contrast, 11-cis-retinyl ester hydrolase activity is mostly recovered in plasma membrane-enriched fractions, while lecithin retinol acyl transferase LRAT activity is found only in endoplasmic reticulum-enriched membranes 16020 170681 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase membrane - 16020 719240, 719809 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane - 16020 656216, 685680, 689453 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane a transmembrane enzyme 16020 687094 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane bound, isozyme HMGR2, about 25% of total enzyme content 16020 654546 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane contains two transmembrane domains 16020 700117 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane integral 16020 657004 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane lutoid 16020 286568 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) membrane transmembrane protein 16020 654559 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) membrane membrane-associated. The enzyme is located in both the cytoplasm and membrane 16020 -, 761070 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase membrane bound 16020 672317 1.1.1.391 3beta-hydroxycholanate 3-dehydrogenase (NAD+) membrane membrane-bound 16020 -, 286228, 735471 1.1.1.402 D-erythritol 1-phosphate dehydrogenase membrane - 16020 -, 641259 1.1.1.42 isocitrate dehydrogenase (NADP+) membrane - 16020 -, 762504 1.1.1.47 glucose 1-dehydrogenase [NAD(P)+] membrane - 16020 639119, 654400 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase membrane - 16020 659176 1.1.1.62 17beta-estradiol 17-dehydrogenase membrane isoforms 4 and 10 16020 656654 1.1.1.69 gluconate 5-dehydrogenase membrane - 16020 -, 654316, 669549 1.1.1.71 alcohol dehydrogenase [NAD(P)+] membrane - 16020 655563 1.1.1.71 alcohol dehydrogenase [NAD(P)+] membrane integral-membrane protein 16020 740291 1.1.2.11 glucoside 3-dehydrogenase (cytochrome c) membrane - 16020 -, 763936 1.1.2.3 L-lactate dehydrogenase (cytochrome) membrane - 16020 760998 1.1.2.4 D-lactate dehydrogenase (cytochrome) membrane - 16020 684629 1.1.2.6 polyvinyl alcohol dehydrogenase (cytochrome) membrane - 16020 -, 287625 1.1.2.7 methanol dehydrogenase (cytochrome c) membrane - 16020 -, 724402 1.1.2.8 alcohol dehydrogenase (cytochrome c) membrane - 16020 -, 725154 1.1.2.8 alcohol dehydrogenase (cytochrome c) membrane bound 16020 -, 725041 1.1.3.13 alcohol oxidase membrane - 16020 -, 484921, 685404, 698659 1.1.3.13 alcohol oxidase membrane bound 16020 672339 1.1.3.15 (S)-2-hydroxy-acid oxidase membrane membrane associated 16020 659039 1.1.3.18 secondary-alcohol oxidase membrane membrane-bound 16020 -, 287623 1.1.3.18 secondary-alcohol oxidase membrane membranous matrix 16020 -, 287623, 348178, 348180 1.1.3.19 4-hydroxymandelate oxidase (decarboxylating) membrane bound 16020 389729 1.1.3.20 long-chain-alcohol oxidase membrane - 16020 -, 389732, 389734, 389735, 389736, 389737, 389738, 655590, 724083, 94404 1.1.3.20 long-chain-alcohol oxidase membrane bound 16020 672339 1.1.3.20 long-chain-alcohol oxidase membrane located on the inner face of the membrane 16020 -, 710901 1.1.3.20 long-chain-alcohol oxidase membrane sequence contains a predicted membrane binding helix within the substrate binding domain 16020 762915 1.1.3.21 glycerol-3-phosphate oxidase membrane - 16020 -, 741462 1.1.3.21 glycerol-3-phosphate oxidase membrane a minor fraction of GlpD is associated with the membrane 16020 -, 698631 1.1.3.21 glycerol-3-phosphate oxidase membrane membrane-spanning protein 16020 -, 698631 1.1.3.4 glucose oxidase membrane 10% of glucose oxidase activity in the stationary phase and 18% of glucose oxidase activity in the mid-exponential phase is localised in the membrane 16020 -, 696884 1.1.3.4 glucose oxidase membrane 34% of glucose oxidase activity in the stationary phase and 26% of glucose oxidase activity in the mid-exponential phase is localised in the membrane 16020 -, 696884 1.1.3.6 cholesterol oxidase membrane - 16020 697915 1.1.3.6 cholesterol oxidase membrane membrane-bound, not secreted 16020 763657 1.1.3.7 aryl-alcohol oxidase membrane - 16020 389844 1.1.5.10 D-2-hydroxyacid dehydrogenase (quinone) membrane membrane-associated 16020 763205 1.1.5.11 1-butanol dehydrogenase (quinone) membrane - 16020 -, 724087 1.1.5.12 D-lactate dehydrogenase (quinone) membrane - 16020 -, 740028, 740029, 761384 1.1.5.12 D-lactate dehydrogenase (quinone) membrane membrane-associated 16020 763205 1.1.5.14 fructose 5-dehydrogenase membrane - 16020 -, 655081, 724031, 724735, 739769, 740360, 740362, 740364, 740365, 740366, 740368, 760332, 760337, 760656, 760974, 760975, 761604, 762826 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane - 16020 -, 639196, 639197, 639200, 639213, 654865, 687745, 712800, 725039, 741032, 741370 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane bound enzyme m-GDH 16020 -, 654938 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane bound to 16020 639201, 639202, 639207, 639215 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane bound, enzyme mGDH 16020 654864 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane enzyme exists as a soluble form and a membrane-bound form 16020 -, 639199 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane enzyme mGDH 16020 655791 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane inner membrane, the enzyme has a ubiquinone reacting site close to the periplasmic side of the membrane, and thus its electron transfer to ubiquinone appears to be incapable of forming a proton electrochemical gradient across the inner membrane 16020 639211 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane isozyme mPQQGDH 16020 -, 724852 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane isozyme PQQGDH-A 16020 655363 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane it is likely that the C-terminal periplasmic domain of glucose dehydrogenase possesses a ubiquinone-reacting site and transfers electrons directly to ubiquinone 16020 639207 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane membrane-bound enzyme form mGDH 16020 762524 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane membrane-bound, enzyme GDH1 16020 763173 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane outer surface of cytoplasmic membrane 16020 639200 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane outer surface of the cytoplasmic membrane 16020 762778 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone) membrane the enzyme is a membrane integral quinoprotein 16020 724081 1.1.5.3 glycerol-3-phosphate dehydrogenase membrane - 16020 287807, 287813, 287818 1.1.5.3 glycerol-3-phosphate dehydrogenase membrane associated with membrane 16020 287817 1.1.5.4 malate dehydrogenase (quinone) membrane - 16020 -, 287737, 287738, 673714, 723124 1.1.5.4 malate dehydrogenase (quinone) membrane a peripheral membrane protein that can be released from the membrane by addition of chelators 16020 287733 1.1.5.4 malate dehydrogenase (quinone) membrane bound to the cell-wall membrane 16020 -, 696072 1.1.5.4 malate dehydrogenase (quinone) membrane firmly bound to 16020 -, 287619 1.1.5.4 malate dehydrogenase (quinone) membrane mainly 16020 673714 1.1.5.4 malate dehydrogenase (quinone) membrane membrane bound 16020 762760 1.1.5.5 alcohol dehydrogenase (quinone) membrane - 16020 -, 684589, 684665, 685650, 686622, 690794, 711032, 711227, 725154 1.1.5.5 alcohol dehydrogenase (quinone) membrane associated, ADH-GS 16020 677303 1.1.5.5 alcohol dehydrogenase (quinone) membrane bound 16020 -, 685685, 687166, 724087 1.1.5.5 alcohol dehydrogenase (quinone) membrane ubiquinone-reacting subunit, i.e., the subunit II, is responsible for binding to the membrane 16020 -, 724044 1.1.5.7 cyclic alcohol dehydrogenase (quinone) membrane localization of the enzyme on the outer surface of the organism is advantageous to facilitate the oxidative fermentation of the cyclic alcohols. Since cyclic alcohols have some biological toxicity to living cells, according to the mechanism of the oxidative fermentation, there is no need to incorporate such toxic compounds into the cytoplasm 16020 -, 696803 1.1.5.8 quinate/shikimate dehydrogenase (quinone) membrane - 16020 -, 655045, 655046 1.1.5.8 quinate/shikimate dehydrogenase (quinone) membrane transmembrane protein 16020 -, 762315 1.1.5.9 glucose 1-dehydrogenase (FAD, quinone) membrane - 16020 -, 696897, 697670 1.1.5.B1 quinoprotein inositol dehydrogenase membrane bound 16020 688870 1.1.98.4 F420H2:quinone oxidoreductase membrane - 16020 -, 722162, 722290 1.1.99.1 choline dehydrogenase membrane - 16020 -, 389890 1.1.99.1 choline dehydrogenase membrane peripheral membrane protein 16020 389889 1.1.99.13 glucoside 3-dehydrogenase (acceptor) membrane - 16020 389895 1.1.99.2 L-2-hydroxyglutarate dehydrogenase membrane - 16020 699377 1.1.99.20 alkan-1-ol dehydrogenase (acceptor) membrane - 16020 389907, 389908, 389911 1.1.99.21 D-sorbitol dehydrogenase (acceptor) membrane - 16020 -, 724595, 762527 1.1.99.21 D-sorbitol dehydrogenase (acceptor) membrane cytoplasmic membrane 16020 654267 1.1.99.21 D-sorbitol dehydrogenase (acceptor) membrane membrane-bound dehydrogenase 16020 740006 1.1.99.21 D-sorbitol dehydrogenase (acceptor) membrane the membrane-bound dehydrogenase locates on the outer surface of the cytoplasmic membrane. The oxidation products accumulate in the culture medium 16020 -, 740961 1.1.99.22 glycerol dehydrogenase (acceptor) membrane - 16020 -, 287791, 740188, 760731 1.1.99.22 glycerol dehydrogenase (acceptor) membrane bound 16020 -, 721866 1.1.99.22 glycerol dehydrogenase (acceptor) membrane bound to 16020 -, 685690 1.1.99.22 glycerol dehydrogenase (acceptor) membrane cytoplasmic membrane 16020 654267 1.1.99.27 (R)-pantolactone dehydrogenase (flavin) membrane bound 16020 10899 1.1.99.28 glucose-fructose oxidoreductase membrane translocated across the membrane in fully folded form. A twin-arginine motif in the signal peptide directs it to a Sec-independent pathway by which it is translocated, in fully folded form, into the periplasm where it functions to produce sorbitol for osmoprotection 16020 654586 1.1.99.3 gluconate 2-dehydrogenase (acceptor) membrane - 16020 -, 389915, 389916, 656696, 695781, 697598, 700265, 740963 1.1.99.3 gluconate 2-dehydrogenase (acceptor) membrane bound to 16020 684567 1.1.99.3 gluconate 2-dehydrogenase (acceptor) membrane membrane bound 16020 654319 1.1.99.3 gluconate 2-dehydrogenase (acceptor) membrane reconstitutive experiments on the enzyme with membrane fraction from which the enzyme has been solubilized and removed 16020 389919 1.1.99.30 2-oxo-acid reductase membrane bound 16020 287841, 644550, 655713 1.1.99.31 (S)-mandelate dehydrogenase membrane - 16020 762768 1.1.99.31 (S)-mandelate dehydrogenase membrane associated 16020 667565 1.1.99.31 (S)-mandelate dehydrogenase membrane associated, wild-type enzyme 16020 667564 1.1.99.32 L-sorbose 1-dehydrogenase membrane - 16020 -, 677427, 740183, 740220 1.1.99.4 dehydrogluconate dehydrogenase membrane - 16020 -, 389925, 389927, 739910 1.1.99.4 dehydrogluconate dehydrogenase membrane outer surface of cytoplasmic membrane 16020 389926 1.1.99.42 4-pyridoxic acid dehydrogenase membrane - 16020 -, 745235 1.1.99.42 4-pyridoxic acid dehydrogenase membrane recombinant enzyme in Escherichia coli, integral monotopic protein, protruding into a cytoplasm side from the bacterial membrane 16020 -, 745237 1.1.99.6 D-lactate dehydrogenase (acceptor) membrane more than 85% of the enzyme is associated with the membrane, integral membrane protein, a significant portion including part of the FAD-binding pocket, is outside the membrane facing the S-layer. NADH oxidase (NoxA2) co-localized to the same sites in the membrane (NoxA2) may protect proteins involved in electron transfer by reducing O2 to H2O2 or H2O 16020 721463 1.1.99.B7 menaquinol-acceptor oxidoreductase membrane - 16020 -, 739964 1.1.99.B7 menaquinol-acceptor oxidoreductase membrane membrane-bound enzyme complex 16020 722177 1.10.3.1 catechol oxidase membrane - 16020 658955 1.10.3.1 catechol oxidase membrane bound 16020 673001, 674108 1.10.3.1 catechol oxidase membrane membrane-bound 16020 744954 1.10.3.1 catechol oxidase membrane PPO from membrane shows no diphenolase activity unless it is activated by trypsin or sodium dodecyl sulfate 16020 674774 1.10.3.11 ubiquinol oxidase (non-electrogenic) membrane - 16020 -, 715401, 726386 1.10.3.11 ubiquinol oxidase (non-electrogenic) membrane bound to 16020 763818 1.10.3.11 ubiquinol oxidase (non-electrogenic) membrane cytochrome bo3 is the major respiratory oxidase located in the cytoplasmic membrane of Escherichia coli when grown under high oxygen tension 16020 714308 1.10.3.11 ubiquinol oxidase (non-electrogenic) membrane membrane-bound enzyme 16020 764519 1.10.3.11 ubiquinol oxidase (non-electrogenic) membrane outer surface of the cytoplasmic membrane 16020 -, 725319 1.10.3.17 superoxide oxidase membrane - 16020 756071, 757121 1.10.3.17 superoxide oxidase membrane integral membrane protein 16020 757739 1.10.3.2 laccase membrane membrane-bound. Adding nonionic detergents (Triton X100 and Tween-20) does not solubilize the enzyme from the cell membrane. The highest solubilization of MmPPOA is achieved by adding 1% SDS to the lysis buffer 16020 -, 746372 1.10.3.3 L-ascorbate oxidase membrane - 16020 712792 1.10.3.9 photosystem II membrane - 16020 714136, 724348, 724408, 724455, 725119, 742428, 743649 1.10.3.9 photosystem II membrane presence of monogalactosyldiacylglycerol leads to a dimerization of isolated, monomeric PSII core complexes. Presence of sulfoquinovosyldiacylglycerol and phosphatidylglycerol induce a detachment of CP43 from the PSII core, thereby disturbing the intrinsic PSII electron transport 16020 743552 1.11.1.1 NADH peroxidase membrane - 16020 660156 1.11.1.1 NADH peroxidase membrane 40% of enzyme activity in cytoplam and membrane fraction 16020 658146 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase membrane - 16020 672372, 673343 1.11.1.24 thioredoxin-dependent peroxiredoxin membrane 0.05% of cellular Prx2 is bound to the membrane 16020 684498 1.11.1.24 thioredoxin-dependent peroxiredoxin membrane associated with erythrocyte membrane 16020 657380 1.11.1.27 glutathione-dependent peroxiredoxin membrane treatment of A-549 cells with peroxides leads to translocation of Prdx6 from the cytosol to the cell membrane 16020 695877 1.11.1.29 mycoredoxin-dependent peroxiredoxin membrane - 16020 -, 745315 1.11.1.5 cytochrome-c peroxidase membrane - 16020 725756 1.11.1.5 cytochrome-c peroxidase membrane the enzyme is a lipoprotein sarkosyl-soluble 16020 657830 1.11.1.7 peroxidase membrane - 16020 439733, 658949, 743009 1.11.1.8 iodide peroxidase membrane - 16020 439721, 439726, 671592 1.11.1.8 iodide peroxidase membrane integral membrane protein 16020 439716, 439724, 673799 1.11.1.9 glutathione peroxidase membrane - 16020 701160 1.11.1.9 glutathione peroxidase membrane bound to, GPX4 16020 675985 1.11.1.9 glutathione peroxidase membrane GPx-4 16020 684496 1.11.1.9 glutathione peroxidase membrane secreted bound to, GPX5 16020 675985 1.11.2.3 plant seed peroxygenase membrane - 16020 711277, 712329, 712776, 713295, 713303 1.11.2.3 plant seed peroxygenase membrane associated with membrane 16020 724973, 726222 1.11.2.3 plant seed peroxygenase membrane integral membrane protein 16020 712359 1.11.2.4 fatty-acid peroxygenase membrane - 16020 -, 712346 1.12.1.2 hydrogen dehydrogenase membrane - 16020 684199 1.12.2.1 cytochrome-c3 hydrogenase membrane - 16020 -, 395569, 395570, 686734, 701586 1.12.2.1 cytochrome-c3 hydrogenase membrane bound to 16020 -, 395559, 395560, 395567 1.12.7.2 ferredoxin hydrogenase membrane - 16020 -, 439643, 439652, 439657, 659110, 701537, 712301, 712307, 722171, 742859 1.12.7.2 ferredoxin hydrogenase membrane bound to 16020 673529 1.12.7.2 ferredoxin hydrogenase membrane cytoplasmic 16020 439659 1.12.7.2 ferredoxin hydrogenase membrane membrane bound 16020 656734 1.12.7.2 ferredoxin hydrogenase membrane native 14-subunit membrane-bound subcomplex of respiratory membrane-bound hydrogenase 16020 730867 1.12.98.1 coenzyme F420 hydrogenase membrane associated 16020 395085, 395090, 395092 1.12.98.1 coenzyme F420 hydrogenase membrane associated to cytoplasmatic membrane and to inside-out membrane vesicles, attached to membrane by linker peptide of 10000-20000 Da 16020 -, 395098 1.12.98.1 coenzyme F420 hydrogenase membrane membrane-associated protein 16020 673769 1.12.98.1 coenzyme F420 hydrogenase membrane transmembrane protein 16020 764762 1.12.98.3 Methanosarcina-phenazine hydrogenase membrane - 16020 741956 1.12.98.3 Methanosarcina-phenazine hydrogenase membrane membrane-bound enzyme 16020 -, 727829 1.12.98.4 sulfhydrogenase membrane - 16020 -, 437770, 437772, 437774, 437778 1.12.98.4 sulfhydrogenase membrane bound to 16020 659878 1.12.98.4 sulfhydrogenase membrane location of subunit C 16020 674514 1.12.98.4 sulfhydrogenase membrane main activity membrane-bound 16020 437771 1.12.98.4 sulfhydrogenase membrane oriented toward the periplasmic side 16020 437774 1.12.99.6 hydrogenase (acceptor) membrane - 16020 -, 439630, 439646, 658082, 703746, 704518, 711516, 713368, 713401, 726107, 742788, 764975 1.12.99.6 hydrogenase (acceptor) membrane losely membrane-bound, 30% of total activity 16020 710951 1.12.99.6 hydrogenase (acceptor) membrane membrane bound 16020 657739, 659878 1.12.99.6 hydrogenase (acceptor) membrane membrane-bound 16020 -, 764154 1.12.99.6 hydrogenase (acceptor) membrane membrane-bound, enzyme is oriented to the periplasmic space 16020 659355 1.12.99.6 hydrogenase (acceptor) membrane periplasmic-facing membrane-bound complex 16020 -, 764102 1.12.99.6 hydrogenase (acceptor) membrane the hydrogenase dimer is electronically connected to a membrane-integral cytochrome b 16020 704489 1.13.11.31 arachidonate 12-lipoxygenase membrane - 16020 671591, 688759 1.13.11.31 arachidonate 12-lipoxygenase membrane bound to 16020 395433 1.13.11.31 arachidonate 12-lipoxygenase membrane membrane binding activities of wild-type platelet 12-lipoxygenase and mutant enzymes at pH 7.4, role of the PLAT domain membrane binding, overview 16020 688398 1.13.11.33 arachidonate 15-lipoxygenase membrane - 16020 672376, 673030 1.13.11.33 arachidonate 15-lipoxygenase membrane Ca2+ binds to the PLAT domain of 15-LOX-2, resulting in a translocation from the cytosol to the membrane 16020 741942 1.13.11.33 arachidonate 15-lipoxygenase membrane enzyme is translocated to the membrane upon calcium challenge 16020 706579 1.13.11.33 arachidonate 15-lipoxygenase membrane the enzyme associates to biomembranes primarily via hydrophobic interactions between surface-exposed apolar amino acid side chains and membrane lipids. Calcium supports membrane binding probably by forming salt bridges between the negatively charged head groups of membrane phospholipids and acidic surface amino acids of the membrane 16020 659378 1.13.11.33 arachidonate 15-lipoxygenase membrane the enzyme translocates to the membrane upon calcium challenge. In the presence of Ca2+/Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is present in the membrane fraction 16020 703628 1.13.11.34 arachidonate 5-lipoxygenase membrane calcium binds to allosteric sites in the 5-LOX N-terminal polycystin-1/lipoxygenase/alpha-toxin (PLAT) domain, promoting attachment to the membrane via conserved tryptophan residues that embed into the lipid bilayer 16020 741898 1.13.11.34 arachidonate 5-lipoxygenase membrane the enzyme is activated by a Ca2+-mediated translocation to membranes. The enzyme binds to membranes at a defined orientation with the symmetry axis of the putative N-terminal beta-barrel tilted about 45° from the membrane normal 16020 658043 1.13.11.34 arachidonate 5-lipoxygenase membrane translocates from the cytosol to the membrane upon stimulation in female neutrophils 16020 704997 1.13.11.58 linoleate 9S-lipoxygenase membrane - 16020 674121 1.13.11.75 all-trans-8'-apo-beta-carotenal 15,15'-oxygenase membrane monotopic membrane protein 16020 707425 1.13.11.84 crocetin dialdehyde synthase membrane - 16020 744176 1.13.12.5 Renilla-type luciferase membrane membrane-anchored 16020 700367 1.13.12.8 Watasenia-luciferin 2-monooxygenase membrane - 16020 439323, 671720 1.14.11.16 peptide-aspartate beta-dioxygenase membrane membrane-associated 16020 725118 1.14.11.16 peptide-aspartate beta-dioxygenase membrane transmembrane protein 16020 743882 1.14.11.16 peptide-aspartate beta-dioxygenase membrane type 2 transmembrane protein. The enzyme can translocate to cell membrane from the endoplasmic reticulum membrane when it is overexpressed in cancer cell, which hydroxylate proteins such as Notch, Jagged, and cellular adhesion molecules that regulate cell migration and invasion 16020 742226 1.14.11.2 procollagen-proline 4-dioxygenase membrane - 16020 676492 1.14.11.2 procollagen-proline 4-dioxygenase membrane of endoplasmic reticulum, the catalytic site is inside the lumen 16020 687622 1.14.11.4 procollagen-lysine 5-dioxygenase membrane enzyme binds to membrane via weak electrostatic interactions 16020 439163 1.14.11.4 procollagen-lysine 5-dioxygenase membrane peripheral 16020 657816 1.14.12.17 nitric oxide dioxygenase membrane - 16020 658796 1.14.12.17 nitric oxide dioxygenase membrane associated 16020 658747 1.14.13.101 senecionine N-oxygenase membrane bound to 16020 689412 1.14.13.114 6-hydroxynicotinate 3-monooxygenase membrane bound to 16020 -, 697700 1.14.13.14 trans-cinnamate 2-monooxygenase membrane lamellar, 50% of the hydroxylase activity 16020 439038 1.14.13.148 trimethylamine monooxygenase membrane - 16020 717229 1.14.13.161 (+)-camphor 6-exo-hydroxylase membrane light membrane fraction 16020 717146 1.14.13.161 (+)-camphor 6-exo-hydroxylase membrane microsomal membrane 16020 718227 1.14.13.195 L-ornithine N5-monooxygenase (NADPH) membrane a substantial amount of the enzyme is located in the membrane fraction. It is mainly clustered at the old cell pole of bacteria, indicating a polar segregation of the protein 16020 724860 1.14.13.25 methane monooxygenase (soluble) membrane - 16020 685262 1.14.13.25 methane monooxygenase (soluble) membrane bound 16020 675083 1.14.13.25 methane monooxygenase (soluble) membrane membrane-bound particulate enzyme form termed pMMO 16020 438946 1.14.13.38 anhydrotetracycline 6-monooxygenase membrane predominantly, low-production strain 16020 -, 438863 1.14.13.39 nitric-oxide synthase (NADPH) membrane - 16020 -, 440202, 440230, 673804, 675520, 725610 1.14.13.39 nitric-oxide synthase (NADPH) membrane constitutive endothelial enzyme: predominantly membrane-bound, inducible macrophage enzyme: equally distributed between cytosol and membrane, small constitutive membrane-bound portion in murine macrophages 16020 440204 1.14.13.39 nitric-oxide synthase (NADPH) membrane NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya 16020 743260 1.14.13.39 nitric-oxide synthase (NADPH) membrane total NOS activity is enriched in the intracellular membrane fraction at normal salt diet 16020 697412 1.14.13.50 pentachlorophenol monooxygenase membrane enzyme is synthesized in the cytoplasm, then integrated in the inner membranes and finally translocated to the periplasm 16020 438821 1.14.13.59 L-lysine N6-monooxygenase (NADPH) membrane enzyme from strain EN222 and strain GR143 16020 207906 1.14.13.8 flavin-containing monooxygenase membrane - 16020 684678, 764051, 764558, 764559, 764561 1.14.13.8 flavin-containing monooxygenase membrane associated 16020 671599 1.14.13.8 flavin-containing monooxygenase membrane FMO3 is membrane-bound 16020 764033 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase membrane - 16020 636329, 728517 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase membrane significant portion of the protein is not accessible to proteases, chlorosome envelop is a special lipid monolayer, complement of chlorophyll pigments, self-assembled into antenna structures 16020 -, 698617 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase membrane the aerobic cyclase is composed of three gene products, a soluble protein, a membrane-bound component encoded by xantha-l, and another membrane-bound component encoded by viridis-k 16020 676791 1.14.13.9 kynurenine 3-monooxygenase membrane - 16020 764298 1.14.13.9 kynurenine 3-monooxygenase membrane enzyme is hydrophobis and contains 2 transmembrane segments 16020 -, 658919 1.14.13.9 kynurenine 3-monooxygenase membrane specifically, KMO is localised to the outer membrane of mitochondria where it associates with the lipid membrane using C-terminal transmembrane domains, which are also crucial for the catalytic activity of KMO 16020 764034 1.14.13.92 phenylacetone monooxygenase membrane associated 16020 659371 1.14.14.1 unspecific monooxygenase membrane - 16020 764521 1.14.14.107 ent-kaurenoic acid monooxygenase membrane - 16020 660237 1.14.14.117 aflatoxin B synthase membrane - 16020 -, 722440 1.14.14.126 beta-amyrin 28-monooxygenase membrane - 16020 744248, 746004 1.14.14.126 beta-amyrin 28-monooxygenase membrane a transmembrane enzyme 16020 746049 1.14.14.127 methyl farnesoate epoxidase membrane the enzyme has a membrane anchor region at amino acids 2-19, the transmembrane region is located at amino acids 141-158 16020 746473 1.14.14.136 deoxysarpagine hydroxylase membrane associated 16020 658260 1.14.14.142 8-dimethylallylnaringenin 2'-hydroxylase membrane the enzyme is tightly bound to the membrane 16020 676359 1.14.14.154 sterol 14alpha-demethylase membrane - 16020 -, 285344, 285349, 285350, 671727, 672337, 674700, 676589, 684486, 701727, 710892 1.14.14.154 sterol 14alpha-demethylase membrane membrane-bound 16020 -, 285344, 285355 1.14.14.17 squalene monooxygenase membrane - 16020 438200, 684673 1.14.14.17 squalene monooxygenase membrane integral membrane protein 16020 734315 1.14.14.17 squalene monooxygenase membrane membrane-associated enzyme 16020 686339 1.14.14.17 squalene monooxygenase membrane PgSQE1 contains 4 putative transmembrane helices 16020 700657 1.14.14.17 squalene monooxygenase membrane PgSQE2 contains 3 putative transmembrane helices 16020 700657 1.14.14.174 geranylhydroquinone 3''-hydroxylase membrane protein is anchored to the endoplasmic reticulum membrane 16020 758052 1.14.14.176 taxadiene 5alpha-hydroxylase membrane - 16020 746375 1.14.14.177 ultra-long-chain fatty acid omega-hydroxylase membrane type I membrane protein that locates in the endoplasmic reticulum 16020 762269 1.14.14.18 heme oxygenase (biliverdin-producing) membrane - 16020 685099, 701661, 727284 1.14.14.18 heme oxygenase (biliverdin-producing) membrane presence of the membrane-spanning region on HO-1 is required for efficient membrane incorporation, which is achieved after a 2 h preincubation period at room temperature 16020 703420 1.14.14.18 heme oxygenase (biliverdin-producing) membrane recombinant heme oxygenase-2 expressed in Escherichia coli 16020 438263 1.14.14.19 steroid 17alpha-monooxygenase membrane - 16020 688687, 733413 1.14.14.19 steroid 17alpha-monooxygenase membrane bound 16020 680978, 685308 1.14.14.25 cholesterol 24-hydroxylase membrane - 16020 695874 1.14.14.25 cholesterol 24-hydroxylase membrane associated 16020 712869 1.14.14.25 cholesterol 24-hydroxylase membrane truncated enzymes are distributed at about a 1:1 ratio between the membrane fraction and the cytosol in low ionic strength buffer, when expressed in Escherichia coli 16020 657671 1.14.14.3 bacterial luciferase membrane - 16020 348550 1.14.14.36 tyrosine N-monooxygenase membrane - 16020 390080, 738563, 739318 1.14.14.37 4-hydroxyphenylacetaldehyde oxime monooxygenase membrane - 16020 723366, 739318 1.14.14.58 trimethyltridecatetraene synthase membrane - 16020 746029 1.14.14.83 geraniol 8-hydroxylase membrane - 16020 714525, 715004, 715234, 715730, 716446, 717532, 718237, 744287 1.14.14.83 geraniol 8-hydroxylase membrane G10H is a transmembrane protein containing a transmembrane helix at the N-terminus 16020 746070 1.14.14.83 geraniol 8-hydroxylase membrane membrane-bound 16020 -, 743431 1.14.14.86 ent-kaurene monooxygenase membrane membrane associated 16020 660237 1.14.14.87 2-hydroxyisoflavanone synthase membrane - 16020 727120 1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase membrane - 16020 -, 710753 1.14.14.90 isoflavone 2'-hydroxylase membrane transmembrane enzyme 16020 746367 1.14.14.91 trans-cinnamate 4-monooxygenase membrane endomembrane-bound, colocalization with L-Phe ammonia lyase 16020 660129 1.14.14.92 benzoate 4-monooxygenase membrane membrane associated 16020 440254 1.14.14.B11 nicotine demethylase membrane putative N-terminal hydrophobic trans-membrane domain 16020 700634 1.14.15.16 vitamin D3 24-hydroxylase membrane CYP24A1 is a membrane-bound hemoprotein 16020 736086 1.14.15.17 pheophorbide a oxygenase membrane - 16020 676564 1.14.15.24 beta-carotene 3-hydroxylase membrane - 16020 -, 728232 1.14.15.26 toluene methyl-monooxygenase membrane - 16020 745194, 745471 1.14.15.3 alkane 1-monooxygenase membrane - 16020 -, 658713, 659024, 659063, 659069, 744267 1.14.15.3 alkane 1-monooxygenase membrane AlkB is an integral membrane monooxygenase 16020 -, 723970 1.14.15.3 alkane 1-monooxygenase membrane AlkB is the integral membrane component of the Pseudomonas putida alkane hydroxylase system 16020 -, 724025 1.14.15.3 alkane 1-monooxygenase membrane integral membrane protein with six membrane-spanning segments 16020 661999 1.14.15.3 alkane 1-monooxygenase membrane integral membrane-bound protein 16020 -, 713529 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) membrane - 16020 704039, 744728 1.14.16.2 tyrosine 3-monooxygenase membrane particle-bound 16020 438687 1.14.16.5 alkylglycerol monooxygenase membrane - 16020 696542 1.14.16.5 alkylglycerol monooxygenase membrane bound to 16020 438648 1.14.17.1 dopamine beta-monooxygenase membrane - 16020 438597, 438626 1.14.17.1 dopamine beta-monooxygenase membrane recombinant enzyme 16020 438627 1.14.17.1 dopamine beta-monooxygenase membrane the membranous enzyme may be the physiologically functional form 16020 659320 1.14.17.3 peptidylglycine monooxygenase membrane - 16020 438579, 438581, 659916, 699036 1.14.17.3 peptidylglycine monooxygenase membrane enzyme PAM is a type I integral membrane protein 16020 745296 1.14.17.3 peptidylglycine monooxygenase membrane from neurosecretory vesicles 16020 438587 1.14.17.3 peptidylglycine monooxygenase membrane integral membrane 16020 438587 1.14.17.3 peptidylglycine monooxygenase membrane particulate form, except for abdominal ganglia 16020 438586 1.14.17.3 peptidylglycine monooxygenase membrane recombinant bifunctional enzyme form 2, uncleaved in insect cells 16020 438583 1.14.17.3 peptidylglycine monooxygenase membrane transmembranal protein 16020 438584 1.14.17.3 peptidylglycine monooxygenase membrane transmembrane protein with lumenal and cytoplasmic parts, overview, abundant in atrial secretory vesicles 16020 658458 1.14.18.1 tyrosinase membrane - 16020 636401, 687224 1.14.18.1 tyrosinase membrane a transmembrane enzyme 16020 745746 1.14.18.1 tyrosinase membrane bound 16020 673001, 674108 1.14.18.1 tyrosinase membrane membrane associated enzyme, deletion of the anchoring helix does not affect the tyrosinase activity 16020 744758 1.14.18.1 tyrosinase membrane membrane-bound 16020 744671 1.14.18.1 tyrosinase membrane tyrosinase is a membrane glycoprotein 16020 744758 1.14.18.10 plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase membrane - 16020 728806 1.14.18.2 CMP-N-acetylneuraminate monooxygenase membrane bound to 16020 639320, 639331 1.14.18.3 methane monooxygenase (particulate) membrane - 16020 -, 438940, 438942, 673739, 684112, 685113, 686085, 686796, 687284, 689789, 690034, 701759, 702170, 702501, 703343, 705192, 706752, 712040, 713934, 715208, 716108, 716109, 716110, 726954, 727340, 728079, 745154, 745721, 745730, 746420 1.14.18.3 methane monooxygenase (particulate) membrane an integral membrane metalloenzyme 16020 -, 745067 1.14.18.3 methane monooxygenase (particulate) membrane associated 16020 -, 657810, 659033, 675831 1.14.18.3 methane monooxygenase (particulate) membrane bound 16020 -, 672301 1.14.18.3 methane monooxygenase (particulate) membrane bound to 16020 -, 660351 1.14.18.3 methane monooxygenase (particulate) membrane bound, pMMO 16020 -, 671965 1.14.18.3 methane monooxygenase (particulate) membrane enzyme from cells grown under conditions of high copper availability is membrane-bound 16020 -, 438927, 438952 1.14.18.3 methane monooxygenase (particulate) membrane integral membrane protein 16020 684114 1.14.18.3 methane monooxygenase (particulate) membrane intracytoplasmic membrane 16020 671477 1.14.18.3 methane monooxygenase (particulate) membrane membrane-bound 16020 -, 744325, 745305, 745389, 746420 1.14.18.3 methane monooxygenase (particulate) membrane membrane-bound particulate enzyme form termed pMMO 16020 -, 438944, 438951, 438952 1.14.18.3 methane monooxygenase (particulate) membrane membrane-bound pMMO is expressed abundantly in high surface area 16020 -, 745857 1.14.18.4 phosphatidylcholine 12-monooxygenase membrane an integral membrane protein, proposed topological model, overview 16020 -, 746157 1.14.18.5 sphingolipid C4-monooxygenase membrane integral membrane protein 16020 -, 719795 1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase membrane protein contains four potential transmembrane domains 16020 734146 1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase membrane protein is predicted to have two hydrophobic domains, each capable of spanning the membrane twice, and has the HX(2-3)(XH)H motifs that are characteristic of membrane-bound fatty acid desaturases 16020 734124 1.14.18.9 4alpha-methylsterol monooxygenase membrane - 16020 -, 658182, 698075 1.14.19.1 stearoyl-CoA 9-desaturase membrane - 16020 688772, 746212, 746433 1.14.19.1 stearoyl-CoA 9-desaturase membrane bound 16020 -, 437650, 437666, 437667, 437670 1.14.19.1 stearoyl-CoA 9-desaturase membrane integral 16020 -, 687427 1.14.19.1 stearoyl-CoA 9-desaturase membrane membrane-bound enzyme 16020 -, 699599 1.14.19.1 stearoyl-CoA 9-desaturase membrane transmembrane enzyme 16020 745668, 746444 1.14.19.13 acyl-CoA 15-desaturase membrane integral membrane enzyme 16020 745061 1.14.19.13 acyl-CoA 15-desaturase membrane membrane-bound 16020 746012 1.14.19.17 sphingolipid 4-desaturase membrane - 16020 734141 1.14.19.18 sphingolipid 8-(E)-desaturase membrane - 16020 726865, 728540 1.14.19.19 sphingolipid 10-desaturase membrane - 16020 -, 733169, 746436 1.14.19.20 DELTA7-sterol 5(6)-desaturase membrane - 16020 733470 1.14.19.20 DELTA7-sterol 5(6)-desaturase membrane a transmembrane protein 16020 746220 1.14.19.20 DELTA7-sterol 5(6)-desaturase membrane bound 16020 682873 1.14.19.21 cholesterol 7-desaturase membrane the enzyme sequence contains the transmembrane motif 33WxxF59 16020 744745 1.14.19.21 cholesterol 7-desaturase membrane transmembrane protein 16020 735284 1.14.19.22 acyl-lipid omega-6 desaturase (cytochrome b5) membrane transmembrane enzyme 16020 745739 1.14.19.23 acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) membrane - 16020 732837 1.14.19.24 acyl-CoA 11-(E)-desaturase membrane bound to 16020 285465 1.14.19.25 acyl-lipid omega-3 desaturase (cytochrome b5) membrane transmembrane domains analysis 16020 746063 1.14.19.28 sn-1 stearoyl-lipid 9-desaturase membrane - 16020 -, 745749 1.14.19.28 sn-1 stearoyl-lipid 9-desaturase membrane according to transmembrane helices prediction, the protein has two hydrophobic domains located between amino acids 10-32 and 135-157 and thought to be long enough to span the membrane bilayer two times with the two protein termini facing the cytosol 16020 -, 746210 1.14.19.28 sn-1 stearoyl-lipid 9-desaturase membrane membrane-bound 16020 -, 745715, 746429 1.14.19.29 sphingolipid 8-(E/Z)-desaturase membrane - 16020 726865 1.14.19.3 acyl-CoA 6-desaturase membrane - 16020 -, 700115, 745702 1.14.19.3 acyl-CoA 6-desaturase membrane bound 16020 745517 1.14.19.3 acyl-CoA 6-desaturase membrane prediction of transmembrane helices and topology for Ma-FADS6 16020 -, 745514 1.14.19.3 acyl-CoA 6-desaturase membrane prediction of transmembrane helices and topology for MpFADS6 16020 -, 745514 1.14.19.3 acyl-CoA 6-desaturase membrane the enzyme contains three presumptive transmembrane regions located at regions of 194-216, 249-266 and 360-382 bp 16020 -, 744584 1.14.19.30 acyl-lipid (8-3)-desaturase membrane - 16020 734131 1.14.19.31 acyl-lipid (7-3)-desaturase membrane membrane-bound enzyme, showing all characteristic features of a membrane-bound desaturase, including three histidine boxes and a transit peptide for chloroplast targeting 16020 733753 1.14.19.35 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) membrane - 16020 -, 733913, 734666, 734740, 746058 1.14.19.35 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) membrane enzymes FAD8 and FAD7 might be located in close vicinity in the envelope membrane 16020 -, 745809 1.14.19.36 sn-1 acyl-lipid omega-3 desaturase (ferredoxin) membrane enzymes FAD8 and FAD7 might be located in close vicinity in the envelope membrane 16020 -, 745809 1.14.19.36 sn-1 acyl-lipid omega-3 desaturase (ferredoxin) membrane transmembrane domains at residues 43-65, 71-93, 200-222, and 231-253 16020 733245 1.14.19.39 acyl-lipid DELTA12-acetylenase membrane an integral membrane-bound protein 16020 -, 679861 1.14.19.39 acyl-lipid DELTA12-acetylenase membrane transmembrane enzyme 16020 745739 1.14.19.4 acyl-lipid (11-3)-desaturase membrane - 16020 726865 1.14.19.40 hex-5-enoyl-[acyl-carrier protein] acetylenase membrane - 16020 734746 1.14.19.43 palmitoyl-[glycerolipid] 3-(E)-desaturase membrane integral membrane protein 16020 734910 1.14.19.44 acyl-CoA (8-3)-desaturase membrane - 16020 734131 1.14.19.45 sn-1 oleoyl-lipid 12-desaturase membrane - 16020 -, 733169 1.14.19.45 sn-1 oleoyl-lipid 12-desaturase membrane integral membrane enzyme 16020 745061 1.14.19.45 sn-1 oleoyl-lipid 12-desaturase membrane membrane-bound 16020 746429 1.14.19.46 sn-1 linoleoyl-lipid 6-desaturase membrane - 16020 733373 1.14.19.5 acyl-CoA 11-(Z)-desaturase membrane bound to 16020 285465 1.14.19.6 acyl-CoA (9+3)-desaturase membrane - 16020 -, 687603, 733844, 735250 1.14.19.6 acyl-CoA (9+3)-desaturase membrane bound to, solubilization of membrane bound enzyme 16020 660085 1.14.19.6 acyl-CoA (9+3)-desaturase membrane membrane-bound 16020 746012 1.14.19.6 acyl-CoA (9+3)-desaturase membrane presence of more than three transmembrane helices in the enzyme 16020 744071 1.14.19.6 acyl-CoA (9+3)-desaturase membrane transmembrane enzyme 16020 745739 1.14.19.68 (S)-canadine synthase membrane bound to 16020 743234 1.14.19.76 flavone synthase II membrane bound to 16020 751827 1.14.19.77 plasmanylethanolamine desaturase membrane - 16020 755545 1.14.19.77 plasmanylethanolamine desaturase membrane bound 16020 727110 1.14.19.77 plasmanylethanolamine desaturase membrane transmembrane protein 16020 758252 1.14.99.1 prostaglandin-endoperoxide synthase membrane - 16020 671047, 672161, 673508, 674649, 744393 1.14.99.1 prostaglandin-endoperoxide synthase membrane associated 16020 715514 1.14.99.1 prostaglandin-endoperoxide synthase membrane bound 16020 727083 1.14.99.1 prostaglandin-endoperoxide synthase membrane membrane associated glycoprotein 16020 728736 1.14.99.14 progesterone 11alpha-monooxygenase membrane - 16020 438358, 438359, 438360, 438363 1.14.99.24 steroid 9alpha-monooxygenase membrane - 16020 -, 438296 1.14.99.38 cholesterol 25-monooxygenase membrane - 16020 727109 1.14.99.38 cholesterol 25-monooxygenase membrane polytopic membrane protein 16020 659137 1.14.99.39 ammonia monooxygenase membrane - 16020 727758 1.14.99.39 ammonia monooxygenase membrane associated 16020 697922, 697923 1.14.99.39 ammonia monooxygenase membrane bound 16020 -, 727350 1.14.99.39 ammonia monooxygenase membrane bound to 16020 657688, 697600 1.14.99.39 ammonia monooxygenase membrane membrane-associated 16020 -, 744103 1.14.99.39 ammonia monooxygenase membrane membrane-bound 16020 -, 744760, 746404 1.14.99.39 ammonia monooxygenase membrane the enzyme resides in the cytoplasm of the bacteria in addition to its location in the membrane and is distributed approximately equally in both subcellular fractions 16020 696547 1.14.99.52 L-cysteinyl-L-histidinylsulfoxide synthase membrane - 16020 -, 733647 1.14.99.60 3-demethoxyubiquinol 3-hydroxylase membrane - 16020 748149 1.16.1.10 ferric-chelate reductase [NAD(P)H] membrane - 16020 -, 722516 1.16.1.7 ferric-chelate reductase (NADH) membrane lower activity compared to cytosol 16020 -, 727183 1.16.1.7 ferric-chelate reductase (NADH) membrane structure contains 8 transmembrane helices, 4 of which build up the highly conserved core of the protein. The large water soluble domain contains NADPH, FAD and oxidoreductase sequence motifs and is situated on the inside of the membrane 16020 676551 1.16.1.9 ferric-chelate reductase (NADPH) membrane - 16020 723258, 728418 1.16.1.9 ferric-chelate reductase (NADPH) membrane a transmembrane protein 16020 676551 1.16.3.1 ferroxidase membrane - 16020 438028, 438029 1.16.3.1 ferroxidase membrane membrane associated probably by lipidation after export across the inner membrane by the twin-arginine translocation system 16020 -, 763203 1.16.3.1 ferroxidase membrane no predicted signal peptide, but a putative N-terminal transmembrane helix, from amino acid 61-83, is predicted from the enzyme sequence. AaMco1 presents a predicted N-terminal transmembrane helix and lacks the COOH-terminal transmembrane domain common to ferroxidases 16020 -, 744437 1.16.9.1 iron:rusticyanin reductase membrane - 16020 713816, 715046 1.16.9.1 iron:rusticyanin reductase membrane an outer membrane protein 16020 -, 715348 1.16.9.1 iron:rusticyanin reductase membrane the cytochrome c Cyc2 is outer membrane-bound 16020 715493 1.17.1.4 xanthine dehydrogenase membrane milk phospholipid membrane, mixture of xanthine oxidase and xanthine dehydrogenase, with a clear predominance of xanthine dehydrogenase 16020 687105 1.17.1.5 nicotinate dehydrogenase membrane - 16020 -, 644529 1.17.1.9 formate dehydrogenase membrane - 16020 740775, 740974 1.17.3.2 xanthine oxidase membrane co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin 16020 684329 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane - 16020 724119, 724460, 725987 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane contains at least one transmembrane domain 16020 656866 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane integral protein 16020 676838 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane intramembrane enzyme 16020 745849 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane topological view of the the membrane spanning enzyme with these four exoplasmic cysteine residues 16020 745224 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane transmembrane protein 16020 701401 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane transmembrane protein with 5 transmembrane helices, membrane topology, overview 16020 716060 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane VKOR is an integral membrane protein 16020 715657 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive) membrane VKORC1L1 is a four-transmembrane domain protein with both its termini located in the cytoplasm 16020 745318 1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive) membrane - 16020 724119 1.17.5.1 phenylacetyl-CoA dehydrogenase membrane bound 16020 644661, 644662 1.17.5.3 formate dehydrogenase-N membrane alpha and beta subunits of Fdh-N are on the periplasmic side of the membrane 16020 677117 1.17.5.3 formate dehydrogenase-N membrane bound to 16020 695312, 698645, 698681 1.17.5.3 formate dehydrogenase-N membrane bound to. The FdnG subunit carries a Tat-dependent signal peptide, which localizes the protein complex to the periplasmic side of the membrane 16020 698568 1.17.5.3 formate dehydrogenase-N membrane in the proton motive system of the formate dehydrogenase the donor oxidation and quinone reduction sites are located at opposite sides of the membrane 16020 696383 1.17.9.1 4-methylphenol dehydrogenase (hydroxylating) membrane a tightly membrane-bound PCMH complex exists in anaerobic organisms in contrast to aerobic ones, where the enzyme is soluble and periplasmic, nevertheless the membrane complex has soluble components, overview 16020 687426 1.17.9.1 4-methylphenol dehydrogenase (hydroxylating) membrane a tightly membrane-bound PCMH complex exists in anaerobic organisms in cotrast to aerobic ones, where the enzyme is soluble and periplasmic, overview 16020 674335 1.17.98.4 formate dehydrogenase (hydrogenase) membrane bound to. The alphabeta catalytic dimer is located in the cytoplasm, with a C-terminal anchor for beta protruding into the periplasm. The gamma subunit, which specifies cytochrome b, crosses the cytoplasmic membrane four times, with the N and C termini exposed to the cytoplasm 16020 698554 1.17.99.2 ethylbenzene hydroxylase membrane - 16020 -, 285472 1.17.99.9 heme a synthase membrane - 16020 -, 759424, 759427 1.17.99.9 heme a synthase membrane membrane protein with 8 transmembrane segments 16020 -, 759191 1.17.99.9 heme a synthase membrane membrane-bound enzyme 16020 -, 759190 1.17.99.9 heme a synthase membrane the deduced protein sequence indicates that the enzyme is a 35-kDa intrinsic membrane protein with seven hydrophobic segments 16020 758929 1.17.99.9 heme a synthase membrane the enzyme has eight transmembrane helices 16020 -, 759435 1.18.1.2 ferredoxin-NADP+ reductase membrane - 16020 744415 1.18.1.2 ferredoxin-NADP+ reductase membrane weakly bound 16020 660065 1.18.1.3 ferredoxin-NAD+ reductase membrane - 16020 -, 727962, 745194, 745340, 745970 1.18.1.6 adrenodoxin-NADP+ reductase membrane - 16020 719398, 746501 1.18.1.6 adrenodoxin-NADP+ reductase membrane the enzyme is partly embedded in the membrane 16020 719386 1.18.1.6 adrenodoxin-NADP+ reductase membrane the enzyme is weakly associated with the membrane 16020 718572 1.2.1.10 acetaldehyde dehydrogenase (acetylating) membrane - 16020 738721 1.2.1.104 pyruvate dehydrogenase system membrane - 16020 348971 1.2.1.105 2-oxoglutarate dehydrogenase system membrane - 16020 655234 1.2.1.107 glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) membrane - 16020 761413 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) membrane - 16020 654849, 672330, 673629, 673706, 675023, 676259, 724415 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) membrane intact ex vivo larvae and 5 day old in vitro grown larvae express glyceraldehyde 3-phosphate dehydrogenase on their surface membrane 16020 698033 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) membrane isolated from human erytrocyt ghosts 16020 287945, 287950 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) membrane membrane proteins extracted from rat heart 16020 674503 1.2.1.4 aldehyde dehydrogenase (NADP+) membrane - 16020 437830, 437831 1.2.1.4 aldehyde dehydrogenase (NADP+) membrane intracytoplasmic membrane 16020 437832 1.2.1.42 hexadecanal dehydrogenase (acylating) membrane - 16020 288211, 724656, 763440 1.2.1.48 long-chain-aldehyde dehydrogenase membrane also present in other cellular membranes 16020 389732 1.2.1.48 long-chain-aldehyde dehydrogenase membrane localized primarily in the membrane of wax bodies 16020 389732, 94404 1.2.1.48 long-chain-aldehyde dehydrogenase membrane membrane-bound. Membrane interaction of FALDH via its C-terminal transmembrane membrane domain, detailed overview 16020 743336 1.2.1.5 aldehyde dehydrogenase [NAD(P)+] membrane isoforms ALDH3F1 and ALDH3H1 16020 741167 1.2.1.50 long-chain acyl-protein thioester reductase membrane - 16020 -, 288215 1.2.1.70 glutamyl-tRNA reductase membrane - 16020 763567 1.2.1.84 alcohol-forming fatty acyl-CoA reductase membrane - 16020 656242 1.2.1.84 alcohol-forming fatty acyl-CoA reductase membrane a membrane-associated enzyme 16020 743538 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase membrane - 16020 -, 392044, 740744 1.2.2.1 formate dehydrogenase (cytochrome) membrane - 16020 695921 1.2.2.1 formate dehydrogenase (cytochrome) membrane cytoplasmic membrane. Transmembranous locations of the 32000 Da subunit and the 110000 Da subunit 16020 390368 1.2.2.B1 quinoprotein formaldehyde dehydrogenase (cytochrome b559/569) membrane associated 16020 -, 288469 1.2.2.B2 quinoprotein formaldehyde dehydrogenase (cytochrome cL) membrane the enzyme is loosely bound to the intracellular membrane 16020 389944 1.2.3.4 oxalate oxidase membrane - 16020 288380, 288381 1.2.3.4 oxalate oxidase membrane localization close to the membranous structures of the cell membranes 16020 763142 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) membrane subunits PdhA and PdhB are found both on the surface membrane and within soluble cytosolic fractions 16020 -, 763445 1.2.5.1 pyruvate dehydrogenase (quinone) membrane peripheral membrane enzyme 16020 288353 1.2.5.1 pyruvate dehydrogenase (quinone) membrane peripheral membrane-associated enzyme 16020 -, 707462 1.2.5.2 aldehyde dehydrogenase (quinone) membrane - 16020 -, 288470, 288472, 288474, 685650 1.2.5.2 aldehyde dehydrogenase (quinone) membrane bound 16020 687166 1.2.5.2 aldehyde dehydrogenase (quinone) membrane membrane-bound complex 16020 -, 731999 1.2.5.3 aerobic carbon monoxide dehydrogenase membrane role of the pleckstrin homology domain of enzyme CoxG in recruiting CO dehydrogenase to the cytoplasmic membrane enabling electron transfer from the enzyme to the respiratory chain 16020 736513 1.2.5.3 aerobic carbon monoxide dehydrogenase membrane the enzyme's physiological position is on the inner side of the cytoplasmic membrane, membrane associated, if not membrane-integral 16020 736514 1.2.7.1 pyruvate synthase membrane - 16020 -, 725902 1.2.7.1 pyruvate synthase membrane about 4% of activity detected in membrane 16020 725907 1.2.7.12 formylmethanofuran dehydrogenase membrane - 16020 741352 1.2.7.4 anaerobic carbon-monoxide dehydrogenase membrane - 16020 655446, 674921 1.20.2.1 arsenate reductase (cytochrome c) membrane - 16020 -, 714842 1.20.9.1 arsenate reductase (azurin) membrane about 90% of enzyme activity within the membrane fraction 16020 696599 1.21.1.1 iodotyrosine deiodinase membrane - 16020 704417 1.21.1.1 iodotyrosine deiodinase membrane enzyme SUP-18 is a type-I transmembrane protein that can function independently of membrane anchoring 16020 734996 1.21.1.1 iodotyrosine deiodinase membrane transmembrane enzyme 16020 734321 1.21.1.1 iodotyrosine deiodinase membrane transmembrane protein, partly exposed to cell surface, protein accumulates at the apical pole of thyrocytes 16020 703608 1.21.3.1 isopenicillin-N synthase membrane inactive associated form 16020 -, 440316 1.21.3.3 reticuline oxidase membrane - 16020 660256 1.21.3.3 reticuline oxidase membrane membrane-bound 16020 743234 1.21.4.1 D-proline reductase membrane - 16020 -, 484934 1.21.4.1 D-proline reductase membrane membrane-bound 16020 484929, 484933 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase membrane - 16020 -, 764107 1.21.99.3 thyroxine 5-deiodinase membrane - 16020 718384 1.21.99.3 thyroxine 5-deiodinase membrane integral membrane protein 16020 716049, 733907 1.21.99.4 thyroxine 5'-deiodinase membrane - 16020 639398, 718384 1.21.99.4 thyroxine 5'-deiodinase membrane bound to 16020 659748 1.21.99.4 thyroxine 5'-deiodinase membrane bound, type II integral in neurolemmal membranes 16020 639403, 639404 1.21.99.4 thyroxine 5'-deiodinase membrane integral membrane protein 16020 716049 1.21.99.4 thyroxine 5'-deiodinase membrane integral membrane protein. Once assembled the D1 holoenzyme is sorted to the plasma membrane in both kidney and liver cells, where it can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell 16020 659155 1.21.99.4 thyroxine 5'-deiodinase membrane isoenzyme type I and type II are both integral membrane proteins 16020 639407 1.21.99.4 thyroxine 5'-deiodinase membrane type II in membranes of stromal cells and thymocytes 16020 639415 1.21.99.5 tetrachloroethene reductive dehalogenase membrane - 16020 657587, 657605 1.21.99.5 tetrachloroethene reductive dehalogenase membrane in cells grown on pyruvate plus fumarate, a major part of the enzyme is either localized in the cytoplasm or membrane associated facing the cytoplasm. In cells grown on pyruvate or formate as electron donors and tetrachloroethene as electron acceptor, most of the enzyme is at the periplasmic side of the cytoplasmic membrane 16020 671649 1.23.5.1 violaxanthin de-epoxidase membrane - 16020 726336 1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] membrane membrane associated protein 16020 719758 1.3.1.105 2-methylene-furan-3-one reductase membrane protein contains a calmodulin-binding region 16020 743480 1.3.1.21 7-dehydrocholesterol reductase membrane - 16020 725923, 741356 1.3.1.21 7-dehydrocholesterol reductase membrane 9 putative transmembrane segments, predicted membrane topology of the enzyme 16020 654193 1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) membrane - 16020 396193 1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) membrane of endoplasmic reticulum 16020 396209 1.3.1.24 biliverdin reductase membrane - 16020 701357 1.3.1.24 biliverdin reductase membrane role for the enzyme in intracellular traffic of protein kinase C betaII and its membrane translocation 16020 674899 1.3.1.33 protochlorophyllide reductase membrane - 16020 697892 1.3.1.33 protochlorophyllide reductase membrane associated with 16020 758042 1.3.1.33 protochlorophyllide reductase membrane LPOR is an integral monotopic membrane protein which is permanently attached to one side of the plastid inner membrane. Tubuloreticular prolamellar body membrane, envelope membrane 16020 763100 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) membrane - 16020 740725 1.3.1.6 fumarate reductase (NADH) membrane - 16020 390837, 390839, 390840, 390843 1.3.1.6 fumarate reductase (NADH) membrane released by incubation with 300 mM KCl 16020 390841 1.3.1.70 DELTA14-sterol reductase membrane integral membrane enzyme, the enzyme contains ten transmembrane segments, TM1-10 16020 -, 745882 1.3.1.70 DELTA14-sterol reductase membrane membrane-bound 16020 288490, 288491, 288493 1.3.1.70 DELTA14-sterol reductase membrane patient, mutant TM7SF2 16020 654166 1.3.1.70 DELTA14-sterol reductase membrane transmembrane domains 16020 288492 1.3.1.72 DELTA24-sterol reductase membrane - 16020 744737 1.3.1.72 DELTA24-sterol reductase membrane bound 16020 654502 1.3.1.72 DELTA24-sterol reductase membrane DHCR24 membrane association 16020 746354 1.3.1.72 DELTA24-sterol reductase membrane DHCR24 possesses a putative transmembrane segment 16020 690082 1.3.1.72 DELTA24-sterol reductase membrane membrane-bound 16020 288496 1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) membrane - 16020 639379, 639380, 639381 1.3.1.83 geranylgeranyl diphosphate reductase membrane - 16020 694738 1.3.1.96 Botryococcus squalene synthase membrane - 16020 -, 718688 1.3.1.96 Botryococcus squalene synthase membrane bound 16020 741903 1.3.1.97 botryococcene synthase membrane - 16020 -, 718688 1.3.2.3 L-galactonolactone dehydrogenase membrane - 16020 698838 1.3.3.15 coproporphyrinogen III oxidase (coproporphyrin-forming) membrane - 16020 -, 738501 1.3.3.4 protoporphyrinogen oxidase membrane - 16020 390988, 654442 1.3.3.4 protoporphyrinogen oxidase membrane associated to 16020 666643 1.3.3.4 protoporphyrinogen oxidase membrane both isozymes 16020 655018 1.3.3.4 protoporphyrinogen oxidase membrane isozymes PPO1 and PPO2, binding domain and structure 16020 655341 1.3.3.4 protoporphyrinogen oxidase membrane membrane interaction/orientation 16020 674722 1.3.5.1 succinate dehydrogenase membrane - 16020 -, 391087, 391101, 391103, 391104, 391134, 391137, 391145, 391149, 654172, 655999, 656178, 656275, 656276, 657074, 657158, 685281, 685357, 689109, 707470, 707949, 708975, 724407, 726316, 743206 1.3.5.1 succinate dehydrogenase membrane bound 16020 -, 672406, 723986, 724561 1.3.5.1 succinate dehydrogenase membrane cytoplasmic membrane 16020 707291, 707545 1.3.5.1 succinate dehydrogenase membrane membrane anchoring based on the amphipathic nature of the putative helices found in subunit SdhC, is suggested 16020 724162 1.3.5.1 succinate dehydrogenase membrane membrane bound 16020 654092, 655573 1.3.5.1 succinate dehydrogenase membrane membrane-bound enzyme is used 16020 698668 1.3.5.1 succinate dehydrogenase membrane membrane-bound SDH is used 16020 698668 1.3.5.1 succinate dehydrogenase membrane membrane-bound, the catalytic domain is bound to the cytoplasmic membrane by 2 hydrophobic membrane anchor subunits that also form the sites of interaction with quinones 16020 654820 1.3.5.1 succinate dehydrogenase membrane presence of 2 B type haem in the membrane anchoring subunits 16020 655570 1.3.5.1 succinate dehydrogenase membrane QFR is an integral membrane protein with membrane-spanning subunits FrdC and FrdD 16020 763400 1.3.5.1 succinate dehydrogenase membrane quinol:fumarate reductase (QFR) is an integral membrane protein 16020 -, 763727 1.3.5.1 succinate dehydrogenase membrane SDH is attached to the membrane through Sdh3 and Sdh4 subunits 16020 654819 1.3.5.1 succinate dehydrogenase membrane the formate-fumarate reductase electron transport system is localized in the membrane fraction of the bacterium, together with acid-extractable and covalently-bound FAD, menaquinone, iron-sulfur protein and h and c cytochromes 16020 708369 1.3.5.1 succinate dehydrogenase membrane the membrane part of the enzyme is functionally connected to the active site 16020 -, 724421 1.3.5.1 succinate dehydrogenase membrane the SdhABE complex is membrane associated rather than tightly membrane bound 16020 700278 1.3.5.2 dihydroorotate dehydrogenase (quinone) membrane - 16020 390914, 390918, 390919, 390922 1.3.5.2 dihydroorotate dehydrogenase (quinone) membrane associated to 16020 655794 1.3.5.2 dihydroorotate dehydrogenase (quinone) membrane electron spin resonance spectra show that the N-terminal binds to membranes and experiences a somewhat high flexibility that could be related to the role of this region as a molecular lid controlling the entrance of the enzyme's active site and thus allowing the enzyme to give access to quinones that are dispersed in the membrane and that are necessary for the catalysis 16020 724182 1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone) membrane associated 16020 726366 1.3.5.5 15-cis-phytoene desaturase membrane associated to 16020 743580 1.3.5.6 9,9'-dicis-zeta-carotene desaturase membrane transmembrane enzyme, model, overview 16020 -, 711020 1.3.7.12 red chlorophyll catabolite reductase membrane - 16020 676395 1.3.7.13 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) membrane - 16020 744270 1.3.7.7 ferredoxin:protochlorophyllide reductase (ATP-dependent) membrane cytoplasmic or thylakoid membranes 16020 713251 1.3.7.8 benzoyl-CoA reductase membrane - 16020 700199 1.3.8.1 short-chain acyl-CoA dehydrogenase membrane enzyme activity is at least partially membrane-associated 16020 391303 1.3.8.2 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) membrane it can be assumed that diapophytoene desaturase forms a complex in the membrane that keeps the substrate carotenoids bound until all three double bonds are introduced in the desaturation process 16020 715338 1.3.98.1 dihydroorotate dehydrogenase (fumarate) membrane - 16020 710846 1.3.98.1 dihydroorotate dehydrogenase (fumarate) membrane anchored 16020 711915 1.3.98.1 dihydroorotate dehydrogenase (fumarate) membrane peripheral membrane protein 16020 657413 1.3.98.3 coproporphyrinogen dehydrogenase membrane in vivo, HemW occurs as a heme-free cytosolic form, as well as a heme-containing membrane-associated form 16020 724235 1.3.99.23 all-trans-retinol 13,14-reductase membrane - 16020 672228 1.3.99.23 all-trans-retinol 13,14-reductase membrane associated to 16020 659418 1.3.99.28 phytoene desaturase (neurosporene-forming) membrane - 16020 712333 1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming) membrane - 16020 -, 759253 1.3.99.31 phytoene desaturase (lycopene-forming) membrane - 16020 -, 712337, 759253 1.3.99.31 phytoene desaturase (lycopene-forming) membrane CrtI from Pantoea ananas associates spontaneously to liposomal membranes but no membrane-spanning region per se is evidenced, suggesting a monotopic binding to membranes 16020 759253 1.3.99.31 phytoene desaturase (lycopene-forming) membrane membrane-peripheral enzyme, phosphatidyl-choline liposome membranes 16020 726300 1.3.99.33 urocanate reductase membrane - 16020 -, 723218 1.3.99.4 3-oxosteroid 1-dehydrogenase membrane enzyme AcmB is located on the cytoplasmic side of the inner membranes of Sterolibacterium denitrificans 16020 763443 1.3.99.4 3-oxosteroid 1-dehydrogenase membrane partly, recombinant protein in Escherichia coli 16020 391396 1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) membrane - 16020 391397, 713519, 713520 1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) membrane the enzyme is a system of two membrane bound NADPH-dependent enzymes at the level of prostatic stromal and basal cells 16020 713519 1.4.1.1 alanine dehydrogenase membrane enzyme is partly associated with the membrane fraction 16020 349553 1.4.1.1 alanine dehydrogenase membrane major fraction 16020 -, 725267 1.4.1.10 glycine dehydrogenase membrane major fraction 16020 -, 725267 1.4.1.2 glutamate dehydrogenase membrane - 16020 391577 1.4.1.2 glutamate dehydrogenase membrane bound to cytoplasmic membrane 16020 661800 1.4.1.3 glutamate dehydrogenase [NAD(P)+] membrane peripheral membrane protein 16020 391626 1.4.2.B1 D-alanine dehydrogenase (cytochrome) membrane bound to 16020 746930 1.4.3.2 L-amino-acid oxidase membrane - 16020 -, 740632, 740922 1.4.3.2 L-amino-acid oxidase membrane enzyme is part of photosystem II particles 16020 391807 1.4.3.2 L-amino-acid oxidase membrane photosynthetic membranes 16020 391809 1.4.3.21 primary-amine oxidase membrane - 16020 686052, 687449, 701612, 703130, 711430, 712188 1.4.5.1 D-amino acid dehydrogenase (quinone) membrane - 16020 -, 394968, 696481, 697970 1.4.5.1 D-amino acid dehydrogenase (quinone) membrane enzyme activity depends on membrane integrity 16020 700217 1.4.9.2 aralkylamine dehydrogenase (azurin) membrane - 16020 288289 1.4.99.2 taurine dehydrogenase membrane - 16020 -, 395284, 395285, 656739, 720393 1.4.99.5 glycine dehydrogenase (cyanide-forming) membrane membrane-bound flavoenzyme 16020 -, 392034, 392036 1.4.99.B3 L-amino acid dehydrogenase (cytochrome b) membrane - 16020 391786 1.4.99.B3 L-amino acid dehydrogenase (cytochrome b) membrane presene of a membrane environment is required for activity 16020 740746 1.5.1.54 methylenetetrahydrofolate reductase (NADH) membrane associated to membrane 16020 -, 761018 1.5.3.16 spermine oxidase membrane SMOX localizes to the bile canalicular lumen of hepatocytes 16020 765802 1.5.3.26 fructosyl amine oxidase (fructosamine-forming) membrane - 16020 765029 1.5.5.1 electron-transferring-flavoprotein dehydrogenase membrane - 16020 654538, 688239 1.5.5.2 proline dehydrogenase membrane - 16020 392560 1.5.5.2 proline dehydrogenase membrane cytoplasmic 16020 392555, 392556 1.5.7.2 coenzyme F420 oxidoreductase (ferredoxin) membrane - 16020 741987 1.5.7.2 coenzyme F420 oxidoreductase (ferredoxin) membrane when the Fpo protein is connected to the membrane integral Fpo complex, it functions as an electron input module of the Fpo complex 16020 -, 724960 1.5.8.3 sarcosine dehydrogenase membrane - 16020 655081 1.5.98.1 methylenetetrahydromethanopterin dehydrogenase membrane 8% of the activity 16020 13748 1.5.98.3 coenzyme F420:methanophenazine dehydrogenase membrane - 16020 -, 742431, 742483, 742769, 742775 1.5.99.13 D-proline dehydrogenase membrane associated to 16020 684424 1.5.99.13 D-proline dehydrogenase membrane associated with 16020 -, 394966 1.5.99.3 L-pipecolate dehydrogenase membrane - 16020 392531 1.5.99.4 nicotine dehydrogenase membrane present both as soluble and membrane-associated form 16020 392431 1.5.99.5 methylglutamate dehydrogenase membrane - 16020 -, 437742, 437743, 437744, 437745, 437746, 437748 1.5.99.6 spermidine dehydrogenase membrane - 16020 675842 1.5.99.B2 proline dehydrogenase (acceptor) membrane - 16020 392558, 392559, 392562, 392563 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) membrane - 16020 657928, 657959, 659015, 659181, 659243, 673613, 711879 1.6.1.2 NAD(P)+ transhydrogenase (Re/Si-specific) membrane bound 16020 684605 1.6.2.2 cytochrome-b5 reductase membrane - 16020 392811, 394194, 394199, 394202, 394210, 394229, 394252, 724801, 725047, 742236 1.6.2.2 cytochrome-b5 reductase membrane bound 16020 725046 1.6.2.2 cytochrome-b5 reductase membrane cytoplasmic side of erythrocyte membrane 16020 394196 1.6.2.2 cytochrome-b5 reductase membrane enzyme binds in vitro to a variety of membrane preparations, protease treatment removes a hydrophobic segment that is responsible for membrane binding 16020 394226 1.6.2.2 cytochrome-b5 reductase membrane full length form contains a 3 kDa membrane anchoring domain 16020 657675, 657966 1.6.2.2 cytochrome-b5 reductase membrane membrane of endoplasmic reticulum, outer mitochondrial membrane, tightly bound to cytoplasmic face of membrane 16020 394198 1.6.2.2 cytochrome-b5 reductase membrane membrane-binding domain resides in the NH2-terminal region 16020 394214 1.6.2.2 cytochrome-b5 reductase membrane microsomal enzyme, COOH-terminal domain constitutes the hydrophobic moiety which is responsible for membrane-binding 16020 394224 1.6.2.2 cytochrome-b5 reductase membrane plasma membrane 16020 394244 1.6.2.2 cytochrome-b5 reductase membrane subcellular distribution, high concentration in outer mitochondrial membrane 16020 394207 1.6.2.4 NADPH-hemoprotein reductase membrane - 16020 -, 657619, 657728, 659104, 659807, 711027, 711112, 713019, 725687, 741783, 743406, 743656, 764770 1.6.2.4 NADPH-hemoprotein reductase membrane bound to 16020 672278 1.6.2.4 NADPH-hemoprotein reductase membrane bound, the N-terminal membrane anchor is functionally dispensable 16020 724794 1.6.2.4 NADPH-hemoprotein reductase membrane colocalization with cytochromes P450 16020 713071 1.6.2.4 NADPH-hemoprotein reductase membrane CPR can exist as a peripheral membrane protein in the absence of NADPH and will transition to an integral membrane protein in the presence of stoichiometric amounts of NADPH or greater 16020 764968 1.6.2.4 NADPH-hemoprotein reductase membrane CPR is membrane-bound 16020 713233 1.6.2.4 NADPH-hemoprotein reductase membrane cytochrome b5 is a membrane-bound protein that is inserted into the membrane via an alpha-helix at its carboxy terminus. A random-coil linker of 15 amino acids connects the acidic soluble cytosolic heme domain to the membrane anchor 16020 724112 1.6.2.4 NADPH-hemoprotein reductase membrane membrane of endoplasmic reticulum 16020 765230 1.6.2.4 NADPH-hemoprotein reductase membrane membrane-anchored 16020 725134 1.6.2.4 NADPH-hemoprotein reductase membrane membrane-bound protein associated with the cytoplasmic side of the endoplasmic reticulum 16020 724127 1.6.2.4 NADPH-hemoprotein reductase membrane the enzyme contains membrane anchor regions 16020 726325 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane - 16020 -, 392725, 394273, 394275, 700073, 710782, 710816, 710897, 711090, 711166, 711645, 711688, 711763, 711856, 712075, 712136, 712713, 712826, 713338, 713366, 724012, 742197, 742310, 742557 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane active subunit Nox1 endogenously co-localizes with its regulatory components p22phox, NOXO1, NOXA1 and Rac1 16020 685016 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane different membrane fractions enriched either in transversal tubules, triads containing transverse tubules attached to sarcoplasmic reticulum vesicles, and junctional sarcoplasmic reticulum vesicles. Enzyme subunits gp91phox, p47phox, p67phox, p22phox are enriched in transversal tubules and triads, but not in sarcoplasmic reticulum 16020 674633 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane exposure to taxol induces translocation of p47phox protein to the membrane in cortical cultures 16020 689225 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules 16020 711166 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane Nox1, like Nox2, associates with p22phox to form a membrane-bound cytochrome 16020 724778 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane small GTPase Rac is involved in membrane translocation of subunit p67phox 16020 685410 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane subunit gp91-phox of cytochrome b558 of the multicomponent complex is an integral membrane protein with several membrane-spanning regions 16020 394275 1.6.3.1 NAD(P)H oxidase (H2O2-forming) membrane the electron current depolarises the neutrophil plasma membrane at a rate of 2.3 V per s and this depolarisation is opposed when voltage-gated proton channels are activated. 3 mM ZnCl2 depolarises the membrane potential to +97.8 mV , and this depolarisation is abolished after NADPH oxidase inhibition 16020 684904 1.6.5.10 NADPH dehydrogenase (quinone) membrane - 16020 699999 1.6.5.10 NADPH dehydrogenase (quinone) membrane mitochondrial outer membrane 16020 392827 1.6.5.10 NADPH dehydrogenase (quinone) membrane NADPH oxidase complex consists of membrane and cytosolic subunits. The gp91phox and p22phox are integral membrane proteins that form a heterodimeric flavocytochrome b558, the catalytic core of the enzyme 16020 699129 1.6.5.2 NAD(P)H dehydrogenase (quinone) membrane - 16020 392725, 724356 1.6.5.2 NAD(P)H dehydrogenase (quinone) membrane the membrane-bound respiratory enzymes differs from the canonical NADH: dehydrogenase (complex I), because it is not involved in the vectorial transfer of protons across membranes. The enzyme possesses an amphipathic alpha-helix, which is likely to anchor the enzyme into the lipid bilayer 16020 700003 1.6.5.4 monodehydroascorbate reductase (NADH) membrane - 16020 392738, 392752 1.6.5.4 monodehydroascorbate reductase (NADH) membrane glyoxysomal membrane 16020 392729 1.6.5.4 monodehydroascorbate reductase (NADH) membrane integrity of glucan moieties of the cell surface glycoconjugates are necessary for the optimal function of the enzyme activity 16020 392732 1.6.5.4 monodehydroascorbate reductase (NADH) membrane outer mitochondrial membrane, highest activity in the cis-Golgi membrane fraction 16020 392734, 392745 1.6.5.4 monodehydroascorbate reductase (NADH) membrane plasma membrane 16020 392732, 392736, 392753 1.6.5.9 NADH:quinone reductase (non-electrogenic) membrane cytoplasmic membrane 16020 -, 743308 1.6.5.9 NADH:quinone reductase (non-electrogenic) membrane Ndi1 is a peripheral membrane protein forming an intimate dimer, in which packing of the monomeric units within the dimer creates an amphiphilic membrane-anchor domain structure, membrane-anchor domain, overview 16020 726384 1.6.5.9 NADH:quinone reductase (non-electrogenic) membrane the enzyme is peripheral membrane-bound 16020 724488 1.6.99.1 NADPH dehydrogenase membrane - 16020 726193 1.7.1.1 nitrate reductase (NADH) membrane constitutive nitrate reductase exists mostly in membranes 16020 -, 392908 1.7.1.1 nitrate reductase (NADH) membrane two isozymes, a membranebound, and a cytosolic form 16020 657105 1.7.1.10 hydroxylamine reductase (NADH) membrane firmly attached to mitochondrial membrane 16020 394436, 394438 1.7.1.16 nitrobenzene nitroreductase membrane membrane-associated 16020 739974 1.7.2.1 nitrite reductase (NO-forming) membrane - 16020 -, 727084 1.7.2.1 nitrite reductase (NO-forming) membrane equally distributed between the soluble- and the membrane fraction 16020 394526 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming) membrane - 16020 288629, 288632, 658624, 698876 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming) membrane bound 16020 673685 1.7.2.3 trimethylamine-N-oxide reductase membrane - 16020 654560 1.7.2.3 trimethylamine-N-oxide reductase membrane constitutive enzyme 16020 392756, 392762 1.7.2.4 nitrous-oxide reductase membrane - 16020 394526 1.7.2.5 nitric oxide reductase (cytochrome c) membrane - 16020 -, 395112, 395113, 395115, 395120, 395121, 395127, 395129, 395136, 395137, 395139, 395141, 658986, 659327, 671883, 671948, 674003, 692888, 742714 1.7.2.5 nitric oxide reductase (cytochrome c) membrane an integral membrane protein 16020 742847 1.7.2.5 nitric oxide reductase (cytochrome c) membrane binuclear reaction centre of the enzyme is localised inside the lipidic bilayer of the cytoplasmic membrane 16020 395120 1.7.2.5 nitric oxide reductase (cytochrome c) membrane cNOR enzyme is integral to the membrane 16020 -, 741684 1.7.2.5 nitric oxide reductase (cytochrome c) membrane integral membrane enzyme 16020 701110 1.7.2.5 nitric oxide reductase (cytochrome c) membrane integral membrane protein 16020 395121 1.7.2.5 nitric oxide reductase (cytochrome c) membrane membrane bound, NorCB is expressed during fully aerobic nitrification 16020 659044 1.7.2.5 nitric oxide reductase (cytochrome c) membrane NorBC is a complex integral membrane protein 16020 -, 699991 1.7.3.3 factor-independent urate hydroxylase membrane the enzyme is mainly localized in the membrane of PEX5-defective mutant cells 16020 657736 1.7.5.1 nitrate reductase (quinone) membrane - 16020 -, 395164, 696212, 696375, 697207, 697689, 697691, 697693, 712493, 741971 1.7.5.1 nitrate reductase (quinone) membrane alpha and beta polypeptides, and therefore the active site for nitrate reduction, are located on the cytoplasmic side of the membrane. The gamma polypeptide is the only subunit which is embedded in the membrane 16020 395162 1.7.5.1 nitrate reductase (quinone) membrane bound to 16020 698645 1.7.5.1 nitrate reductase (quinone) membrane nitrate reductase A (encoded by narGHJI operon) and nitrate reductase Z (encoded by narZYWv operon) are membrane-bound 16020 695649 1.7.5.1 nitrate reductase (quinone) membrane the enzyme-specific chaperone NarJ controls the quality of the enzyme addressed to the membrane via binding to the N-terminal tail of the iron-sulfur containing subunit NarG 16020 674613 1.7.5.1 nitrate reductase (quinone) membrane the membrane-anchored protein directs electrons from quinol oxidation at the membrane anchor, NarI, to the site of nitrate reduction in the membrane extrinsic [Fe-S] cluster and Mo-bis-MGD containing dimer, NarGH 16020 395191 1.7.5.1 nitrate reductase (quinone) membrane the membrane-intrinsic subunit NarI anchors NarGH to the membrane through a predominantly hydrophobic interface with both subunits 16020 700372 1.7.5.1 nitrate reductase (quinone) membrane the NarI subunit anchors the NarGH subunits to the inside of the cytoplasmic membrane 16020 741900 1.7.7.2 ferredoxin-nitrate reductase membrane - 16020 -, 658201, 726801 1.7.7.2 ferredoxin-nitrate reductase membrane tightly bound to chlorophyll-containing membrane fractions 16020 208103 1.8.1.17 dimethylsulfone reductase membrane - 16020 -, 713986, 713987 1.8.1.4 dihydrolipoyl dehydrogenase membrane outer membrane 16020 -, 765872 1.8.1.6 cystine reductase membrane - 16020 765683 1.8.1.9 thioredoxin-disulfide reductase membrane calveolar membrane 16020 697613 1.8.1.9 thioredoxin-disulfide reductase membrane the Grx domain of TXNRD1_v3 localizes first in the emerging protrusion and is then followed into the protrusions by actin and subsequently by tubulin. TXNRD1_v3 can guide actin polymerization in relation to cell membrane restructuring 16020 687762 1.8.2.1 sulfite dehydrogenase (cytochrome) membrane - 16020 764725 1.8.2.1 sulfite dehydrogenase (cytochrome) membrane bound to 16020 -, 394088 1.8.2.1 sulfite dehydrogenase (cytochrome) membrane the enzyme is a component of the membrane-associated thiosulfate-oxidizing complex 16020 394075 1.8.2.2 thiosulfate dehydrogenase membrane - 16020 673503 1.8.2.3 sulfide-cytochrome-c reductase (flavocytochrome c) membrane - 16020 -, 713981, 715342 1.8.3.2 thiol oxidase membrane - 16020 393047, 659585, 659862, 690893 1.8.3.2 thiol oxidase membrane type I membrane protein 16020 724281 1.8.3.5 prenylcysteine oxidase membrane - 16020 -, 669763, 710018, 710279 1.8.3.6 farnesylcysteine lyase membrane - 16020 -, 710018, 710279 1.8.4.11 peptide-methionine (S)-S-oxide reductase membrane - 16020 657754, 659964, 725480 1.8.4.11 peptide-methionine (S)-S-oxide reductase membrane enzyme form Mem-R,S-Msr 16020 658212 1.8.4.11 peptide-methionine (S)-S-oxide reductase membrane membrane-associated isozyme, MsrA 16020 657734 1.8.4.11 peptide-methionine (S)-S-oxide reductase membrane outer cell membrane 16020 658214 1.8.4.12 peptide-methionine (R)-S-oxide reductase membrane - 16020 657734, 657754, 659964 1.8.4.12 peptide-methionine (R)-S-oxide reductase membrane enzyme form Mem-R,S-Msr 16020 658212 1.8.4.12 peptide-methionine (R)-S-oxide reductase membrane membrane-associated enzyme MsrB 16020 657754 1.8.4.12 peptide-methionine (R)-S-oxide reductase membrane outer cell membrane 16020 658214 1.8.4.13 L-methionine (S)-S-oxide reductase membrane enzyme form Mem-R,S-Msr 16020 658212 1.8.4.16 thioredoxin:protein disulfide reductase membrane - 16020 -, 755729, 756029, 756030, 756154, 756583, 756588, 757129, 757131, 757204, 757694, 758208, 758258 1.8.4.2 protein-disulfide reductase (glutathione) membrane - 16020 3067, 394818, 670810 1.8.4.2 protein-disulfide reductase (glutathione) membrane bound to 16020 394810 1.8.4.2 protein-disulfide reductase (glutathione) membrane membrane-associated with its thioredoxin-like domain on the outside of the cytoplasmic membrane 16020 659204 1.8.4.2 protein-disulfide reductase (glutathione) membrane membrane-bound enzyme 16020 745224 1.8.4.2 protein-disulfide reductase (glutathione) membrane membrane-bound, the enzyme is a transmembrane protein 16020 -, 765004 1.8.4.2 protein-disulfide reductase (glutathione) membrane outer cytoplasmic membrane, protein termini localised in the periplasm 16020 394853 1.8.4.2 protein-disulfide reductase (glutathione) membrane plasma membrane 16020 394821 1.8.4.2 protein-disulfide reductase (glutathione) membrane weakly bound to membrane phospholipid components 16020 394823 1.8.5.2 thiosulfate dehydrogenase (quinone) membrane - 16020 656833, 765755 1.8.5.3 respiratory dimethylsulfoxide reductase membrane - 16020 -, 712148 1.8.5.3 respiratory dimethylsulfoxide reductase membrane membrane-intrinsic subunit DmsC is necessary for anchoring, stability, and electron transport. The C-terminal region of DmsB appears to interact with the anchor peptide and facilitates the membrane assembly of the catalytic dimer 16020 712267 1.8.5.3 respiratory dimethylsulfoxide reductase membrane the terminal reductase and the dehyrogenases linking the various electron donors to the electron transport chain are membrane bound 16020 711803 1.8.5.4 bacterial sulfide:quinone reductase membrane - 16020 -, 713985, 714148, 714172, 714519, 715343, 715434, 715911, 716746, 716875, 764199 1.8.5.4 bacterial sulfide:quinone reductase membrane CmSQR oligomerization is necessary for membrane binding, analysis of the binding of recombiant hetero-oligomers of differentially tagged CmSQR mutant variants 16020 -, 764197 1.8.5.4 bacterial sulfide:quinone reductase membrane monotopic membrane enzyme 16020 714310 1.8.5.4 bacterial sulfide:quinone reductase membrane the C-terminal amphiphilic helix is important for membrane binding 16020 -, 727080 1.8.5.4 bacterial sulfide:quinone reductase membrane the enzyme is strictly membrane-bound 16020 713984 1.8.5.6 sulfite dehydrogenase (quinone) membrane the enzyme is membrane-bound and quinone reactive (via the SoeC subunit), facing the cytoplasm where SoeB (a module that carries FeeS centers) and the SoeA (the Mo-carrying catalytic subunit) are exposed. The enzyme is a large membrane-bound complex, formerly called SreABC 16020 764198 1.8.5.9 protein dithiol:quinone oxidoreductase DsbB membrane - 16020 -, 669136, 755706, 756589, 756872, 756909, 757124, 757136, 757516, 757614, 758183, 758212, 758257, 758288 1.8.5.B1 peptide-methionine (S)-S-oxide reductase (quinone) membrane subunit MsrQ 16020 742907 1.8.7.3 ferredoxin:CoB-CoM heterodisulfide reductase membrane - 16020 -, 765831 1.8.7.3 ferredoxin:CoB-CoM heterodisulfide reductase membrane membrane-bound 16020 764654 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase membrane - 16020 -, 639393, 655400, 742500, 742541 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase membrane bound to 16020 440299, 654386, 655396, 655402, 655532, 655825 1.8.98.5 H2:CoB-CoM heterodisulfide,ferredoxin reductase membrane the catalytic subunit of heterodisulfide reductase (HdrD) is located at the cytoplasmic side of the cytoplasmic membrane. The oxidation of H2 takes place via a membrane-bound hydrogenase (VhoGAC) 16020 -, 764660 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase membrane the catalytic subunit of heterodisulfide reductase (HdrD) is located at the cytoplasmic side of the cytoplasmic membrane. The oxidation of formate is catalyzed by a membrane-bound formate dehydrogenase (FdhGHI) 16020 -, 764660 1.8.99.5 dissimilatory sulfite reductase membrane - 16020 -, 394066 1.8.99.5 dissimilatory sulfite reductase membrane the sulfur globules of Allochromatium vinosum are located in the extracytoplasmic space whilst the dissimilatory sulfite reductase appear to be either cytoplasmic or membrane-bound 16020 -, 734636 1.8.99.B2 tetrathionate reductase membrane - 16020 -, 737877, 742121 1.8.99.B2 tetrathionate reductase membrane TsdC from Wolinella succinogenes mediates membrane attachment of TsdA 16020 764683 1.97.1.1 chlorate reductase membrane - 16020 437686 1.97.1.9 selenate reductase membrane - 16020 -, 644812, 644815, 644816, 657903, 671304, 671468 1.97.1.9 selenate reductase membrane membrane-bound enzyme 16020 -, 745727 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase membrane - 16020 485023, 485029, 485033, 485034, 485035, 485039, 485043, 485045, 659510, 672103, 674465, 719060 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase membrane an integral membrane protein 16020 719233, 719860 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase membrane integral membrane protein 16020 720465, 734273 2.1.1.103 phosphoethanolamine N-methyltransferase membrane - 16020 735175 2.1.1.106 tryptophan 2-C-methyltransferase membrane possibly loosely membrane-bound 16020 485082 2.1.1.11 magnesium protoporphyrin IX methyltransferase membrane embedded within one leaflet of the membrane 16020 485108 2.1.1.142 cycloartenol 24-C-methyltransferase membrane - 16020 288661 2.1.1.15 fatty-acid O-methyltransferase membrane membrane-associated 16020 -, 758148 2.1.1.163 demethylmenaquinone methyltransferase membrane intracellular membrane domain 16020 -, 756797 2.1.1.165 methyl halide transferase membrane bound to 16020 677650 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane - 16020 485174, 485182 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane associated to 16020 485166 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane enzyme attaches to the membrane via electrostatic interactions with anionic lipids, which do not serve as substrate. Increasing phosphatidylcholine concentrations trigger membrane dissociation suggesting that membrane binding of PmtA is negatively regulated by its end product phosphatidylcholine. alpha-Helical regions alphaA and alphaF contribute to membrane binding. The latter undergoes a structural transition from disordered to alpha-helical conformation in the presence of anionic lipids. The basic amino acids R8 and K12 and the hydrophobic amino acid F19 are critical for membrane binding by alphaA as well as for activity of full-length PmtA 16020 734723 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane enzyme form PEMT2 16020 485180 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane intrinsic membrane protein 16020 485193 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane loosely bound to membrane 16020 485172 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane mitochondria-associated membrane 16020 485179, 485182, 485192 2.1.1.17 phosphatidylethanolamine N-methyltransferase membrane topographical model: 4 transmembrane regions span the membrane such that both the N and C termini of the enzyme are localized external to the ER. Two hydrophilic connecting loops protrude into the luminal face of the microsomes whereas a corresponding loop protrudes on the cytosolic side remains proximate to the membrane 16020 485182 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase membrane - 16020 733306, 734623 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase membrane integral-membrane protein 16020 733281 2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase membrane the membrane-binding region of UbiG gates the entrance of methyl donor 16020 758360 2.1.1.25 phenol O-methyltransferase membrane from erythrocyte 16020 485241 2.1.1.250 trimethylamine-corrinoid protein Co-methyltransferase membrane transmembrane enzyme 16020 -, 737168 2.1.1.262 squalene methyltransferase membrane - 16020 -, 720061 2.1.1.263 botryococcene C-methyltransferase membrane - 16020 -, 720061 2.1.1.294 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase membrane peripheral membrane protein 16020 736468 2.1.1.294 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase membrane the WbdD protein is tethered to the membrane via a C-terminal region containing amphipathic helices located between residues 601 and 669 16020 -, 722664 2.1.1.317 sphingolipid C9-methyltransferase membrane membrane-bound 16020 -, 734154 2.1.1.319 type I protein arginine methyltransferase membrane PRMT1 enzyme localization is concentrated in the cytosolic, membrane, and myonuclear compartments of mature myofibers 16020 755764 2.1.1.319 type I protein arginine methyltransferase membrane PRMT4 enzyme localization is concentrated in the cytosolic, membrane, and myonuclear compartments of mature myofibers 16020 755764 2.1.1.320 type II protein arginine methyltransferase membrane PRMT5 enzyme localization is concentrated in the cytosolic, membrane, and myonuclear compartments of mature myofibers 16020 755764 2.1.1.334 methanethiol S-methyltransferase membrane - 16020 -, 741048, 757759 2.1.1.49 amine N-methyltransferase membrane hepatic membrane-bound enzyme 16020 441356 2.1.1.56 mRNA (guanine-N7)-methyltransferase membrane lipid-binding site, membrane binding activity of wild-type and diverse mutants 16020 485465 2.1.1.59 [cytochrome c]-lysine N-methyltransferase membrane - 16020 485475 2.1.1.6 catechol O-methyltransferase membrane - 16020 441524, 702121, 719315 2.1.1.6 catechol O-methyltransferase membrane bound to 16020 685455, 687048 2.1.1.6 catechol O-methyltransferase membrane bound to, MB-COMT 16020 657526 2.1.1.6 catechol O-methyltransferase membrane bound to.In all brain areas membrane-bound enzyme activity is lower than soluble enzyme activity 16020 657525 2.1.1.6 catechol O-methyltransferase membrane exists in a soluble cytosolic and in a particulate membrane-bound form 16020 441512 2.1.1.6 catechol O-methyltransferase membrane integral membrane protein 16020 441535 2.1.1.6 catechol O-methyltransferase membrane isoform COMT-mb 16020 705937 2.1.1.6 catechol O-methyltransferase membrane isoform MB-COMT 16020 702405, 703772, 732991 2.1.1.6 catechol O-methyltransferase membrane isoform mbCOMT 16020 703190 2.1.1.6 catechol O-methyltransferase membrane MB-COMT 16020 702948, 705247 2.1.1.6 catechol O-methyltransferase membrane membrane-bound enzyme form MB-COMT 16020 686075 2.1.1.6 catechol O-methyltransferase membrane two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT). MB-COMT is an integral membrane protein with the catalytic portion of the enzyme oriented toward the cytoplasmic side of the membrane 16020 686194 2.1.1.64 3-demethylubiquinol 3-O-methyltransferase membrane associated. In vivo, the methyltransferase reaction probably occurs at the internal surface of the cytoplasmic membrane 16020 485507 2.1.1.64 3-demethylubiquinol 3-O-methyltransferase membrane the membrane-binding region of UbiG gates the entrance of methyl donor 16020 758360 2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase membrane - 16020 485560 2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase membrane synaptosomal plasma membrane 16020 485193 2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase membrane - 16020 -, 485599 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase membrane - 16020 485635 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase membrane loosely associated with the inner membrane 16020 485631 2.1.1.86 tetrahydromethanopterin S-methyltransferase membrane - 16020 758365 2.1.1.86 tetrahydromethanopterin S-methyltransferase membrane membrane associated enzyme 16020 -, 727407 2.1.1.86 tetrahydromethanopterin S-methyltransferase membrane membrane-associated enzyme 16020 -, 727499 2.1.1.86 tetrahydromethanopterin S-methyltransferase membrane MtrA-H 16020 734072 2.1.1.9 thiol S-methyltransferase membrane - 16020 441593 2.1.1.95 tocopherol C-methyltransferase membrane - 16020 485675, 485676, 485677, 485678, 485680, 485682 2.1.1.95 tocopherol C-methyltransferase membrane loosely bound to outer chloroplast membrane 16020 485679 2.1.1.97 3-hydroxyanthranilate 4-C-methyltransferase membrane intracellular membrane associated 16020 485686 2.1.1.B3 sialate-8-O-methyltransferase membrane - 16020 673429 2.1.3.1 methylmalonyl-CoA carboxytransferase membrane - 16020 4552 2.2.1.1 transketolase membrane isoform transketolase I is primarily associated with the intracytoplasmic membrane 16020 720844 2.3.1.105 alkylglycerophosphate 2-O-acetyltransferase membrane - 16020 660411 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase membrane - 16020 658661, 658662, 672075 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase membrane boound 16020 719417 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase membrane bound, membrane topology model of LRAT using I-TASSER, membrane interaction probes of LRAT and truncated LRAT with phospholipid monolayers, circular dichroism, overview 16020 720353 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase membrane integral 16020 658001 2.3.1.135 phosphatidylcholine-retinol O-acyltransferase membrane membrane-associated protein 16020 685367 2.3.1.137 carnitine O-octanoyltransferase membrane - 16020 657546 2.3.1.141 galactosylacylglycerol O-acyltransferase membrane - 16020 486322 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) membrane - 16020 16275 2.3.1.149 Platelet-activating factor acetyltransferase membrane - 16020 16279 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase membrane - 16020 -, 486392, 662902, 684683, 687685, 688229, 688948, 756014 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase membrane exogenously expressed protein. Isoform GPAT2 protein has two transmembrane segments and the N-terminal and C-terminal regions face the cytoplasm. The enzymatically active motifs I-III of the GPAT2 protein face the cytosol, while motif IV is within the membrane 16020 718756 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase membrane the enzyme sequence contains three possible transmembrane domains 16020 -, 758180 2.3.1.158 phospholipid:diacylglycerol acyltransferase membrane - 16020 720694 2.3.1.158 phospholipid:diacylglycerol acyltransferase membrane soluble form is produced for comparison with the native membrane bound enzyme 16020 685341 2.3.1.16 acetyl-CoA C-acyltransferase membrane strain D-1ML, 83% of activity 16020 486426 2.3.1.17 aspartate N-acetyltransferase membrane - 16020 486458 2.3.1.17 aspartate N-acetyltransferase membrane membrane-associated, the enzyme contains a membrane anchor region 16020 737193 2.3.1.198 glycerol-3-phosphate 2-O-acyltransferase membrane a transmembrane enzyme 16020 758037 2.3.1.198 glycerol-3-phosphate 2-O-acyltransferase membrane modeling data indicate this localisation 16020 723629 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase membrane - 16020 -, 487614, 719400, 719787, 719791, 720698, 737127 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase membrane integral membrane protein 16020 720125 2.3.1.20 diacylglycerol O-acyltransferase membrane - 16020 -, 486511, 486513, 659670, 672340, 675269, 675754, 676379, 755760, 756249, 757321, 757544, 757988, 758011, 758036, 758048, 758049, 758149 2.3.1.20 diacylglycerol O-acyltransferase membrane a transmembrane enzyme 16020 756249 2.3.1.20 diacylglycerol O-acyltransferase membrane DGAT1 has 8 to 10 transmembrane domains 16020 758047 2.3.1.20 diacylglycerol O-acyltransferase membrane DGAT2 is an integral membrane protein with both the N and C terminus oriented toward the cytosol, the loop between the two transmembrane domains of DGAT2is not exposed to the cytosol 16020 674734 2.3.1.20 diacylglycerol O-acyltransferase membrane embedded in the membrane lipid bilayer 16020 757544 2.3.1.20 diacylglycerol O-acyltransferase membrane firmly bound 16020 486499 2.3.1.20 diacylglycerol O-acyltransferase membrane integral transmembrane enzyme 16020 -, 756310 2.3.1.20 diacylglycerol O-acyltransferase membrane isozymes HpDGAT2B and HpDGAT2D contain two transmembrane domains each, while isozymes HpDGAT2A and HpDGAT2E do not 16020 -, 757545 2.3.1.20 diacylglycerol O-acyltransferase membrane protein is mainly localised on the cytoplasmic site of the plasma membrane and on the surface of intracellular wax ester inclusions 16020 672451 2.3.1.20 diacylglycerol O-acyltransferase membrane the enzyme contains three putative transmembrane domains 16020 -, 758140 2.3.1.20 diacylglycerol O-acyltransferase membrane tung tree DGAT1 appears to have two termini localized in the cytosol, suggesting the presence of even-numbered transmembrane domains 16020 757544 2.3.1.20 diacylglycerol O-acyltransferase membrane yolk sac membrane 16020 486514 2.3.1.203 UDP-N-acetylbacillosamine N-acetyltransferase membrane - 16020 -, 718901 2.3.1.21 carnitine O-palmitoyltransferase membrane - 16020 486529, 486540 2.3.1.21 carnitine O-palmitoyltransferase membrane membrane-bound 16020 486522 2.3.1.22 2-acylglycerol O-acyltransferase membrane - 16020 659670, 672340, 675260 2.3.1.22 2-acylglycerol O-acyltransferase membrane for the enzyme activity, both the N-terminal transmembrane domain and catalytic HPHG motif are required. The transmembrane domain consists of two hydrophobic regions in the N-terminus, the consensus sequence FLXLXXXn, a putative neutral lipid-binding domain, exists in the first transmembrane domain 16020 756283 2.3.1.22 2-acylglycerol O-acyltransferase membrane small enzyme amout 16020 -, 659060 2.3.1.22 2-acylglycerol O-acyltransferase membrane transmembrane protein 16020 659195 2.3.1.225 protein S-acyltransferase membrane - 16020 718958, 719789 2.3.1.225 protein S-acyltransferase membrane associated 16020 720482 2.3.1.225 protein S-acyltransferase membrane localized to synaptic membranes 16020 709096 2.3.1.225 protein S-acyltransferase membrane PAT activity is highly enriched in low density membranes dependent upon cholesterol 16020 719807 2.3.1.225 protein S-acyltransferase membrane PATs are transmembrane proteins 16020 720754 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane - 16020 486617, 486619, 486621, 486653, 486656, 756094, 756737 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane 2 distinct enzymes: a peripheral and a CHAPS insoluble integral membrane enzyme 16020 486646 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane membrane-bound 16020 735571 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane plasma membrane 16020 486621, 486641 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane the enzyme contains 3 transmembrane domains 16020 674602 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase membrane the enzyme contains a transmembrane domain 16020 676806 2.3.1.24 sphingosine N-acyltransferase membrane Lass family members contain four to seven predicted transmembrane domains 16020 753417 2.3.1.24 sphingosine N-acyltransferase membrane membrane-associated 16020 -, 754360 2.3.1.243 acyl-Kdo2-lipid IVA acyltransferase membrane - 16020 727820 2.3.1.250 [Wnt protein] O-palmitoleoyl transferase membrane bound 16020 733873 2.3.1.251 lipid IVA palmitoyltransferase membrane outer membrane 16020 -, 733720 2.3.1.26 sterol O-acyltransferase membrane - 16020 486678, 486698, 486703, 674216, 684882 2.3.1.26 sterol O-acyltransferase membrane of yolk sac 16020 756510 2.3.1.265 phosphatidylinositol dimannoside acyltransferase membrane - 16020 -, 743339, 743729, 755684 2.3.1.269 apolipoprotein N-acyltransferase membrane - 16020 748078, 748084, 748159, 748169, 748683, 748746 2.3.1.269 apolipoprotein N-acyltransferase membrane an integral membrane protein 16020 -, 747441 2.3.1.269 apolipoprotein N-acyltransferase membrane inner cytoplasmic membrane 16020 -, 747801 2.3.1.269 apolipoprotein N-acyltransferase membrane integral membrane protein 16020 756949, 757766, 758353, 758448 2.3.1.275 acyl phosphate:glycerol-3-phosphate acyltransferase membrane integral membrane protein. PlsY has five membrane-spanning segments with the amino terminus and two short loops located on the external face of the membrane. Each of the three larger cytoplasmic domains contains a highly conserved sequence motif. Site-directed mutagenesis reveals that each conserved domain was critical for PlsY catalysis 16020 -, 748161 2.3.1.275 acyl phosphate:glycerol-3-phosphate acyltransferase membrane transmembrane protein with five membrane-spanning helices 16020 -, 748647 2.3.1.284 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase membrane membrane-associated 16020 -, 751035 2.3.1.288 2-O-sulfo trehalose long-chain-acyltransferase membrane membrane-associated 16020 -, 751035 2.3.1.291 sphingoid base N-palmitoyltransferase membrane membrane-associated 16020 -, 754360 2.3.1.297 very-long-chain ceramide synthase membrane LASS3 has up to six transmembrane spanning domains 16020 752701 2.3.1.297 very-long-chain ceramide synthase membrane liver microsomal membranes from CerS2 null mice display higher membrane fluidity and show morphological changes. Membrane morphology is studied by fluorescence microscopy, overview 16020 754089 2.3.1.3 glucosamine N-acetyltransferase membrane - 16020 486751 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase membrane - 16020 486872 2.3.1.4 glucosamine-phosphate N-acetyltransferase membrane attached to cytoplasmic membrane leaflet of Golgi and other intracellular membranes 16020 486909 2.3.1.4 glucosamine-phosphate N-acetyltransferase membrane endomembrane system 16020 718794 2.3.1.40 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase membrane - 16020 486913 2.3.1.40 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase membrane inner 16020 486912 2.3.1.42 glycerone-phosphate O-acyltransferase membrane - 16020 486356, 486964 2.3.1.45 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase membrane - 16020 487041, 672480, 686986 2.3.1.50 serine C-palmitoyltransferase membrane - 16020 736559 2.3.1.50 serine C-palmitoyltransferase membrane bound 16020 -, 704496 2.3.1.50 serine C-palmitoyltransferase membrane in mitochondria-associated membrane 16020 736184 2.3.1.50 serine C-palmitoyltransferase membrane membrane-bound enzyme 16020 735744 2.3.1.50 serine C-palmitoyltransferase membrane the Lcb1p and Lcb2p subunits of the SPT heterodimer may interact in the cytosol, as well as within the membrane and/or the lumen of the endoplasmic reticulum 16020 659428 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase membrane - 16020 -, 486339, 486373, 486374, 486375, 487179, 487180, 487192, 487198, 487199, 487207, 487211, 687624, 755967, 756093 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase membrane CrLPAAT1 is an integral membrane protein with two potential transmembrane domains (TM), namely TM1 (residues 94-116) and TM2 (residues 188-205), along with a chloroplast transit peptide (cTP) of 46 amino acid residues at the N-terminus. The segment between cTP and TM1 is enriched with serine (Ser) and proline (Pro) residues, the Ser/Pro-rich domain together with a transmembrane alpha-helix might be a sorting/insertion signal for the post-import sorting pathway 16020 755759 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase membrane integral membrane protein 16020 -, 748130 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase membrane more than 60% of total activity associated with membranes in white adipose tissue 16020 687752 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase membrane the N-terminal two-helix motif associates with the membrane. Full-length TmPlsC is membrane-bound and not removed by a 0.5 M NaCl wash 16020 -, 757793 2.3.1.52 2-acylglycerol-3-phosphate O-acyltransferase membrane - 16020 486375 2.3.1.54 formate C-acetyltransferase membrane - 16020 736638 2.3.1.6 choline O-acetyltransferase membrane - 16020 487330, 657464, 658548 2.3.1.6 choline O-acetyltransferase membrane associated 16020 487288 2.3.1.6 choline O-acetyltransferase membrane bound 16020 487290 2.3.1.62 2-acylglycerophosphocholine O-acyltransferase membrane - 16020 756094 2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase membrane - 16020 487358 2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase membrane - 16020 487385, 658623 2.3.1.75 long-chain-alcohol O-fatty-acyltransferase membrane - 16020 659670, 672451, 675260, 743538, 757376 2.3.1.75 long-chain-alcohol O-fatty-acyltransferase membrane cytoplasm membrane 16020 659060 2.3.1.76 retinol O-fatty-acyltransferase membrane - 16020 658662, 659670, 672075, 672340, 675260 2.3.1.76 retinol O-fatty-acyltransferase membrane the enzyme is is very hydrophobic and has multiple predicted membrane-spanning domains 16020 675260 2.3.1.84 alcohol O-acetyltransferase membrane - 16020 -, 737129, 758549 2.3.1.84 alcohol O-acetyltransferase membrane cell membrane bound 16020 487555 2.3.1.84 alcohol O-acetyltransferase membrane membrane associated 16020 487556 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane - 16020 487735, 487753, 487756, 659297, 671705 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane associated at the cytoplasmic side of the membrane 16020 718896 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane caspase-mediated cleavage of the predominantly membrane bound isoform NMT1 removes a polybasic domain stretch and leads to a cytosolic relocalization 16020 736079 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane minor part 16020 487766 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane NMT activity remains associated with the transmembrane fraction even after extensive washings 16020 671705 2.3.1.97 glycylpeptide N-tetradecanoyltransferase membrane peripheral membrane protein 16020 487735 2.3.1.B36 glycerophosphocholine O-acyltransferase membrane - 16020 737051 2.3.1.B36 glycerophosphocholine O-acyltransferase membrane Gpc1p is an intergral membrane protein 16020 757164 2.3.1.B36 glycerophosphocholine O-acyltransferase membrane Gpc1p is an intergral membrane protein with eight transmembrane helices 16020 -, 757164 2.3.1.B45 heptaprenylglycerol processing acetyltransferase membrane not an integral membrane protein 16020 -, 757157 2.3.1.B46 1-acylglycerophosphatidylinositol O-acyltransferase membrane - 16020 756102 2.3.1.B46 1-acylglycerophosphatidylinositol O-acyltransferase membrane membrane-bound 16020 -, 757632 2.3.2.1 D-glutamyltransferase membrane - 16020 487791 2.3.2.11 alanylphosphatidylglycerol synthase membrane - 16020 487794 2.3.2.11 alanylphosphatidylglycerol synthase membrane a transmembrane protein which is located in the inner membrane 16020 720495 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane - 16020 487830, 759166 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane isoform tTG activity is associated with syncytial mircovillus membrane 16020 676394 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane keratocytes 16020 487830 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane liver transglutaminase, plasma-membrane associated, lateral domain 16020 -, 487846 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane outer mitochondrial membrane of cells overexpressing enzyme 16020 659430 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane TG1 protein is expressed at inner side of cell membrane 16020 736069 2.3.2.13 protein-glutamine gamma-glutamyltransferase membrane transglutaminase 1, membrane-anchored 16020 487870 2.3.2.2 gamma-glutamyltransferase membrane - 16020 -, 487901, 487902, 487907, 487911, 487913, 487914, 487915, 487920, 487921, 487922, 487923, 487924, 487926, 487929, 487935, 487936, 487962, 487967, 659102, 719952 2.3.2.2 gamma-glutamyltransferase membrane associated 16020 671171 2.3.2.2 gamma-glutamyltransferase membrane associated to 16020 660108 2.3.2.2 gamma-glutamyltransferase membrane associated with milk-membranes 16020 487910 2.3.2.2 gamma-glutamyltransferase membrane bound to vascular membrane 16020 487970 2.3.2.2 gamma-glutamyltransferase membrane extrinsic to plasma membrane 16020 487928, 487932 2.3.2.2 gamma-glutamyltransferase membrane intrinsic membrane protein 16020 487931 2.3.2.2 gamma-glutamyltransferase membrane membrane-bound 16020 487964, 487972 2.3.2.2 gamma-glutamyltransferase membrane polarized, outer apical surface alveolar epithelium 16020 487960 2.3.2.2 gamma-glutamyltransferase membrane the enzyme is a lipoprotein and is attached to the outer side of the cytoplasmic membrane 16020 -, 757270 2.3.2.2 gamma-glutamyltransferase membrane the functional VvGGT3 is probably associated with membrane-like structures. VvGGT3-GFP fusion protein does not localize to the vacuole in transformed Nicotiana benthamiana cells 16020 756810 2.3.2.2 gamma-glutamyltransferase membrane wild-type, membrane-bound 16020 487961 2.3.2.26 HECT-type E3 ubiquitin transferase membrane the isoform Smurf1 C2 domain exerts a key role in localization to the plasma membrane. Lysine residues, Lys-28 and Lys-85, within the C2 domain are important for Smurf1 localization at the plasma membrane 16020 715601 2.3.2.27 RING-type E3 ubiquitin transferase membrane integral membrane protein 16020 692490 2.3.2.27 RING-type E3 ubiquitin transferase membrane membrane-associated 16020 652301 2.3.2.27 RING-type E3 ubiquitin transferase membrane sequence contains 13 predicted transmembrane domains. The N-terminal region of TEB4 is located in the cytoplasm, whereas the C-terminus of TEB4 has a luminal deposition 16020 726899 2.3.2.27 RING-type E3 ubiquitin transferase membrane the protein contains a RING-H2 motif and an N-terminal transmembrane domain 16020 728278 2.3.2.3 lysyltransferase membrane - 16020 487973, 659890, 705529, 706461, 706463 2.3.2.3 lysyltransferase membrane an integral membrane protein 16020 720483 2.3.2.3 lysyltransferase membrane septal membranes 16020 -, 659064 2.3.3.10 hydroxymethylglutaryl-CoA synthase membrane - 16020 488113 2.3.3.16 citrate synthase (unknown stereospecificity) membrane cytoplasmic membrane 16020 757999 2.4.1.1 glycogen phosphorylase membrane - 16020 736783 2.4.1.10 levansucrase membrane associated 16020 -, 488321 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane - 16020 394591, 488365, 488368, 488369, 488370, 722739, 760144 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane membrane-bound recombinant chimeras 16020 488377 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane not 16020 488362, 488366 2.4.1.101 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane transferase A 16020 488363 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase membrane - 16020 -, 489427, 489453, 638312, 638330, 638331, 638332, 638334, 638336, 638337, 638341, 638343, 736741 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase membrane a membrane protein 16020 722731 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase membrane bound 16020 489426 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase membrane integral, multiple transmembranal domains 16020 638338, 638342 2.4.1.109 dolichyl-phosphate-mannose-protein mannosyltransferase membrane transmembrane helical structure 16020 -, 758674 2.4.1.113 alpha-1,4-glucan-protein synthase (ADP-forming) membrane - 16020 488462 2.4.1.12 cellulose synthase (UDP-forming) membrane - 16020 703825 2.4.1.12 cellulose synthase (UDP-forming) membrane bound 16020 703730 2.4.1.12 cellulose synthase (UDP-forming) membrane integral membrane protein with cytoplasmic loops 16020 702850 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase membrane - 16020 638319, 638321, 638322 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase membrane associated 16020 638325 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase membrane inner surface 16020 638318 2.4.1.129 peptidoglycan glycosyltransferase membrane - 16020 -, 488531, 488532, 488533, 488534, 488535, 671367, 706545, 759431, 759728, 759785 2.4.1.129 peptidoglycan glycosyltransferase membrane the PGT domain of penicillin-binding protein is anchored on the outer surface of the bacterial cell membrane by a transmembrane helix 16020 758901 2.4.1.129 peptidoglycan glycosyltransferase membrane transmembrane protein 16020 -, 759785 2.4.1.13 sucrose synthase membrane a mechanism involving protein phosphorylation/dephosphorylation and/or calcium would in part control the association of the isoforms of sucrose synthase with membranes in developing fruit 16020 676648 2.4.1.13 sucrose synthase membrane bound to 16020 660272 2.4.1.13 sucrose synthase membrane membrane-bound 16020 488557 2.4.1.13 sucrose synthase membrane partial membrane localization when expressed in Escherichia coli. Two regions of SUS1 contribute to membrane affinity: the amino-terminal noncatalytic domain, and a region with sequence similarity to the C-terminal pleckstrin homology domain of human pleckstrin. Alanine substitutions within the pleckstrin homology-like domain of SUS1 reduce membrane association in Escherichia coli and with plant microsomes in vitro without reducing enzymatic activity 16020 676601 2.4.1.13 sucrose synthase membrane SUS-SH1 is associated with membranes 16020 676470 2.4.1.13 sucrose synthase membrane SUS1 is associated with membranes 16020 676470 2.4.1.13 sucrose synthase membrane there are soluble and membrane-bound forms of SuS in Anabaena 16020 689691 2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase membrane - 16020 707436, 707472, 708974, 710284 2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase membrane membrane-bound 16020 638569, 638570, 638571 2.4.1.132 GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase membrane - 16020 -, 636763, 707472, 709008, 759165 2.4.1.132 GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase membrane type II transmembrane proteins 16020 -, 636757, 636762 2.4.1.133 xylosylprotein 4-beta-galactosyltransferase membrane - 16020 637184, 637191, 637192, 718777, 723155 2.4.1.133 xylosylprotein 4-beta-galactosyltransferase membrane of Schwann cells 16020 704010 2.4.1.134 galactosylxylosylprotein 3-beta-galactosyltransferase membrane - 16020 637184 2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase membrane - 16020 676957 2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase membrane bound 16020 393083, 393084 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase membrane - 16020 639513, 722362 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase membrane Alg13p protein localizes both to the membrane and cytosol 16020 674482 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase membrane Alg14p protein is exclusively membrane-bound 16020 674482 2.4.1.142 chitobiosyldiphosphodolichol beta-mannosyltransferase membrane membrane topology of Alg1, overview. A conserved alpha-helix domain, Alg1 Nalpha3 domain, contributes to the membrane association of Alg1 protein 16020 -, 759312 2.4.1.143 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane - 16020 488365, 488370, 644865, 644867 2.4.1.143 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase membrane enzyme exhibits a type II transmembrane protein topology with a putative N-terminal cytoplasmic tail of 9 amino acids followed by transmembrane domain of 18 residues, and a C-terminal luminal domain of 405 residues 16020 658859 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase membrane - 16020 488370, 638213, 638214, 638223, 638227, 638228 2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase membrane - 16020 488370, 637306 2.4.1.146 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase membrane - 16020 488370 2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase membrane - 16020 638140, 638141, 758840 2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase membrane - 16020 638606 2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase membrane membrane-bound 16020 638576 2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase membrane type II membrane protein topology, longest transmembrane domain among glycosyltransferases cloned so far 16020 638582 2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase membrane type II transmembrane topology 16020 638563, 638567 2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase membrane - 16020 637652, 639541 2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase membrane bound to 16020 489362, 639530 2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase membrane type II membrane protein, membrane-bound form in trans cistermae of Golgi 16020 637644, 637649, 637652 2.4.1.153 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminyltransferase membrane the enzyme initiates the N-linked glycan biosynthesis in the cytoplasm by transfer of N-acetyl-alpha-D-glucosamine to the membrane bound acceptor dolichyl phosphate. The recombinant enzyme produced in Escherichia coli sediments with the membrane fraction and requires detergent for solubility, suggesting it may contain hydrophobic regions that associate with the membrane 16020 -, 732558 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase membrane - 16020 638544, 638546, 638547, 638548, 638549 2.4.1.16 chitin synthase membrane - 16020 -, 488647, 685019, 685896, 686465, 686825, 687096, 706474, 736445 2.4.1.16 chitin synthase membrane assembly mechanism of the chitin synthase Ar-CS1 via its extracellular domain ArCS1_E22 16020 736703 2.4.1.16 chitin synthase membrane CHSB contains 5 transmembrane regions 16020 686220 2.4.1.16 chitin synthase membrane integral membrane protein 16020 658597 2.4.1.16 chitin synthase membrane integral, analysis of the transmembrane helices of CHSA 16020 687088 2.4.1.16 chitin synthase membrane predicted to be a transmembrane protein 16020 719599 2.4.1.16 chitin synthase membrane transmembrane CHS2 with an extracellular C-terminal domain 16020 688068 2.4.1.16 chitin synthase membrane transmembrane protein 16020 756846 2.4.1.16 chitin synthase membrane transmembrane protein, the insect chitin synthase contains multiple transmembrane helices reflecting their association with either the plasma membrane or intracellular vesicles such as chitosomes 16020 736241 2.4.1.165 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase membrane - 16020 657827 2.4.1.168 xyloglucan 4-glucosyltransferase membrane - 16020 488687, 488690, 488691, 488692 2.4.1.17 glucuronosyltransferase membrane - 16020 488745, 488749, 658515, 658519, 659571, 659783, 659973, 735648, 759116, 759553, 759930 2.4.1.17 glucuronosyltransferase membrane amino-half of GelK is involved in protein association to the membrane 16020 488796 2.4.1.17 glucuronosyltransferase membrane bound 16020 695269 2.4.1.17 glucuronosyltransferase membrane integral 16020 659971 2.4.1.173 sterol 3beta-glucosyltransferase membrane - 16020 488870, 637767, 637771, 706323 2.4.1.173 sterol 3beta-glucosyltransferase membrane associated 16020 -, 759680 2.4.1.173 sterol 3beta-glucosyltransferase membrane at lipid rafts 16020 722093 2.4.1.173 sterol 3beta-glucosyltransferase membrane bound 16020 723149 2.4.1.173 sterol 3beta-glucosyltransferase membrane during micropexophagy, the glucosyltransferase is associated with the micropexophagic apparatus. GRAM domain is essential for proper protein association with its target membrane 16020 -, 658544 2.4.1.173 sterol 3beta-glucosyltransferase membrane membrane bound 50% of the activity 16020 637766 2.4.1.173 sterol 3beta-glucosyltransferase membrane membrane fraction 16020 488869, 637773, 637777 2.4.1.173 sterol 3beta-glucosyltransferase membrane membrane-bound 16020 690224 2.4.1.173 sterol 3beta-glucosyltransferase membrane organelles membrane 16020 208429, 637771 2.4.1.173 sterol 3beta-glucosyltransferase membrane sonicated homogenate 16020 637769 2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase membrane type II membrane protein topology 16020 638346, 638347 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase membrane type II membrane protein 16020 659262 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase membrane type II membrane protein topology 16020 638346, 638347, 638349 2.4.1.179 lactosylceramide beta-1,3-galactosyltransferase membrane - 16020 488980, 638376, 638380 2.4.1.180 lipopolysaccharide N-acetylmannosaminouronosyltransferase membrane - 16020 -, 488808 2.4.1.182 lipid-A-disaccharide synthase membrane LpxB activity is dependent upon the bulk surface concentration of ist substrates in a mixed micelle assay system, suggesting that catalysis occurs at the membrane interface 16020 -, 702266 2.4.1.182 lipid-A-disaccharide synthase membrane LpxB is a membrane-associated lipid A enzyme 16020 -, 758842 2.4.1.182 lipid-A-disaccharide synthase membrane membrane-associated. LpxB is a membrane surface active enzyme. The hydrophobic patch (V66, V68, L69, L72, L75, and L76) is essential for productive membrane association or substrate binding 16020 759836 2.4.1.188 N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase membrane - 16020 -, 488821 2.4.1.197 high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase membrane - 16020 488874 2.4.1.197 high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase membrane membrane-associated 16020 488873 2.4.1.198 phosphatidylinositol N-acetylglucosaminyltransferase membrane - 16020 288963, 638128, 638129, 638131, 703326 2.4.1.199 beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase membrane - 16020 638243 2.4.1.205 galactogen 6beta-galactosyltransferase membrane endomembrane-associated, probably in Golgi complex 16020 488883 2.4.1.206 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase membrane - 16020 638232, 638236 2.4.1.208 diglucosyl diacylglycerol synthase (1,2-linking) membrane - 16020 488884 2.4.1.208 diglucosyl diacylglycerol synthase (1,2-linking) membrane lipid bilayer binding by the enzyme 16020 -, 661626 2.4.1.210 limonoid glucosyltransferase membrane - 16020 288691 2.4.1.212 hyaluronan synthase membrane - 16020 395247, 395248, 395251, 395253, 395257, 658093, 691191, 692221, 693368, 722741, 722816 2.4.1.212 hyaluronan synthase membrane are integral membrane proteins with transmembrane domains in addition to membrane-associated domains 16020 736145 2.4.1.212 hyaluronan synthase membrane associated 16020 672412 2.4.1.212 hyaluronan synthase membrane bound 16020 659171 2.4.1.212 hyaluronan synthase membrane enzyme is predicted to be an integral membrane protein 16020 395246 2.4.1.212 hyaluronan synthase membrane fraction containing membrane proteins from the endoplasmic reticulum and Golgi apparatus 16020 704558 2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase membrane - 16020 661836 2.4.1.219 vomilenine glucosyltransferase membrane - 16020 488936 2.4.1.22 lactose synthase membrane - 16020 488939, 488943, 488946, 488947 2.4.1.22 lactose synthase membrane B4GALT1 is a type II transmembrane enzyme 16020 695081 2.4.1.22 lactose synthase membrane Golgi apparatus, galactosyl-transferase 16020 488939 2.4.1.221 peptide-O-fucosyltransferase membrane - 16020 441440 2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase membrane apical and surface membranes 16020 658503 2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase membrane human EXTL3 is inserted into the Golgi apparatus membrane by an N-terminal transmembrane helix of 20 residues, followed by an unstructured protein segment of about 18 residues, rich in charged amino acids, and then around 80 residues of coiled-coil structure that may play a role in positioning and/or orienting the following catalytic domains on the Golgi membrane 16020 758808 2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase membrane - 16020 -, 488957 2.4.1.224 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase membrane transmembrane protein 16020 488962 2.4.1.225 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase membrane - 16020 -, 488957 2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase membrane enzyme is a type II membrane protein 16020 659234 2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase membrane - 16020 -, 488970, 488972, 736947 2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase membrane associated 16020 722525 2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase membrane intracellular membrane-associated 16020 735347 2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase membrane the enzyme localization to the membrane depends on the phospholipid cardiolipin 16020 735983 2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase membrane - 16020 659273 2.4.1.232 initiation-specific alpha-1,6-mannosyltransferase membrane - 16020 690519, 692139 2.4.1.232 initiation-specific alpha-1,6-mannosyltransferase membrane Mnn9p is a membrane-associated protein, type II transmembrane protein 16020 -, 636762 2.4.1.241 digalactosyldiacylglycerol synthase membrane DGD2 is localized to the outer side of chloroplast envelope membranes 16020 660126 2.4.1.241 digalactosyldiacylglycerol synthase membrane integral membrane protein of the outer envelope of the chloroplast 16020 659157 2.4.1.241 digalactosyldiacylglycerol synthase membrane located on the symbiosome membranes in the infected cells 16020 759791 2.4.1.241 digalactosyldiacylglycerol synthase membrane outer chloroplast envelope membrane 16020 760062 2.4.1.251 GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase membrane monotopic membrane protein 16020 722357 2.4.1.252 GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase membrane associated with 16020 704396 2.4.1.257 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase membrane - 16020 707472, 709008, 759165 2.4.1.258 dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase membrane - 16020 707606 2.4.1.258 dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase membrane potential ER-transmembrane protein 16020 708619 2.4.1.264 D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase membrane - 16020 703881, 704434 2.4.1.265 dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase membrane - 16020 -, 736726 2.4.1.274 glucosylceramide beta-1,4-galactosyltransferase membrane - 16020 714364 2.4.1.275 neolactotriaosylceramide beta-1,4-galactosyltransferase membrane - 16020 715137 2.4.1.276 zeaxanthin glucosyltransferase membrane weakly membrane-associated, without apparent membrane-spanning regions 16020 716795 2.4.1.287 rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase membrane - 16020 -, 719707 2.4.1.291 N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase membrane asociated 16020 -, 720888 2.4.1.292 GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase membrane asociated 16020 -, 720888 2.4.1.293 GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase membrane - 16020 -, 720888 2.4.1.305 UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase membrane - 16020 -, 722520 2.4.1.315 diglucosyl diacylglycerol synthase (1,6-linking) membrane localization is independent of phosphoglucomutase PgcA and hence the production of UDP-Glc 16020 -, 736829 2.4.1.32 glucomannan 4-beta-mannosyltransferase membrane - 16020 489049, 489050, 489051 2.4.1.335 dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase membrane the enzyme is purified from membrane fraction of recombinant Escherichia coli 16020 -, 732558 2.4.1.336 monoglucosyldiacylglycerol synthase membrane - 16020 639546, 735699 2.4.1.336 monoglucosyldiacylglycerol synthase membrane enzyme binds to the membrane in a fairly upright manner, mainly by residues in the N-terminal domain, and in a way that induces local enrichment of anionic lipids and a local curvature deformation 16020 736087 2.4.1.336 monoglucosyldiacylglycerol synthase membrane integral membrane protein 16020 735136 2.4.1.336 monoglucosyldiacylglycerol synthase membrane plasma and thylakoid membranes 16020 735136 2.4.1.336 monoglucosyldiacylglycerol synthase membrane predominant localisation 16020 703718 2.4.1.337 1,2-diacylglycerol 3-alpha-glucosyltransferase membrane - 16020 639548, 639550, 658012 2.4.1.337 1,2-diacylglycerol 3-alpha-glucosyltransferase membrane associated with, in vitro enzyme binds less efficiently to liposomes containing only zwitterionic lipids whereas increasing fractions of anionic phosphatidyglycerol or cardiolipin strongly promote binding 16020 658012 2.4.1.337 1,2-diacylglycerol 3-alpha-glucosyltransferase membrane bound to 16020 639549 2.4.1.34 1,3-beta-glucan synthase membrane - 16020 489060, 701700, 736983 2.4.1.34 1,3-beta-glucan synthase membrane inner membrane of both Escherichia coli or Agrobacterium sp., integral membrane protein 16020 -, 658842 2.4.1.34 1,3-beta-glucan synthase membrane integral membrane protein 16020 -, 736852 2.4.1.34 1,3-beta-glucan synthase membrane transmembrane protein 16020 660182 2.4.1.341 alpha-1,2-colitosyltransferase membrane - 16020 -, 736206 2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase membrane - 16020 489346 2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase membrane recombinant protein 16020 756726 2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase membrane sequence predicts a type II transmembrane protein 16020 741349 2.4.1.345 phosphatidyl-myo-inositol alpha-mannosyltransferase membrane - 16020 -, 736430 2.4.1.345 phosphatidyl-myo-inositol alpha-mannosyltransferase membrane PimA attaches to the membrane through its N-terminal domain and this association leads to enzyme activation 16020 680790 2.4.1.345 phosphatidyl-myo-inositol alpha-mannosyltransferase membrane sequence contains a putative transmembrane segment, residues 275-298 16020 -, 659183 2.4.1.346 phosphatidyl-myo-inositol dimannoside synthase membrane - 16020 -, 704533, 740664 2.4.1.348 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase membrane - 16020 745794 2.4.1.349 mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase membrane - 16020 745794 2.4.1.35 phenol beta-glucosyltransferase membrane - 16020 -, 489105, 489107 2.4.1.35 phenol beta-glucosyltransferase membrane associated to 16020 489103 2.4.1.356 glucosyl-dolichyl phosphate glucuronosyltransferase membrane - 16020 747217 2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase membrane the enzyme catalyzing the transfer of galactose to 2'-fucosyllactose is much more tightly attached to membrane than the transferase which utilizes N-acetyllactosamine 16020 489128 2.4.1.371 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase membrane - 16020 765040 2.4.1.375 rhamnogalacturonan I galactosyltransferase membrane - 16020 758084 2.4.1.377 dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase membrane - 16020 -, 761365 2.4.1.378 GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase membrane - 16020 -, 761365 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase membrane - 16020 489510, 489516, 489522, 489530, 489531, 489535, 489550, 489551, 685737, 704010, 736539 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase membrane N-terminal hydrophobic segment serves as the membrane anchor, the C-terminal region is oriented within the lumen of the Golgi membranes 16020 489505 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase membrane plasma membrane enriched fraction 16020 489525 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase membrane the enzyme from kidney appears to be an intrinsic membrane protein 16020 489527 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase membrane trans-membrane protein 16020 686257 2.4.1.380 GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase membrane - 16020 -, 761365 2.4.1.381 dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase membrane - 16020 -, 761365 2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase membrane - 16020 489152 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane - 16020 489173, 489182, 489184, 489185, 736774 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane GalNAc-T7: type II transmembrane protein with a hydrophobic signal anchor sequence in residues 10-24 16020 489180 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane GalNAc-T9: type II membrane protein with a 20-amino acid transmembrane domain, a 7-amino acid cytoplasmic domain and a 91-amino acid stem region 16020 489181 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane membrane-bound 16020 489167, 489170, 489172, 489174, 489175, 489177 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane ppGalNAc-T14: type II membrane protein 16020 489183 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane ppGaNTase-T13: type II membrane protein with a 20-amino acid transmembrane segment and an 8-amino acid N-terminal cytoplasmic domain 16020 489184 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane ppGaNTase-T6: type II membrane protein with a 27-amino acid hydrophobic region 16020 489185 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane ppGaNTase-T9: type II integral membrane protein with a 20-amino acid transmembrane domain, a 9-amino acid cytoplasmic domain and a 94-amino acid stem region 16020 489182 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane type II membrane protein 16020 489189, 489190 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane type II membrane protein containing a 23-amino acid transmembrane domain and an 8-amino acid cytoplasmic tail 16020 489175, 489191 2.4.1.41 polypeptide N-acetylgalactosaminyltransferase membrane type II membrane protein, 22-amino acid transmembrane sequence 16020 489194 2.4.1.43 polygalacturonate 4-alpha-galacturonosyltransferase membrane - 16020 489205, 489207, 489208, 671292, 676856 2.4.1.44 lipopolysaccharide 3-alpha-galactosyltransferase membrane bound 16020 -, 489212 2.4.1.46 monogalactosyldiacylglycerol synthase membrane membrane-bound 16020 489227 2.4.1.47 N-acylsphingosine galactosyltransferase membrane - 16020 489220 2.4.1.47 N-acylsphingosine galactosyltransferase membrane membrane-bound 16020 489217, 489218 2.4.1.47 N-acylsphingosine galactosyltransferase membrane with C-terminal 23 amino acids transmembrane domain 16020 489220 2.4.1.47 N-acylsphingosine galactosyltransferase membrane with transmembrane helical domain, hydrophobic sequence of 20 amino acids in the C-terminal domain 16020 489222 2.4.1.48 heteroglycan alpha-mannosyltransferase membrane cell wall associated 16020 -, 489241 2.4.1.50 procollagen galactosyltransferase membrane associated with membrane structures 16020 489281, 489284 2.4.1.52 poly(glycerol-phosphate) alpha-glucosyltransferase membrane - 16020 489286 2.4.1.54 undecaprenyl-phosphate mannosyltransferase membrane - 16020 489291 2.4.1.54 undecaprenyl-phosphate mannosyltransferase membrane membrane-bound 16020 489289, 489290 2.4.1.58 lipopolysaccharide glucosyltransferase I membrane - 16020 -, 489212 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase membrane - 16020 637637, 637649, 637650, 637651, 637652, 637653, 637654, 637655, 637656, 637657, 637658, 637659, 637660, 639545, 736817 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase membrane FUT10-419 and FUT10-479 have a type II trans-membrane topology. FUT10-479 has, in addition, a COOH-endoplasmic reticulum membrane retention signal 16020 704613 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase membrane stable BHK-21 cell lines express the Golgi bound form and two secretory forms of the enzyme 16020 637648 2.4.1.66 procollagen glucosyltransferase membrane associated with membrane structures 16020 636777 2.4.1.66 procollagen glucosyltransferase membrane membrane-bound 16020 636772, 636773, 636774, 636785, 636787 2.4.1.66 procollagen glucosyltransferase membrane membrane-bound and soluble forms in platelets, lymphocytes and granulocytes 16020 636786 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase membrane - 16020 489332 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase membrane a transmembrane protein 16020 721723 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase membrane enzyme has a cytosolic part and a stem region which is very suceptible to proteolysis 16020 441440 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase membrane - 16020 489346, 489367, 703885 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase membrane bound to 16020 489362 2.4.1.78 phosphopolyprenol glucosyltransferase membrane - 16020 489379 2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase membrane - 16020 489383 2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase membrane bound to 16020 489382 2.4.1.80 ceramide glucosyltransferase membrane - 16020 -, 489404, 489405, 489407, 489409, 489410, 489412 2.4.1.80 ceramide glucosyltransferase membrane bound 16020 658310 2.4.1.80 ceramide glucosyltransferase membrane enzyme contains a membrane-spanning region 16020 659376 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane - 16020 489427, 489455, 723410 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane bound to 16020 489426 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane DPMS has one membrane spanning region 16020 703922 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane DPMS is an integral membrane protein 16020 -, 757762 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane enzyme is anchored with both its N-termini and C-termini in the membrane, while the main part of the protein is oriented towards the lumen of the endoplasmic reticulum 16020 489428 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane enzyme is closely associated with membranes of the endoplasmic reticulum 16020 489446 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane microsomal 16020 489443 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane N-terminal domain is membrane-bound 16020 692257 2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase membrane of the endoplasmic reticulum 16020 489449 2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase membrane - 16020 489463, 489465, 489471 2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase membrane bound 16020 489464, 489478 2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase membrane - 16020 489481, 489482, 489485 2.4.1.90 N-acetyllactosamine synthase membrane - 16020 489510, 489516, 489522, 489530, 489531, 489535, 489550, 489551, 659700, 660309 2.4.1.90 N-acetyllactosamine synthase membrane integral, the catalytic site of the enzyme faces the lumen 16020 660308 2.4.1.90 N-acetyllactosamine synthase membrane N-terminal hydrophobic segment serves as the membrane anchor, the C-terminal region is oriented within the lumen of the Golgi membranes 16020 489505 2.4.1.90 N-acetyllactosamine synthase membrane plasma membrane enriched fraction 16020 489525 2.4.1.90 N-acetyllactosamine synthase membrane the enzyme from kidney appears to be an intrinsic membrane protein 16020 489527 2.4.1.90 N-acetyllactosamine synthase membrane type II membrane-bound protein 16020 658032, 658502 2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase membrane - 16020 659865 2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase membrane mitochondria-associated membrane, i.e. a membrane bridge between the endoplasmic reticulum and mitochondria 16020 657819 2.4.1.94 protein N-acetylglucosaminyltransferase membrane - 16020 489608 2.4.1.B3 alpha-1,4-glucan synthase membrane - 16020 692995 2.4.1.B51 diglucosylarchaeol synthase membrane - 16020 -, 719709 2.4.1.B58 dolichol phosphate-mannose mannosyltransferase membrane multispanning membrane protein 16020 -, 727764 2.4.1.B64 glucosyltransferase Waag membrane WaaG is membrane-bound, membrane association mechanism, overview. Binding of WaaG to membranes is analyzed by stopped-flow fluorescence and NMR diffusion experiments. Electrostatic interactions are required to bind WaaG to membranes while mere hydrophobic interactions are not sufficient. WaaG senses the membrane's surface charge density but there is no preferential binding to specific anionic lipids. The binding is weaker than expected for monotopic GTs but similar to peripheral GTs. Therefore, WaaG may be a peripheral GT and this can be of functional relevance in vivo since LPS synthesis occurs only when WaaG is membrane-bound. No C-terminal domain movement is observed under the experimental conditions 16020 758841 2.4.1.B72 C-mannosyltransferase membrane transmembrane protein, membrane topology prediction and spacing between transmembrane domains of DPY-19, overview 16020 736804 2.4.1.B80 alpha-dystroglycan glucuronosyltransferase membrane - 16020 759304 2.4.2.24 1,4-beta-D-xylan synthase membrane - 16020 660079 2.4.2.24 1,4-beta-D-xylan synthase membrane associated 16020 489791 2.4.2.24 1,4-beta-D-xylan synthase membrane bound 16020 489790, 489792 2.4.2.24 1,4-beta-D-xylan synthase membrane microsomal membrane 16020 682462 2.4.2.26 protein xylosyltransferase membrane isoform XT-II, type II transmembrane protein 16020 637619 2.4.2.30 NAD+ ADP-ribosyltransferase membrane membrane localization domain 16020 -, 663377 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane - 16020 638113, 638115, 669719, 675027 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane anchored to membranes by glycosylphosphatidylinositol 16020 638109, 638123, 638124, 638125 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane associated with 16020 638105 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane glycosyl-phosphatidylinositol-anchored protein 16020 657869 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane glycosylphosphatidylinositol-anchored membrane protein 16020 638115 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane membranes of the nuclear envelope 16020 723565 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane the enzyme is likely to be linked to the cell surface via a glycosylphosphatidylinositol 16020 638117 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane Yac-1 enzyme is anchored to membranes by glycosylphosphatidylinositol 16020 638124 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase membrane Yac-2 enzyme is membrane-bound but appears not to be glycosylphosphatidylinositol-anchored 16020 638115, 638124 2.4.2.32 dolichyl-phosphate D-xylosyltransferase membrane - 16020 637245 2.4.2.33 dolichyl-xylosyl-phosphate-protein xylosyltransferase membrane - 16020 637245 2.4.2.38 glycoprotein 2-beta-D-xylosyltransferase membrane - 16020 676122 2.4.2.38 glycoprotein 2-beta-D-xylosyltransferase membrane enzyme possesses a transmembrane domain 16020 660169 2.4.2.39 xyloglucan 6-xylosyltransferase membrane - 16020 488687, 488690, 489821 2.4.2.41 xylogalacturonan beta-1,3-xylosyltransferase membrane type II membrane protein 16020 700732 2.4.2.43 lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase membrane - 16020 -, 739657, 739708, 759062 2.4.2.43 lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase membrane inner membrane 16020 698718 2.4.2.43 lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase membrane integral inner membrane protein 16020 738342 2.4.2.45 decaprenyl-phosphate phosphoribosyltransferase membrane - 16020 -, 719830, 739737 2.4.2.46 galactan 5-O-arabinofuranosyltransferase membrane - 16020 738344 2.4.2.47 arabinofuranan 3-O-arabinosyltransferase membrane - 16020 -, 718461, 738344, 759766 2.4.2.47 arabinofuranan 3-O-arabinosyltransferase membrane trans-membrane protein 16020 -, 720490 2.4.2.61 alpha-dystroglycan beta1,4-xylosyltransferase membrane type II transmembrane protein 16020 749531 2.4.2.62 xylosyl alpha-1,3-xylosyltransferase membrane - 16020 759815 2.4.2.7 adenine phosphoribosyltransferase membrane - 16020 638147 2.4.2.8 hypoxanthine phosphoribosyltransferase membrane - 16020 638391 2.4.2.8 hypoxanthine phosphoribosyltransferase membrane isozyme HXGPRT-II possessisng the 49-amino acid insertion, localizes to the inner membrane complex (IMC) of the parasite 16020 674442 2.4.2.B18 alpha-dystroglycan xylosyltransferase membrane - 16020 759304 2.4.2.B4 (KDO)2-lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase membrane inner membrane 16020 698718 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase membrane - 16020 -, 636887, 636888, 637267, 637268, 637269, 637270, 637271, 637272, 637283, 637286, 637288, 721384 2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase membrane is a type II membrane-bound protein with a short cytosolic region of 11 amino acids (M1-G11), a single transmembrane region of 19 amino acids (M12-F30) and a luminal domain of 465 amino acids (T31-A495) 16020 703887 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase membrane - 16020 637736, 637741 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase membrane Golgi membrane 16020 744380 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase membrane - 16020 636794, 636800 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase membrane bound to 16020 636796 2.4.3.4 beta-galactoside alpha-2,3-sialyltransferase membrane - 16020 745248 2.4.3.5 galactosyldiacylglycerol alpha-2,3-sialyltransferase membrane - 16020 489823, 757119 2.4.3.7 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase membrane - 16020 637982, 638768, 638771, 671891 2.4.3.7 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase membrane type II membrane protein 16020 674352 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase membrane - 16020 -, 587166, 587167, 636879, 636888, 637736, 638784, 638788, 639650, 639653, 765028, 765331 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase membrane membrane association is not essential for enzyme functionality. Analyses performed with crude membrane fractions as enzyme source 16020 700260 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase membrane - 16020 -, 636888, 637736, 638784, 736209 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase membrane level of GM3 synthase in membrane-fractions isolated from the atherosclerotic intima are higher compared to those in non-dieased arterial tissue 16020 657703 2.4.99.12 lipid IVA 3-deoxy-D-manno-octulosonic acid transferase membrane - 16020 723660 2.4.99.12 lipid IVA 3-deoxy-D-manno-octulosonic acid transferase membrane membrane-bound 16020 698707 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane - 16020 -, 488510, 488513, 686393, 686969, 709145 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane associated 16020 718745 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane bound to 16020 488496, 488498, 488499, 488505, 488513 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane membrane protein complex. Ost2p and Stt3p have only their N terminus located in the cytosol. Ost3p and Swp1p have only their C terminus oriented in the cytosol. In the case of Ost5p and Ost6p, both their N and C termini are present in the cytosol 16020 676793 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane multiple oligosaccharyl transferase isoforms with different affinities for the translocon and ribosome and with heterogeneous subunit composition might exist in the endoplasmic reticulum membrane, thereby providing a means of regulating protein N-glycosylation 16020 677125 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Ost4p is a minimembrane protein 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Ost5p is a membrane protein 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Swp1p probably possesses three transmembrane segments, with its N-terminus in the lumen and C-terminus in the cytosol 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The functional domain of Ost1p is its membrane-anchored lumenal domain 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The Ost2 protein possesses three transmembrane segments, with its N-terminus in the cytosol and C-terminus directed towards the lumen 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The sequence of the lumen-oriented half of the transmembrane domain is important for the function of the Wbp1 protein 16020 684130 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane OST48, ribophorin I and ribophorin II possess a type I membrane topolyogy with the bulk of their polypeptide chains directed towards the lumen of the endoplasmic reticulum 16020 488512 2.4.99.18 dolichyl-diphosphooligosaccharide-protein glycotransferase membrane PglB possesses 11 transmembrane segments and two relatively large periplasmic regions other than the C-terminal domain 16020 707399 2.4.99.19 undecaprenyl-diphosphooligosaccharide-protein glycotransferase membrane - 16020 -, 709145 2.4.99.19 undecaprenyl-diphosphooligosaccharide-protein glycotransferase membrane topological model of PglB with periplasmic, transmembrane, and cytoplasmic parts, overview 16020 707399 2.4.99.19 undecaprenyl-diphosphooligosaccharide-protein glycotransferase membrane transmembrane protein 16020 720542 2.4.99.20 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase membrane of heavy sarcoplasmic reticulum 16020 726898 2.4.99.21 dolichyl-phosphooligosaccharide-protein glycotransferase membrane - 16020 733612 2.4.99.21 dolichyl-phosphooligosaccharide-protein glycotransferase membrane the recombinant enzyme is purified from membrane fraction from Escherichia coli 16020 732558 2.4.99.23 lipopolysaccharide heptosyltransferase I membrane - 16020 727824 2.5.1.115 homogentisate phytyltransferase membrane - 16020 724994, 728504 2.5.1.115 homogentisate phytyltransferase membrane membrane-bound 16020 726214 2.5.1.115 homogentisate phytyltransferase membrane of chloroplast 16020 738919 2.5.1.117 homogentisate solanesyltransferase membrane - 16020 727867 2.5.1.136 2-acylphloroglucinol 4-prenyltransferase membrane sequence contains membrane-spanning domains 16020 741131 2.5.1.138 coumarin 8-geranyltransferase membrane protein contains multiple transmembrane domains 16020 741201 2.5.1.139 umbelliferone 6-dimethylallyltransferase membrane - 16020 741126 2.5.1.141 heme o synthase membrane - 16020 -, 759239 2.5.1.145 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase membrane - 16020 -, 747929, 748062, 748741, 749229 2.5.1.145 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase membrane an integral inner membrane protein, the enzyme's signature motif faces the periplasm 16020 748085 2.5.1.145 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase membrane peripheral membrane protein on the cytoplasmic side of the inner-membrane 16020 747214 2.5.1.145 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase membrane weakly associated to the inner membrane 16020 759617 2.5.1.148 lycopaoctaene synthase membrane lycopaoctaene synthase (LOS) activity is localized to a membrane system, possibly the endoplasmic reticulum as is seen for squalene synthase 16020 743340 2.5.1.18 glutathione transferase membrane - 16020 685137 2.5.1.18 glutathione transferase membrane associated, MGST1 16020 701919 2.5.1.18 glutathione transferase membrane GSTF2 association with membrane vesicles 16020 721531 2.5.1.18 glutathione transferase membrane integral 16020 702529 2.5.1.18 glutathione transferase membrane integral membrane protein 16020 737674 2.5.1.20 rubber cis-polyprenylcistransferase membrane bound 16020 723103 2.5.1.21 squalene synthase membrane - 16020 -, 489835, 489845, 489859, 739582, 739589 2.5.1.21 squalene synthase membrane a membrane associated enzyme 16020 739290 2.5.1.21 squalene synthase membrane bound 16020 738718, 738856, 741903 2.5.1.21 squalene synthase membrane bound, the membrane-binding domains of the human enzyme are 30 residues of the N-terminus and 47 residues of the C-terminus 16020 738718 2.5.1.21 squalene synthase membrane membrane-bound 16020 759271 2.5.1.21 squalene synthase membrane model of the secondary structure and its possible membrane orientation 16020 489834 2.5.1.21 squalene synthase membrane the enzyme has two transmembrane domains at its C-terminus 16020 758957 2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] membrane - 16020 -, 637488, 722345 2.5.1.32 15-cis-phytoene synthase membrane - 16020 676344 2.5.1.32 15-cis-phytoene synthase membrane isoform PSY1 is localized to amyloplast envelope membrane 16020 689617 2.5.1.32 15-cis-phytoene synthase membrane membrane-associated. Treatment with high ionic strength buffer or mild non-ionic detergent is required for solubilization 16020 637885 2.5.1.32 15-cis-phytoene synthase membrane peripheral plastid membrane 16020 637876 2.5.1.32 15-cis-phytoene synthase membrane the soluble enzyme is complexed and inactive, the membrane-bound enzyme is active 16020 637882 2.5.1.36 trihydroxypterocarpan dimethylallyltransferase membrane bound 16020 722715 2.5.1.39 4-hydroxybenzoate polyprenyltransferase membrane - 16020 -, 637001, 637002, 637003, 703208 2.5.1.39 4-hydroxybenzoate polyprenyltransferase membrane membrane-bound protein 16020 704240 2.5.1.39 4-hydroxybenzoate polyprenyltransferase membrane the enzyme contains 6 transmembrane sequences 16020 657846 2.5.1.39 4-hydroxybenzoate polyprenyltransferase membrane the enzyme has nine transmembrane helices and an extramembrane cap domain that surround a large central cavity containing the active site. To facilitate the catalysis inside membranes, UbiA has an unusual active site that opens laterally to the lipid bilayer 16020 -, 728802 2.5.1.41 phosphoglycerol geranylgeranyltransferase membrane - 16020 -, 638437 2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase membrane - 16020 -, 638437 2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase membrane integral membrane protein 16020 704412 2.5.1.43 nicotianamine synthase membrane isozyme MxNAS2 is preferentially localized in vesicles and cytoplasmic membrane 16020 739648 2.5.1.61 hydroxymethylbilane synthase membrane - 16020 687782 2.5.1.62 chlorophyll synthase membrane - 16020 658095 2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase membrane minor activity 16020 -, 669077 2.5.1.70 naringenin 8-dimethylallyltransferase membrane - 16020 702765, 722715, 739272 2.5.1.71 leachianone-G 2''-dimethylallyltransferase membrane bound, determination of enzyme distibution in membranes 16020 676566 2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase membrane - 16020 696178, 698675 2.5.1.86 trans,polycis-decaprenyl diphosphate synthase membrane associated 16020 669077 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] membrane - 16020 -, 738313 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] membrane enzyme NgBR is a polytypic membrane protein 16020 738001 2.5.1.93 4-hydroxybenzoate geranyltransferase membrane - 16020 702133, 737898 2.5.1.93 4-hydroxybenzoate geranyltransferase membrane membrane-bound 16020 738205 2.5.1.B45 8-prenyltransferase membrane - 16020 759856 2.6.1.1 aspartate transaminase membrane - 16020 639866 2.6.1.1 aspartate transaminase membrane isozyme AAT-2, very low activity of isoenzyme AAT-1 16020 639819 2.6.1.52 phosphoserine transaminase membrane inner part of the cell membrane 16020 739236 2.7.1.1 hexokinase membrane in both cytosol and membrane fractions, hexokinase weakly associates with the membrane or particulate fraction 16020 -, 640260 2.7.1.1 hexokinase membrane sperm 16020 640229 2.7.1.107 diacylglycerol kinase (ATP) membrane - 16020 640357, 640361, 640362, 640363, 640379, 640380, 640387, 660956, 661105, 661459, 662389, 706762, 737685 2.7.1.107 diacylglycerol kinase (ATP) membrane at early stages of T cell immunological synapse formation, isoform zeta translocates rapidly to the plasma membrane 16020 723137 2.7.1.107 diacylglycerol kinase (ATP) membrane bound to 16020 640354, 640357, 640364, 640371 2.7.1.107 diacylglycerol kinase (ATP) membrane DGK IV 16020 640364 2.7.1.107 diacylglycerol kinase (ATP) membrane DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function 16020 701582 2.7.1.107 diacylglycerol kinase (ATP) membrane in lymphocytes the basal activity is 1.6fold higher in the membrane fraction than in cytosol. In neutrophils the basal activity is identical in cytosol and membrane-fraction 16020 640374 2.7.1.107 diacylglycerol kinase (ATP) membrane integral membrane protein 16020 640369, 661062 2.7.1.107 diacylglycerol kinase (ATP) membrane intrinsic membrane-protein 16020 640355 2.7.1.107 diacylglycerol kinase (ATP) membrane mainly associated with internal membranes 16020 691660 2.7.1.107 diacylglycerol kinase (ATP) membrane recruitment of diacylglycerol kinase alpha to the membrane is mediated both via its proline-rich sequence and phosphorylation of Y335 16020 694499 2.7.1.107 diacylglycerol kinase (ATP) membrane rhabdomeral membrane, the enzyme is located predominantly in the cytoplasmic subrhabdomeral cisternae, a cytoplasmic membrane system located at close distance from the microvilli. Excised membrane patches retain a functional enzyme DGK 16020 -, 738902 2.7.1.107 diacylglycerol kinase (ATP) membrane segment from amino acid residues 18 to 42 forms a bent helix that enters and leaves the same side of the membrane 16020 693667 2.7.1.107 diacylglycerol kinase (ATP) membrane sterile alpha-motif of diacylglycerol kinase delta1 forms helical polymers through a head-to-tail interaction. Disruption of polymerization by mutations constitutively localizes the enzyme to the plasma membrane 16020 695158 2.7.1.107 diacylglycerol kinase (ATP) membrane the enzyme is an integral membrane protein 16020 739164, 739255 2.7.1.107 diacylglycerol kinase (ATP) membrane the hydrophobic domain of DGKepsilo does not contribute to substrate specificity but plays a role in permanently sequestering the enzyme to a membrane 16020 672259 2.7.1.107 diacylglycerol kinase (ATP) membrane the region of transmembrane helix 1 spanning the hydrophobic core of the bilayer runs from Glu28 on the cytoplasmic side to Asp49 or Val50 on the periplasmic side. This locates the charged/polar cluster 32RQE34 within the hydrophobic core of the bilayer. Hydrophobic matching between the protein and the surrounding lipid bilayer is highly efficient 16020 690881 2.7.1.107 diacylglycerol kinase (ATP) membrane tightly associated with the inner membrane 16020 640352 2.7.1.107 diacylglycerol kinase (ATP) membrane upon activation of T lymphocytes, diacylglycerol kinase alpha is phosphorylated, and the phosphoprotein is located at the plasma membrane 16020 693457 2.7.1.108 dolichol kinase membrane - 16020 -, 640390, 640392, 640393, 640398, 640399, 640401 2.7.1.11 6-phosphofructokinase membrane - 16020 640450 2.7.1.121 phosphoenolpyruvate-glycerone phosphotransferase membrane enzyme II complex 16020 -, 640691 2.7.1.127 inositol-trisphosphate 3-kinase membrane membrane-bound, intrinsic membrane protein, accounts for about 25% of total activity 16020 640744 2.7.1.130 tetraacyldisaccharide 4'-kinase membrane - 16020 640805 2.7.1.130 tetraacyldisaccharide 4'-kinase membrane probably a membrane protein 16020 640806 2.7.1.130 tetraacyldisaccharide 4'-kinase membrane the enzyme is an integral membrane protein 16020 738621 2.7.1.137 phosphatidylinositol 3-kinase membrane - 16020 640908, 707454, 707877, 707915, 707930, 708681, 709868, 710354 2.7.1.138 ceramide kinase membrane - 16020 661763, 662592, 671880, 675274, 691938 2.7.1.138 ceramide kinase membrane bound 16020 661860, 662592 2.7.1.138 ceramide kinase membrane bound to, probably via the pleckstrin homology domain of the enzyme 16020 660886 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase membrane PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus 16020 721247 2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase membrane - 16020 737640, 739357 2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase membrane - 16020 707877, 707974, 709907, 710350 2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase membrane - 16020 739146 2.7.1.154 phosphatidylinositol-4-phosphate 3-kinase membrane predominantly localised to intracellular membranes 16020 672858 2.7.1.166 3-deoxy-D-manno-octulosonic acid kinase membrane - 16020 698707 2.7.1.174 diacylglycerol kinase (CTP) membrane - 16020 -, 687738, 761456 2.7.1.181 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase membrane the WbdD protein is tethered to the membrane via a C-terminal region containing amphipathic helices located between residues 601 and 669 16020 -, 722664 2.7.1.183 glycoprotein-mannosyl O6-kinase membrane Homo sapiens POMK (HsPOMK) contains a type II transmembrane (TM) domain and a lumenal kinase domain 16020 760981 2.7.1.183 glycoprotein-mannosyl O6-kinase membrane type II transmembrane protein 16020 762066 2.7.1.191 protein-Npi-phosphohistidine-D-mannose phosphotransferase membrane - 16020 -, 641881, 735566, 735736, 736355, 736386, 736390, 761305 2.7.1.191 protein-Npi-phosphohistidine-D-mannose phosphotransferase membrane integral membrane protein 16020 735488 2.7.1.193 protein-Npi-phosphohistidine-N-acetyl-D-glucosamine phosphotransferase membrane - 16020 736182 2.7.1.194 protein-Npi-phosphohistidine-L-ascorbate phosphotransferase membrane - 16020 -, 736666 2.7.1.195 protein-Npi-phosphohistidine-2-O-alpha-mannosyl-D-glycerate phosphotransferase membrane - 16020 715472 2.7.1.196 protein-Npi-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase membrane - 16020 737219 2.7.1.197 protein-Npi-phosphohistidine-D-mannitol phosphotransferase membrane - 16020 -, 641875, 641879, 735654, 735658, 736126, 736381, 736389, 736402, 736549, 736794, 737220 2.7.1.197 protein-Npi-phosphohistidine-D-mannitol phosphotransferase membrane integral membrane protein 16020 641866 2.7.1.199 protein-Npi-phosphohistidine-D-glucose phosphotransferase membrane - 16020 -, 735653, 736043, 736232, 736345, 736353, 736383, 736391, 736756, 736764, 736825, 737177, 737178, 762512 2.7.1.199 protein-Npi-phosphohistidine-D-glucose phosphotransferase membrane integral membrane protein 16020 761762 2.7.1.200 protein-Npi-phosphohistidine-galactitol phosphotransferase membrane - 16020 -, 736327, 737202, 9567, 9568 2.7.1.201 protein-Npi-phosphohistidine-trehalose phosphotransferase membrane - 16020 736332, 736338, 736763, 737143 2.7.1.202 protein-Npi-phosphohistidine-D-fructose phosphotransferase membrane - 16020 -, 641880, 642507, 736034, 736035, 736349, 736577, 736754, 736811, 761246 2.7.1.204 protein-Npi-phosphohistidine-D-galactose phosphotransferase membrane - 16020 -, 735483, 736837 2.7.1.205 protein-Npi-phosphohistidine-cellobiose phosphotransferase membrane - 16020 -, 735473, 736233, 736263, 736335, 736767, 736826, 761711 2.7.1.205 protein-Npi-phosphohistidine-cellobiose phosphotransferase membrane integral membrane protein 16020 737219 2.7.1.206 protein-Npi-phosphohistidine-L-sorbose phosphotransferase membrane - 16020 -, 736344, 736814 2.7.1.207 protein-Npi-phosphohistidine-lactose phosphotransferase membrane - 16020 -, 735722, 736039, 736112, 736330, 736348, 736384, 736385, 736388, 736533, 736547, 736768, 736824, 737173, 761709 2.7.1.208 protein-Npi-phosphohistidine-maltose phosphotransferase membrane - 16020 -, 736584, 761388 2.7.1.211 protein-Npi-phosphohistidine-sucrose phosphotransferase membrane - 16020 -, 738364, 738492, 739076, 761831 2.7.1.211 protein-Npi-phosphohistidine-sucrose phosphotransferase membrane the protein has the hydropathic profile of an integral membrane protein lacking extended alpha-helical structures 16020 739094 2.7.1.216 farnesol kinase membrane - 16020 741171 2.7.1.227 inositol phosphorylceramide synthase membrane - 16020 -, 752745 2.7.1.23 NAD+ kinase membrane five forms of NAD+ kianse: 1. a solvent Ca2+ sensitive form, 2. and 3. two Ca2+-calmodulin independent forms, one solvent and one membranal, 4. and 5. two Ca2+-calmodulin dependent forms, one solvent and one membranal. In dry seeds the membranal-Ca2+-calmodulin-dependent form represents 100% of the total pelletable activity 16020 641197 2.7.1.23 NAD+ kinase membrane the Ca2+-calmodulin-dependent NAD+ kinase isoforms, amongst which is the isoform bound to mitochondrial membranes play an important role at the end of sensu stricto germination and during the following growth of Avena sativa 16020 641198 2.7.1.24 dephospho-CoA kinase membrane - 16020 759246 2.7.1.46 L-arabinokinase membrane - 16020 641632 2.7.1.58 2-dehydro-3-deoxygalactonokinase membrane protoplasmic 16020 641687 2.7.1.66 undecaprenol kinase membrane - 16020 641758, 641760, 641761, 641762, 641763, 641766 2.7.1.66 undecaprenol kinase membrane bound to 16020 641759 2.7.1.66 undecaprenol kinase membrane exclusively found in the cell membrane fraction 16020 641756 2.7.1.67 1-phosphatidylinositol 4-kinase membrane - 16020 641768, 641771, 641776, 641778, 641792, 641797, 641812, 676541, 723138, 723791, 739027 2.7.1.67 1-phosphatidylinositol 4-kinase membrane associated 16020 641783, 641785 2.7.1.67 1-phosphatidylinositol 4-kinase membrane bound to 16020 641794, 641798, 641800, 641802 2.7.1.67 1-phosphatidylinositol 4-kinase membrane enzyme form mPIK-I and mPIK-II 16020 641801 2.7.1.67 1-phosphatidylinositol 4-kinase membrane firmly associated with plasma membrane 16020 641815 2.7.1.67 1-phosphatidylinositol 4-kinase membrane integral membrane protein 16020 641788, 641800 2.7.1.67 1-phosphatidylinositol 4-kinase membrane isozyme PI4KIIalpha exists almost exclusively as a constitutively active integral membrane protein because of its palmitoylation 16020 722700 2.7.1.67 1-phosphatidylinositol 4-kinase membrane isozyme PI4KIIbeta is distributed almost evenly between membranes and cytosol 16020 722700 2.7.1.67 1-phosphatidylinositol 4-kinase membrane isozyme Pik1 16020 722704 2.7.1.67 1-phosphatidylinositol 4-kinase membrane PI4K230 is distributed evenly on membranes that are ultra structurally cisterns of the rough endoplasmic reticulum, outer membranes of mitochondria, multivesicular bodies and are in close vicinity of synaptic contacts 16020 641806 2.7.1.67 1-phosphatidylinositol 4-kinase membrane type II enzyme is almost exclusively found in membrane fraction 16020 641812 2.7.1.67 1-phosphatidylinositol 4-kinase membrane type II PI 4-kinase enzymes 16020 721555 2.7.1.67 1-phosphatidylinositol 4-kinase membrane vacuolar 16020 660950 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase membrane - 16020 641771, 641823, 641833, 641835, 641842, 641849, 675019, 675959, 676432 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase membrane associated 16020 641851, 661660 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase membrane associated with, peripheral membrane protein 16020 641834 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase membrane isozyme PIP5Kalpha 16020 722784 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase membrane type I kinase is membrane bound and type II kinase is both membrane bound and cytosolic 16020 641825 2.7.1.77 nucleoside phosphotransferase membrane - 16020 642003 2.7.1.77 nucleoside phosphotransferase membrane bound to 16020 641993 2.7.1.91 sphingosine kinase membrane - 16020 660975, 672942, 673473, 674746, 737737 2.7.1.91 sphingosine kinase membrane 75% of total activity in leaves, associated with, the cytosolic enzyme is 20fold less active than the membrane-associated enzyme 16020 663137 2.7.1.91 sphingosine kinase membrane about 30% of total activity 16020 660860 2.7.1.91 sphingosine kinase membrane deleting the N-terminal domain with residues 1-175 reduces Sphk2 membrane localisation in cells 16020 702037 2.7.1.91 sphingosine kinase membrane subcellular localization depends on the tissue type 16020 661860 2.7.1.94 acylglycerol kinase membrane proliferative diabetic retinopathy and proliferative vitreoretinopathy epiretinal membranes 16020 721244 2.7.1.B19 geranylgeraniol kinase membrane - 16020 719754 2.7.10.1 receptor protein-tyrosine kinase membrane - 16020 489976, 490155, 490177, 490200, 490261, 490309, 490323, 490415, 490429, 490529, 490563, 490616, 490618, 490643, 490657, 490797, 490931, 660678, 660729, 660919, 660921, 661030, 661031, 661457, 661551, 662236, 662556, 662557, 662679, 662856 2.7.10.1 receptor protein-tyrosine kinase membrane borderline tumors and invasive cancers 16020 690295 2.7.10.1 receptor protein-tyrosine kinase membrane CD3epsilon chain induces the membrane colocalization of Emt/Itk with TCR/CD3 16020 490554 2.7.10.1 receptor protein-tyrosine kinase membrane contains a VHS membrane association domain 16020 490416 2.7.10.1 receptor protein-tyrosine kinase membrane EGFR tyrosine kinase 16020 661483 2.7.10.1 receptor protein-tyrosine kinase membrane enzyme contains a juxtamembrane domain acting as a pseudosubstrate responsible for autoinhibition of the enzyme, structure overview 16020 662242 2.7.10.1 receptor protein-tyrosine kinase membrane EphA1 transmembrane segments associate in a right-handed parallel alpha-helical bundle, region (544-569)2, through the N-terminal glycine zipper motif A550X3G554X3G558. Dimerization of the transmembrane fragment of the EphA1 receptor 16020 693156 2.7.10.1 receptor protein-tyrosine kinase membrane Gly2, Cys3, Lys7, and Lys9 are required for plasma membrane targeting of p59fyn 16020 490417 2.7.10.1 receptor protein-tyrosine kinase membrane inner membrane protein 16020 490027 2.7.10.1 receptor protein-tyrosine kinase membrane located in the inner-membrane fraction 16020 490034 2.7.10.1 receptor protein-tyrosine kinase membrane nuclear membrane of neurons 16020 490568 2.7.10.1 receptor protein-tyrosine kinase membrane palmitoylation of p59fyn is reversible and sufficient for plasma membrane association 16020 490418 2.7.10.1 receptor protein-tyrosine kinase membrane RTKs consist of an extracellular ligand-binding domain, a transmembrane domain, a highly conserved intracellular kinase domain and a C-terminal tail 16020 691636 2.7.10.1 receptor protein-tyrosine kinase membrane the extracellular domain contains a cadherin-related sequence, important for Ca(2+)-dependent homophilic binding of cadherins 16020 490390 2.7.10.1 receptor protein-tyrosine kinase membrane the transmembrane domain is encoded by the nucleotide residues 519-543 16020 490109 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane enzyme 16020 490251, 490267, 490285 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane protein 16020 490110, 490141, 490147, 490157, 490174, 490175, 490176, 490178, 490179, 490180, 490215, 490313, 490314, 490315, 490316, 490333, 490361, 490385, 490387, 490388, 490390, 490402, 490405, 490473, 490495, 490500, 490506, 490510, 490522, 490523, 490527, 490539, 490613, 660873 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane protein containing a transmembrane domain but only a short, or virtually non-existent, extracellular domain 16020 490374 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane protein with extracellular epidermal growth factor homology domains 16020 490391 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane proteins with a single transmembrane pass, a cytoplasmic domain, and an extracellular domain, overview 16020 660727 2.7.10.1 receptor protein-tyrosine kinase membrane transmembrane tyrosine protein kinase receptor 16020 490108, 490109 2.7.10.1 receptor protein-tyrosine kinase membrane unusual membrane protein lacking an extracellular domain 16020 490376 2.7.10.2 non-specific protein-tyrosine kinase membrane - 16020 490114, 490131, 490617, 491998, 491999, 492022, 663021, 690368, 691143, 693137, 693239 2.7.10.2 non-specific protein-tyrosine kinase membrane anchored to the plasma membrane 16020 490446 2.7.10.2 non-specific protein-tyrosine kinase membrane associated 16020 490342 2.7.10.2 non-specific protein-tyrosine kinase membrane associated, v-Src 16020 489976 2.7.10.2 non-specific protein-tyrosine kinase membrane enzyme has a single transmembrane domain 16020 491952 2.7.10.2 non-specific protein-tyrosine kinase membrane likely to be a peripheral membrane protein 16020 490170 2.7.10.2 non-specific protein-tyrosine kinase membrane membrane spanning enzyme 16020 492026 2.7.10.2 non-specific protein-tyrosine kinase membrane RLK5 protein contains an extracellular domain that has 21 tandemly repeated leucine-rich motifs linked, via a transmembrane hydrophobic region 16020 492024 2.7.10.2 non-specific protein-tyrosine kinase membrane Syk is colocalized with EGFR 16020 661457 2.7.10.2 non-specific protein-tyrosine kinase membrane the activin receptor consists of an extracellular domain that specifically binds activin A, a single-membrane spanning domain, and an intracellular kinase domain with serine/threonine specificity 16020 491997 2.7.10.2 non-specific protein-tyrosine kinase membrane the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment 16020 671253 2.7.10.2 non-specific protein-tyrosine kinase membrane transmembrane kinase, the cytoplasmic domain of the receptor is a functional kinase 16020 491994 2.7.10.3 bacterial tyrosine kinase membrane inner cell membrane 16020 762969, 763232 2.7.10.3 bacterial tyrosine kinase membrane integral membrane protein 16020 -, 763040 2.7.11.1 non-specific serine/threonine protein kinase membrane - 16020 -, 532722, 660911, 661685, 662053, 663304, 719695, 739098, 742853 2.7.11.1 non-specific serine/threonine protein kinase membrane a hydrophobicity plot indicates the presence of a putative transmembrane spanning sequence downstream of the catalytic domain, suggesting that PkaD is a transmembrane protein kinase 16020 691388 2.7.11.1 non-specific serine/threonine protein kinase membrane a pattern of basic residues is followed by a predicted transmembrane domain suggesting that the N-terminal region (residues 1-338) is orientated toward the cytoplasm 16020 723058 2.7.11.1 non-specific serine/threonine protein kinase membrane a transmembrane enzyme 16020 532799, 532801 2.7.11.1 non-specific serine/threonine protein kinase membrane all isozymes, except for CPK11 and CPK4 16020 -, 721543 2.7.11.1 non-specific serine/threonine protein kinase membrane associated 16020 -, 680439, 680448 2.7.11.1 non-specific serine/threonine protein kinase membrane bound to 16020 491605 2.7.11.1 non-specific serine/threonine protein kinase membrane CK2beta in hypoxia 16020 661900 2.7.11.1 non-specific serine/threonine protein kinase membrane deduced amino acid sequence contains two transmembrane segments, which flank a highly repetitive region, suggesting a receptor-like anchoring 16020 532698 2.7.11.1 non-specific serine/threonine protein kinase membrane distinct lateral and/or basal plasma membrane domains in different epithelial cell types 16020 491321 2.7.11.1 non-specific serine/threonine protein kinase membrane Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus 16020 532799 2.7.11.1 non-specific serine/threonine protein kinase membrane isozyme PKNalpha 16020 662053 2.7.11.1 non-specific serine/threonine protein kinase membrane mainly 16020 662855 2.7.11.1 non-specific serine/threonine protein kinase membrane membrane anchored kinase domain 16020 671795 2.7.11.1 non-specific serine/threonine protein kinase membrane membrane-associated 16020 723931 2.7.11.1 non-specific serine/threonine protein kinase membrane membrane-associated protein, synaptic plasma membranes 16020 491431 2.7.11.1 non-specific serine/threonine protein kinase membrane membrane-spanning protein 16020 -, 760526 2.7.11.1 non-specific serine/threonine protein kinase membrane phosphorylation of the hydrophobic motif at the extreme C terminus of PKB gamma may facilitate translocation of the kinase to the membrane 16020 491061 2.7.11.1 non-specific serine/threonine protein kinase membrane Pkn2 is a transmembrane protein with the kinase domain in the cytoplasm and the 207-residue carboxy-terminal domain outside the cytoplasmic membrane 16020 532718 2.7.11.1 non-specific serine/threonine protein kinase membrane PknH is a transmembrane protein 16020 661782 2.7.11.1 non-specific serine/threonine protein kinase membrane postnuclear fraction 16020 662053 2.7.11.1 non-specific serine/threonine protein kinase membrane role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK) 16020 738583 2.7.11.1 non-specific serine/threonine protein kinase membrane the enzyme contains membrane localization signals 16020 491199 2.7.11.1 non-specific serine/threonine protein kinase membrane the enzyme's N-terminal Cys13 to -15 track is essential for Env7 vacuolar membrane anchoring and kinase activity 16020 -, 723177 2.7.11.1 non-specific serine/threonine protein kinase membrane the kinase contains a membrane-spanning domain 16020 532802 2.7.11.1 non-specific serine/threonine protein kinase membrane the Pkn6-PhoA fusion protein in Escherichia coli has a single transmembrane domain with the N-terminal domain in the cytoplasm and the C-terminal domain outside the cytoplasmic membrane 16020 532719 2.7.11.1 non-specific serine/threonine protein kinase membrane transmembrane protein 16020 491322 2.7.11.1 non-specific serine/threonine protein kinase membrane YabT is a putative transmembrane kinase that lacks the canonical extracellular signal receptor domain. In vivo YabT is expressed during sporulation and localizes to the asymmetric septum. Septal localization of YabT is growth stage specific, its enrichment at the septum occurs specifically during sporulation, and requires the putative transmembrane domain of YabT 16020 743306 2.7.11.10 IkappaB kinase membrane in T-cells 16020 662568 2.7.11.11 cAMP-dependent protein kinase membrane cAMP/PKA-dependent anx 2–S100A10 complex 16020 675892 2.7.11.12 cGMP-dependent protein kinase membrane - 16020 491018, 738700 2.7.11.12 cGMP-dependent protein kinase membrane isozyme cGK II bound by a myristoyl moiety 16020 661814 2.7.11.12 cGMP-dependent protein kinase membrane isozyme PKG II 16020 722412 2.7.11.13 protein kinase C membrane - 16020 491114, 660959, 661662, 662331, 672842, 673479, 703109, 704684 2.7.11.13 protein kinase C membrane associated with 16020 491142 2.7.11.13 protein kinase C membrane bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting 16020 661911 2.7.11.13 protein kinase C membrane cellular membrane translocation mechanism of isozyme PKCalpha and PKCgamma 16020 662165 2.7.11.13 protein kinase C membrane isozyme epsilon, gamma, and alpha 16020 661408 2.7.11.13 protein kinase C membrane jejunal brush border membrane 16020 662146 2.7.11.13 protein kinase C membrane PKC is commonly associated with a rapid redistribution of the kinase from the cytosol to membranes 16020 671653 2.7.11.13 protein kinase C membrane translocation 16020 662215 2.7.11.14 rhodopsin kinase membrane - 16020 664267, 664862, 665682, 666451, 666708, 689386 2.7.11.14 rhodopsin kinase membrane also found associated with the rhabdomeric membranes 16020 640713 2.7.11.14 rhodopsin kinase membrane binds to photobleached rod outer segment membranes 16020 640709 2.7.11.14 rhodopsin kinase membrane Ca2+-bound enzyme 16020 674596 2.7.11.14 rhodopsin kinase membrane enzyme is released from rhodopsin-containing eye membranes 16020 640708 2.7.11.14 rhodopsin kinase membrane located on the external surface of the disc membrane, the affinity of membrane for the enzyme increases upon photobleaching of rhodopsin 16020 640697 2.7.11.14 rhodopsin kinase membrane membrane-bound 16020 640696, 640697, 640702, 640708, 640720, 640727, 640730 2.7.11.14 rhodopsin kinase membrane phosphorylation occurs preferentially in newly formed discs 16020 640696 2.7.11.14 rhodopsin kinase membrane photoreceptor microvillar membranes, in both the soluble and membrane fractions 16020 640725 2.7.11.14 rhodopsin kinase membrane rod disc membranes 16020 640702 2.7.11.14 rhodopsin kinase membrane rod membranes 16020 490996, 490997, 640696, 640697, 640700, 640706, 640714 2.7.11.15 beta-adrenergic-receptor kinase membrane - 16020 490989, 661667, 662332, 662767, 672951, 676904, 685121, 689792 2.7.11.15 beta-adrenergic-receptor kinase membrane after beta-AR agonist stimulation beta-ARK is partially translocated to the membranes 16020 645017 2.7.11.15 beta-adrenergic-receptor kinase membrane associated with, membrane association is required for activity on G protein-coupled receptors, and mediated by the C-terminal Gbetagamma binding domain 16020 662131 2.7.11.15 beta-adrenergic-receptor kinase membrane associated, GRK2 in complex with G protein beta1gamma2 subunits 16020 660579, 661202, 663391 2.7.11.15 beta-adrenergic-receptor kinase membrane cardiac, total cytosolic activity amount to values almost 3times those of membrane activity, during myocardial ischemia the membrane activity of beta-ARK is increased, but the cytosolic activity is not altered 16020 645024 2.7.11.15 beta-adrenergic-receptor kinase membrane enzyme activity depends upon its translocation from the cytoplasm to the membrane, the betagamma subunits of G proteins bind to enzyme and recruit it to the membrane, beta-ARK 1 binds to Gbeta2 16020 645013 2.7.11.15 beta-adrenergic-receptor kinase membrane enzyme is localized to the specific membrane compartment by betagamma subunits of G proteins and phosphatidylinositol phosphates that specifically and coordinately bind to the C- and N-terminal half, respectively, of the PH domain 16020 645015 2.7.11.15 beta-adrenergic-receptor kinase membrane G protein betagamma-subunit targets beta-ARK 1 to the membrane 16020 645027 2.7.11.15 beta-adrenergic-receptor kinase membrane GRK2 16020 661684 2.7.11.15 beta-adrenergic-receptor kinase membrane GRK2 membrane translocation is induced by insulin 16020 674831 2.7.11.15 beta-adrenergic-receptor kinase membrane insulin causes GRK2 translocation to the membranes, which is blocked by genistein, wortmannin, chelerythrine chloride, and GRK2-specific siRNA 16020 671267 2.7.11.15 beta-adrenergic-receptor kinase membrane isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane 16020 490989 2.7.11.15 beta-adrenergic-receptor kinase membrane microsomal and plasma membrane, anchoring of beta-ARK to cellular membranes under basal conditions is independent of the availability of heterotrimeric G protein subunits, additional anchoring mechanisms, Gbetagamma subunits may play a role in agonist-mediated targeting of beta-ARK to the membrane in intact cells 16020 645021 2.7.11.15 beta-adrenergic-receptor kinase membrane myocardial sarcolemmal membrane 16020 684461 2.7.11.15 beta-adrenergic-receptor kinase membrane the PH domain ligands betagamma subunits of G proteins and phosphatidylinositol 4,5-bisphosphate affect membrane localization of enzyme, simultaneous presence of both ligands is required for effective membrane localization, cooperative binding of the ligands, membrane translocation 16020 645023 2.7.11.16 G-protein-coupled receptor kinase membrane - 16020 661667, 672408, 685121 2.7.11.16 G-protein-coupled receptor kinase membrane anchoring of GRK4 by palmitoyl residue at the C-terminus 16020 662921 2.7.11.16 G-protein-coupled receptor kinase membrane anchoring via palmitoylation 16020 662767 2.7.11.16 G-protein-coupled receptor kinase membrane cytosolic side of the plasma membrane 16020 762419 2.7.11.16 G-protein-coupled receptor kinase membrane GRK5 protein does not undergo agonist-dependent translocation from cytosol to membranes as do beta-adrenergic receptor kinase and rhodopsin kinase, but rather appears to associate with membranes constitutively 16020 491154 2.7.11.16 G-protein-coupled receptor kinase membrane the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation: unphosphorylated enzyme preferentially localizes to synaptic membranes 16020 726308 2.7.11.17 Ca2+/calmodulin-dependent protein kinase membrane anchored 16020 665484 2.7.11.17 Ca2+/calmodulin-dependent protein kinase membrane bound, isolated innervated membranes of electrocytes 16020 665648 2.7.11.17 Ca2+/calmodulin-dependent protein kinase membrane isozymes CaMKII alpha and CaMKIIbeta, contents of isozymes in membrane and cytosol of Pb2+ treated and untreated rats, overview 16020 664472 2.7.11.19 phosphorylase kinase membrane KPI-2 is a transmembrane protein 16020 675990 2.7.11.19 phosphorylase kinase membrane of sarcoplasmic reticulum 16020 662530 2.7.11.22 cyclin-dependent kinase membrane - 16020 666466, 695204 2.7.11.22 cyclin-dependent kinase membrane associated to membrane in YC-8 and proliferating salivary cells 16020 491542 2.7.11.22 cyclin-dependent kinase membrane Cdk5-p35 16020 666467 2.7.11.22 cyclin-dependent kinase membrane mainly 16020 662855 2.7.11.22 cyclin-dependent kinase membrane membrane association of Cdk5 via myristoylation of p35 at Gly2. When p35 is cleaved to p25 by calpain, the active Cdk5 complex is liberated from the membrane. The half-life of Cdk5 activators is increased by dissociation from membranes, and the kinase activity of Cdk5 is stimulated several fold by release from suppression after dissociation from the membrane 16020 723022 2.7.11.26 tau-protein kinase membrane mainly 16020 662855 2.7.11.30 receptor protein serine/threonine kinase membrane - 16020 663984, 664036, 664318, 665481, 665532, 665554, 665640, 666312, 666359, 666443, 666512 2.7.11.30 receptor protein serine/threonine kinase membrane the isozymes all possess an extracellular domain 16020 666283 2.7.11.30 receptor protein serine/threonine kinase membrane transmembrane protein 16020 664282, 665487 2.7.11.30 receptor protein serine/threonine kinase membrane with a cytoplasmic domain 16020 665699 2.7.11.30 receptor protein serine/threonine kinase membrane with a large cytoplasmic domain 16020 664721 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase membrane - 16020 741016 2.7.11.7 myosin-heavy-chain kinase membrane associated 16020 640778 2.7.11.7 myosin-heavy-chain kinase membrane association of the enzyme to membranes enhances the activity 16020 640797 2.7.11.7 myosin-heavy-chain kinase membrane binding to the plasma membrane enhances the activity of unphosphorylated enzyme 20fold, substrate myosin I 16020 640792 2.7.11.7 myosin-heavy-chain kinase membrane bound 16020 -, 640791 2.7.11.9 Goodpasture-antigen-binding protein kinase membrane 91 kDa GPBP 16020 693162 2.7.12.1 dual-specificity kinase membrane - 16020 532657, 664458 2.7.12.2 mitogen-activated protein kinase kinase membrane associated with 16020 491921 2.7.13.1 protein-histidine pros-kinase membrane - 16020 441639, 441640, 441641 2.7.13.1 protein-histidine pros-kinase membrane HpkA possesses one membrane-spanning segment located at the extreme N-terminus 16020 -, 748064 2.7.13.3 histidine kinase membrane - 16020 -, 441656, 441697, 441717, 441727, 441779, 441840, 441884, 680813, 690397, 702080, 704324, 705559, 705772, 760673, 761846, 762137, 762192, 762425 2.7.13.3 histidine kinase membrane a large periplasmic domain is lacking and an extended cytoplasmic domain is present besides the kinase domain 16020 441712 2.7.13.3 histidine kinase membrane a periplasmic sensor domain is flanked by transmembrane alpha-helices which link it to conserved cytoplasmic catalytic domains 16020 740103 2.7.13.3 histidine kinase membrane an integral membrane protein, protein transmembrane topology in proteoliposomes is determined using membrane-impermeable and membrane-permeable thiol-reactive reagents, overview 16020 741283 2.7.13.3 histidine kinase membrane associated with 16020 441809 2.7.13.3 histidine kinase membrane bound to 16020 441639 2.7.13.3 histidine kinase membrane CitA contains in the N-terminal half, two putative transmembrane helices which enclosed a presumably periplasmic domain of about 130 amino acids 16020 441842 2.7.13.3 histidine kinase membrane CitA represents a membrane-bound sensor kinase consisting of a periplasmic domain flanked by two transmembrane helices, a linker domain and the conserved kinase or transmitter domain 16020 441843 2.7.13.3 histidine kinase membrane CusS is a membrane-associated histidine kinase with a periplasmic sensor domain connected to the cytoplasmic ATP-binding and catalytic domains through two transmembrane helices 16020 740082 2.7.13.3 histidine kinase membrane cytoplasmic side of inner membrane 16020 441682 2.7.13.3 histidine kinase membrane dctB-encoded protein includes a putative periplasmic N-terminal domain that senses the presence of dicarboxylates and a C-terminal cytoplasmic domain that activates the dctD-encoded protein 16020 441740 2.7.13.3 histidine kinase membrane DcuS contains two putative transmembrane helices flanking an approximately 140-residue N-terminal domain apparently located in the periplasm 16020 441812 2.7.13.3 histidine kinase membrane DcuS is a membrane-integral sensor kinase, and the sensory and kinase domains are located on opposite sides of the cytoplasmic membrane 16020 441813 2.7.13.3 histidine kinase membrane EnvZ contained two hydrophobic stretches typical of transmembrane regions 16020 441718 2.7.13.3 histidine kinase membrane EnvZ is a transmembrane protein with histidine kinase activity in its cytoplasmic region. The cytoplasmic region contains two functional domains: domain A, residues 223-289, contains the conserved histidine residue H243, a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR 16020 441688 2.7.13.3 histidine kinase membrane FixL contains four transmembrane segments 16020 680184 2.7.13.3 histidine kinase membrane FixL has features of a transmembrane protein 16020 441729 2.7.13.3 histidine kinase membrane FixL is a membrane protein containing four possible transmembrane segments 16020 441731 2.7.13.3 histidine kinase membrane Hik33 perceives the cold signal via rigidification of membrane lipids 16020 682274 2.7.13.3 histidine kinase membrane integral membrane protein 16020 705793 2.7.13.3 histidine kinase membrane KdpD has four membrane-spanning segments in the middle of the polypeptide chain, whereas N and C terminus are both cytoplasmic 16020 441776 2.7.13.3 histidine kinase membrane KdpD is anchored to the membrane by four membrane-spanning segments near its middle, with both C-terminal and N-terminal portions in the cytoplasm 16020 441775 2.7.13.3 histidine kinase membrane may be a membrane protein 16020 441711 2.7.13.3 histidine kinase membrane membrane-bound protein comprising at least three cytoplasmic domains 16020 441778 2.7.13.3 histidine kinase membrane membrane-bound sensor-kinase with two potential membrane-spanning sequences in the N-terminal region 16020 441811 2.7.13.3 histidine kinase membrane membrane-integral protein, DcuS and CitA accumulate at the cell poles 16020 705553 2.7.13.3 histidine kinase membrane N-terminal region may be located in the periplasm and its C-terminal region in the cytoplasm 16020 441725 2.7.13.3 histidine kinase membrane NH2-terminal periplasmic domain 16020 441676 2.7.13.3 histidine kinase membrane NtrY is likely to represent the transmembrane sensor protein element in the two-component regulatory system 16020 441862 2.7.13.3 histidine kinase membrane the enzyme structure displays an N-terminal sensor domain (about 150 residues) with almost no extracellular region, other than the loops that connect the four or five transmembrane segments 16020 -, 740689 2.7.13.3 histidine kinase membrane the region between the hydrophobic segments of CpxA is periplasmic, whereas the region carboxy-terminal to the second such segment is cytoplasmic. CpxA functions as a trans-membrane sensory protein 16020 441710 2.7.13.3 histidine kinase membrane the YycG kinase is associated in the membrane as a complex with YycH and YycI through interaction of their transmembrane domains 16020 -, 741018 2.7.13.3 histidine kinase membrane transmembrane enzyme 16020 662609, 741136 2.7.13.3 histidine kinase membrane transmembrane protein 16020 -, 441690, 441761, 739809, 741293 2.7.13.3 histidine kinase membrane transmembrane regions of EnvZ play roles in transmembrane signaling 16020 441689 2.7.3.2 creatine kinase membrane - 16020 737427 2.7.3.2 creatine kinase membrane acetylcholine receptor membrane 16020 642379 2.7.3.2 creatine kinase membrane association of brain-type creatine kinase with membrane structures such as synaptic vesicles and mitochondria, involving hydrophobic and electrostatic interactions, respectively. Membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. Recruitment of BCK to submembrane domains also supports formation of dynamic actin-based protrusions 16020 737427 2.7.3.2 creatine kinase membrane association of brain-type creatine kinase with membrane structures such as synaptic vesicles and mitochondria, involving hydrophobic and electrostatic interactions, respectively. Membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. Recruitment of BCK to submembrane domains also supports formation of dynamic actin-based protrusions. Hypothetical model of BCK localization at cellular membranes, overview 16020 -, 737427 2.7.3.3 arginine kinase membrane ciliary membrane. Arginine kinase AK3 is likely located in the ciliary membrane 16020 761041 2.7.3.3 arginine kinase membrane the amino acid sequence of Tetrahymena pyriformis isozyme AK1, but not isozyme AK2, has a distinct myristoylation signal sequence at the N-terminus, suggesting that 40-kDa AK1 targets the membrane 16020 738078 2.7.3.9 phosphoenolpyruvate-protein phosphotransferase membrane bound to cytoplasmic membrane 16020 642506 2.7.4.1 ATP-polyphosphate phosphotransferase membrane - 16020 -, 676086, 705787, 737521 2.7.4.1 ATP-polyphosphate phosphotransferase membrane crude membrane fractions contain virtually all the polyphosphate kinase activity catalyzing the synthesis of ATP from ADP and polyphosphate 16020 645125 2.7.4.1 ATP-polyphosphate phosphotransferase membrane vesicles 16020 694850 2.7.4.20 dolichyl-diphosphate-polyphosphate phosphotransferase membrane - 16020 642549, 642550 2.7.4.3 adenylate kinase membrane N-myristoylation is required to target isoform AK2 to the parasitophorous vacuole membrane 16020 722281 2.7.4.33 AMP-polyphosphate phosphotransferase membrane - 16020 -, 645130 2.7.4.6 nucleoside-diphosphate kinase membrane - 16020 691024, 692061, 694346, 705675 2.7.4.8 guanylate kinase membrane - 16020 675510, 700950, 722117, 723031, 737590 2.7.4.8 guanylate kinase membrane membrane-associated enzyme 16020 761735 2.7.4.8 guanylate kinase membrane post-synaptic density-95 membrane associated, association with N-methyl-D-aspartate receptor NR2 subunits via their C-terminal glutamate serine, aspartate/glutamate, valine motifs 16020 700475 2.7.7.14 ethanolamine-phosphate cytidylyltransferase membrane - 16020 642888 2.7.7.14 ethanolamine-phosphate cytidylyltransferase membrane associated with the membranes of the rough endoplasmic reticulum 16020 671816 2.7.7.15 choline-phosphate cytidylyltransferase membrane - 16020 642889, 642906, 642913, 642914, 722861 2.7.7.15 choline-phosphate cytidylyltransferase membrane distributed between cytosol and membrane, lipid environment required for activity 16020 662689 2.7.7.15 choline-phosphate cytidylyltransferase membrane enzyme is activated when bound to vesicles 16020 660981, 661213, 661238, 662237, 662320, 662364, 662451, 662689, 663437 2.7.7.41 phosphatidate cytidylyltransferase membrane - 16020 643314, 738826 2.7.7.41 phosphatidate cytidylyltransferase membrane an integral membrane protein with multiple membrane spanning domains 16020 -, 741020 2.7.7.41 phosphatidate cytidylyltransferase membrane colocalizes with phospholipids in the domains located in the septal membrane 16020 -, 659064 2.7.7.41 phosphatidate cytidylyltransferase membrane integral membrane protein 16020 761129 2.7.7.41 phosphatidate cytidylyltransferase membrane integral protein of the inner membrane 16020 643321 2.7.7.41 phosphatidate cytidylyltransferase membrane localized exclusively in the membrane fraction 16020 643306 2.7.7.41 phosphatidate cytidylyltransferase membrane peripheral membrane protein that is trafficked outside the parasite to the parasitophorous vacuole 16020 722419 2.7.7.41 phosphatidate cytidylyltransferase membrane the enzyme contains eight predicted transmembrane-spanning domains 16020 643324 2.7.7.41 phosphatidate cytidylyltransferase membrane the enzyme is mainly localized in close association with the membrane of the endoplasmic reticulum of the transfected cells. Several possible membrane-spanning regions 16020 643325 2.7.7.52 RNA uridylyltransferase membrane - 16020 643498 2.7.7.6 DNA-directed RNA polymerase membrane 74% of the RNA polymerase activity is associated with the rickettsial cell membrane at a high salt concentration, 600 mM NaCl 16020 643566 2.7.7.65 diguanylate cyclase membrane - 16020 -, 738964 2.7.7.65 diguanylate cyclase membrane AdrA is a predicted membrane protein with a putative sensory domain 16020 -, 762464 2.7.7.65 diguanylate cyclase membrane both MifA and MifB are membrane-associated 16020 680474 2.7.7.65 diguanylate cyclase membrane both PBPb-I domains are membrane-distal with the pockets oriented relatively upwards, and both PBPb-II domains are membrane-proximal with the pockets relatively downwards. The two C-terminal alpha8' helices serving as pre-transmembrane sequences at the membrane-proximal end of the structure locate adjacent to each one and can be connected to the subsequent transmembrane helices 16020 -, 762429 2.7.7.65 diguanylate cyclase membrane domain analysis of PA0847 shows a unique molecular architecture with an N-terminal periplasmic sensory domain and a C-terminal intracellular GGDEF domain 16020 -, 761240 2.7.7.65 diguanylate cyclase membrane inner membrane 16020 680510 2.7.7.65 diguanylate cyclase membrane isoform Dgc1 has two possible transmembrane helices and Dgc2 has one 16020 680432 2.7.7.65 diguanylate cyclase membrane membrane topology with 6 transmembrane segments and 6 cytoplasmic loops, overview 16020 -, 762317 2.7.7.65 diguanylate cyclase membrane protein harbors 10 predicted C-terminal transmembrane domains 16020 -, 739021 2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase membrane - 16020 738041 2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase membrane the enzyme comprises a transmembrane (TM) domain with five helices and cytoplasmic loops that together form a large charged cavity. The cytoplasmic cavity primarily comprises TM1, TM2, TM3 and TM4, and is loosely occluded by TM5. The remaining portion of the cavity is formed by two cytoplasmic loops (CLs): CL1 (between TM1 and TM2) and CL2 (between TM3 and TM4). CL1 and CL2 form the cytoplasmic domain (CPD), which caps the transmembrance domain (TMD). CL1, which is longer than CL2, is stabilized by packing against one side of TM3 16020 -, 760843 2.7.7.8 polyribonucleotide nucleotidyltransferase membrane localizes to the intermembrane space of mitochondria as a peripheral membrane protein in a multimeric complex 16020 675974 2.7.7.8 polyribonucleotide nucleotidyltransferase membrane membrane vesicles 16020 643680 2.7.7.85 diadenylate cyclase membrane - 16020 -, 738541, 760936 2.7.7.85 diadenylate cyclase membrane CdaA contains three transmembrane domains (TM) 16020 -, 760995 2.7.7.85 diadenylate cyclase membrane CdaA is an integral membrane protein that interacts with its potential regulatory protein, CdaR, via the transmembrane protein domain. The presence of the CdaR protein is not required for the membrane localization and abundance of CdaA 16020 -, 738543 2.7.7.86 cyclic GMP-AMP synthase membrane upon infection with Chlamydia trachomatis cGAS localizes in punctate regions on the cytosolic side of the chlamydial inclusion membrane in association with stimulator of genes STING 16020 738789 2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase membrane - 16020 643753 2.7.7.B25 GPI ethanolamine phosphate transferase membrane - 16020 761867 2.7.8.1 ethanolaminephosphotransferase membrane - 16020 644361 2.7.8.1 ethanolaminephosphotransferase membrane an integral membrane protein 16020 737738 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase membrane - 16020 -, 645301, 645302, 645304, 645307, 645308, 645312, 645314, 645316, 645320, 645324, 677090, 739273 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase membrane membrane fraction of overexpressing Escherichia coli 16020 690824 2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase membrane membrane-bound 16020 645294, 645303, 645305, 645311, 645315, 645316 2.7.8.12 teichoic acid poly(glycerol phosphate) polymerase membrane - 16020 645326 2.7.8.12 teichoic acid poly(glycerol phosphate) polymerase membrane cell or protoplast 16020 -, 645327 2.7.8.12 teichoic acid poly(glycerol phosphate) polymerase membrane protoplast membrane 16020 645326 2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferase membrane - 16020 -, 645330, 645331, 645334, 645335, 645339, 645341, 645342, 675899 2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferase membrane integral membrane protein 16020 662239 2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase membrane - 16020 -, 645348, 703322, 762002 2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase membrane AglH possesses ten transmembrane helices separated by five internal and four external hydrophilic loops 16020 -, 761051 2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase membrane enzyme with multiple transmembrane spans 16020 645367 2.7.8.17 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase membrane associated with 16020 -, 645372, 645376, 645379 2.7.8.17 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase membrane the alpha/beta-subunit precursor is a type III membrane protein of 1256 amino acids with two transmembrane domains. Its exit from the endoplasmic reticulum requires a combinatorial sorting motif located in the N- and C-terminal cytoplasmic tails. The luminal alpha-subunit exhibits a conserved modular structure 16020 738351 2.7.8.19 UDP-glucose-glycoprotein glucose phosphotransferase membrane - 16020 639424, 639428 2.7.8.19 UDP-glucose-glycoprotein glucose phosphotransferase membrane membrane-associated enzyme, faces the cytosol 16020 639424, 639428 2.7.8.19 UDP-glucose-glycoprotein glucose phosphotransferase membrane primarily present on the cytosolic side of the cells internal membranes 16020 639425 2.7.8.2 diacylglycerol cholinephosphotransferase membrane - 16020 676472 2.7.8.2 diacylglycerol cholinephosphotransferase membrane an integral membrane protein 16020 737738 2.7.8.2 diacylglycerol cholinephosphotransferase membrane integral membrane protein 16020 662748 2.7.8.2 diacylglycerol cholinephosphotransferase membrane membrane of platelets 16020 644350 2.7.8.2 diacylglycerol cholinephosphotransferase membrane nuclear membrane, integral membrane protein 16020 644329 2.7.8.20 phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase membrane membrane-bound 16020 694042 2.7.8.24 phosphatidylcholine synthase membrane - 16020 -, 676078 2.7.8.24 phosphatidylcholine synthase membrane a transmembrane protein 16020 721725 2.7.8.24 phosphatidylcholine synthase membrane an integral membrane protein 16020 -, 721740 2.7.8.24 phosphatidylcholine synthase membrane localization of phosphatidylcholine in the outer and inner membranes by LC/ESI-MS analysis 16020 738417 2.7.8.24 phosphatidylcholine synthase membrane the enzyme is an integral membrane protein, that consists of eight transmembrane segments with its N- and C-termini located in the cytoplasm, membrane topology of the enzyme, reaction mechanism, overview 16020 -, 738208 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase membrane - 16020 662778 2.7.8.27 sphingomyelin synthase membrane - 16020 669649, 691550, 721280, 738936 2.7.8.27 sphingomyelin synthase membrane functional reconstitution of sphingomyelin synthase in Chinese hamster ovary cell membranes 16020 667767 2.7.8.27 sphingomyelin synthase membrane lipid raft 16020 739087 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane - 16020 722906 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane integral membrane protein 16020 722906 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane integral membrane protein, membrane topology overview 16020 741056 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane presence of 8-9 membrane spanning regions 16020 -, 748671 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane PSS2 of CHO-K1 cells is present only in mitochondria-associated membranes 16020 717762 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase membrane PSS2 of CHO-K1 cells is restricted to mitochondria-associated membranes 16020 717762 2.7.8.32 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase membrane the Xpt1 sequence contains a single preducted transmembrane domain 16020 704602 2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase membrane - 16020 708621, 723725 2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase membrane design of a vector system to generate C-terminal protein fusions to the FLAG epitope, which is used to find conditions to monitor WecA by immunoblot analysis with anti-FLAG antibodies, to determine the correct site for initiation of translation, and to investigate the localization of hybrid proteins in the cytoplasmic membrane 16020 709837 2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase membrane integral membrane protein 16020 -, 707104, 708920 2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase membrane integral membrane protein. the C terminus of WecA is exposed to the cytosol. Localizes to discrete regions in the bacterial plasma membrane 16020 708918 2.7.8.33 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase membrane modelling of the topology of WecA taking into account the available experimental data from the topological analysis of MraY 16020 709837 2.7.8.36 undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase membrane - 16020 -, 721604 2.7.8.39 archaetidylinositol phosphate synthase membrane - 16020 704559 2.7.8.40 UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase membrane - 16020 -, 722529 2.7.8.40 UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase membrane the cytosolic face of the inner membrane 16020 -, 739417 2.7.8.41 cardiolipin synthase (CMP-forming) membrane septal membrane 16020 -, 762369 2.7.8.42 Kdo2-lipid A phosphoethanolamine 7''-transferase membrane inner memebrane. Sequence predicts five trans-membrane segments within the N-terminal region 16020 734149 2.7.8.42 Kdo2-lipid A phosphoethanolamine 7''-transferase membrane membranes from Escherichia coli grown on 5-50 mM CaCl2 contain a phosphoethanolamine transferase that uses the precursor Kdo2-[4*-32P]lipid IVA as an acceptor. Transferase is not present in membranes of Escherichia coli grown with 5 mM MgCl2, BaCl2, or ZnCl2 16020 734135 2.7.8.43 lipid A phosphoethanolamine transferase membrane LptA is an integral membrane protein 16020 -, 739495 2.7.8.44 teichoic acid glycerol-phosphate primase membrane - 16020 -, 740610 2.7.8.5 CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase membrane associated 16020 644286 2.7.8.5 CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase membrane bound 16020 94817 2.7.8.5 CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase membrane exclusively in septal membranes 16020 -, 659064 2.7.8.6 undecaprenyl-phosphate galactose phosphotransferase membrane - 16020 -, 674323, 722344, 722358, 722529 2.7.8.6 undecaprenyl-phosphate galactose phosphotransferase membrane membrane fraction, differential centrifugation, Western blot 16020 -, 674323 2.7.8.8 CDP-diacylglycerol-serine O-phosphatidyltransferase membrane - 16020 643797, 661745 2.7.8.8 CDP-diacylglycerol-serine O-phosphatidyltransferase membrane normal function of the enzyme involves membrane association which is primarily induced by the presence of a membrane-associated substrate 16020 643791 2.7.8.8 CDP-diacylglycerol-serine O-phosphatidyltransferase membrane possible regulatory mechanism: cross-feedback regulatory model which assumes two forms of phosphatidylserine synthase, only molecules bound with acidic phospholipids of the membrane are active in phosphatidylserine synthesis, whereas others in the cytoplasm are latent 16020 643797 2.7.8.8 CDP-diacylglycerol-serine O-phosphatidyltransferase membrane sequence contains contains eight transmembrane domains 16020 762210 2.7.8.B10 cardiolipin synthase A membrane - 16020 -, 727789, 738526, 738626 2.7.8.B10 cardiolipin synthase A membrane associated to membrane 16020 -, 727710 2.7.8.B10 cardiolipin synthase A membrane bound to 16020 727063 2.7.8.B10 cardiolipin synthase A membrane ClsA is membrane-anchored, with dual, cytoplasmic, catalytic domains 16020 761920 2.7.8.B10 cardiolipin synthase A membrane enzyme Cls447a is tightly associated with the membrane and colocalizes with its substrate phosphatidylglycerol and product cardiolipin 16020 -, 726689 2.7.8.B10 cardiolipin synthase A membrane enzyme Cls613a is tightly associated with the membrane and colocalizes with its substrate phosphatidylglycerol and product cardiolipin 16020 -, 726689 2.7.8.B10 cardiolipin synthase A membrane septal membranes. Recombinant GFP fusion proteins of enzyme ClsA with N-terminal and internal deletions retain septal localization. Enzyme mutants with deletions starting from the C-terminus (Leu482) cease to localize to the septum once the deletion passes the Ile residue at 448, indicating that the sequence responsible for septal localization is confined within a short distance from the C-terminus. Enzyme ClsA contains a specific region responsible for the septal membrane localization 16020 -, 739625 2.7.8.B10 cardiolipin synthase A membrane strongly associated with 16020 -, 726689 2.7.99.1 triphosphate-protein phosphotransferase membrane - 16020 662083 2.8.1.11 molybdopterin synthase sulfurtransferase membrane cytoplasmic membranes 16020 721512 2.8.1.5 thiosulfate-dithiol sulfurtransferase membrane - 16020 725273 2.8.2.1 aryl sulfotransferase membrane - 16020 645645 2.8.2.15 steroid sulfotransferase membrane - 16020 645729, 645732 2.8.2.20 protein-tyrosine sulfotransferase membrane - 16020 645803, 645804, 645805, 645806, 645807, 645809, 645810, 645811, 737793, 738875, 739085 2.8.2.20 protein-tyrosine sulfotransferase membrane a type II membrane enzyme 16020 760269, 760336 2.8.2.20 protein-tyrosine sulfotransferase membrane integral membrane-protein 16020 645808, 645813 2.8.2.20 protein-tyrosine sulfotransferase membrane TPST-1 displays type II transmembrane topology with a short N-terminal cytoplasmic domain, a single 17-residue transmembrane domain, and a luminal catalytic domain 16020 674372 2.8.2.20 protein-tyrosine sulfotransferase membrane TPST-2 displays type II transmembrane topology with a short N-terminal cytoplasmic domain, a single 17-residue transmembrane domain, and a luminal catalytic domain 16020 674372 2.8.2.20 protein-tyrosine sulfotransferase membrane TPST1 is a transmembrane enzyme 16020 674717 2.8.2.20 protein-tyrosine sulfotransferase membrane TPST2 are transmembrane enzymes 16020 674717 2.8.2.20 protein-tyrosine sulfotransferase membrane transmembrane protein 16020 675396 2.8.2.20 protein-tyrosine sulfotransferase membrane type II transmembrane protein 16020 657791 2.8.2.21 keratan sulfotransferase membrane - 16020 645831, 645834 2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1 membrane transmembrane enzyme with a short cytoplasmic tail at the N-terminus 16020 675769 2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2 membrane transmembrane enzyme with a short cytoplasmic tail at the N-terminus 16020 675769 2.8.2.33 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase membrane OVCAR-3 cell 16020 690332 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase membrane - 16020 645930, 725458 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase membrane NDST isozymes are all type II membrane proteins. They have a short cytoplasmic tail (12 to 18 amino acids), transmembrane and stem regions consisting of about 40 amino acids and a catalytic domain responsible for their independent N-deacetylation and N-sulfation activities 16020 760812 2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase membrane NDST isozymes are all type II membrane proteins. They have have a short cytoplasmic tail (12 to 18 amino acids), transmembrane and stem regions consisting of about 40 amino acids and a catalytic domain responsible for their independent N-deacetylation and N-sulfation activities 16020 760812 2.8.3.9 butyrate-acetoacetate CoA-transferase membrane membrane-associated 16020 -, 643837 2.8.4.1 coenzyme-B sulfoethylthiotransferase membrane on the inner surface of the cytoplasmic membrane 16020 -, 393248, 393256 3.1.1.1 carboxylesterase membrane - 16020 -, 170979, 651369, 729647 3.1.1.1 carboxylesterase membrane autotransporter protein which exposes its catalytically active esterase domain on the cell surface 16020 680503 3.1.1.1 carboxylesterase membrane enzyme is located in the outer membrane with the catalytic domain exposed to the surface 16020 661993 3.1.1.1 carboxylesterase membrane membrane-associated enzyme 16020 748423 3.1.1.103 teichoic acid D-alanine hydrolase membrane - 16020 -, 744047 3.1.1.116 sn-1-specific diacylglycerol lipase membrane - 16020 760575, 761578, 761722, 761805, 761970 3.1.1.118 phospholipid sn-1 acylhydrolase membrane - 16020 760614 3.1.1.13 sterol esterase membrane - 16020 133856 3.1.1.13 sterol esterase membrane brush border, intestine 16020 650646 3.1.1.13 sterol esterase membrane integral membrane protein 16020 666346 3.1.1.13 sterol esterase membrane NCEH is a single-membrane-spanning type II membrane protein 16020 715834 3.1.1.13 sterol esterase membrane transmembrane protein 16020 715324 3.1.1.14 chlorophyllase membrane - 16020 652956 3.1.1.17 gluconolactonase membrane - 16020 -, 691393 3.1.1.20 tannase membrane intracellular enzyme 16020 -, 651738 3.1.1.20 tannase membrane mucous membrane 16020 651389 3.1.1.23 acylglycerol lipase membrane - 16020 -, 649803, 664469, 664576, 681285, 693824, 707118, 708263, 714314, 716864 3.1.1.23 acylglycerol lipase membrane bound 16020 663883 3.1.1.3 triacylglycerol lipase membrane the enzyme is associated to the outer membrane 16020 -, 692254 3.1.1.32 phospholipase A1 membrane - 16020 650395, 652486, 694548 3.1.1.32 phospholipase A1 membrane associated 16020 716184 3.1.1.32 phospholipase A1 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta 16020 678494 3.1.1.32 phospholipase A1 membrane associated, phosphatidic acid-specific isozymes mPA-PLA1alpha or lipase H, and mPA-PLA1beta or lacrimal lipase 16020 678494 3.1.1.32 phospholipase A1 membrane bound, mainly 16020 682242 3.1.1.32 phospholipase A1 membrane the enzyme is a membrane-bound/secreted enzyme in the infective stages of Trypanosoma cruzi 16020 730354 3.1.1.34 lipoprotein lipase membrane - 16020 715190 3.1.1.34 lipoprotein lipase membrane small pool is present in low density membrane vesicles 16020 652173 3.1.1.4 phospholipase A2 membrane - 16020 650327, 678735, 691482, 693203, 729100 3.1.1.4 phospholipase A2 membrane after expression in Sf9, lung fibroblasts and HEK293 cells 16020 652286 3.1.1.4 phospholipase A2 membrane binding of the GIVA PLA2 to the membrane is mediated through three mechanisms: Ca2+ mediated translocation, binding of secondary lipid messengers, and phosphorylation 16020 691654 3.1.1.4 phospholipase A2 membrane calcium, phosphorylation at Ser505 and the putative phosphatidylinositol 4,5-bisphosphate binding site regulate translocation and arachidonic acid release, overview 16020 693262 3.1.1.4 phospholipase A2 membrane GIVA phospholipase A2 associates with natural membranes in response to an increase in intracellular Ca2+ along with increases in certain lipid mediators, overview 16020 693169 3.1.1.4 phospholipase A2 membrane hIBPLA2, structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2, overview 16020 678155 3.1.1.4 phospholipase A2 membrane iPLA2 16020 709365 3.1.1.4 phospholipase A2 membrane isozyme-specific membrane insertion of secretory phospholipase A2 is controlled by membrane fluidity and is necessary for the full activity of the enzyme, membrane anionic surface charge facilitates membrane Recruitment and ActiVity of hIBPLA2, overview 16020 678154 3.1.1.4 phospholipase A2 membrane localizes to the inner leaflet of the plasma membrane following injection into mammalian cells 16020 750740 3.1.1.4 phospholipase A2 membrane the adipose-specific phospholipase A2 AdPLA is membrane-associated 16020 693127 3.1.1.4 phospholipase A2 membrane upon bacterial challenge, hemocytes from control larvae show intracellular translocation of their PLA2s near to cell membrane 16020 708283 3.1.1.42 chlorogenate hydrolase membrane - 16020 -, 649390 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane - 16020 652697, 670659 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane bound, plasma isozyme 16020 650057 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane cell surface 16020 650339 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane isozyme II 16020 651794 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane membrane associated 16020 670102 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane membrane binding of HpPAF-AH increases the activity of enzyme, by interfacial activation. The lipid composition of membrane vesicles, by changing the physicochemical properties, differentially modulates the binding, partial membrane penetration and the activity of the enzyme, detailed overview 16020 714337 3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase membrane platelet-activating factor-dependent transacetylase 16020 652034 3.1.1.5 lysophospholipase membrane - 16020 751505, 94367, 94372, 94373, 94381 3.1.1.5 lysophospholipase membrane fetal 16020 94374 3.1.1.5 lysophospholipase membrane membrane-bound 16020 94386 3.1.1.5 lysophospholipase membrane tightly bound to membrane 16020 94375 3.1.1.50 wax-ester hydrolase membrane - 16020 94402 3.1.1.53 sialate O-acetylesterase membrane - 16020 673893 3.1.1.53 sialate O-acetylesterase membrane extracellular membrane-anchored protein 16020 750104 3.1.1.58 N-acetylgalactosaminoglycan deacetylase membrane - 16020 730413 3.1.1.64 retinoid isomerohydrolase membrane - 16020 714150, 714161, 714951, 714986, 714991, 715473, 715501, 715577, 716114 3.1.1.64 retinoid isomerohydrolase membrane membrane association of RPE65 is essential for its catalytic activity. The RPE65 membrane-binding affinity is significantly facilitated by incorporation of its substrate all-trans retinyl ester into liposomal membrane 16020 714103 3.1.1.64 retinoid isomerohydrolase membrane microsome 16020 704711, 706574 3.1.1.64 retinoid isomerohydrolase membrane microsone 16020 706518 3.1.1.64 retinoid isomerohydrolase membrane Rpe65 is strongly associated with membranes but contains no membrane-spanning segments 16020 715577 3.1.1.64 retinoid isomerohydrolase membrane the wild type enzyme is predominantly present in the membrane fraction 16020 714020 3.1.1.64 retinoid isomerohydrolase membrane the wild type enzyme predominantly exists in the membrane (60%) 16020 680672 3.1.1.64 retinoid isomerohydrolase membrane wild type RPE65 is predominantly present in the membrane fraction 16020 714020 3.1.1.67 fatty-acyl-ethyl-ester synthase membrane both cytosolic and membrane-bound 16020 646073 3.1.1.68 xylono-1,4-lactonase membrane - 16020 643847 3.1.1.7 acetylcholinesterase membrane - 16020 653349, 654021, 664486, 664580, 664737, 664897, 666542, 728999 3.1.1.7 acetylcholinesterase membrane anchored to erythrocyte membranes 16020 678228 3.1.1.7 acetylcholinesterase membrane bound 16020 678101, 695202 3.1.1.7 acetylcholinesterase membrane enzyme anchorage in the membrane is established via the proline rich membrane anchor transmembrane protein 16020 729568 3.1.1.7 acetylcholinesterase membrane integral membrane enzyme 16020 -, 749869, 750070 3.1.1.7 acetylcholinesterase membrane isoform AChE2 is associated with the cell membrane via the glycophosphatidylinositol anchor 16020 730711 3.1.1.7 acetylcholinesterase membrane membrane-bound enzyme 16020 749759 3.1.1.7 acetylcholinesterase membrane the enzyme is cell-surface-exposed and possesses a glycosyl-phosphatidylinositol membrane anchor 16020 715182 3.1.1.7 acetylcholinesterase membrane the majority (81%) of the AChE activity in fleas is membrane-bound 16020 715174 3.1.1.71 acetylalkylglycerol acetylhydrolase membrane 90% of total activity 16020 23590 3.1.1.74 cutinase membrane 110000 Da enzyme, bound to membrane or cell wall 16020 -, 208325 3.1.1.77 acyloxyacyl hydrolase membrane - 16020 246549 3.1.1.8 cholinesterase membrane - 16020 654021 3.1.1.90 all-trans-retinyl ester 13-cis isomerohydrolase membrane - 16020 714991 3.1.13.1 exoribonuclease II membrane RNase II is associated with the cytoplasmic membrane by its amino-terminal amphipathic helix. The helix also acts as an autonomous transplantable membrane binding domain capable of directing normally cytoplasmic proteins to the membrane 16020 730030 3.1.13.2 exoribonuclease H membrane bound 16020 751635 3.1.13.4 poly(A)-specific ribonuclease membrane residues 506-525 in HsPNLDC1-1 represent a putative transmembrane domain 16020 751734 3.1.2.20 acyl-CoA hydrolase membrane - 16020 728689 3.1.2.25 phenylacetyl-CoA hydrolase membrane bound 16020 644661 3.1.2.6 hydroxyacylglutathione hydrolase membrane associated 16020 692050 3.1.21.3 type I site-specific deoxyribonuclease membrane associated to, intact enzyme complex, R subunits of EcoKI and EcoR124I are partly accessible at external surface of cytoplasmic membrane, EcoAI subunits are not accessible 16020 649639 3.1.21.3 type I site-specific deoxyribonuclease membrane the EcoR124I holoenzyme is particularly exposed on the periplasmic side of the cytoplasmic membrane 16020 700022 3.1.25.1 deoxyribonuclease (pyrimidine dimer) membrane - 16020 666546 3.1.26.12 ribonuclease E membrane - 16020 670298 3.1.26.12 ribonuclease E membrane localized to the inner cytoplasmic membrane, segment-A is necessary and sufficient for RNase E binding to membranes 16020 -, 694243 3.1.3.1 alkaline phosphatase membrane - 16020 -, 94612, 94636 3.1.3.1 alkaline phosphatase membrane ALP is found in the soluble form as well as in the insoluble form bound to the mebrane via a GPI anchor 16020 691134 3.1.3.1 alkaline phosphatase membrane associated to the outside of cell membranes of chondrocytes 16020 649496 3.1.3.1 alkaline phosphatase membrane BALP is an ectoenzyme attached to the osteoblast cell membrane by a glycosylphosphatidylinositol anchor 16020 650752 3.1.3.1 alkaline phosphatase membrane bone isoenzyme is oriented towards the outside of the plasma membrane in linkage to phosphatidylinositol 16020 94588 3.1.3.1 alkaline phosphatase membrane bound 16020 652666 3.1.3.1 alkaline phosphatase membrane bound to 16020 94603, 94604 3.1.3.1 alkaline phosphatase membrane covalent attachment of the hydrophobic phosphatidylinositol membrane anchor causes the amphiphilic form to behave anomalously on electrophoresis 16020 94623 3.1.3.1 alkaline phosphatase membrane decidual cell membrane, apical plasma membrane of the syncytiotrophoblast 16020 653452 3.1.3.1 alkaline phosphatase membrane enzyme is associated with the outer membrane 16020 94596 3.1.3.1 alkaline phosphatase membrane exclusively a membrane protein 16020 94640 3.1.3.1 alkaline phosphatase membrane insoluble membrane-bound protein 16020 713978 3.1.3.1 alkaline phosphatase membrane membrane-bound exoenzyme which faces the extracellular compartment 16020 94633 3.1.3.1 alkaline phosphatase membrane particulate enzyme form is membrane bound 16020 94561 3.1.3.1 alkaline phosphatase membrane the enzyme is secreted during phosphate starvation 16020 727721 3.1.3.100 thiamine phosphate phosphatase membrane - 16020 737294 3.1.3.106 2-lysophosphatidate phosphatase membrane the active site of the enzyme is on the outer surface of plasma membranes, or the lumenal surface of internal membranes 16020 714378 3.1.3.12 trehalose-phosphatase membrane - 16020 -, 679880 3.1.3.16 protein-serine/threonine phosphatase membrane - 16020 134635, 654407, 666403 3.1.3.16 protein-serine/threonine phosphatase membrane appears to be an integral membrane protein 16020 134659 3.1.3.16 protein-serine/threonine phosphatase membrane membrane-associated, N-terminus is neccessary for membrane association 16020 656009 3.1.3.16 protein-serine/threonine phosphatase membrane phosphatase PP3 16020 134659 3.1.3.16 protein-serine/threonine phosphatase membrane PP2A activity is present in the membrane fraction 16020 693756 3.1.3.16 protein-serine/threonine phosphatase membrane the 63000 Da isoform, integral membran protein 16020 657061 3.1.3.19 glycerol-2-phosphatase membrane double 16020 94710 3.1.3.2 acid phosphatase membrane - 16020 -, 134804, 682239, 715888, 729509 3.1.3.2 acid phosphatase membrane acid phosphatase B and C 16020 134724 3.1.3.2 acid phosphatase membrane at least 2 membrane-bound enzymes 16020 134779 3.1.3.2 acid phosphatase membrane bound to 16020 653409 3.1.3.2 acid phosphatase membrane localised to the bacterial outer membrane 16020 715922 3.1.3.2 acid phosphatase membrane MAP, membrane-bound acid phosphatase 16020 651546 3.1.3.2 acid phosphatase membrane one enzyme is largely membrane-bound, a second enzyme is mainly found in the soluble fraction 16020 134793 3.1.3.2 acid phosphatase membrane the MapA protein is shown to be localized to the outer membrane and is not detected either in the soluble cytoplasmic fraction from disrupted Moraxella catarrhalis cells or in the spent culture supernatant fluid from Moraxella catarrhalis 16020 -, 692842 3.1.3.23 sugar-phosphatase membrane associated 16020 94727 3.1.3.23 sugar-phosphatase membrane sugar phosphate phosphatase I is membrane associated 16020 94725 3.1.3.25 inositol-phosphate phosphatase membrane - 16020 114245, 114246 3.1.3.25 inositol-phosphate phosphatase membrane colocalizes with 5-phosphatase OCRL on endocytic membranes including vesicles formed by clathrin-mediated endocytosis, macropinosomes, and Rab5 endosomes 16020 751172 3.1.3.26 4-phytase membrane integral membrane protein 16020 -, 750848 3.1.3.26 4-phytase membrane storage body membrane 16020 94801 3.1.3.27 phosphatidylglycerophosphatase membrane - 16020 -, 4778, 750277, 94809, 94810, 94817 3.1.3.27 phosphatidylglycerophosphatase membrane integral membrane protein 16020 -, 751064 3.1.3.27 phosphatidylglycerophosphatase membrane trans-membrane protein 16020 -, 730834 3.1.3.36 phosphoinositide 5-phosphatase membrane - 16020 -, 134805, 134807, 134808, 134809, 713723, 716345, 716657 3.1.3.36 phosphoinositide 5-phosphatase membrane dOCRL dephosphorylates PI(4,5)P2 on internal membranes 16020 714782 3.1.3.36 phosphoinositide 5-phosphatase membrane upon insulin stimulation, the adaptor protein APS and SHIP2 are recruited to cell membranes as seen by immunofluorescence studies 16020 681038 3.1.3.36 phosphoinositide 5-phosphatase membrane voltage-sensitive phosphoinositide phosphatase Ci-VSP 16020 716022 3.1.3.4 phosphatidate phosphatase membrane - 16020 -, 134878, 664569, 666452, 677543, 680744, 680814, 681760, 693525, 694357, 716166, 730329, 751022, 752337 3.1.3.4 phosphatidate phosphatase membrane associated 16020 665748 3.1.3.4 phosphatidate phosphatase membrane associated with 16020 650322 3.1.3.4 phosphatidate phosphatase membrane association 16020 693238 3.1.3.4 phosphatidate phosphatase membrane bound to microsomal and plasma membranes 16020 693521 3.1.3.4 phosphatidate phosphatase membrane cell surface membrane, PAP-2b acts at the outer leaflet of cell surface bilayers 16020 651767 3.1.3.4 phosphatidate phosphatase membrane integral 16020 663975, 663994, 666926 3.1.3.4 phosphatidate phosphatase membrane integral membrane protein 16020 664454 3.1.3.4 phosphatidate phosphatase membrane isozyme PAP1, PAP2s are integral membrane proteins 16020 682952 3.1.3.4 phosphatidate phosphatase membrane lipid phosphate phosphatase enzymes possess a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane 16020 681768 3.1.3.4 phosphatidate phosphatase membrane LPP1 and LPP3 are distributed in distinct lipid rafts that may provide unique microenvironments defining their non-redundant physiological functions. LPP1 is associated with rafts, which are segregated from those harboring LPP3, in a Triton-100-sensitive but CHAPS-resistant manner 16020 680546 3.1.3.4 phosphatidate phosphatase membrane LPPs are integral membrane proteins with six transmembrane domains 16020 708068 3.1.3.4 phosphatidate phosphatase membrane microsome 16020 714316 3.1.3.4 phosphatidate phosphatase membrane recruitment of the yeast lipin (Pah1p) is regulated by PA levels onto the nuclear/endoplasmic reticulum membrane. Recruitment requires the transmembrane protein phosphatase complex Nem1p-Spo7p 16020 716758 3.1.3.4 phosphatidate phosphatase membrane six-transmembrane topology 16020 -, 691384 3.1.3.4 phosphatidate phosphatase membrane the more phosphorylated enzyme forms are associated to membranes 16020 680814 3.1.3.4 phosphatidate phosphatase membrane the phosphorylated forms of lipins 1 and 2 in HeLa cells and adipocytes are enriched in the cytosolic fraction, whereas the dephosphorylated forms are enriched in the membrane fraction 16020 693238 3.1.3.4 phosphatidate phosphatase membrane two membrane-associated forms, 45000 Da and 104000 Da, of the Mg2+-dependent phosphatidate phosphatase 16020 653123 3.1.3.4 phosphatidate phosphatase membrane wild-type and lipin-2 are present at similar levels in cytosolic and membrane fractions in the absence of oleate, and it translocates to the membrane fraction with increasing levels of oleate 16020 -, 709065 3.1.3.41 4-nitrophenylphosphatase membrane - 16020 751293 3.1.3.48 protein-tyrosine-phosphatase membrane - 16020 681516, 682959, 693866 3.1.3.48 protein-tyrosine-phosphatase membrane a structurally unique transmembrane protein tyrosine phosphatase 16020 752091 3.1.3.48 protein-tyrosine-phosphatase membrane associated to plasma membrane 16020 650805 3.1.3.48 protein-tyrosine-phosphatase membrane bound 16020 751789 3.1.3.48 protein-tyrosine-phosphatase membrane in metacyclic stage, membrane-associated 16020 666531 3.1.3.48 protein-tyrosine-phosphatase membrane PTP1B 16020 692702 3.1.3.48 protein-tyrosine-phosphatase membrane PTP1B and LAR 16020 692702 3.1.3.48 protein-tyrosine-phosphatase membrane receptor protein tyrosine phosphatases (PTPRs) are a family of cell surface receptor proteins 16020 749850 3.1.3.48 protein-tyrosine-phosphatase membrane receptor tyrosine phosphatases, overview on structure and membrane orientation 16020 651550 3.1.3.48 protein-tyrosine-phosphatase membrane receptor-type isoform PTPBR7 is a transmembrane protein 16020 691726 3.1.3.48 protein-tyrosine-phosphatase membrane the majority of STEP61 is found in membrane-bound compartments 16020 692182 3.1.3.5 5'-nucleotidase membrane - 16020 653347, 653772, 664650, 677542, 678104, 679085, 681753, 682108, 682918, 690362, 692002, 710619, 714927, 750661, 752292 3.1.3.5 5'-nucleotidase membrane anchored by a phospholipase C sensitive glycosyl phosphoinositol linkage 16020 649279 3.1.3.5 5'-nucleotidase membrane glycosylphosphatidyl-inositol-anchored 16020 649751 3.1.3.5 5'-nucleotidase membrane integral membrane enzyme 16020 649524 3.1.3.5 5'-nucleotidase membrane membrane-bound 5'-nucleotidases are ectoenzymes 16020 716355 3.1.3.50 sorbitol-6-phosphatase membrane association with 16020 668943 3.1.3.53 [myosin-light-chain] phosphatase membrane enzyme may interact with membranes, phosphorylation by protein kinase A may modify interaction, distribution of the 130/133 kDa myosin-binding subunit at the membrane 16020 646357 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane - 16020 646383, 646391, 646392 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane 5 times higher Vmax than soluble enzyme 16020 646387 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane 85-90% of total activity, can be solubilized by cholate or to lesser extent by 2 M KCl 16020 646373 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane associated 16020 665810 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane is most effectively solubilized with 1% Nonidet P40 16020 646385 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane major part of activity is membrane bound 16020 646382, 646395 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane membrane associated enzyme has lower specific activity than soluble enzyme 16020 646398 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane roughly 70% of total activity 16020 646385 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane ruffling membranes 16020 646399 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane sarcotubular membrane, 60-65% of total activity 16020 646378 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane two isoforms postulated one of which is membrane associated 16020 646372, 646399 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane type I enzyme predominantly membrane associated 16020 646397 3.1.3.56 inositol-polyphosphate 5-phosphatase membrane using a GFP-fusion construct it is shown that in most cells, the GFP fluorescence retracts from the cell wall, and is most concentrated in a ring, consistent with a cell surface or plasma membrane location 16020 694699 3.1.3.59 alkylacetylglycerophosphatase membrane - 16020 646420 3.1.3.6 3'-nucleotidase membrane - 16020 714930 3.1.3.6 3'-nucleotidase membrane cell surface membrane-anchored protein, the C-terminal domain of the enzyme functions to anchor this protein into the parasite cell surface membrane 16020 651998 3.1.3.6 3'-nucleotidase membrane outer membrane 16020 -, 690524 3.1.3.6 3'-nucleotidase membrane surface membrane 16020 651547 3.1.3.6 3'-nucleotidase membrane surface membrane anchored enzyme 16020 -, 653205 3.1.3.64 phosphatidylinositol-3-phosphatase membrane - 16020 646448, 646449 3.1.3.64 phosphatidylinositol-3-phosphatase membrane associated, MTMR2-MTMR13 complex 16020 665651 3.1.3.64 phosphatidylinositol-3-phosphatase membrane when hypoosmotic stress is induced in COS7 cells, a condition that increases PtdIns(3,5)P2 levels, MTMR2 delocalizes to membranes of intracellular vacuoles 16020 682009 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase membrane RHD4 is selectively recruited to RabA4-blabeled membranes that are involved in polarized expansion of root hair cells. In conjunction with the phosphoinositide kinase PI-4Kb1, RHD4 regulates the accumulation of phosphatidylinositol-4-phosphate on membrane compartments at the tips of growing root hairs 16020 694636 3.1.3.7 3'(2'),5'-bisphosphate nucleotidase membrane bound to. Stress markedly influences the accumulation of the membrane-bound enzyme form in the cell. The N-terminal hydrophobic region is necessary for the synthesis of the membrane-bound isoform 16020 668452 3.1.3.72 5-phytase membrane integral component of the storage body membrane 16020 94801 3.1.3.8 3-phytase membrane integral membrane protein 16020 -, 750848 3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase membrane - 16020 661582, 714939, 714946 3.1.3.9 glucose-6-phosphatase membrane - 16020 134932, 651203, 652517 3.1.3.9 glucose-6-phosphatase membrane membrane topology: a model with six transmembrane domains are first propsed, but has been superseded by a model with nine transmembrane domains 16020 649729 3.1.3.9 glucose-6-phosphatase membrane the enzyme contains several transmembrane helices 16020 666372 3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase membrane isoform MTMR2 and myotubularin-related protein MTMR13 cofractionate in both a light membrane fraction and a cytosolic fraction. MTMR13 membrane association is mediated by the segment of the protein which contains the pseudophosphatase domain 16020 665651 3.1.3.B13 sn-2-glycerol-3-phosphate phosphatase membrane modeling data indicate 16020 723629 3.1.3.B14 archaetidylinositol phosphate phosphatase membrane - 16020 704559 3.1.3.B4 phosphatidylinositol-4-phosphate phosphatase membrane an integral membrane protein 16020 752310 3.1.3.B4 phosphatidylinositol-4-phosphate phosphatase membrane RHD4 is selectively recruited to RabA4blabeled membranes that are involved in polarized expansion of root hair cells 16020 694636 3.1.4.1 phosphodiesterase I membrane - 16020 649302, 697620 3.1.4.1 phosphodiesterase I membrane PC-1 is a class II transmembrane glycoprotein 16020 707668 3.1.4.11 phosphoinositide phospholipase C membrane - 16020 -, 135119, 135127, 285217, 682121, 710328, 751269, 751530 3.1.4.11 phosphoinositide phospholipase C membrane associated 16020 285219 3.1.4.11 phosphoinositide phospholipase C membrane associated with 16020 135122, 135142 3.1.4.11 phosphoinositide phospholipase C membrane bound to 16020 135123 3.1.4.11 phosphoinositide phospholipase C membrane enzyme subtype beta1 and beta3 16020 135139 3.1.4.11 phosphoinositide phospholipase C membrane isoforms PLCdelta4, PLCepsilon, and PLCgamma1 16020 751185 3.1.4.11 phosphoinositide phospholipase C membrane one of the isozymes is a membrane-associated PI-PLC 16020 714877 3.1.4.11 phosphoinositide phospholipase C membrane PI-PLCm represents the main activity detected in the membrane, while PI-PLCc is the main activity present in the cytoplasm 16020 285237 3.1.4.11 phosphoinositide phospholipase C membrane PLC-beta 16020 649330 3.1.4.11 phosphoinositide phospholipase C membrane PTEN induces translocation of PLC-gamma from the cytosol to the membrane 16020 680080 3.1.4.11 phosphoinositide phospholipase C membrane rat parotid gland membranes 16020 135138 3.1.4.12 sphingomyelin phosphodiesterase membrane - 16020 -, 135163, 135175, 135181, 135183, 135184, 135188, 649682, 650584, 651315, 653120, 653652, 663803, 678142, 705258, 716252 3.1.4.12 sphingomyelin phosphodiesterase membrane age-related decreases in the hippocampal and striatal cytosolic N-Sase activities are accompanied by increases in the membrane N-Sase activities. Significant increase in cortical membrane-associated N-Sase activity with age 16020 -, 666446 3.1.4.12 sphingomyelin phosphodiesterase membrane associated 16020 -, 652972, 714926 3.1.4.12 sphingomyelin phosphodiesterase membrane bound 16020 729171 3.1.4.12 sphingomyelin phosphodiesterase membrane catalytic region of nSMase2 localizes to the cytosolic side of the plasma membrane, proposed membrane topology model, overview 16020 680745 3.1.4.12 sphingomyelin phosphodiesterase membrane intestinal microvillar membrane 16020 678434 3.1.4.12 sphingomyelin phosphodiesterase membrane nSMase1 contains two putative transmembrane domains at the C-terminus 16020 678142 3.1.4.12 sphingomyelin phosphodiesterase membrane nSMase2 is predominantly membrane-bound 16020 678375 3.1.4.12 sphingomyelin phosphodiesterase membrane phosphorylation of a specific serine residue on ASM (S508) by protein kinase C-delta is required for its translocation to the cell surface 16020 692274 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase membrane - 16020 135240 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase membrane isoforms PDE2,PDE3, PDE10, PDE11 16020 678445 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase membrane PDE10A is found almost exclusively in the membrane fraction 16020 694373 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase membrane PDE2A2 and PDE2A3, and PDE3A and PDE3B 16020 716435 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase membrane PDE9A localizes to the membrane in all organs except the bladder 16020 751697 3.1.4.3 phospholipase C membrane - 16020 -, 135289, 135291, 135294, 649812, 714335, 749482 3.1.4.3 phospholipase C membrane associated to 16020 652656, 653699 3.1.4.3 phospholipase C membrane bound 16020 730853 3.1.4.3 phospholipase C membrane ectoplasmic, IL-2-dependent distribution between cytoplasm and ectoplasmic membrane surface in human NK cells 16020 652678 3.1.4.3 phospholipase C membrane high level of enzyme expression on the outer membrane surface of natural killer cells. Enzyme expression level on the membrane closely correlates with that of the CD16 receptor 16020 679640 3.1.4.3 phospholipase C membrane mPC-PLC 16020 668524 3.1.4.3 phospholipase C membrane of stamens and pistils 16020 730853 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase membrane - 16020 667518, 694285, 716199 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase membrane approximately 37% of cGMP degradation activity is localized in the detergent-resistant membrane 16020 692087 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase membrane generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes 16020 667521 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase membrane of rod outer segment 16020 680735 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase membrane rod outer segment membrane 16020 680648 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane - 16020 -, 135403, 135407, 135409, 729185, 730238, 750212 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane a 13 residue C-terminal fragment is responsible for enzyme membrane anchoring. Lipidation of the 13 residue fragment is essential for the peptide to be folded and correctly positioned on the membrane surface 16020 678336 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane cytosolic side of the membrane 16020 135395, 135399 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane exclusively associated with the cytosolic side of the membrane 16020 135394 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane integral membrane protein, inner and outer mitochondrial membrane 16020 135396, 135408 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane membrane-anchored enzyme present on the cytosolic side of non-compact myelin 16020 730475 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane membrane-bound, microtubule-associated protein, membrane anchor for tubulin 16020 653684 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane myelin membranes 16020 135380, 135381, 135394, 135397, 135401, 135418, 135423 3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase membrane single and double-unit membrane, from non-compact regions of myelin 16020 135392 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane - 16020 95156, 95159, 95160, 95161, 95162, 95163 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane 44-50% activity in myelin 16020 95158 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane 75% of activity 16020 95144 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane 8-27% activity in microsomes 16020 95158 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane myelin 16020 95155, 95164, 95165 3.1.4.38 glycerophosphocholine cholinephosphodiesterase membrane two forms of brain GPC-Cpde, a membrane-linked, mGPC-Cpde, and a soluble, sGPC-Cpde 16020 -, 730472 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase membrane - 16020 -, 714339 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase membrane N-terminal transmembrane type glycoprotein 16020 682694 3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase membrane recombinant enzyme 16020 749951 3.1.4.4 phospholipase D membrane - 16020 135429, 135433, 135449, 135452, 652644, 666584, 677845, 710008, 710014, 729710 3.1.4.4 phospholipase D membrane associated to 16020 651126 3.1.4.4 phospholipase D membrane detergent insoluble fraction 16020 135440 3.1.4.4 phospholipase D membrane interaction of the PLD1 PX domain with phosphatidylinositol 3,4,5-trisphosphate and/or phosphatidic acid (or phosphatidylserine) may be an important factor in the spatiotemporal regulation and activation of PLD1 16020 665597 3.1.4.4 phospholipase D membrane membrane-associated enzyme 16020 707481 3.1.4.4 phospholipase D membrane PLD is predominantly a membrane-bound enzyme 16020 709924 3.1.4.4 phospholipase D membrane PLD-1, about 80% of total activity, PLD-2, about 20% of total acttivity 16020 653224 3.1.4.4 phospholipase D membrane PLD1 and PLD2 are observed over the entire platelet mass. PLD1 is observed in small dots while PLD2 is concentrated close to the membrane. After stimulation with thrombin PLD1 and PLD2 rapidly translocate to the proximity of the plasma membrane of platelets 16020 694792 3.1.4.4 phospholipase D membrane PLD1 and PLD2 exhibit three lipid-binding domains in addition to the active site, a PX domain, a PH domain and a polybasic domain that is responsible for PIP2 stimulated enzyme activity and is sufficient for the membrane recruitment of PLD2. ARF is a PLD1 effector in membrane trafficking, mechanism, detailed overview 16020 707544 3.1.4.4 phospholipase D membrane transmembrane enzyme 16020 665039 3.1.4.41 sphingomyelin phosphodiesterase D membrane associated to 16020 653121 3.1.4.41 sphingomyelin phosphodiesterase D membrane associated, SMase-C activity is detected in soluble and particulate fractions 16020 -, 714926 3.1.4.44 glycerophosphoinositol glycerophosphodiesterase membrane - 16020 679873 3.1.4.44 glycerophosphoinositol glycerophosphodiesterase membrane integral membrane protein 16020 679873 3.1.4.44 glycerophosphoinositol glycerophosphodiesterase membrane integral membrane protein, the catalytic GDE domain faces the lumen/extracellular space and the C-terminus faces the cytoplasm 16020 653592 3.1.4.46 glycerophosphodiester phosphodiesterase membrane inner or outer membrane 16020 646466 3.1.4.46 glycerophosphodiester phosphodiesterase membrane isozyme GDE2 contains a 43-amino acid intracellular N-terminal region, six transmembrane domains, an intracellular C-terminal domain of 82-amino acid residues and two 13-amino acid intracellular connecting loops between the transmembrane domains 16020 729721 3.1.4.46 glycerophosphodiester phosphodiesterase membrane membrane fraction, mainly plasma membrane 16020 729721 3.1.4.46 glycerophosphodiester phosphodiesterase membrane the enzyme is a hydrophilic lipoprotein that is also assumed to be anchored by N-terminal lipids to the periplasmic leaflet(s) of the peptidoglycan cytoplasmic membrane, and not to be exposed on the outer membrane of the pathogen 16020 729721 3.1.4.46 glycerophosphodiester phosphodiesterase membrane the enzyme is most probably bound to the periplasmic side of the inner or outer membrane 16020 729721 3.1.4.50 glycosylphosphatidylinositol phospholipase D membrane - 16020 646472 3.1.4.52 cyclic-guanylate-specific phosphodiesterase membrane inner membrane 16020 680510 3.1.4.52 cyclic-guanylate-specific phosphodiesterase membrane the transmembrane protein contains two transmembrane segments, positions 7 to 29 and 230 to 252 16020 -, 729929 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane - 16020 669475, 670189, 688524, 694373 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane about 20% of protein is associated with membrane, recombinant protein expressed in COS-7 cell 16020 678086 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane accociated 16020 670189 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane DdPDE4 is a unique membrane-bound phosphodiesterase with an extracellular catalytic domain regulating intercellular cAMP during multicellular development 16020 669475 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane helix-1 is important for intracellular targeting of PDE4A1 in living cells, facilitating membrane association, targeting to the trans-Golgi stack and conferring Ca2+-stimulated intracellular redistribution in a manner that is dependent on the phospholipase-D-mediated generation of phosphatidic acid 16020 687912 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane isozyme PDE4A 16020 716435 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane membrane-bound enzyme with an extracellular domain 16020 669475 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase membrane when expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme is associated with membrane fractions 16020 678086 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D membrane - 16020 708982, 710098, 710454 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D membrane associated to membrane. At the membrane interface, the NAPE-PLD dimer forms a hydrophobic nook that contains two molecules of phosphatidylethanolamine, one bound to each monomer 16020 752275 3.1.4.59 cyclic-di-AMP phosphodiesterase membrane protein possesses two transmembrane helices 16020 750954 3.1.4.59 cyclic-di-AMP phosphodiesterase membrane transmembrane protein 16020 -, 751453 3.1.4.60 pApA phosphodiesterase membrane protein possesses two transmembrane helices 16020 750954 3.1.4.61 cyclic 2,3-diphosphoglycerate hydrolase membrane - 16020 -, 760445 3.1.4.61 cyclic 2,3-diphosphoglycerate hydrolase membrane bound 16020 -, 760446 3.1.6.1 arylsulfatase (type I) membrane 63-kDa single-chain precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes. Proteolytically processed arylsulfatase G fragments of 34-, 18-, and 10-kDa are found in lysosomal fractions and lost their membrane association 16020 730056 3.1.6.1 arylsulfatase (type I) membrane 68% of arylsulfatase acivity is membrane-associated 16020 -, 730337 3.1.6.1 arylsulfatase (type I) membrane 99% of arylsulfatase activity is membrane-associated 16020 -, 730337 3.1.6.14 N-acetylglucosamine-6-sulfatase membrane - 16020 -, 651356 3.1.6.2 steryl-sulfatase membrane - 16020 714821, 716214 3.1.6.2 steryl-sulfatase membrane bound to the membrane of the endoplasmic reticulum 16020 656641 3.1.6.2 steryl-sulfatase membrane integral membrane protein 16020 135595 3.1.6.2 steryl-sulfatase membrane STS activity is enriched in the membrane fraction of the temporal lobe 16020 656590 3.1.6.8 cerebroside-sulfatase membrane - 16020 677796 3.1.7.5 geranylgeranyl diphosphate diphosphatase membrane bound to 16020 694599 3.1.7.5 geranylgeranyl diphosphate diphosphatase membrane deduced amino acid sequence shows 6 hydrophobic transmembrane regions 16020 730572 3.1.8.1 aryldialkylphosphatase membrane external membrane 16020 646522 3.1.8.1 aryldialkylphosphatase membrane organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex 16020 750549 3.1.8.1 aryldialkylphosphatase membrane the enzyme is displayed on cell surface 16020 693606 3.12.1.B1 tetrathionate hydrolase membrane outer membrane 16020 725036 3.13.1.1 UDP-sulfoquinovose synthase membrane photosynthetic 16020 393361, 393362 3.13.1.1 UDP-sulfoquinovose synthase membrane polar lipid matrix 16020 393363 3.2.1.1 alpha-amylase membrane - 16020 -, 731776 3.2.1.1 alpha-amylase membrane bound 16020 693640 3.2.1.1 alpha-amylase membrane bound to, the enzyme is latent in membrane vesicles 16020 -, 393416 3.2.1.10 oligo-1,6-glucosidase membrane - 16020 326255, 654808, 655009, 655668, 656123 3.2.1.10 oligo-1,6-glucosidase membrane intestinal brush border membrane protein 16020 702506 3.2.1.10 oligo-1,6-glucosidase membrane membrane-associated 16020 751091 3.2.1.104 steryl-beta-glucosidase membrane the intracellular localization is changed depending on the growth phase. Distributed in the cytosol until the initial logarithmic phase (12 h), then delivered to an organelle with a granule structure in the middle logarithmic phase (14 h), and finally localized at the vacuole membranes in the stationary phase (18-20 h) 16020 -, 750706 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane - 16020 170972 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane endoplasmic reticulum resident membrane protein, the 18-amino acid long transmembrane domain of GCSI is not sufficient to target this glycosidase in the endoplasmic reticulum membrane 16020 682320 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane integral membrane protein 16020 170952 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane membrane orientation 16020 170970 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane membrane-bound 16020 -, 170950, 170953, 170954, 170955, 170958, 170960, 170961, 170962, 170964, 170967, 170968, 170970, 170971 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane microsomal membranes 16020 136905, 170952 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane proteolytic cleavage of the transmembrane form between residues Ala24 and Thr25 results in a soluble form 16020 -, 655684 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane transmembrane, endoplasmic reticular N-linked glycoprotein with distinct domains within its structure. It contains distinct membrane anchoring and luminally oriented catalytic domains, the enzyme has a cytoplasmically exposed tail 16020 170970 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane type-II transmembrane protein 16020 170955, 170956, 170964, 170965, 170966, 170967, 170968 3.2.1.106 mannosyl-oligosaccharide glucosidase membrane X-2180, equally distributed between particulate and supernatant fractions 16020 -, 170949 3.2.1.108 lactase membrane - 16020 700144, 749964, 756114 3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase membrane - 16020 -, 135992, 135998, 646570, 646572, 646574, 646579, 646582, 646583, 646585 3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase membrane type II membrane protein 16020 135959 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase membrane - 16020 646584 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase membrane 2 enzymes: a membrane-bound microsomal and a soluble cytoplasmic one 16020 646575 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase membrane Golgi alpha-mannosidase II is a type II membrane protein 16020 666601 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase membrane membrane-bound, predominantly in the microsomal pellet 16020 -, 646636 3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase membrane type II transmembrane protein with short cytoplasmic tail, single transmembrane domain and large hydrophilic C-terminal domain 16020 646633 3.2.1.121 polymannuronate hydrolase membrane associated with outer cell membrane 16020 646679 3.2.1.122 maltose-6'-phosphate glucosidase membrane - 16020 680661 3.2.1.123 endoglycosylceramidase membrane - 16020 680770 3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase membrane - 16020 -, 646724, 646725, 646726 3.2.1.130 glycoprotein endo-alpha-1,2-mannosidase membrane rat endomannosidase is a type II membrane protein, its transmembrane domain is required for its efficient Golgi localization, i.e. is necessary for the Golgi retention 16020 697210 3.2.1.139 alpha-glucuronidase membrane - 16020 665367 3.2.1.14 chitinase membrane associated with the outer side of cell membrane 16020 655520 3.2.1.140 lacto-N-biosidase membrane a membrane-anchored extracellular enzyme 16020 732092 3.2.1.147 thioglucosidase membrane - 16020 666657 3.2.1.147 thioglucosidase membrane associated with the cytoplasmic side of internal membranes 16020 208580 3.2.1.15 endo-polygalacturonase membrane - 16020 695297 3.2.1.176 cellulose 1,4-beta-cellobiosidase (reducing end) membrane outer membrane 16020 714590 3.2.1.18 exo-alpha-sialidase membrane - 16020 -, 656030, 728971, 729808 3.2.1.18 exo-alpha-sialidase membrane associated 16020 717257 3.2.1.18 exo-alpha-sialidase membrane associated, NEU3 16020 717641 3.2.1.18 exo-alpha-sialidase membrane Neu1 is localized in the outer membrane of the nuclear envelope 16020 705255 3.2.1.18 exo-alpha-sialidase membrane NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility 16020 677929 3.2.1.18 exo-alpha-sialidase membrane Neu3 is localized in the inner membrane of the nuclear envelope 16020 705255 3.2.1.18 exo-alpha-sialidase membrane outer mitochondrial membrane, NEU4 long 16020 703906 3.2.1.183 UDP-N-acetylglucosamine 2-epimerase (hydrolysing) membrane - 16020 728341 3.2.1.20 alpha-glucosidase membrane - 16020 393262, 729647 3.2.1.20 alpha-glucosidase membrane bound 16020 136510, 393292, 681471, 681555 3.2.1.20 alpha-glucosidase membrane brush border membrane vesicles 16020 678601 3.2.1.20 alpha-glucosidase membrane brush-border membrane 16020 393260 3.2.1.20 alpha-glucosidase membrane isozymes alphaGlu1-alpha-Glu3 are membrane-bound 16020 679317 3.2.1.20 alpha-glucosidase membrane perimicrovillar membranes 16020 393341, 708224 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase membrane - 16020 751386 3.2.1.207 mannosyl-oligosaccharide alpha-1,3-glucosidase membrane 50% of total enzyme activity in a mixed membrane fraction 16020 -, 713777 3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase membrane - 16020 -, 135981, 700048 3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase membrane from microsomal membranes 16020 135972 3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase membrane type II membrane protein 16020 646613 3.2.1.21 beta-glucosidase membrane - 16020 326292, 698307 3.2.1.21 beta-glucosidase membrane cell bound activity if cellobiose dominating in the medium 16020 326321 3.2.1.21 beta-glucosidase membrane extracellular localization 16020 326287 3.2.1.23 beta-galactosidase membrane - 16020 171352 3.2.1.24 alpha-mannosidase membrane - 16020 135959, 135973, 135982, 646586 3.2.1.24 alpha-mannosidase membrane bound to vacuolar tonoplast 16020 135979 3.2.1.24 alpha-mannosidase membrane from Golgi-enriched membrane fraction 16020 135971, 135998 3.2.1.24 alpha-mannosidase membrane from microsomal membranes 16020 135974 3.2.1.28 alpha,alpha-trehalase membrane - 16020 664664, 696991, 715826, 729110 3.2.1.28 alpha,alpha-trehalase membrane about 10% 16020 665191 3.2.1.28 alpha,alpha-trehalase membrane bound, isozyme SfTre2 16020 708733 3.2.1.28 alpha,alpha-trehalase membrane cell surface, the isozyme type 2 contains one transmembrane segment and lacks the omega site 16020 665197 3.2.1.28 alpha,alpha-trehalase membrane isoform Treh2 16020 729803 3.2.1.28 alpha,alpha-trehalase membrane membrane-bound isozyme SeTre-2 16020 710386 3.2.1.28 alpha,alpha-trehalase membrane NlTre2, contains a putative transmembrane domain 16020 709400 3.2.1.28 alpha,alpha-trehalase membrane the acid trehalase contains either a transmembrane segment or a signal sequence at the N-terminus 16020 665006 3.2.1.3 glucan 1,4-alpha-glucosidase membrane - 16020 750886 3.2.1.3 glucan 1,4-alpha-glucosidase membrane bound 16020 681471 3.2.1.3 glucan 1,4-alpha-glucosidase membrane the enzyme is anchored in the membrane of small intestinal epithelial cells 16020 679741 3.2.1.31 beta-glucuronidase membrane form I and II 16020 26850 3.2.1.35 hyaluronoglucosaminidase membrane - 16020 703288 3.2.1.35 hyaluronoglucosaminidase membrane 130 kDa enzyme form 16020 649571 3.2.1.35 hyaluronoglucosaminidase membrane bound 16020 651288 3.2.1.35 hyaluronoglucosaminidase membrane Hyal2 is strongly associated with cell membrane fractions from which it can be extracted using a Triton X-114 treatment, but not an osmotic shock or an alkaline carbonate solution. Treatment of membrane preparations with phosphatidylinositol-specific phospholipase C releases immunoreactive Hyal2 into the aqueous phase. The protein is attached to the membrane through a functional GPI anchor. Hyal2 transfected in COS-7 cells is associated with detergent-resistant, cholesterol-rich membranes known as lipid rafts 16020 714065 3.2.1.35 hyaluronoglucosaminidase membrane inner acrosomal membrane 16020 651601 3.2.1.37 xylan 1,4-beta-xylosidase membrane - 16020 655522 3.2.1.4 cellulase membrane - 16020 717220 3.2.1.4 cellulase membrane membrane-bound cellulase 16020 393580 3.2.1.4 cellulase membrane recombinant enzyme, membrane of Escherichia coli 16020 -, 393555 3.2.1.4 cellulase membrane wild-type enzyme is anchored to membrane 16020 657034 3.2.1.41 pullulanase membrane - 16020 -, 136406, 731776 3.2.1.41 pullulanase membrane 18% membrane associated 16020 136402 3.2.1.41 pullulanase membrane the Klebsiella lipoprotein pullulanase (PulA) is exported to the periplasm, triacylated, and anchored via lipids in the inner membrane prior to its transport to the bacterial surface through a type II secretion system 16020 752281 3.2.1.45 glucosylceramidase membrane - 16020 136459, 136470 3.2.1.45 glucosylceramidase membrane bound 16020 136448, 136449, 136461 3.2.1.45 glucosylceramidase membrane bound to acidic lipids in membranes 16020 136449 3.2.1.48 sucrose alpha-glucosidase membrane - 16020 655706, 664558, 665315, 665799, 751091 3.2.1.48 sucrose alpha-glucosidase membrane membrane-associated 16020 751091 3.2.1.48 sucrose alpha-glucosidase membrane the isomaltase subunit is membrane associated and the sucrase subunit is hydrophilic 16020 656071 3.2.1.49 alpha-N-acetylgalactosaminidase membrane - 16020 663573 3.2.1.50 alpha-N-acetylglucosaminidase membrane a membrane-anchored extracellular enzyme 16020 749725 3.2.1.51 alpha-L-fucosidase membrane - 16020 208716, 655143 3.2.1.51 alpha-L-fucosidase membrane bound in membrane of monocytes 16020 699333 3.2.1.51 alpha-L-fucosidase membrane fucosidase is broadly distributed over the membrane systems of human sperm, but is relatively enriched within the equatorial segment 16020 682040 3.2.1.51 alpha-L-fucosidase membrane is present to some degree in most of the sperm membranes, with a portion detectable on the outer surface of intact sperm. Larger quantities are present within cells, and particularly within the acrosomal compartment, and in the equatorial segment of the human sperm cell 16020 682040 3.2.1.52 beta-N-acetylhexosaminidase membrane - 16020 26851, 655514, 656839, 679260, 698129 3.2.1.62 glycosylceramidase membrane - 16020 -, 656061, 732073, 756114 3.2.1.63 1,2-alpha-L-fucosidase membrane - 16020 -, 752322 3.2.1.65 levanase membrane outer membrane 16020 -, 713736 3.2.1.74 glucan 1,4-beta-glucosidase membrane - 16020 326287, 698578 3.2.1.76 L-iduronidase membrane - 16020 171557, 171563 3.2.1.8 endo-1,4-beta-xylanase membrane - 16020 -, 679721 3.2.1.8 endo-1,4-beta-xylanase membrane most XynA remains cell associated in the outer membrane 16020 -, 680515 3.2.1.86 6-phospho-beta-glucosidase membrane - 16020 750733 3.2.1.B40 Pyrococcus horikoshii beta-glycosidase membrane - 16020 -, 744888, 746400 3.2.1.B40 Pyrococcus horikoshii beta-glycosidase membrane bound to 16020 -, 744197, 746400 3.2.1.B40 Pyrococcus horikoshii beta-glycosidase membrane membrane bound 16020 -, 744197 3.2.2.14 NMN nucleosidase membrane - 16020 171775 3.2.2.22 rRNA N-glycosylase membrane - 16020 716963, 716967 3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase membrane - 16020 -, 489806, 646957, 646960, 646963 3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase membrane associated to membrane after an ammonium shock 16020 670320 3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase membrane associated to membrane. Purified enzyme reversibly binds to bacterial pellet fractions requiring a protein component in the membrane. Guanosine and uridine tri- and di-nucleotides specifically dissociate enzyme from membrane fractions 16020 646972 3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase membrane DraG reversibly associates with the cell membrane 16020 710412 3.2.2.27 uracil-DNA glycosylase membrane - 16020 710138 3.2.2.5 NAD+ glycohydrolase membrane - 16020 -, 670414, 750254 3.2.2.5 NAD+ glycohydrolase membrane bound 16020 655232 3.2.2.5 NAD+ glycohydrolase membrane cell surface protein 16020 656433 3.2.2.5 NAD+ glycohydrolase membrane no solubilization by phosphatidylinositol-specific phospholipase C or 0.5 M KCl, but by Triton X-100 16020 656169 3.2.2.5 NAD+ glycohydrolase membrane transmembrane protein with a catalytically active extracellular domain 16020 654609 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase membrane - 16020 326409, 716910 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase membrane CD38 is a type II membrane protein with an extracellular C-terminal enzymatic domain with NADase/NADPase and ADPR cyclase activity and a short cytoplasmic N-terminal tail 16020 714921 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase membrane CD38 is a type II transmembrane protein 16020 731987 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase membrane most frog enzyme (81%) is distributed in the membrane fraction (5% in mitochondrial fraction and 14% in microsomal fraction) 16020 732501 3.3.2.1 isochorismatase membrane small fraction membrane-bound, predominantly cytosolic 16020 326415 3.3.2.10 soluble epoxide hydrolase membrane - 16020 208877 3.3.2.6 leukotriene-A4 hydrolase membrane - 16020 731424 3.3.2.9 microsomal epoxide hydrolase membrane - 16020 208935, 655359, 657394 3.3.2.9 microsomal epoxide hydrolase membrane mEH is also associated with the nuclear and plasma membranes 16020 700587 3.3.2.9 microsomal epoxide hydrolase membrane orientation of the enzyme depends on the membrane type 16020 660713 3.4.11.1 leucyl aminopeptidase membrane - 16020 95221, 95224 3.4.11.14 cytosol alanyl aminopeptidase membrane 20% of the PSA is associated with the membrane 16020 682118 3.4.11.16 Xaa-Trp aminopeptidase membrane integral membrane protein, microvillar membrane 16020 665097 3.4.11.2 membrane alanyl aminopeptidase membrane - 16020 -, 35874, 651265, 653004, 663842, 664281, 665112, 665837, 666534, 683478, 683496, 683712, 683811, 695499, 695577, 695929, 695995, 696227, 696265, 696626, 697036, 697497, 698298, 698381, 699428, 699938, 701354, 708731, 709194, 754542 3.4.11.2 membrane alanyl aminopeptidase membrane bound 16020 651832, 653859, 664725, 665146 3.4.11.2 membrane alanyl aminopeptidase membrane bound, brush border 16020 666997 3.4.11.2 membrane alanyl aminopeptidase membrane brush border 16020 665113 3.4.11.2 membrane alanyl aminopeptidase membrane brush border membrane 16020 35866, 35870, 35873, 35878, 35880, 35881, 35883, 35887, 35890, 35891, 664831 3.4.11.2 membrane alanyl aminopeptidase membrane brush border membranes 16020 665112 3.4.11.2 membrane alanyl aminopeptidase membrane cell surface 16020 652749 3.4.11.2 membrane alanyl aminopeptidase membrane cerebral membrane 16020 35871 3.4.11.2 membrane alanyl aminopeptidase membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. In all cell types, cystinyl aminopeptidase predominates over aminopepetidase N 16020 683431 3.4.11.2 membrane alanyl aminopeptidase membrane epithelial cell, brush border 16020 665431 3.4.11.2 membrane alanyl aminopeptidase membrane intergral 16020 665244 3.4.11.2 membrane alanyl aminopeptidase membrane membrane aminopeptidase N is the minor aminopeptidase N in Eimeria tenella oocysts compared to cytosolic aminopeptidase N, EC 3.4.11.14 16020 666144 3.4.11.2 membrane alanyl aminopeptidase membrane memebrane-bound 16020 753446 3.4.11.2 membrane alanyl aminopeptidase membrane microvillus membrane 16020 35877, 35885 3.4.11.2 membrane alanyl aminopeptidase membrane mucosal membrane 16020 35867, 35876 3.4.11.2 membrane alanyl aminopeptidase membrane plasma membrane 16020 35888 3.4.11.2 membrane alanyl aminopeptidase membrane transmembrane protein 16020 707799 3.4.11.2 membrane alanyl aminopeptidase membrane type II transmembrane protein expressed on the cell suface 16020 663607 3.4.11.22 aminopeptidase I membrane - 16020 650310 3.4.11.22 aminopeptidase I membrane glycosylated enzyme form 16020 665104 3.4.11.22 aminopeptidase I membrane the enzyme exists in a membrane and a soluble variant with slightly differing substrate specificities and thermostabilities 16020 665108 3.4.11.3 cystinyl aminopeptidase membrane - 16020 651116, 667549, 668760, 696727, 753723 3.4.11.3 cystinyl aminopeptidase membrane after exposure of 3T3-L1 adipocytes to insulin, IRAP translocates to the plasma membrane 16020 669191 3.4.11.3 cystinyl aminopeptidase membrane bound to 16020 651074, 663814 3.4.11.3 cystinyl aminopeptidase membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N 16020 683431 3.4.11.3 cystinyl aminopeptidase membrane insulin-regulated aminopeptidase (IRAP) is a membrane-bound zinc metallopeptidase 16020 752375 3.4.11.3 cystinyl aminopeptidase membrane IRAP is a transmembrane aminopeptidase 16020 -, 754109 3.4.11.3 cystinyl aminopeptidase membrane membrane-bound 16020 -, 754571 3.4.11.3 cystinyl aminopeptidase membrane membrane-bound placental enzyme is released into maternal blood flow via proteolytic cleavage by metalloproteases and metalloproteinases 16020 664275 3.4.11.3 cystinyl aminopeptidase membrane the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity by posttranslational proteolytic cleavage between Phe154 and Ala155. P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells 16020 670742 3.4.11.3 cystinyl aminopeptidase membrane transmembrane enzyme 16020 755404 3.4.11.3 cystinyl aminopeptidase membrane type II transmembrane protein 16020 668760 3.4.11.3 cystinyl aminopeptidase membrane type III integral membrane protein, converted to a soluble form existing in maternal serum by metalloproteases 16020 667810 3.4.11.3 cystinyl aminopeptidase membrane type III integral membrane spanning protein 16020 667888 3.4.11.4 tripeptide aminopeptidase membrane inner cytoplasmic membrane 16020 678441 3.4.11.5 prolyl aminopeptidase membrane membrane bound 16020 -, 753839 3.4.11.6 aminopeptidase B membrane - 16020 664535 3.4.11.6 aminopeptidase B membrane synaptic membrane 16020 682114 3.4.11.7 glutamyl aminopeptidase membrane - 16020 36011, 36012, 36036, 681000, 683508, 683521, 683663, 683799, 696103, 698879 3.4.11.7 glutamyl aminopeptidase membrane bound 16020 666460 3.4.11.7 glutamyl aminopeptidase membrane bound, type II integral membrane protein, the enzyme contains an ectodomain 16020 663609 3.4.11.7 glutamyl aminopeptidase membrane integral, cell surface 16020 665570 3.4.11.7 glutamyl aminopeptidase membrane intracellular 16020 665836 3.4.11.7 glutamyl aminopeptidase membrane membrane-bound 16020 753088, 755153 3.4.11.7 glutamyl aminopeptidase membrane membrane-bound aspartyl aminopeptidase 16020 663814 3.4.11.7 glutamyl aminopeptidase membrane the enzyme has cytosolic and transmembrane regions 16020 663456, 665074, 665110 3.4.11.7 glutamyl aminopeptidase membrane type II enzyme 16020 655731 3.4.11.7 glutamyl aminopeptidase membrane type II membrane-bound enzyme, membrane-spanning 16020 665723 3.4.11.7 glutamyl aminopeptidase membrane wild-type enzyme 16020 36030 3.4.11.9 Xaa-Pro aminopeptidase membrane - 16020 667488, 698447 3.4.11.9 Xaa-Pro aminopeptidase membrane attached to the membranes via a glycosylphosphatidylinositol anchor 16020 36056, 36062 3.4.11.9 Xaa-Pro aminopeptidase membrane bound 16020 649942 3.4.11.9 Xaa-Pro aminopeptidase membrane membrane-bound 16020 752870 3.4.13.18 cytosol nonspecific dipeptidase membrane - 16020 137186 3.4.13.19 membrane dipeptidase membrane - 16020 647086, 647087, 647092, 647093, 647094, 647096, 647103, 678065, 732980 3.4.13.19 membrane dipeptidase membrane anchoring site 16020 647100 3.4.13.19 membrane dipeptidase membrane bound to 16020 647112 3.4.13.19 membrane dipeptidase membrane membrane-bound dipeptidase-1, membrane-bound dipeptidase-2, membrane-bound dipeptidase-3 16020 647113 3.4.13.19 membrane dipeptidase membrane plasma membrane 16020 647114 3.4.14.10 tripeptidyl-peptidase II membrane cerebral 16020 665981 3.4.14.10 tripeptidyl-peptidase II membrane cholecystokinin-8-inactivating peptidase is a membrane bound isoform 16020 647155 3.4.14.10 tripeptidyl-peptidase II membrane inner cytoplasmic membrane 16020 678441 3.4.14.10 tripeptidyl-peptidase II membrane PTP-A is secreted to the surface of the outer membrane 16020 -, 699739 3.4.14.11 Xaa-Pro dipeptidyl-peptidase membrane improvement of fermentation conditions for the production of the enzyme 16020 667007 3.4.14.11 Xaa-Pro dipeptidyl-peptidase membrane the C-terminal moiety probably plays a role in tropism of the enzyme towards the cellular membrane 16020 647177 3.4.14.2 dipeptidyl-peptidase II membrane enzyme form DPP II-S 16020 95229 3.4.14.4 dipeptidyl-peptidase III membrane - 16020 36138, 36179, 36191, 36192, 708575, 754681 3.4.14.4 dipeptidyl-peptidase III membrane outer cell membrane 16020 36191 3.4.14.5 dipeptidyl-peptidase IV membrane - 16020 36219, 36246, 36259, 36265, 650432, 650930, 651514, 653593, 665942, 703569, 732205 3.4.14.5 dipeptidyl-peptidase IV membrane anchored 16020 36246 3.4.14.5 dipeptidyl-peptidase IV membrane bound 16020 36252, 649276 3.4.14.5 dipeptidyl-peptidase IV membrane bound, type II 16020 649274 3.4.14.5 dipeptidyl-peptidase IV membrane cell surface 16020 649277 3.4.14.5 dipeptidyl-peptidase IV membrane cell surface-associated 16020 652293 3.4.14.5 dipeptidyl-peptidase IV membrane ectoenzyme in cell membrane of lymphocytes 16020 36244 3.4.14.5 dipeptidyl-peptidase IV membrane enzyme has a transmembrane domain 16020 666369 3.4.14.5 dipeptidyl-peptidase IV membrane in P and A549 cells the enzyme is associated with the plasmalemma while in SK-MES-1 cells it is bound to intracellular membranes 16020 732939 3.4.14.5 dipeptidyl-peptidase IV membrane integral membrane protein 16020 679973 3.4.14.5 dipeptidyl-peptidase IV membrane loosely bound to inner cell membrane 16020 -, 36245 3.4.14.5 dipeptidyl-peptidase IV membrane membrane-bound enzyme loses its transmembrane domain upon release into the serum 16020 36254 3.4.14.5 dipeptidyl-peptidase IV membrane type II membrane protein, bound, on the cell surface 16020 649229 3.4.14.5 dipeptidyl-peptidase IV membrane type II transmembrane enzyme 16020 653298 3.4.14.5 dipeptidyl-peptidase IV membrane type II transmembrane glycoprotein, cell surface 16020 651076 3.4.14.5 dipeptidyl-peptidase IV membrane type II transmembrane protein 16020 649200, 653810 3.4.15.1 peptidyl-dipeptidase A membrane - 16020 -, 651335, 679708, 697822, 701190, 710160, 752444, 81210, 81242, 81248, 81270 3.4.15.1 peptidyl-dipeptidase A membrane a highly hydrophobic sequence located near the carboxy-terminal extremity of the molecule most likely constitutes the anchor to the plasma membrane 16020 81278 3.4.15.1 peptidyl-dipeptidase A membrane anchored to plasma membrane, the bulk of its mass exposed at the extracellular surface of the cell 16020 81241 3.4.15.1 peptidyl-dipeptidase A membrane anchored to the plasma membrane by the C-terminal transmembrane domain 16020 81212 3.4.15.1 peptidyl-dipeptidase A membrane anchored to the plasma membrane via its C-terminus 16020 81267 3.4.15.1 peptidyl-dipeptidase A membrane associated, sACE 16020 755554 3.4.15.1 peptidyl-dipeptidase A membrane bound 16020 707126 3.4.15.1 peptidyl-dipeptidase A membrane cell surface 16020 710612 3.4.15.1 peptidyl-dipeptidase A membrane inserted in plasma membrane via the carboxyl terminus 16020 81241 3.4.15.1 peptidyl-dipeptidase A membrane integral membrane protein 16020 649747 3.4.15.1 peptidyl-dipeptidase A membrane membrane-bound 16020 755108, 81226, 81228, 81238, 81282 3.4.15.1 peptidyl-dipeptidase A membrane the enzyme is not anchored in the membrane by a glycosyl-phosphatidyl-inositol moiety. The small hydrophobic membrane anchor is a peptide that contains at least 50% hydrophobic amino acids, MW about 5000 Da 16020 81228 3.4.15.1 peptidyl-dipeptidase A membrane the integral membrane protein is located on the luminal surface of the plasma membrane 16020 81268 3.4.15.1 peptidyl-dipeptidase A membrane vascular surface membrane 16020 81253 3.4.15.4 Peptidyl-dipeptidase B membrane - 16020 28727, 28729 3.4.15.6 cyanophycinase membrane enzyme is detected only in germinated spore membranes 16020 -, 745222 3.4.16.2 lysosomal Pro-Xaa carboxypeptidase membrane - 16020 650716 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane - 16020 -, 36281, 36292, 36294, 36296, 36298, 36301, 36307, 36311, 36314, 672145, 683346 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane localized in the outer leaflet of the cytosolic membrane 16020 708885 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane lysozyme releasable 16020 36287 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane membrane anchoring 16020 701353 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane membrane-bound, the active site is present on the outside surface of the membrane 16020 -, 653156 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase membrane protein harbors two protein domains separated by a putative hydrophobic transmembrane region 16020 -, 755422 3.4.16.6 carboxypeptidase D membrane - 16020 698771 3.4.17.1 carboxypeptidase A membrane present in ruffles of macrophages, absent from outer plasma membrane 16020 687160 3.4.17.10 carboxypeptidase E membrane - 16020 668816, 669586, 683819, 683877, 698162, 81289, 81302, 81305 3.4.17.10 carboxypeptidase E membrane anchored to secretory granules via a C-terminal transmembrane insertion. The membrane-binding domain of the enzyme must adopt an alpha-helical configuration to bind to lipids and the enzyme may require another integral membrane chaperone protein to insert through the lipid bilayer in a transmembrane fashion 16020 650156 3.4.17.10 carboxypeptidase E membrane bound 16020 667483 3.4.17.10 carboxypeptidase E membrane membrane-associated via a C-terminal amphipathic sequence 16020 683932 3.4.17.10 carboxypeptidase E membrane pH-dependent membrane anchor 16020 81301 3.4.17.10 carboxypeptidase E membrane secretory granule membrane derived from trans-Golgi network, associated with detergent-resistant lipid domains, or rafts, within secretory granule membranes 16020 652040 3.4.17.10 carboxypeptidase E membrane the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms 16020 753432 3.4.17.10 carboxypeptidase E membrane the enzyme is sorted into the secretory pathway via its C-terminal domain 16020 668816 3.4.17.12 carboxypeptidase M membrane - 16020 668124, 683186, 683544, 683693, 683976, 684055, 684066, 696532, 697395, 697627 3.4.17.12 carboxypeptidase M membrane anchored via glycosylphosphatidylinositol 16020 668124 3.4.17.12 carboxypeptidase M membrane bound 16020 668817 3.4.17.13 Muramoyltetrapeptide carboxypeptidase membrane - 16020 -, 28882 3.4.17.14 Zinc D-Ala-D-Ala carboxypeptidase membrane - 16020 683097 3.4.17.21 Glutamate carboxypeptidase II membrane - 16020 -, 137212, 137216, 137218, 137222, 137223, 137224, 137225, 137226, 667114, 668408, 668484, 668866, 669923, 669943, 669962, 670685, 670740, 670857, 696330, 697394, 699452, 701206, 707988, 710006, 710007, 710456, 710458, 710460, 710658 3.4.17.21 Glutamate carboxypeptidase II membrane extracellular site of Schwann cell membrane 16020 137220 3.4.17.21 Glutamate carboxypeptidase II membrane GCPII 16020 708479 3.4.17.21 Glutamate carboxypeptidase II membrane inner face of plasma membrane 16020 137230 3.4.17.21 Glutamate carboxypeptidase II membrane membrane-bound 16020 754505 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA 16020 709440 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a transmembrane glycoprotein 16020 709649 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer 16020 709648 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a type II membrane protein 16020 709812 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a type II transmembrane glycoprotein 16020 708256 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a type II transmembrane metallopeptidase 16020 708666 3.4.17.21 Glutamate carboxypeptidase II membrane PSMA is a type II transmembrane protein 16020 710204 3.4.17.21 Glutamate carboxypeptidase II membrane synaptic plasma membranes 16020 137228 3.4.17.21 Glutamate carboxypeptidase II membrane the enzyme is associated with the cell surface membrane. The recombinant enzyme and the mutant enzyme omitting the transmembrane domain is associated with the cell surface membrane, the recombinantly expressed extracellular domain has a cytosolic localization 16020 656634 3.4.17.21 Glutamate carboxypeptidase II membrane transmembrane enzyme 16020 755286 3.4.17.21 Glutamate carboxypeptidase II membrane transmembrane protein 16020 755336 3.4.17.21 Glutamate carboxypeptidase II membrane type II membrane glycoprotein 16020 670363 3.4.17.21 Glutamate carboxypeptidase II membrane type II membrane protein 16020 670817 3.4.17.21 Glutamate carboxypeptidase II membrane type II transmembrane glycoprotein 16020 656468 3.4.17.21 Glutamate carboxypeptidase II membrane type II transmembrane protein 16020 670794 3.4.17.22 metallocarboxypeptidase D membrane - 16020 28967, 669448 3.4.17.22 metallocarboxypeptidase D membrane bound to internal and surface membranes 16020 28974 3.4.17.22 metallocarboxypeptidase D membrane CPD contains one transmembrane domain 16020 684108 3.4.17.22 metallocarboxypeptidase D membrane metallocarboxypeptidase D is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways 16020 755155 3.4.17.23 angiotensin-converting enzyme 2 membrane - 16020 658459, 659147, 679300, 679706, 679708, 680388, 710171 3.4.17.23 angiotensin-converting enzyme 2 membrane ACE 2 is shedded 16020 707074 3.4.17.23 angiotensin-converting enzyme 2 membrane ACE2 also undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane 16020 679705 3.4.17.23 angiotensin-converting enzyme 2 membrane ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 16020 694170 3.4.17.23 angiotensin-converting enzyme 2 membrane ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding 16020 707055 3.4.17.23 angiotensin-converting enzyme 2 membrane enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture 16020 658455 3.4.17.23 angiotensin-converting enzyme 2 membrane integral membrane protein 16020 692972 3.4.17.23 angiotensin-converting enzyme 2 membrane the larger form of ACE2 is a type I membrane-anchored protein with a catalytically active ectodomain, that undergoes shedding resulting in the smaller soluble enzyme form 16020 707055 3.4.17.23 angiotensin-converting enzyme 2 membrane the monomer of homodimeric ACE2 is a type 1 transmembrane protein with a single transmembrane alpha-helix in the C-terminal region similar to the collectrin domain 16020 762898 3.4.17.23 angiotensin-converting enzyme 2 membrane transmembrane enzyme 16020 678102 3.4.17.23 angiotensin-converting enzyme 2 membrane type I transmembrane metallocarboxypeptidase 16020 763160 3.4.17.4 Gly-Xaa carboxypeptidase membrane integral membrane protein, destined for the vacuolar lumen 16020 681922 3.4.17.4 Gly-Xaa carboxypeptidase membrane sorting of integral membrane protein Cps1p into the luminal vesicles of multivesicular bodies 16020 688900 3.4.17.8 muramoylpentapeptide carboxypeptidase membrane - 16020 36429 3.4.19.11 gamma-D-glutamyl-meso-diaminopimelate peptidase membrane bound 16020 -, 28882 3.4.19.12 ubiquitinyl hydrolase 1 membrane membrane associated form UCH-L1M, C-terminal farnesylation promotes the association of UCH-L1 with cellular membranes, including the endoplasmic reticulum 16020 710422 3.4.19.12 ubiquitinyl hydrolase 1 membrane minor enzyme portion of UCHL1/PGP 9.5, tightly bound 16020 710451 3.4.19.12 ubiquitinyl hydrolase 1 membrane minor enzyme portion of UCHL1/PGP 9.5, tightly bound, UCHL3 16020 710451 3.4.19.12 ubiquitinyl hydrolase 1 membrane UCH-L1 is membrane-associated and co-localizes with the ribosomal subunit RPS6 and the ER retention signal KDEL. UCH-L1 is partially co-localized to the site of CFTR protein synthesis 16020 709086 3.4.19.14 leukotriene-C4 hydrolase membrane - 16020 717049, 717066, 717756 3.4.19.3 pyroglutamyl-peptidase I membrane - 16020 682252, 95288, 95299, 95312 3.4.19.3 pyroglutamyl-peptidase I membrane bound to 16020 95279, 95315 3.4.19.3 pyroglutamyl-peptidase I membrane synaptosomal 16020 95278, 95279, 95281 3.4.19.6 pyroglutamyl-peptidase II membrane - 16020 647279, 647283, 647286, 647288, 697633, 700461, 700583, 95299 3.4.19.6 pyroglutamyl-peptidase II membrane bound to 16020 668870 3.4.19.6 pyroglutamyl-peptidase II membrane soluble and membrane-bound forms. Membrane-bound activity is highest in kidney, heart (atrium and ventricle) and liver, the lowest activities is observed in testis and lung 16020 753360 3.4.21.10 acrosin membrane - 16020 36460 3.4.21.10 acrosin membrane bound 16020 36464 3.4.21.10 acrosin membrane peripheral 16020 36466 3.4.21.102 C-terminal processing peptidase membrane - 16020 755032 3.4.21.102 C-terminal processing peptidase membrane integral membrane protein 16020 137252 3.4.21.102 C-terminal processing peptidase membrane thylakoid membrane 16020 137253 3.4.21.105 rhomboid protease membrane - 16020 -, 683980, 683993, 684003, 710565, 755544 3.4.21.105 rhomboid protease membrane integral membrane protein with six transmembrane segments, membrane topology of a rhomboid protease and its substrate, overview 16020 683916 3.4.21.105 rhomboid protease membrane intramembrane enzyme 16020 658404 3.4.21.105 rhomboid protease membrane intramembrane enzyme with 6 transmembrane segments 16020 683867 3.4.21.105 rhomboid protease membrane intramembrane enzyme with seven transmembrane segments, the enzyme contains a serine proteaselike catalytic apparatus embedded within the membrane bilayer, buried in a hydrophilic cavity formed by a protein ring 16020 683499 3.4.21.105 rhomboid protease membrane intramembrane enzyme, contains a ring of transmembrane segments 16020 684013 3.4.21.105 rhomboid protease membrane Rhomboid is an intramembrane protein 16020 683408 3.4.21.105 rhomboid protease membrane rhomboid protease is an intramembrane protease 16020 718193 3.4.21.105 rhomboid protease membrane the enzyme contains 6 transmembrane helices and an N-terminal cytoplasmic part 16020 684012 3.4.21.105 rhomboid protease membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview 16020 683501 3.4.21.105 rhomboid protease membrane the internal and hydrophilic active site of the intramembrane protease is positioned in the lipid bilayer to facilitate peptide bond hydrolysis in the membrane 16020 684010 3.4.21.105 rhomboid protease membrane the intramembrane enzyme contains six transmembrane helices 16020 683913 3.4.21.105 rhomboid protease membrane the intramembrane enzyme possesses a intramembraneously located active site, which is accessible to water and hydrolyses an extramembrane peptide bond of substrates 16020 683901 3.4.21.105 rhomboid protease membrane the intramembrane enzyme possesses an N-terminal cytosolic domain, solution structure and dynamics, membrane protein topology, overview 16020 683773 3.4.21.105 rhomboid protease membrane Toxoplasma gondii contains six rhomboids that are expressed in different life cycle stages and localized to different cellular compartments, ROM1 is not released onto the parasite surface during cell invasion, subcellular localization of HA9-tagged ROM1 in intracellular parasites, overview 16020 683419 3.4.21.106 hepsin membrane - 16020 650281, 651852 3.4.21.106 hepsin membrane has an integral transmembrane domain near the N-terminus 16020 686903 3.4.21.106 hepsin membrane hepsin is detected in the cytoplasm and membrane of hepatocytes. In ovarian tumor cells, cytoplasmic localization of hepsin is prevalent in mucinous, endometrioid and transitional cell carcinomas, while the majority of serous and clear cell carcinomas display membranous localization. Membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor 16020 698324 3.4.21.106 hepsin membrane transmembrane isoform 16020 672315 3.4.21.107 peptidase Do membrane bowl-shaped DegP assemblies on membranes have higher proteolytic activity but lower chaperone-Like activity 16020 713406 3.4.21.107 peptidase Do membrane membrane-associated 16020 -, 732041 3.4.21.108 HtrA2 peptidase membrane - 16020 652331 3.4.21.109 matriptase membrane - 16020 652029, 673572, 675024, 683189, 695463, 695506, 696852, 696935, 697182, 698077, 698665, 698819, 699127, 718145 3.4.21.109 matriptase membrane a membrane anchored serine protease 16020 717902 3.4.21.109 matriptase membrane a type II transmembrane serine protease 16020 683674, 731623, 732181 3.4.21.109 matriptase membrane bound 16020 673572, 683047 3.4.21.109 matriptase membrane cell surface type II transmembrane protein 16020 731410 3.4.21.109 matriptase membrane matriptase is a type II transmembrane protein 16020 683494, 683763, 683952 3.4.21.109 matriptase membrane matriptase is a type II transmembrane serine protease 16020 673645, 683040, 717799 3.4.21.109 matriptase membrane matriptase is a type II transmembrane trypsin-like serine protease 16020 680706, 683753 3.4.21.109 matriptase membrane matriptase-2 is a type II transmembrane serine protease 16020 683332, 683493 3.4.21.109 matriptase membrane MT-SP1 is a type II transmembrane serine protease 16020 683492 3.4.21.109 matriptase membrane the enzyme is a type II transmembrane serine protease 16020 683423 3.4.21.109 matriptase membrane transmembrane enzyme 16020 683514 3.4.21.109 matriptase membrane transmembrane protein, composed of a short N-terminal cytoplasmic region followed by a transmembrane domain 16020 657796 3.4.21.109 matriptase membrane transmembrane type II protein 16020 683364 3.4.21.109 matriptase membrane type II transmembrane serine protease 16020 717215 3.4.21.109 matriptase membrane type II transmembrane serine protease matriptase 16020 732096 3.4.21.111 aqualysin 1 membrane - 16020 -, 649556 3.4.21.111 aqualysin 1 membrane precursor protein 16020 653252 3.4.21.112 site-1 protease membrane - 16020 -, 649328, 650785, 673908, 686949, 687607 3.4.21.112 site-1 protease membrane transmembrane protein 16020 732162 3.4.21.112 site-1 protease membrane YpdC contains five transmembrane segments and two larger extracytoplasmic loops 16020 689039 3.4.21.116 SpoIVB peptidase membrane - 16020 -, 755063 3.4.21.116 SpoIVB peptidase membrane belongs to the family of putative membrane metalloproteases 16020 -, 651656 3.4.21.116 SpoIVB peptidase membrane catalytic center is located adjacent tot or within the membrane 16020 653625 3.4.21.120 oviductin membrane expressed in the chicken egg citelline membrane 16020 701139 3.4.21.120 oviductin membrane in unfertilized oocytes, oviductin is detected in membrane invaginations along the oolemma and in some vesicles within multivesicular bodies 16020 669696 3.4.21.122 transmembrane protease serine 2 membrane - 16020 753810, 754529, 754532, 764663 3.4.21.122 transmembrane protease serine 2 membrane in most high-grade cancers, TMPRSS2 is mislocalized, being expressed in the cytoplasm as well as in the cell membrane 16020 753135 3.4.21.122 transmembrane protease serine 2 membrane type II transmembrane protein 16020 753752 3.4.21.19 glutamyl endopeptidase membrane bound 16020 651024 3.4.21.20 cathepsin G membrane - 16020 36519, 36523, 718414 3.4.21.21 coagulation factor VIIa membrane - 16020 752758, 754202, 755008, 755547, 755589 3.4.21.21 coagulation factor VIIa membrane Ca2+ and the Gla domain are required for membrane binding by the enzyme, mechanism of Ca2+-mediated binding, molecular dynamics simulation of complex formation, overview 16020 684070 3.4.21.21 coagulation factor VIIa membrane the major function of the enzyme's Gla domain is to attach FVIIa to membranes, i.e. to add binding energy to the interaction with membrane-associated tissue factor 16020 683347 3.4.21.26 prolyl oligopeptidase membrane - 16020 683389, 683926, 692312, 692518, 718008, 81346 3.4.21.26 prolyl oligopeptidase membrane intracellular 16020 694401 3.4.21.26 prolyl oligopeptidase membrane isoyzme in brain synaptosome membranes 16020 683926 3.4.21.26 prolyl oligopeptidase membrane membrane-bound 16020 710533 3.4.21.26 prolyl oligopeptidase membrane plasma and intracellular membranes of neurons 16020 683708 3.4.21.34 plasma kallikrein membrane complexed with kininogen 16020 651467 3.4.21.4 trypsin membrane trypsinogen and trypsin are localized to the cell membranes surrounding the sperm head 16020 732982 3.4.21.43 classical-complement-pathway C3/C5 convertase membrane - 16020 732572, 81407 3.4.21.45 complement factor I membrane surface-bound form of the serine protease domain 16020 701342 3.4.21.47 alternative-complement-pathway C3/C5 convertase membrane - 16020 732572 3.4.21.53 Endopeptidase La membrane - 16020 -, 651846, 732390 3.4.21.53 Endopeptidase La membrane bound to 16020 727373 3.4.21.53 Endopeptidase La membrane has one transmembrane domains 16020 -, 753673 3.4.21.53 Endopeptidase La membrane has two transmembrane domains 16020 -, 753673 3.4.21.53 Endopeptidase La membrane membrane-bound 16020 651700 3.4.21.53 Endopeptidase La membrane native enzyme and recombinant enzyme in Escherichia coli 16020 668596 3.4.21.53 Endopeptidase La membrane throughout growth 16020 -, 718085 3.4.21.59 Tryptase membrane anchored, gamma-tryptase, i.e. transmembrane tryptase 16020 680108 3.4.21.59 Tryptase membrane bound to 16020 670795 3.4.21.6 coagulation factor Xa membrane - 16020 717253, 717829 3.4.21.6 coagulation factor Xa membrane interaction of factor Xa with factor Va on membranes to form prothrombinase 16020 709147 3.4.21.61 Kexin membrane - 16020 -, 29418, 29419, 29420, 29422 3.4.21.61 Kexin membrane membrane-bound 16020 650257 3.4.21.61 Kexin membrane transmembrane serine proteinase 16020 650220, 650663 3.4.21.68 t-Plasminogen activator membrane - 16020 701276 3.4.21.68 t-Plasminogen activator membrane exocytosed tPA-GFP is retained at the membrane surface without retrieval for more than 5 min in a vascular endothelial cell-specific manner. FnEK1K2 domains are responsible for binding of tPA-GFP to the membrane surface 16020 696949 3.4.21.72 IgA-specific serine endopeptidase membrane IgA protease of Neisseria meningitidis consists of an N-terminal signal sequence, a passenger domain and a C-terminal translocator domain that assists in the secretion of the passenger domain across the outer membrane. The protease domain is released into the extracellular milieu either via autocatalytic processing or via cleavage by the autotransporter NalP 16020 -, 732468 3.4.21.75 Furin membrane - 16020 698780, 699309, 717857, 718256 3.4.21.75 Furin membrane knockdown of Mint3 increases the distribution of furin at the membrane 16020 699103 3.4.21.75 Furin membrane membrane-bound 16020 652060 3.4.21.76 Myeloblastin membrane - 16020 663599, 666198, 666751, 684453, 686188, 687618, 687927, 707316, 753821 3.4.21.76 Myeloblastin membrane behaves as a peripheral membrane protein 16020 708497 3.4.21.76 Myeloblastin membrane behaves as a peripheral membrane protein. The mouse form is globally more electronegative than the human form. As a consequence of differences in sequence and structural properties, mouse PR3 is likely to be able to bind to the plasma membrane using the same region as human PR3, although less strongly and specifically 16020 708497 3.4.21.76 Myeloblastin membrane cell surface membrane 16020 651049 3.4.21.76 Myeloblastin membrane cell surface membrane, membrane-bound 16020 652675 3.4.21.76 Myeloblastin membrane hydrophobic patch F180-F181-L228-F229 is essential for PR3 membrane anchorage. PR3 membrane insertion appears to be pivotal for its proinflammatory activities, such as extracellular proteolysis and impairment of apoptotic cell clearance, but also for myeloid cell proliferation 16020 717959 3.4.21.76 Myeloblastin membrane low levels, CD177 is a receptor for PR3 on the neutrophil membrane, but in CD177 negative neutrophils PR3 is also present and is susceptible to PR3-anti-neutrophil cytoplasmic autoantibodies (ANCA) induced neutrophil activation 16020 707338 3.4.21.76 Myeloblastin membrane membrane-bound 16020 647556 3.4.21.76 Myeloblastin membrane plasma membrane 16020 652337 3.4.21.76 Myeloblastin membrane secretory vesicles and secondary granules 16020 683193 3.4.21.89 Signal peptidase I membrane - 16020 29822, 29834, 651838, 732005 3.4.21.89 Signal peptidase I membrane archaeal enzyme cleaves the signal peptides from preproteins on the external face of the cytoplasmic membrane, thereby releasing the translocated protein from the membrane 16020 -, 651728 3.4.21.89 Signal peptidase I membrane integral membrane protein 16020 -, 29806, 29813, 29814 3.4.21.89 Signal peptidase I membrane it is anchored to the membrane by two transmembrane segments and is oriented with a short domain facing the cytoplasm and a large carboxyl-terminal domain exposed to the periplasmic space 16020 -, 29806 3.4.21.89 Signal peptidase I membrane membrane topology of the 12000 and the 25000 MW subunit 16020 29829 3.4.21.89 Signal peptidase I membrane membrane-bound 16020 31462, 653334 3.4.21.89 Signal peptidase I membrane signal peptide substrate remains in the bilayer and the enzyme active site functions at the membrane surface 16020 718382 3.4.21.89 Signal peptidase I membrane the catalytic domain extends into the periplasmic space and is anchored to the membrane by two transmembrane segments located at the N-terminal end of the protein 16020 29826 3.4.21.89 Signal peptidase I membrane the enzyme is a transmembrane protein. Plsp1 accumulates as a stromal intermediate before ATP hydrolysis-dependent membrane association 16020 754121 3.4.21.89 Signal peptidase I membrane the enzyme is predicted to have a single transmembrane domain 16020 29805 3.4.21.89 Signal peptidase I membrane the enzyme spans the membrane twice, with its large carboxyl-terminal domain protruding into the periplasm 16020 29814 3.4.21.89 Signal peptidase I membrane transcytoplasmic signal peptidase anchored to the inner membrane 16020 700249 3.4.21.89 Signal peptidase I membrane transmembrane domain 16020 696392 3.4.21.9 enteropeptidase membrane - 16020 732888 3.4.21.9 enteropeptidase membrane bound 16020 717409, 95577, 95584 3.4.21.9 enteropeptidase membrane transmembrane protein 16020 732698 3.4.21.91 Flavivirin membrane - 16020 699897, 731292 3.4.21.91 Flavivirin membrane integral membrane protein 16020 752735 3.4.21.92 Endopeptidase Clp membrane - 16020 683643 3.4.21.93 Proprotein convertase 1 membrane - 16020 653696 3.4.21.93 Proprotein convertase 1 membrane full length PC3 is associated with lipid rafts in Neuro2A cells, undergoes stimulated secretion and is colocalized with the secretory granule marker, chromogranin A, by immunocytochemistry 16020 688980 3.4.21.93 Proprotein convertase 1 membrane peripherally attached to the secretory granule membrane, the enzyme is no transmembrane protein, subcellular localization analysis, overview 16020 667660 3.4.21.98 hepacivirin membrane membrane anchoring of enzyme does not affect substrate/inhibitor recognition 16020 667671 3.4.21.B21 trepolisin membrane an outer membrane protein 16020 -, 732466 3.4.21.B21 trepolisin membrane outer membrane 16020 -, 708938, 717662 3.4.21.B26 proprotein convertase 5 membrane PC5-B 16020 652606 3.4.21.B26 proprotein convertase 5 membrane PC5-B isoform 16020 673910 3.4.21.B26 proprotein convertase 5 membrane PC5A is complexed to its prosegment at the plasma membrane 16020 680909 3.4.21.B26 proprotein convertase 5 membrane PC5B-isoform 16020 675967 3.4.21.B26 proprotein convertase 5 membrane proprotein convertase 5/6 (PC5/6) has two splice variants: soluble PC5/6A and membrane-bound PC5/6B 16020 753112 3.4.21.B26 proprotein convertase 5 membrane the membrane-bound isoform is mostly expressed in intestine and kidney 16020 718009 3.4.21.B27 proprotein convertase 7 membrane - 16020 649651, 709057, 717869, 717930 3.4.21.B27 proprotein convertase 7 membrane a transmembrane protein 16020 731888 3.4.21.B27 proprotein convertase 7 membrane active enzyme, proprotein convertase reaches the cell surface by a non-conventional secretory pathway through a brefeldin A- and COPII-coated vesicles independent way 16020 717835 3.4.21.B27 proprotein convertase 7 membrane mature enzyme 16020 651865 3.4.21.B27 proprotein convertase 7 membrane proenzyme 16020 673911 3.4.21.B28 fibroblast activation protein alpha subunit membrane - 16020 651875, 677928, 678329, 678473 3.4.21.B28 fibroblast activation protein alpha subunit membrane a type II integral membrane serine protease 16020 731808 3.4.21.B28 fibroblast activation protein alpha subunit membrane integral membrane protein 16020 753136 3.4.21.B28 fibroblast activation protein alpha subunit membrane the enzyme is an integral membrane protein 16020 731551 3.4.21.B28 fibroblast activation protein alpha subunit membrane transmembrane-anchored 16020 754737 3.4.21.B55 pyrolysin membrane - 16020 722600 3.4.21.B56 Pyrococcus horikoshii membrane protease PH1510 membrane - 16020 -, 722950, 725842, 731822 3.4.21.B56 Pyrococcus horikoshii membrane protease PH1510 membrane membrane-bound enzyme 16020 731295 3.4.21.B56 Pyrococcus horikoshii membrane protease PH1510 membrane the local protein concentration of C-terminal region of enzyme PH1510 may be increased to promote self-assembly on the membrane surface by clustering the membrane-spanning regions (four membrane-spanning regions (residues 237-370) between protease domain 1510-N and OB-fold domain 1510-C) within the hydrophobic lipidbilayer 16020 731379 3.4.21.B6 prostasin membrane - 16020 652134, 671251, 676929, 678440, 680706, 681036 3.4.21.B6 prostasin membrane a membrane-anchored protein 16020 -, 732131 3.4.21.B6 prostasin membrane prostasin contains an N-terminal secretion signal that is cleaved during intracellular transport in the endoplasmic reticulum and a GPI-anchor is attached at the C-terminal. Subsequent to surface localization, prostasin is cleaved at a conserved activation site in the pro-domain and remains attached to the serine protease domain via a disulfide bridge 16020 731623 3.4.21.B6 prostasin membrane prostasin is a GPI-anchored serine protease 16020 717902 3.4.21.B61 transmembrane protease serine 11D membrane - 16020 754529 3.4.22.1 cathepsin B membrane - 16020 681195 3.4.22.26 cancer procoagulant membrane - 16020 651435 3.4.22.28 picornain 3C membrane - 16020 668861 3.4.22.28 picornain 3C membrane recombinant enzyme 16020 648005, 648007 3.4.22.28 picornain 3C membrane rhinovirus, expressed in Escherichia coli 16020 648007 3.4.22.29 picornain 2A membrane - 16020 648033 3.4.22.34 Legumain membrane association of with microvilli shown 16020 683572 3.4.22.34 Legumain membrane bound 16020 -, 670470, 683541 3.4.22.35 Histolysain membrane associated by hydrophobic interaction 16020 653256 3.4.22.35 Histolysain membrane the enzyme contains a transmembrane segment 16020 668769 3.4.22.37 gingipain R membrane - 16020 -, 731334 3.4.22.37 gingipain R membrane associated 16020 688151 3.4.22.37 gingipain R membrane associated to the outer membrane and vesicles 16020 668785 3.4.22.37 gingipain R membrane outer membrane attached 16020 687373 3.4.22.39 adenain membrane bound to 16020 36705 3.4.22.47 gingipain K membrane associated 16020 667854, 670309 3.4.22.49 separase membrane - 16020 718433 3.4.22.52 calpain-1 membrane - 16020 690381 3.4.22.52 calpain-1 membrane membrane-binding of mu-calpain is Ca2+-dependent. Membrane binding of mu-calpain is due to the exposed hydrophobic surface of the active site conformation and does not reduce the Ca2+ requirement for activation 16020 667872 3.4.22.53 calpain-2 membrane - 16020 709566, 717669 3.4.22.53 calpain-2 membrane in isolated rat hearts, ischemia induces a time-dependent translocation of m-calpain to the membrane that is not associated with calpain activation 16020 709566 3.4.22.53 calpain-2 membrane membrane abnormalities and altered signaling pathways observed in Duchenne muscular dystrophy lymphocytes may be due to the increased association of calpain II onto membrane and cytosol 16020 686159 3.4.22.54 calpain-3 membrane - 16020 698178, 700446 3.4.22.56 caspase-3 membrane bound to heavy membrane fraction, the N-termini of activated heavy-membrane-bound and cytoplasmic caspase-3 are slightly different: the heavy membrane caspase-3 begins at Lys14, whereas the cytoplasmic enzyme begins at Ser10 16020 647614 3.4.22.61 caspase-8 membrane lipid rafts 16020 700899 3.4.22.61 caspase-8 membrane procaspase-8 is part of the trans-plasma membrane death-inducing signaling complex and is located on the cytosolic side. The activated enzyme is then released from the complex as caspase-8 16020 717605 3.4.22.68 Ulp1 peptidase membrane - 16020 718246 3.4.22.70 sortase A membrane class A sortases adopt a type II membrane topology (N terminus inside and C terminus outside the cytoplasm), class B enzymes represent type I membrane proteins (N terminus outside, C terminus inside) 16020 647380 3.4.22.70 sortase A membrane sortase A (SrtA) colocalizes with SecA at single foci in the enterococcus. Proteins that localize to single foci in Enterococcus faecalis share a positively charged domain flanking a transmembrane helix. Positively charged domain can act as a localization retention signal for the focal compartmentalization of the membrane protein 16020 692899 3.4.22.B30 calpain 10 membrane - 16020 664720, 666361 3.4.22.B37 calpain B membrane - 16020 649006 3.4.22.B37 calpain B membrane with increasing Ca2+ concentrations the enzyme adheres to intracellular membranes 16020 648418 3.4.22.B63 sortase C membrane - 16020 717581 3.4.22.B63 sortase C membrane focal localization of SrtC is necessary for efficient pilus formation 16020 692899 3.4.22.B8 Tpr proteinase (Porphyromonas gingivalis) membrane associated 16020 647646, 647647 3.4.22.B8 Tpr proteinase (Porphyromonas gingivalis) membrane protein is associated with the bacterial outer membrane 16020 -, 754120 3.4.23.15 renin membrane renin granules 16020 95782 3.4.23.17 Pro-opiomelanocortin converting enzyme membrane - 16020 30548, 30553 3.4.23.17 Pro-opiomelanocortin converting enzyme membrane a soluble and a membrane component of the enzyme 16020 30549 3.4.23.18 Aspergillopepsin I membrane - 16020 30575 3.4.23.34 cathepsin E membrane - 16020 30793, 30798 3.4.23.34 cathepsin E membrane converted to active enzyme in membrane associated form 16020 30783 3.4.23.34 cathepsin E membrane in latent form 16020 30778, 30783 3.4.23.34 cathepsin E membrane on cytoplasmic face of the membrane 16020 30778, 30783 3.4.23.34 cathepsin E membrane plasma membrane 16020 30779 3.4.23.36 Signal peptidase II membrane - 16020 752711, 755537 3.4.23.38 plasmepsin I membrane proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form 16020 648184 3.4.23.39 plasmepsin II membrane proplasmepsin II is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form 16020 648184 3.4.23.42 thermopsin membrane associated with outer membrane 16020 -, 726440 3.4.23.43 prepilin peptidase membrane integral membrane protein 16020 754426 3.4.23.43 prepilin peptidase membrane integral protein 16020 668803 3.4.23.43 prepilin peptidase membrane membrane topology, overview 16020 669116 3.4.23.45 memapsin 1 membrane - 16020 669871, 717461, 753256 3.4.23.45 memapsin 1 membrane transmembrane 16020 683144 3.4.23.45 memapsin 1 membrane transmembrane enzyme with a large extracellular domain 16020 670020 3.4.23.45 memapsin 1 membrane transmembrane protein 16020 686629 3.4.23.46 memapsin 2 membrane - 16020 638908, 700445, 753256 3.4.23.46 memapsin 2 membrane BACE1 is a transmembrane aspartyl protease with a lumenal active site 16020 713355 3.4.23.48 plasminogen activator Pla membrane outer membrane 16020 683251, 712282 3.4.23.48 plasminogen activator Pla membrane outer membrane protein 16020 -, 668759, 683853 3.4.23.49 omptin membrane integral membrane protease, outer membrane, membrane bound 16020 650046, 650422, 650633, 650667, 650983, 651090, 651289 3.4.23.52 preflagellin peptidase membrane - 16020 -, 669116, 687394, 715049, 715346, 716249, 716338 3.4.23.52 preflagellin peptidase membrane integral membrane protein 16020 651717 3.4.23.B1 napsin membrane major part 16020 658158 3.4.23.B19 plasmepsin V membrane - 16020 754690 3.4.23.B19 plasmepsin V membrane integral membrane protein 16020 694061 3.4.23.B24 signal peptide peptidase membrane n-dodecyl-beta-maltoside-solubilized membrane fraction 16020 733567 3.4.23.B24 signal peptide peptidase membrane signal peptide peptidase (SPP) is a membrane-bound enzyme 16020 -, 754637 3.4.24.11 neprilysin membrane - 16020 667856, 685866, 735311, 754907, 81608, 81609, 81610, 81646 3.4.24.11 neprilysin membrane a transmembrane zinc metallopeptidase 16020 735116 3.4.24.11 neprilysin membrane axonal membranes, including those in synaptic junctions 16020 81609 3.4.24.11 neprilysin membrane bound 16020 81639, 81641, 81646 3.4.24.11 neprilysin membrane caudate and synaptic membranes 16020 81636 3.4.24.11 neprilysin membrane glomerular enzyme is membrane-bound 16020 81638 3.4.24.11 neprilysin membrane integral membrane protein 16020 81604, 81615 3.4.24.11 neprilysin membrane isoform A is expressed as a membrane bound protein 16020 709308 3.4.24.11 neprilysin membrane localization of mature neprilysin, glycosylated in the Golgi apparatus, in membrane microdomains, i.e. lipid rafts, which are enriched in cholesterol and glycosphingolipids. Localization of the enzyme in lipid rafts is enhanced by its dimerization 16020 734528 3.4.24.11 neprilysin membrane membrane-bound 16020 735045 3.4.24.11 neprilysin membrane neprilysin is a transmembrane M13 zinc metalloprotease 16020 754501 3.4.24.11 neprilysin membrane neprilysin is a zinc dependent type II integral membrane peptidase 16020 755430 3.4.24.11 neprilysin membrane plasma membrane 16020 81613, 81616 3.4.24.11 neprilysin membrane synaptic 16020 81610 3.4.24.11 neprilysin membrane synaptic membranes 16020 81633 3.4.24.11 neprilysin membrane the enzyme possesses a single transmembrane spanning domain near the N-terminal of the molecule, the active site is located extracellularly, the N-terminal transmembrane region anchors the protein in the membranes, the majority of the protein, including the carboxy terminus is extracellular 16020 81620 3.4.24.13 IgA-specific metalloendopeptidase membrane associated to external side of bacterial membrane. Localization requires the LPNTG sorting motif near the amino terminus of protein 16020 666398 3.4.24.15 thimet oligopeptidase membrane synaptic and fundus membranes in brain 16020 683961 3.4.24.15 thimet oligopeptidase membrane synaptic and smooth muscle cell membranes in brain 16020 683961 3.4.24.16 neurolysin membrane - 16020 -, 37084, 717870, 754607, 754898 3.4.24.16 neurolysin membrane EP24.16c is the cytosolic/membrane-bound enzyme form 16020 37061 3.4.24.16 neurolysin membrane membrane-bound endopeptidase 16020 734522 3.4.24.16 neurolysin membrane plasma membrane 16020 37077 3.4.24.16 neurolysin membrane synaptic 16020 37068 3.4.24.16 neurolysin membrane synaptic and fundus membranes in brain 16020 683961 3.4.24.16 neurolysin membrane synaptic and smooth muscle cell membranes in brain 16020 683961 3.4.24.16 neurolysin membrane synaptosomal 16020 37070 3.4.24.16 neurolysin membrane the enzyme is not attached by a glycosyl-phosphatidylinositol anchor in the emembrane, the enzyme can not be released from the membrane upon trypsinolysis 16020 37087 3.4.24.16 neurolysin membrane the membrane-associated enzyme form increases during neuronal differentation and appears to be responsible for the overall augmentation of endopeptidase activity observed during neuronal maturation 16020 37076 3.4.24.16 neurolysin membrane the transfectants exhibit a membrane-associated form of endopeptidase-24.16, the catalytic site of which clearly faces the extracellular domain 16020 37083 3.4.24.18 meprin A membrane - 16020 -, 31018, 31020, 31022, 31025, 31027, 31029, 31031 3.4.24.18 meprin A membrane ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A 16020 734259 3.4.24.18 meprin A membrane apical membrane of intestinal epithelial cells 16020 -, 31021 3.4.24.18 meprin A membrane beta subunits are type I integral membrane proteins and alpha subunits are disulfide linked to or non-covalently associated with membrane-anchored meprin beta subunits 16020 31030 3.4.24.18 meprin A membrane cell surface metalloproteinase, alphabeta-heterodimers firmly attached to brush border membrane, alpha2-homodimers only associated with membrane 16020 31026 3.4.24.18 meprin A membrane intrinsic protein 16020 31019 3.4.24.18 meprin A membrane membrane-bound 16020 652026, 652414 3.4.24.18 meprin A membrane meprin A, is a membrane-associated neutral metalloendoprotease. Importance of a sheddase involved in the release of membrane-associated meprin A under pathological conditions 16020 -, 733064 3.4.24.18 meprin A membrane renal brush border membrane 16020 -, 31019, 31023, 31024, 31026, 31031 3.4.24.23 matrilysin membrane fetal membranes at term from women with no labor, i.e. cesarean delivery, with labor, i.e. normal delivery, and with labor during premature rupture of membranes, expression and activity of MMP-7 in fetal membranes during premature rupture of membranes is increased, while the TIMP-1 level is reduced, immunohistochemic analysis, overview 16020 684052 3.4.24.23 matrilysin membrane MMP-7 interacts with anionic, cationic and neutral lipid membranes, it interacts strongest with anionic membranes, overview 16020 683475 3.4.24.26 pseudolysin membrane mutants E141D, E141Q, E141G, H223G, H223E, and H223L 16020 665162 3.4.24.34 neutrophil collagenase membrane - 16020 669709 3.4.24.34 neutrophil collagenase membrane membrane-bound MMP-8 accounts for 92% of the matrix metalloproteinase-mediated polymorphonuclear cell surface type I collagenase activity 16020 669709 3.4.24.34 neutrophil collagenase membrane membrane-bound MMP-8 is a more potent MIP-1alpha-degrading enzyme than soluble MMP-8 16020 717929 3.4.24.36 leishmanolysin membrane - 16020 -, 31226, 31227, 31229, 710519 3.4.24.36 leishmanolysin membrane glycosylphosphatidylinositol-anchored 16020 31228, 31229 3.4.24.36 leishmanolysin membrane membrane-bound 16020 -, 653919 3.4.24.56 insulysin membrane bound 16020 683921 3.4.24.56 insulysin membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo 16020 700287 3.4.24.56 insulysin membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo. Membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE 16020 700287 3.4.24.61 nardilysin membrane - 16020 31366 3.4.24.63 meprin B membrane - 16020 -, 31031, 752474, 752709, 753218, 753321, 754028, 754592, 754779, 755294, 755466 3.4.24.63 meprin B membrane membrane anchor: COOH-terminal hydrophobic domain 16020 -, 31379 3.4.24.63 meprin B membrane membrane-bound 16020 -, 652414, 753345, 753536, 753697 3.4.24.63 meprin B membrane meprin beta is a membrane-bound protein with a transmembrane helix and a small C-terminal cytosolic domain 16020 753172 3.4.24.63 meprin B membrane meprin beta is a type I transmembrane protein 16020 734193 3.4.24.63 meprin B membrane meprin beta is expressed as a dimeric type 1 transmembrane protein 16020 734610 3.4.24.63 meprin B membrane microvillar membrane, integral membrane protein 16020 31380 3.4.24.63 meprin B membrane renal brush-border membrane 16020 -, 31024, 31031, 31379 3.4.24.64 mitochondrial processing peptidase membrane - 16020 31398, 31399, 31400, 683997 3.4.24.64 mitochondrial processing peptidase membrane beta-MPP, identical with core I protein of ubiquinol cytochrome c reductase complex 16020 31402 3.4.24.65 macrophage elastase membrane glomerular basement membrane. Irregular glomerular basement membrane that characterizes Alport syndrome may be mediated, in part, by focal degradation of glomerular basement membrane due to MMP dysregulation, in particular, MMP-12 16020 667141 3.4.24.69 bontoxilysin membrane the C2II binding component forms cation-selective and chloroquine-sensitive heptameric channels into lipid bilayer membranes, which is essential for C2I catalytic component transport into target cells 16020 683678 3.4.24.7 interstitial collagenase membrane - 16020 683221, 683451, 683633, 683988 3.4.24.71 endothelin-converting enzyme 1 membrane - 16020 31468, 31469, 683434, 683474 3.4.24.71 endothelin-converting enzyme 1 membrane anchored to the plasma membrane 16020 653706 3.4.24.71 endothelin-converting enzyme 1 membrane ECE-1 is a membrane-bound metalloprotease 16020 683438 3.4.24.71 endothelin-converting enzyme 1 membrane ECE-1 is a type II membrane protease 16020 683321 3.4.24.71 endothelin-converting enzyme 1 membrane ECE-1 is a type II membrane protein 16020 683439 3.4.24.71 endothelin-converting enzyme 1 membrane ECE-1 is a type II membrane zinc metalloprotease 16020 684002 3.4.24.71 endothelin-converting enzyme 1 membrane ECEs are type II integral membrane-bound proteases 16020 710094 3.4.24.71 endothelin-converting enzyme 1 membrane endosomal 16020 683696 3.4.24.71 endothelin-converting enzyme 1 membrane integral membrane protein 16020 31470, 651235 3.4.24.71 endothelin-converting enzyme 1 membrane transmembrane protein 16020 734268 3.4.24.74 fragilysin membrane - 16020 753653 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane - 16020 638795, 638797, 638802, 638804, 638812, 667498, 677477, 679404, 679414, 680884, 681426, 681831, 681832, 682862, 683787, 717536, 717876, 719209, 752872, 753242, 754158, 754175, 755435 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane 80% of MT1-MMP is sorted to detergent-resistant membrane fractions, only 20% of MT1-MMP from detergent-soluble fraction undergoes intracellular processing to the mature form, which is the sole form responsible for extracellular matrix degredation 16020 669582 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane a transmembrane endopeptidase 16020 753019 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane membrane-anchored 16020 753384 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane membrane-bound 16020 753773 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane membrane-type matrix metalloproteinase 1 is a type I membrane protein 16020 753906 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane MMP-1 localizes at membrane structures called lamellipodia and invadopodia 16020 680268 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane normal localisation 16020 681878 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane the enzyme is a membrane type 1 protein 16020 677477 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane transmembrane protein 16020 638801, 638810, 638813 3.4.24.80 membrane-type matrix metalloproteinase-1 membrane transmembrane proteinase 16020 734362 3.4.24.81 ADAM10 endopeptidase membrane - 16020 668181, 668275, 669926 3.4.24.81 ADAM10 endopeptidase membrane the typical multidomain structure of ADAM10 as a type I integral transmembrane protein consists of a prodomain, a catalytical domain with a conserved zinc binding sequence, a cysteine-rich disintegrin-like domain, a transmembrane domain and a rather short cytoplasmic domain 16020 708492 3.4.24.81 ADAM10 endopeptidase membrane transmembrane glycoprotein 16020 709083 3.4.24.84 Ste24 endopeptidase membrane - 16020 652151, 667497 3.4.24.85 S2P endopeptidase membrane - 16020 710497, 752837, 753352, 755137 3.4.24.85 S2P endopeptidase membrane intramembrane protease 16020 -, 754811 3.4.24.85 S2P endopeptidase membrane periplasmic 16020 710497 3.4.24.86 ADAM 17 endopeptidase membrane - 16020 -, 638979, 638982, 638984, 638994, 639010, 719165, 720142, 721093, 752761, 753291, 753926, 755575 3.4.24.86 ADAM 17 endopeptidase membrane detergent-resistant membrane microdomain, i.e. regions of the membrane enriched in cholesterol and sphingolipids 16020 712635 3.4.24.86 ADAM 17 endopeptidase membrane membrane-bound 16020 -, 638987, 638990, 638991, 638994, 638996, 639000, 639005, 639006, 639012, 639013 3.4.24.86 ADAM 17 endopeptidase membrane microsomal membrane, transmembrane domain 16020 638984 3.4.24.B10 ADAM12 endopeptidase membrane - 16020 653225, 677883, 734657, 734812, 735053, 755405 3.4.24.B10 ADAM12 endopeptidase membrane integral 16020 651993 3.4.24.B11 ADAMTS1 endopeptidase membrane associated 16020 652621 3.4.24.B14 neprilysin-2 membrane - 16020 -, 682251 3.4.24.B14 neprilysin-2 membrane due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta) 16020 733906 3.4.24.B14 neprilysin-2 membrane integral membrane protein 16020 690691 3.4.24.B14 neprilysin-2 membrane isozymes SEP and SEPDELTA 16020 651958 3.4.24.B14 neprilysin-2 membrane membrane-bound protease isoform 16020 735280 3.4.24.B14 neprilysin-2 membrane NEP2 exists as a membrane-bound and soluble enzyme, isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane 16020 692350 3.4.24.B14 neprilysin-2 membrane NEP2(m), membrane-bound form of NEP2 16020 690798 3.4.24.B15 PHEX peptidase membrane - 16020 -, 649294, 649754, 668096, 718551 3.4.24.B15 PHEX peptidase membrane bound 16020 649704, 651218 3.4.24.B15 PHEX peptidase membrane integral membrane protein 16020 693297 3.4.24.B15 PHEX peptidase membrane type II membrane-bound zinc metalloprotease 16020 649294 3.4.24.B17 FtsH endopeptidase membrane - 16020 -, 668731, 677963, 678340, 678942, 680531, 681452, 681654, 681659, 681782, 681798, 681983, 719722, 734076, 734084, 734311 3.4.24.B17 FtsH endopeptidase membrane bound to 16020 692881 3.4.24.B17 FtsH endopeptidase membrane cytoplasmic membrane 16020 -, 719733 3.4.24.B17 FtsH endopeptidase membrane inner membrane 16020 718996 3.4.24.B17 FtsH endopeptidase membrane integral 16020 -, 651704, 651768, 651856, 652391, 653690, 653896 3.4.24.B17 FtsH endopeptidase membrane integral to 16020 668355 3.4.24.B17 FtsH endopeptidase membrane integral, active site facing the cytoplasm 16020 652491, 653191 3.4.24.B17 FtsH endopeptidase membrane integral, with the active site in the cytoplasm 16020 649856, 651260, 651418 3.4.24.B18 m-AAA protease membrane - 16020 -, 651889, 754149 3.4.24.B19 i-AAA protease membrane inner membrane 16020 -, 679988 3.4.24.B20 FtsH protease membrane - 16020 -, 712896, 712991, 734848 3.4.24.B20 FtsH protease membrane membrane-spanning enzyme 16020 713403 3.4.24.B20 FtsH protease membrane the hexameric FtsH protease is anchored to the inner membrane by two transmembrane helices per monomer such that both termini protrude into the cytoplasm 16020 713495 3.4.24.B23 stage IV sporulation protein FB membrane - 16020 -, 670316, 710415, 710497, 734089, 754129 3.4.24.B23 stage IV sporulation protein FB membrane after fusion of mother cell and forespore the enzyme density in the mother cell remains constant while the concentration in the forespore increased about sevenfold 16020 -, 670313 3.4.24.B23 stage IV sporulation protein FB membrane intramembrane protease 16020 734080 3.4.24.B23 stage IV sporulation protein FB membrane localized to the outermost membrane surrounding the forespore during sporulation 16020 733388 3.4.24.B24 L-alanine-D-glutamate endopeptidase membrane - 16020 683880 3.4.24.B24 L-alanine-D-glutamate endopeptidase membrane membrane-associated 16020 754598 3.4.24.B28 ADAM15 membrane - 16020 734181, 734701 3.4.24.B28 ADAM15 membrane transmembrane protein 16020 733260 3.4.24.B5 matrix metalloproteinase-15 membrane - 16020 669713, 753226 3.4.24.B5 matrix metalloproteinase-15 membrane membrane-anchored 16020 753384 3.4.24.B5 matrix metalloproteinase-15 membrane on the cell surface 16020 651039, 651754, 652122 3.4.24.B8 ADAM1 endopeptidase membrane - 16020 721017 3.4.24.B8 ADAM1 endopeptidase membrane cell surface fof epididymal sperm, contains exclusively isozyme b 16020 649618 3.4.24.B8 ADAM1 endopeptidase membrane on the cell surface 16020 650941, 653606 3.4.24.B9 ADAM9 endopeptidase membrane - 16020 653225, 719607, 719997, 752720 3.4.24.B9 ADAM9 endopeptidase membrane anchored 16020 649674 3.4.24.B9 ADAM9 endopeptidase membrane anchored on the cell surface 16020 644075, 651966 3.4.24.B9 ADAM9 endopeptidase membrane associated to membrane 16020 668073 3.4.24.B9 ADAM9 endopeptidase membrane bound 16020 653737 3.4.99.B1 RCE1 membrane - 16020 649307, 653118, 668781, 668929, 669285, 669510, 691033, 711466 3.4.99.B1 RCE1 membrane multiple predicted transmembrane domains 16020 651980 3.4.99.B2 D-aspartyl endopeptidase membrane inner mitochondrial membrane 16020 720105 3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylase membrane - 16020 -, 730006 3.5.1.11 penicillin amidase membrane - 16020 -, 710906 3.5.1.12 biotinidase membrane - 16020 -, 669619 3.5.1.137 N-methylcarbamate hydrolase membrane - 16020 763195 3.5.1.2 glutaminase membrane - 16020 655373 3.5.1.2 glutaminase membrane membrane associated 16020 713112 3.5.1.23 ceramidase membrane - 16020 171986, 171989, 711799, 718981 3.5.1.23 ceramidase membrane ACER3 is an intramembrane enzyme with a seven transmembrane domain architecture 16020 754856 3.5.1.23 ceramidase membrane ADIPOR2 contains 7 transmembrane segments 16020 754889 3.5.1.23 ceramidase membrane bound 16020 -, 711710 3.5.1.23 ceramidase membrane enzyme membrane topology, overview 16020 733290 3.5.1.23 ceramidase membrane membrane topology of rat neutral CDase, overview. A rat neutral CDase-GFP chimera protein, with GFP fused to the COOH terminus of the enzyme, is distributed in the ER/Golgi compartments and the plasma membrane of HEK293 cells 16020 733408 3.5.1.23 ceramidase membrane membrane-bound 16020 733984 3.5.1.23 ceramidase membrane membrane-bound, 112 kDa-form, mainly localized at the apical membrane of proximal tubules, distal tubules and collecting ducts of kidney, microsome, sequence contains one possible transmembrane domain 16020 656010 3.5.1.23 ceramidase membrane membrane-bound, brain 16020 655998 3.5.1.23 ceramidase membrane the neutral ceramidase is membrane-bound, enzyme membrane topology, overview 16020 733408 3.5.1.23 ceramidase membrane transmembrane protein 16020 668541 3.5.1.28 N-acetylmuramoyl-L-alanine amidase membrane - 16020 669130 3.5.1.28 N-acetylmuramoyl-L-alanine amidase membrane the enzyme belongs to the divisome. AmiC recruitment to divisome is independent of endopeptidase DipM 16020 -, 753346 3.5.1.28 N-acetylmuramoyl-L-alanine amidase membrane the enzyme posseses transmembrane segments 16020 -, 669091 3.5.1.28 N-acetylmuramoyl-L-alanine amidase membrane the enzyme possesses transmembrane segments 16020 -, 669091 3.5.1.3 omega-amidase membrane membrane-associated, one third to one fourth of total omega-amidase 16020 -, 288887 3.5.1.3 omega-amidase membrane not covalently bound to membrane 16020 -, 288887 3.5.1.4 amidase membrane - 16020 -, 664468, 664469, 681315, 686040, 686058 3.5.1.4 amidase membrane FAAH-1 shows predominantly cytoplasmic orientation 16020 687528 3.5.1.4 amidase membrane FAAH-2 is luminally orientated in the membrane 16020 687528 3.5.1.52 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase membrane minor distribution of Ngly1 in the membrane fraction 16020 754027 3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase membrane proposed membrane interactions via hydrophobic helices alpha3 and alpha6 16020 755270 3.5.1.68 N-formylglutamate deformylase membrane localized in particulate fractions 16020 -, 209222, 209224 3.5.1.69 glycosphingolipid deacylase membrane tightly bound to 16020 171986 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase membrane - 16020 288964, 665179, 665630 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase membrane the enzyme sequence contains three short hydrophobic transmembrane stretches, one at the N-terminus and two at the C-terminus 16020 -, 756746 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase membrane Triton insoluble membrane 16020 663871 3.5.1.9 arylformamidase membrane from embryo yolk sac 16020 -, 755594 3.5.1.92 pantetheine hydrolase membrane - 16020 658888, 718754 3.5.1.92 pantetheine hydrolase membrane a glycosylphosphatidylinositol-anchored membrane pantetheinase 16020 734998 3.5.1.92 pantetheine hydrolase membrane bound 16020 756998, 757002 3.5.1.92 pantetheine hydrolase membrane ectoenzyme, GPI-anchored pantetheinase 16020 658698 3.5.1.92 pantetheine hydrolase membrane membrane-bound 16020 699402 3.5.1.92 pantetheine hydrolase membrane vanin-1 is a ubiquitous membrane-bound enzyme 16020 -, 757352 3.5.1.99 fatty acid amide hydrolase membrane - 16020 681315, 694924, 712699, 720176, 720242 3.5.1.99 fatty acid amide hydrolase membrane bound 16020 -, 733662 3.5.1.99 fatty acid amide hydrolase membrane bound to 16020 690846, 690872 3.5.1.99 fatty acid amide hydrolase membrane bound to intracellular membranes, mainly of the endoplasmic reticulum 16020 719048 3.5.1.99 fatty acid amide hydrolase membrane FAAH-1 shows a predominantly cytoplasmic orientation in the membrane 16020 687528 3.5.1.99 fatty acid amide hydrolase membrane FAAH-2 is luminally orientated in the membrane 16020 687528 3.5.1.99 fatty acid amide hydrolase membrane integral membrane enzyme 16020 692951 3.5.1.99 fatty acid amide hydrolase membrane integral membrane protein 16020 209111, 695131, 720927 3.5.3.6 arginine deiminase membrane associated 16020 209458 3.5.4.11 pterin deaminase membrane extracellular isoform and membrane-bound isoform 16020 755866 3.5.4.16 GTP cyclohydrolase I membrane - 16020 711068 3.5.4.16 GTP cyclohydrolase I membrane GTPCH I is also co-localized with caveolin-1 to caveolar membrane microdomains of endothelial cells 16020 698211 3.5.4.4 adenosine deaminase membrane - 16020 697462, 713127 3.5.4.4 adenosine deaminase membrane large isozyme LADA 16020 667032 3.5.4.6 AMP deaminase membrane reversible association between the catalytic domain of the enzyme and the intracellular membrane 16020 669453 3.6.1.1 inorganic diphosphatase membrane - 16020 -, 209772, 209778, 209783, 209792, 679620, 711140, 719753, 720321, 733863, 734507 3.6.1.1 inorganic diphosphatase membrane bound to 16020 -, 747060 3.6.1.1 inorganic diphosphatase membrane ectoenzyme 16020 209787 3.6.1.1 inorganic diphosphatase membrane membrane bound 16020 -, 209782, 209795, 209818 3.6.1.1 inorganic diphosphatase membrane membrane-bound enzyme 16020 -, 724932 3.6.1.1 inorganic diphosphatase membrane membrane-embedded polypeptide 16020 -, 747756 3.6.1.15 nucleoside-triphosphate phosphatase membrane - 16020 209881, 209883, 209884, 209886, 668745, 696275 3.6.1.15 nucleoside-triphosphate phosphatase membrane the enzyme contains two membrane-spanning helices inserted into the N-terminal Walker B motif 16020 668745 3.6.1.15 nucleoside-triphosphate phosphatase membrane the enzyme is a membrane bound protein facing the extracellular side of the cell 16020 756676 3.6.1.15 nucleoside-triphosphate phosphatase membrane transmembrane protein 16020 -, 668745 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) membrane - 16020 657213 3.6.1.2 trimetaphosphatase membrane - 16020 667198 3.6.1.21 ADP-sugar diphosphatase membrane AspP binds to cell membranes as the bacterial population density increases, 30% of the total enzyme remaining membrane associated as glycogen depletes during the stationary phase, binding of AspP to the cell membrane is not dependent on quorum-sensing autoinducer 2 or glucose availability 16020 697980 3.6.1.26 CDP-diacylglycerol diphosphatase membrane - 16020 210004 3.6.1.27 undecaprenyl-diphosphate phosphatase membrane - 16020 -, 210606, 210607, 713052, 718588, 756478, 757618, 757770, 758127, 758199, 758275 3.6.1.27 undecaprenyl-diphosphate phosphatase membrane inner cytoplasmic membrane 16020 718534 3.6.1.27 undecaprenyl-diphosphate phosphatase membrane integral, PgpB contains six transmembrane segments, a large periplasmic loop, and the type 2 phosphatidic acid phosphatase signature residues at a periplasmic location 16020 687718 3.6.1.28 thiamine-triphosphatase membrane - 16020 210010, 210014, 758528 3.6.1.28 thiamine-triphosphatase membrane associated 16020 -, 210006, 210008, 210009, 210012, 210013, 210019, 210022 3.6.1.39 thymidine-triphosphatase membrane associated 16020 210047 3.6.1.42 guanosine-diphosphatase membrane - 16020 210056, 210057, 655628 3.6.1.42 guanosine-diphosphatase membrane type II integral membrane glycoprotein with a short amino-terminal cytoplasmic domain, which is not sufficient for Golgi localization, a single transmembrane domain , and a large catalytic lumenal domain, which is required for activity 16020 210054 3.6.1.42 guanosine-diphosphatase membrane type II membrane protein with a single hydrophobic stretch acting as an uncleaved signal sequence and anchor to the membrane preceded by a short hydrophilic, cytosolic tail 16020 210058 3.6.1.42 guanosine-diphosphatase membrane type II transmembrane protein with a single hydrophobic domain, which acts as an uncleaved signal sequence and membrane anchor, and is preceded by a short hydrophilic cytosolic tail 16020 210053 3.6.1.43 dolichyldiphosphatase membrane - 16020 134908, 289076, 289082, 687781, 711954 3.6.1.43 dolichyldiphosphatase membrane integral 16020 289079 3.6.1.5 apyrase membrane - 16020 210137, 210138, 210147, 210164, 654862, 655433, 678480, 684829, 700088, 719597, 720442, 735003, 755781 3.6.1.5 apyrase membrane AtAPY3 contains a single putative N-terminal transmembrane domain typical of type II membrane proteins 16020 755996 3.6.1.5 apyrase membrane AtAPY6 (clade II) appears to be type a IV-A membrane protein, AtAPY6 appears to possess both an N- and a C-terminal transmembrane domain 16020 755996 3.6.1.5 apyrase membrane ATPDase2 contains a single N-terminal transmembrane domain 16020 684829 3.6.1.5 apyrase membrane bound, putative transmembrane domain sequence. overview 16020 756841 3.6.1.5 apyrase membrane ectonucleotidase/ectoenzyme 16020 210148, 210149, 210150, 210151, 210159, 210160, 210166, 210167, 210168 3.6.1.5 apyrase membrane isozyme AtAPY5 contains a single putative N-terminal transmembrane domain typical of type II membrane proteins 16020 755996 3.6.1.5 apyrase membrane membrane-bound 16020 210158, 210165 3.6.1.5 apyrase membrane NTPDase8 is a cell surface ectonucleotidase with a large extracellular domain containing the active site and is anchored to the membrane by two transmembrane domains at the N- and C-termini 16020 718863 3.6.1.5 apyrase membrane plant members of the GDA-like clade, such as isozymes AtAPY1 and AtAPY2, are typical type II membrane proteins 16020 755996 3.6.1.5 apyrase membrane synaptic plasma membrane 16020 210161, 656931 3.6.1.5 apyrase membrane tegumental 16020 700083 3.6.1.5 apyrase membrane the enzyme contains two transmembrane domains and five apyrase conserved regions, ACRs. ACR1 is located near the N-terminal transmembrane domain, whereas ACR5 is located near the C-terminal transmembrane domain 16020 695854 3.6.1.5 apyrase membrane the isozyme contains a single putative N-terminal transmembrane domain typical of type II membrane proteins 16020 755996 3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase membrane - 16020 -, 718879 3.6.1.6 nucleoside diphosphate phosphatase membrane - 16020 669238, 670350 3.6.1.6 nucleoside diphosphate phosphatase membrane plant members of the GDA-like clade, such as isozymes AtAPY1 and AtAPY2, are typical type II membrane proteins 16020 755996 3.6.1.75 diacylglycerol diphosphate phosphatase membrane an integral membrane protein with six transmembrane spanning regions 16020 682952 3.6.1.75 diacylglycerol diphosphate phosphatase membrane associated 16020 -, 680601 3.6.1.75 diacylglycerol diphosphate phosphatase membrane DGPP phosphatase is an integral membrane protein with six transmembrane-spanning domains 16020 -, 680606 3.6.1.8 ATP diphosphatase membrane - 16020 210224 3.6.1.8 ATP diphosphatase membrane human erythrocyte membrane 16020 210225, 210227 3.6.1.9 nucleotide diphosphatase membrane - 16020 208378, 208379, 246818, 246831, 657747, 697602, 698337, 756660, 757897 3.6.1.9 nucleotide diphosphatase membrane associated 16020 756172 3.6.1.9 nucleotide diphosphatase membrane characteristics of a transmembrane protein 16020 246802 3.6.1.9 nucleotide diphosphatase membrane contains a putative transmembrane domain 16020 720099 3.6.1.9 nucleotide diphosphatase membrane enriched in matrix vesicles, cytosolic tail motif AAASLLAP is required for correct localization 16020 667143 3.6.1.9 nucleotide diphosphatase membrane isoform NPP1, enriched in matrix vesicles 16020 667143 3.6.1.9 nucleotide diphosphatase membrane NPP1 is a homodimeric type II transmembrane glycoprotein with an N-terminal transmembrane domain 16020 757567 3.6.1.9 nucleotide diphosphatase membrane of COS cells, NPP1 16020 658622 3.6.1.9 nucleotide diphosphatase membrane of COS cells, NPP3 16020 658622 3.6.1.9 nucleotide diphosphatase membrane the mammalian members of the NPP1-3 family are type II (intracellular N-terminus) transmembrane glycoproteins 16020 696406 3.6.1.9 nucleotide diphosphatase membrane transmembrane enzyme 16020 718664 3.6.4.13 RNA helicase membrane - 16020 696133 3.6.4.6 vesicle-fusing ATPase membrane - 16020 -, 733702, 735147, 756698, 758466 3.6.4.6 vesicle-fusing ATPase membrane N-terminal domain of PEX1 is one of the functional modules for membrane binding 16020 668578 3.6.4.6 vesicle-fusing ATPase membrane NSF requires a peripheral membrane protein to bind membranes 16020 687536 3.6.4.7 peroxisome-assembly ATPase membrane - 16020 757000 3.6.4.B6 archaeal flagellar ATPase membrane homologously expressed 6 * His-tagged FlaI in Sulfolobus localizes solely to membranes 16020 -, 725893 3.6.5.1 heterotrimeric G-protein GTPase membrane - 16020 644092, 644093, 644104, 644107, 654813 3.6.5.1 heterotrimeric G-protein GTPase membrane functional reconstitution of purified Gi and Go with mü-opioid receptors in guinea pig striatal membranes 16020 644092 3.6.5.1 heterotrimeric G-protein GTPase membrane lipid rafts 16020 700481 3.6.5.2 small monomeric GTPase membrane - 16020 -, 659191, 665360, 696950, 697499, 699116, 700896, 701098 3.6.5.2 small monomeric GTPase membrane only the membrane-localised form of RhoH is able to downregulate Rac1 efficiently 16020 697169 3.6.5.4 signal-recognition-particle GTPase membrane - 16020 684117, 686249, 686752, 687902, 758489 3.6.5.4 signal-recognition-particle GTPase membrane microsomal membrane 16020 687905 3.6.5.4 signal-recognition-particle GTPase membrane peripheral membrane protein subunit SRalpha, which is anchored to the membrane by the 30 kDa subunit SRbeta, that has a single N-terminal transmembrane domain and short luminal domain 16020 757758 3.6.5.4 signal-recognition-particle GTPase membrane peripheral membrane SRalpha subunit, the transmembrane SRbeta subunit is anchoring SRalpha on the endoplasmic reticulum membrane 16020 757430 3.6.5.4 signal-recognition-particle GTPase membrane SRbeta is an integral membrane component of the signal recognition particle (SRP) receptor 16020 -, 758481 3.6.5.5 dynamin GTPase membrane - 16020 686383, 697236, 697237, 697536, 699100, 720089, 756591 3.6.5.5 dynamin GTPase membrane dynamin I and dynamin II are specifically localized to and highly concentrated in coated pits on the plasma membrane and can assemble in vitro into rings and helical arrays 16020 644197 3.6.5.5 dynamin GTPase membrane dynamin localizes to newly formed cleavage furrow membranes and accumulates at the midbody of dividing embryos 16020 658485 3.6.5.5 dynamin GTPase membrane endothelial plasma membrane 16020 644185 3.6.5.5 dynamin GTPase membrane leukotoxin mobilizes dynamin-2 from mitochondria to the cell membrane 16020 698249 3.6.5.5 dynamin GTPase membrane neurolastin is peripherally associated with membranes via its C-terminus but seems to contains two transmembrane segments 16020 733629 3.6.5.5 dynamin GTPase membrane peripheral membrane fraction 16020 644181, 733785 3.6.5.5 dynamin GTPase membrane the enzyme is expressed in the cytoplasm and is partly associated with membranes of the smooth endoplasmic reticulum 16020 734301 3.7.1.4 phloretin hydrolase membrane - 16020 656061, 749964 3.7.1.7 beta-diketone hydrolase membrane specific activity in membrane fraction is several times higher than that of soluble fraction 16020 -, 287796 4.1.1.112 oxaloacetate decarboxylase membrane - 16020 716673 4.1.1.112 oxaloacetate decarboxylase membrane beta and gamma subunits are integral membrane proteins, alpha subunit is attached to the gamma subunit 16020 650185, 651122 4.1.1.112 oxaloacetate decarboxylase membrane Ef-B is a membrane-bound subunit, while subunits Ef-A, Ef-D, and Ef-H form a cytoplasmic soluble complex, Ef-AHD, which is also associated with the membrane 16020 -, 726737 4.1.1.112 oxaloacetate decarboxylase membrane membrane-bound oxaloacetate decarboxylase complex, the alpha-subunit is a peripheral membrane protein on the cytosolic side of the membrane, where it associates with beta- and gamma-subunits that are embedded in the membrane. The beta-subunit is an integral membrane protein with nine transmembrane segments. The small gamma-subunit is an integral membrane protein with a single membrane-spanning helix at the N-terminus 16020 726821 4.1.1.15 glutamate decarboxylase membrane - 16020 -, 700471, 700474, 748691, 748843 4.1.1.15 glutamate decarboxylase membrane bound to, highest specific activity is present in mitochondrial/vacuolar organellar fraction 16020 654387 4.1.1.15 glutamate decarboxylase membrane isoform GAD65 is localized to the membrane fraction 16020 715982 4.1.1.15 glutamate decarboxylase membrane localized exclusively in cytoplasm at neutral pH, but is recruited to the membrane when the pH falls 16020 655335 4.1.1.15 glutamate decarboxylase membrane targeting of the processed enzyme 16020 695971 4.1.1.15 glutamate decarboxylase membrane the enzyme can become membrane-associated though interactions with a member of the heat shock protein 70 family, heat shock cognate 70, which is then anchored to synaptic vesicles through interactions with an intrinsic synaptic vesicle protein, cysteine string protein 16020 655982 4.1.1.15 glutamate decarboxylase membrane the renal enzyme differs from the brain and pancreatic enzyme by its strong binding to membranes that is not influenced by detergents 16020 655403 4.1.1.15 glutamate decarboxylase membrane three distinct moieties of glutamate decarboxylase localize to membrane compartments, an amphiphilic GAD65 homodimer, an amphiphilic GAD65/67 heterodimer, tethered to membranes via the GAD65 subunit and a hydrophilic GAD67 homodimer, which associates with membranes by a distinct mechanism 16020 655976 4.1.1.17 ornithine decarboxylase membrane - 16020 4037, 653550 4.1.1.22 histidine decarboxylase membrane - 16020 4160 4.1.1.25 tyrosine decarboxylase membrane - 16020 -, 706671 4.1.1.28 aromatic-L-amino-acid decarboxylase membrane - 16020 650436, 653352, 691469, 705269, 716342 4.1.1.28 aromatic-L-amino-acid decarboxylase membrane a population of DDC molecules are intrinsic membrane proteins 16020 691469 4.1.1.31 phosphoenolpyruvate carboxylase membrane the enzyme partially localizes to membranes 16020 706331 4.1.1.35 UDP-glucuronate decarboxylase membrane - 16020 652654, 653532 4.1.1.35 UDP-glucuronate decarboxylase membrane enzyme contains a putative membrane-binding region 16020 663764 4.1.1.57 methionine decarboxylase membrane - 16020 4725 4.1.1.61 4-hydroxybenzoate decarboxylase membrane loosely associated 16020 4741 4.1.1.65 phosphatidylserine decarboxylase membrane - 16020 4766, 4767, 4776, 4781, 4783, 653276 4.1.1.65 phosphatidylserine decarboxylase membrane associated with cytoplasmic membrane 16020 4770, 4786 4.1.1.65 phosphatidylserine decarboxylase membrane bound to 16020 4764, 4780 4.1.1.65 phosphatidylserine decarboxylase membrane exclusively in the inner mitochondrial membrane 16020 4779, 4791 4.1.1.65 phosphatidylserine decarboxylase membrane external side of the inner membrane 16020 4777 4.1.1.65 phosphatidylserine decarboxylase membrane high activity in cytoplasmic membrane and low activity in outer membrane of the cell envelope 16020 4762 4.1.1.65 phosphatidylserine decarboxylase membrane inner mitochondrial membrane 16020 -, 728629 4.1.1.65 phosphatidylserine decarboxylase membrane inner mitochondrial membrane and Golgi/vacuole membrane 16020 4783 4.1.1.65 phosphatidylserine decarboxylase membrane intrinsic membrane protein 16020 4769, 4773 4.1.1.65 phosphatidylserine decarboxylase membrane not tightly bound 16020 4778 4.1.1.65 phosphatidylserine decarboxylase membrane phosphatidylserine flows from the outer membrane to the inner membrane through contact sites between inner and outer membrane to become decarboxylated and the formed phosphatidylethanolamine flows directly back to the outer membrane, without mixing with inner membrane phosphatidylamine 16020 4791 4.1.1.65 phosphatidylserine decarboxylase membrane plasma membrane 16020 4787 4.1.1.65 phosphatidylserine decarboxylase membrane PSD is catalytically active in both soluble and membrane fractions, with a membrane/soluble distribution of 3/1 16020 748688 4.1.1.65 phosphatidylserine decarboxylase membrane septal 16020 -, 659064 4.1.1.65 phosphatidylserine decarboxylase membrane the enzyme is equally distributed between membrane and soluble fractions 16020 727905 4.1.1.69 3,4-dihydroxyphthalate decarboxylase membrane weakly bound 16020 -, 33107 4.1.1.88 biotin-independent malonate decarboxylase membrane - 16020 748747 4.1.1.90 peptidyl-glutamate 4-carboxylase membrane - 16020 438307, 747068 4.1.1.90 peptidyl-glutamate 4-carboxylase membrane 758 residue integral membrane protein 16020 701214 4.1.1.90 peptidyl-glutamate 4-carboxylase membrane integral membrane protein 16020 698705 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase membrane - 16020 727983, 729319 4.1.2.13 fructose-bisphosphate aldolase membrane - 16020 -, 698178, 747808 4.1.2.27 sphinganine-1-phosphate aldolase membrane - 16020 716860 4.1.3.1 isocitrate lyase membrane membrane fraction (3 h, 180000xg) of cell-free extract, increased expression level upon oxidative stress induced by 8 h treatment with 100 microM menadione 16020 700883 4.1.3.4 hydroxymethylglutaryl-CoA lyase membrane - 16020 5371 4.1.3.40 chorismate lyase membrane the recombinant enzyme shows severalfold higher specific activities in membrane than in soluble protein fractions 16020 727983 4.1.99.5 aldehyde oxygenase (deformylating) membrane membrane-associated 16020 -, 648392, 648393, 648395 4.2.1.1 carbonic anhydrase membrane - 16020 699472, 702555, 703005, 748873 4.2.1.1 carbonic anhydrase membrane associated 16020 33539 4.2.1.1 carbonic anhydrase membrane at least half of the carbonic anhydrase IV in lung and kidney is anchored to membranes by phosphatidylinositol-glycan linkages 16020 33581 4.2.1.1 carbonic anhydrase membrane bound 16020 33543, 33574, 33598 4.2.1.1 carbonic anhydrase membrane bound to 16020 665834, 666749 4.2.1.1 carbonic anhydrase membrane CA IX is a transmembrane protein, where the extracellular region consists of the catalytic CA domain and the proteoglycan-like (PG) domain 16020 747489 4.2.1.1 carbonic anhydrase membrane CA XIV is a membrane-associated glycoprotein 16020 748270 4.2.1.1 carbonic anhydrase membrane CAIV is localized exclusively to the apical membrane 16020 698379 4.2.1.1 carbonic anhydrase membrane carbonic anhydrase IV is associated with a lipid or a glycolipid membrane fraction 16020 33585 4.2.1.1 carbonic anhydrase membrane carbonic anhydrase IV is detected in the apical membrane of polarized cells 16020 33586 4.2.1.1 carbonic anhydrase membrane extracellular membrane-bound 16020 747545 4.2.1.1 carbonic anhydrase membrane glycosylphosphatidylinositol-anchored membrane protein 16020 663971 4.2.1.1 carbonic anhydrase membrane integral membrane protein 16020 649577 4.2.1.1 carbonic anhydrase membrane isoenzyme CasCAg 16020 681115 4.2.1.1 carbonic anhydrase membrane isoform CA IX is a transmembrane enzyme 16020 702563 4.2.1.1 carbonic anhydrase membrane isoforms CA XIV, CA IX and CA XII are transmembrane proteins 16020 703558 4.2.1.1 carbonic anhydrase membrane isozyme carbonic anhydrase IV 16020 696635 4.2.1.1 carbonic anhydrase membrane membrane protein overexpressed in certain cancer tumor cells 16020 653675 4.2.1.1 carbonic anhydrase membrane membrane-bound, at apical membrane of some epithelial cells surrounding the tertiary water channels and to a lesser extent at the apical membrane of some epithelial apical immunofluorescence epithelial cells as compared with the control. Presence of two transmembrane regions in the DDCA 16020 747863 4.2.1.1 carbonic anhydrase membrane the enzyme is anchored to membrane surface by a phosphatidylinositol-glycan linkage 16020 33594 4.2.1.1 carbonic anhydrase membrane transmembrane enzyme 16020 700410 4.2.1.1 carbonic anhydrase membrane transmembrane glycoprotein with an active extracellular CA domain 16020 653643 4.2.1.1 carbonic anhydrase membrane transmembrane isozyme IX 16020 652744 4.2.1.1 carbonic anhydrase membrane transmembrane isozymes CA IX and CA XI 16020 714445 4.2.1.1 carbonic anhydrase membrane transmembrane isozymes hCA IX and hCA XII 16020 714439 4.2.1.1 carbonic anhydrase membrane transmembrane isozymes IX and XII 16020 714459 4.2.1.1 carbonic anhydrase membrane transmembrane protein 16020 652564, 698814, 702470 4.2.1.1 carbonic anhydrase membrane transmembrane tumor-associated isozyme IX 16020 652754 4.2.1.10 3-dehydroquinate dehydratase membrane membrane-bound isoform mDQD 16020 -, 714521 4.2.1.10 3-dehydroquinate dehydratase membrane pDQD 16020 -, 691374 4.2.1.11 phosphopyruvate hydratase membrane - 16020 716426 4.2.1.118 3-dehydroshikimate dehydratase membrane membrane-bound isoform mDSD 16020 -, 714521 4.2.1.118 3-dehydroshikimate dehydratase membrane membrane-bound isoform mDSD, the isozyme is stable in contrast to the cytosolic isoform, sDSD 16020 -, 714521 4.2.1.120 4-hydroxybutanoyl-CoA dehydratase membrane enzyme is largely membrane- or particle-bound and may be solubilized by detergent 16020 698004 4.2.1.123 tetrahymanol synthase membrane - 16020 -, 714282 4.2.1.125 dammarenediol II synthase membrane transmembrane enzyme 16020 730302 4.2.1.129 squalene-hopanol cyclase membrane - 16020 726715 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase membrane a membranespanning protein that traverses the membrane six times and has an N-terminus and C-terminus facing the cytosol 16020 719847 4.2.1.165 chlorophyllide a 31-hydratase membrane - 16020 748858 4.2.1.165 chlorophyllide a 31-hydratase membrane BchF is predicted to have four transmembrane helices, suggesting that the later steps of bacteriochlorophyll a synthesis occur within the membrane 16020 749080 4.2.1.165 chlorophyllide a 31-hydratase membrane integral membrane protein, four putative membrane-spanning helices comprising the transmembrane segments Ile23-Tyr42,Thr56-Glu77, Phe94-Gln113, and His118-Gln140 16020 -, 738654 4.2.1.165 chlorophyllide a 31-hydratase membrane integral transmembrane protein, the enzyme contains four putative membrane-spanning helices comprising the transmembrane segments Ile23-Tyr42, Thr56-Glu77, Phe94-Gln113, and His118-Gln140 16020 -, 748192 4.2.1.92 hydroperoxide dehydratase membrane - 16020 -, 730012, 730885 4.2.1.92 hydroperoxide dehydratase membrane membrane-bound 16020 747291 4.2.1.98 16alpha-hydroxyprogesterone dehydratase membrane 20% of the activity 16020 -, 656636 4.2.1.98 16alpha-hydroxyprogesterone dehydratase membrane 40% activity in cytoplasmic, 20% in membrane fractions of crude cell extract 16020 -, 648460 4.2.2.1 hyaluronate lyase membrane cell surface 16020 655681, 656150 4.2.2.1 hyaluronate lyase membrane Hyal-2 activityis detected in the membrane fraction of cells co-expressing Hyal-2 and CD44 16020 680874 4.2.2.10 pectin lyase membrane PnlH, is exported by the Tat system and targeted to the outer membrane by its uncleaved N-terminal Tat signal anchor 16020 700269 4.2.2.2 pectate lyase membrane associated with membranes under certain conditions 16020 37375 4.2.2.B6 muropeptide lyase membrane a periplasmic, outer membrane-attached enzyme 16020 721680 4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase membrane - 16020 648615 4.3.2.5 peptidylamidoglycolate lyase membrane - 16020 648695, 648703 4.3.2.5 peptidylamidoglycolate lyase membrane membrane associated 16020 648700 4.3.3.1 3-ketovalidoxylamine C-N-lyase membrane - 16020 648708, 648709 4.4.1.1 cystathionine gamma-lyase membrane - 16020 691353, 691890 4.4.1.20 leukotriene-C4 synthase membrane - 16020 644485, 644491, 644493, 644497, 666794, 666938, 748662 4.4.1.20 leukotriene-C4 synthase membrane a nuclear membrane enzyme 16020 730555 4.4.1.20 leukotriene-C4 synthase membrane associated with 16020 644498 4.4.1.20 leukotriene-C4 synthase membrane bound to 16020 644489 4.4.1.20 leukotriene-C4 synthase membrane in close association with 5-lipoxygenase activating protein 16020 666717 4.4.1.20 leukotriene-C4 synthase membrane is localized to the outer nuclear membrane, is associated with 5-lipoxygenase activating protein and 5-lipoxygenase. Exclusion from the inner nuclear membrane 16020 709128 4.4.1.20 leukotriene-C4 synthase membrane the enzyme is chiefly membrane-bound, although the cytosol contains some activity 16020 644502 4.4.1.5 lactoylglutathione lyase membrane associated 16020 692050 4.4.1.5 lactoylglutathione lyase membrane bound to outer membrane 16020 -, 749417 4.6.1.1 adenylate cyclase membrane - 16020 -, 34760, 34761, 34763, 34768, 34770, 34771, 34773, 34774, 34775, 34776, 34779, 34780, 34781, 34782, 34783, 34786, 34787, 34792, 34815, 34818, 34820, 34821, 34822, 34824, 34825, 649134, 649292, 649332, 650812, 650992, 651177, 651699, 651929, 652096, 652300, 652379, 652397, 653017, 653132, 653280, 653453, 653862, 663747, 664044, 665877, 678070, 679659, 679824, 681532, 682037, 691561, 691562, 693293, 693757, 693876, 694874, 695074, 707801, 708403, 708469, 709677, 710116, 716341, 729544, 730950 4.6.1.1 adenylate cyclase membrane 6 transmembrane helices and a single cytosolic catalytic domain, which dimerizes to form a 12-transmembrane homodimeric enzyme 16020 651327 4.6.1.1 adenylate cyclase membrane a transmembrane protein 16020 729827 4.6.1.1 adenylate cyclase membrane apical membrane, AC1 and AC8 16020 679862 4.6.1.1 adenylate cyclase membrane in Rv3645 a membrane anchor consisting of 6 putative transmembrane helices is linked to a class IIIb CHD via a HAMP domain, the membrane anchor of Rv3645 may serve as a sensor 16020 -, 679129 4.6.1.1 adenylate cyclase membrane lipid rafts and cavaeolae, the localization mechanism involves the C-terminal C1 and C2 domains, which target the enzyme to the microdomains of the cells, localization of the structural features of C1 and C2 required for interaction with lipid rafts, overview 16020 691723 4.6.1.1 adenylate cyclase membrane membrane-associated 16020 746755 4.6.1.1 adenylate cyclase membrane myocardial membrane 16020 34788 4.6.1.1 adenylate cyclase membrane nine membrane-bound isozymes 16020 692680 4.6.1.1 adenylate cyclase membrane nine transmembrane AC isozymes, of which four are sensitive to Ca2+ 16020 694269 4.6.1.1 adenylate cyclase membrane outer membrane of cell with catalytic domain accessible on the outer surface 16020 34754 4.6.1.1 adenylate cyclase membrane present in the head, acrosomal and mitochondrial area and in flagellar membranes of sperm 16020 677968 4.6.1.1 adenylate cyclase membrane Rv1625c is a six-transmembrane protein with a single class III cyclase domain 16020 -, 679824 4.6.1.1 adenylate cyclase membrane six putative helical transmembrane domains 16020 -, 652170 4.6.1.1 adenylate cyclase membrane the N-terminal half of the class IIIb AC consists of a predicted membrane-associated sensor domain 16020 679129 4.6.1.1 adenylate cyclase membrane the N-terminus is positioned intracellularly 16020 -, 748750 4.6.1.1 adenylate cyclase membrane transmembrane AC isozymes, some of which are sensitive to Ca2+ 16020 694269 4.6.1.1 adenylate cyclase membrane transmembrane enzyme 16020 694405 4.6.1.1 adenylate cyclase membrane transmembrane enzyme form 16020 693876 4.6.1.1 adenylate cyclase membrane transmembrane enzyme tmAC 16020 693876 4.6.1.1 adenylate cyclase membrane transmembrane isozyme tmAC 16020 693876 4.6.1.1 adenylate cyclase membrane transmembrane isozymes 16020 693560 4.6.1.1 adenylate cyclase membrane transmembrane protein 16020 714797 4.6.1.13 phosphatidylinositol diacylglycerol-lyase membrane - 16020 -, 729401, 729893 4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase membrane - 16020 648767, 648768, 747647 4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase membrane GPI-PLC is an integral membrane protein 16020 -, 135294 4.6.1.16 tRNA-intron lyase membrane integral membrane protein 16020 -, 646323, 646326, 646334 4.6.1.16 tRNA-intron lyase membrane soluble and membrane bound 16020 646324 4.6.1.2 guanylate cyclase membrane - 16020 -, 649303, 649950, 651158, 652358, 653210, 677989, 679514, 681631, 691340, 692083, 692788, 693102, 693152, 693267, 693718, 694915, 714257, 715825, 716928, 730028, 748750 4.6.1.2 guanylate cyclase membrane alpha2-subunit, in Purkinje cell somata 16020 679112 4.6.1.2 guanylate cyclase membrane at the apical membrane GCA and GCC both present, at the basolateral membrane only GCA present, GCC is delivered directly to the apical membrane 16020 682935 4.6.1.2 guanylate cyclase membrane CsGC-YO1 is a membrane-associated protein 16020 692464 4.6.1.2 guanylate cyclase membrane GC-A is a single transmembrane spanning protein 16020 694141 4.6.1.2 guanylate cyclase membrane GC-C 16020 694954 4.6.1.2 guanylate cyclase membrane glomerular and papillary membranes 16020 677413 4.6.1.2 guanylate cyclase membrane guanylate cyclase C is a transmembrane enzyme 16020 -, 690355 4.6.1.2 guanylate cyclase membrane membrane-bound guanylate cyclase 16020 693966 4.6.1.2 guanylate cyclase membrane retGC is a transmembrane protein localized in the outer segment 16020 690841 4.6.1.2 guanylate cyclase membrane rod outer segment membrane 16020 692407 4.6.1.2 guanylate cyclase membrane the N-terminus is positioned intracellularly 16020 -, 748750 4.6.1.2 guanylate cyclase membrane three membrane-bound sensory guanylate cyclases in retina 16020 691110 4.6.1.2 guanylate cyclase membrane transmembrane isozyme GC-A 16020 693145 4.6.1.24 ribonuclease T1 membrane - 16020 654991 4.6.1.6 cytidylate cyclase membrane - 16020 -, 648792 4.6.1.6 cytidylate cyclase membrane membrane-bound 16020 -, 648788, 648789, 648791 4.98.1.1 protoporphyrin ferrochelatase membrane - 16020 -, 680525, 738261 4.98.1.1 protoporphyrin ferrochelatase membrane associated via a 12-residue hydrophobic lip 16020 653316 4.98.1.1 protoporphyrin ferrochelatase membrane attached to 16020 650802 4.98.1.1 protoporphyrin ferrochelatase membrane of thylakoid 16020 653574 5.1.1.18 serine racemase membrane - 16020 -, 662887, 706540, 715022 5.1.1.18 serine racemase membrane membrane association via phospholipid binding. The enzyme is prominently associated with the plasma membrane but also is detected in granular structures that may be vesicles associated with the plasma membrane or other cellular components 16020 706532 5.1.1.4 proline racemase membrane membrane-bound and secreted forms of enzyme are present upon differentiation of the parasite into non-dividing infective forms 16020 652377 5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) membrane - 16020 2272 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase membrane a type II transmembrane protein 16020 747914 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase membrane transmembrane enzyme 16020 704649 5.1.3.19 chondroitin-glucuronate 5-epimerase membrane two transmembrane segments 16020 749120 5.1.3.26 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase membrane - 16020 -, 722673 5.1.3.5 UDP-arabinose 4-epimerase membrane a type I membrane protein 16020 749287 5.1.3.6 UDP-glucuronate 4-epimerase membrane membrane-bound 16020 748715 5.2.1.12 zeta-carotene isomerase membrane integral membrane protein 16020 748731 5.2.1.5 linoleate isomerase membrane - 16020 -, 715314 5.2.1.5 linoleate isomerase membrane bound 16020 679570 5.2.1.8 peptidylprolyl isomerase membrane - 16020 -, 716254 5.2.1.8 peptidylprolyl isomerase membrane and/or organelles, isoforms CyP2 and CyP3 16020 2531 5.2.1.8 peptidylprolyl isomerase membrane surface-exposed 16020 662909 5.3.1.1 triose-phosphate isomerase membrane exterior surface of membrane 16020 -, 747796 5.3.1.9 glucose-6-phosphate isomerase membrane - 16020 661423 5.3.3.1 steroid DELTA-isomerase membrane integral membrane protein 16020 389386 5.3.3.12 L-dopachrome isomerase membrane - 16020 648809, 648815 5.3.3.12 L-dopachrome isomerase membrane DCT has a hydrophobic transmembrane anchor 16020 706613 5.3.3.5 cholestenol DELTA-isomerase membrane putative transmembrane spanning domains 16020 653487 5.3.4.1 protein disulfide-isomerase membrane - 16020 3085, 3092, 3093, 661029, 679678, 682951, 706459, 727573, 748929 5.3.4.1 protein disulfide-isomerase membrane associated 16020 704927 5.3.4.1 protein disulfide-isomerase membrane integral, the catalytic reaction takes place on the periplasmic side, PDI contains four transmembrane helices that surround the bound ubiquinone cofactor, overview 16020 680746 5.3.4.1 protein disulfide-isomerase membrane of the P2 fraction 16020 679513 5.3.99.2 Prostaglandin-D synthase membrane rough endoplasmic reticulum membrane 16020 726906 5.3.99.3 prostaglandin-E synthase membrane - 16020 653633, 678584, 690320, 690374, 690714, 691241, 691476, 692588, 693240, 693372, 693841, 694863, 694942, 747606 5.3.99.3 prostaglandin-E synthase membrane associated 16020 667165 5.3.99.3 prostaglandin-E synthase membrane associated, mPEGS-1 and mPEGS-2 16020 667830 5.3.99.3 prostaglandin-E synthase membrane membrane-associated prostaglandin E synthase-2 16020 727942 5.3.99.4 prostaglandin-I synthase membrane anchors to the membrane with a single N-terminal transmembrane domain, the bulk of the enzyme is located at the cytosolic side of ER 16020 660924 5.3.99.4 prostaglandin-I synthase membrane membrane-bound 16020 660808 5.3.99.4 prostaglandin-I synthase membrane the recombinant enzyme associates with host cell membranes 16020 661260 5.3.99.5 thromboxane-A synthase membrane intrinsic protein 16020 694313 5.3.99.7 styrene-oxide isomerase membrane integral membrane protein 16020 -, 726724 5.4.4.8 linalool isomerase membrane inner membrane. Protein is predicted to have four transmembrane helices at the N-terminal domain and a cytosolic domain 16020 -, 742193 5.4.99.17 squalene-hopene cyclase membrane - 16020 -, 440047, 440050, 440056, 440057, 440058, 440059, 690936, 702829 5.4.99.32 protostadienol synthase membrane - 16020 714021 5.4.99.7 Lanosterol synthase membrane - 16020 662943 5.4.99.7 Lanosterol synthase membrane monotopic, integral membrane protein 16020 649634 5.4.99.8 cycloartenol synthase membrane - 16020 3626 5.5.1.19 lycopene beta-cyclase membrane the N-terminus of the protein contains six transmembrane regions 16020 -, 727786 5.5.1.4 inositol-3-phosphate synthase membrane - 16020 704559, 716519 5.5.1.4 inositol-3-phosphate synthase membrane associated, isozyme MIPS1 16020 -, 715523 5.5.1.9 Cycloeucalenol cycloisomerase membrane - 16020 3789 5.6.1.1 microtubule-severing ATPase membrane - 16020 688549 5.6.1.3 plus-end-directed kinesin ATPase membrane associated 16020 210551 5.6.1.4 minus-end-directed kinesin ATPase membrane associated with Triton X-100 insoluble membrane organelles 16020 656339 5.6.1.6 channel-conductance-controlling ATPase membrane - 16020 -, 210422, 210432, 654579, 674414, 675622, 676761, 696099, 697846, 698081, 699616, 699787, 700093, 700104, 700296, 700618, 700965, 733100, 734231, 734313, 734544 5.6.1.6 channel-conductance-controlling ATPase membrane apical membrane of epithelia 16020 210422, 210427, 210432 5.6.1.6 channel-conductance-controlling ATPase membrane apical side 16020 675158 5.6.1.6 channel-conductance-controlling ATPase membrane CFTR contains an uncleavable signal sequence and its membrane targeting and insertion may depend on the signal recognition particle and the signal recognition particle receptor 16020 210430 5.6.1.6 channel-conductance-controlling ATPase membrane endocytosis and recycling of CFTR at the apical membrane 16020 210435 5.6.1.6 channel-conductance-controlling ATPase membrane integral membrane protein 16020 210420 5.6.1.6 channel-conductance-controlling ATPase membrane microsomal membrane 16020 210430 5.6.1.6 channel-conductance-controlling ATPase membrane the CFTR chloride channel is a membrane-integral protein 16020 698823 5.6.1.6 channel-conductance-controlling ATPase membrane the enzyme possesses two transmembrane domains, each of which comprises six transmembrane segments 16020 735191 5.6.1.6 channel-conductance-controlling ATPase membrane the enzyme possesses two transmembrane domains, each of which comprises six transmembrane segments. Function of several transmembrane segments (TMs), including TM1, TM3, TM6, TM9, TM11, and TM12, as pore-lining segments the enzyme. Screening of the entire transmembrane segment 5 defined by the original topology model and its cytoplasmic extension in a Cys-less background, the segment of TM5 between F311 and L323 is concealed from the pore by other TMs and/or lipid bilayers, the cytoplasmic portion of TM5 lines the pore 16020 733359 5.6.1.6 channel-conductance-controlling ATPase membrane transmembrane protein 16020 733357, 734266 5.6.1.6 channel-conductance-controlling ATPase membrane wild type in BHK cells 16020 675188 5.6.1.7 chaperonin ATPase membrane - 16020 -, 733223 5.6.2.2 DNA topoisomerase (ATP-hydrolysing) membrane the products of gene 39, MW 57000, and gene 52, MW 48000, are tightly membrane-associated 16020 3856 6.1.1.13 D-alanine-poly(phosphoribitol) ligase membrane - 16020 1056 6.1.1.15 proline-tRNA ligase membrane transmembrane segment analysis of lysyl-tRNA synthetase 16020 -, 746197 6.1.1.16 cysteine-tRNA ligase membrane transmembrane segment analysis of lysyl-tRNA synthetase 16020 -, 746197 6.1.1.6 lysine-tRNA ligase membrane KRS is released fromMSC and translocates to the cell membrane, where it binds to p67LR 16020 744423 6.1.1.6 lysine-tRNA ligase membrane transmembrane segment analysis of lysyl-tRNA synthetase 16020 -, 746197 6.2.1.1 acetate-CoA ligase membrane constitutive membrane-associated (but not an integral) protein complex, localized at the outermost membrane 16020 -, 727756 6.2.1.1 acetate-CoA ligase membrane outermost membrane 16020 -, 727756 6.2.1.15 arachidonate-CoA ligase membrane - 16020 642, 645 6.2.1.20 long-chain-fatty-acid-[acyl-carrier-protein] ligase membrane - 16020 683, 684, 685 6.2.1.20 long-chain-fatty-acid-[acyl-carrier-protein] ligase membrane AasC is a peripheral membrane protein 16020 -, 745328 6.2.1.20 long-chain-fatty-acid-[acyl-carrier-protein] ligase membrane inner membrane 16020 657235 6.2.1.3 long-chain-fatty-acid-CoA ligase membrane - 16020 -, 671234, 671606, 672419, 674830, 728248 6.2.1.3 long-chain-fatty-acid-CoA ligase membrane mitochondria-associated membrane, ACS1, ACS4 16020 652139 6.2.1.3 long-chain-fatty-acid-CoA ligase membrane most highly active in light membrane fraction 16020 653493 6.2.1.4 succinate-CoA ligase (GDP-forming) membrane - 16020 687185 6.2.1.5 succinate-CoA ligase (ADP-forming) membrane - 16020 687185 6.3.1.12 D-aspartate ligase membrane - 16020 669171 6.3.1.12 D-aspartate ligase membrane attached to 16020 669172 6.3.1.2 glutamine synthetase membrane - 16020 656201 6.3.1.2 glutamine synthetase membrane 83% of total activity associated with cytoplasmic membrane, 20% of the enzyme exposed to the outer surface 16020 655892 6.3.2.2 glutamate-cysteine ligase membrane - 16020 694060 6.3.4.14 biotin carboxylase membrane might be associated with the membrane, BC of the undissociated complex acetyl-CoA carboxylase 16020 654339 6.4.1.2 acetyl-CoA carboxylase membrane - 16020 675028 6.4.1.2 acetyl-CoA carboxylase membrane of granular cytoplasmic reticulum 16020 37593 6.6.1.1 magnesium chelatase membrane - 16020 644254, 644269 7.1.1.1 proton-translocating NAD(P)+ transhydrogenase membrane - 16020 -, 392619, 392668, 657468, 657960, 658003, 658022, 658162, 658197, 658712, 659274, 659437, 659725, 660435, 672325, 673613, 674550, 675352, 687656, 689135, 698677, 733148, 733317, 733318, 733369, 733371, 733372, 733374, 733378, 733380, 733850, 742240, 743841, 764573, 765193 7.1.1.1 proton-translocating NAD(P)+ transhydrogenase membrane found almost exclusively in the thylakoid membrane fraction 16020 743367 7.1.1.1 proton-translocating NAD(P)+ transhydrogenase membrane the enzyme is composed of three components. The dI and dIII components, which house the binding site for NAD(H) and NADP(H), respectively, are peripheral to the membrane, and dII spans the membrane 16020 672325 7.1.1.10 ferredoxin---quinone oxidoreductase (H+-translocating) membrane the proton pumping subunits of NDH-1 are located in the membrane domain of the enzyme, and comprise subunits NdhA, NdhC, NdhE, NdhG, in addition to NdhB, NdhD1 (D2), and NdhF1 in the NDH-1L (NDH-1L') isoform 16020 760616 7.1.1.12 succinate dehydrogenase (electrogenic, proton-motive force generating) membrane - 16020 -, 763727, 764191, 764193 7.1.1.12 succinate dehydrogenase (electrogenic, proton-motive force generating) membrane membrane-bound 16020 -, 764131 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) membrane - 16020 -, 392678, 392681, 392706, 392717, 392718, 392725, 658700, 672043, 672403, 696387, 698670, 724310, 725142, 725443, 741830, 742028, 742759, 742879 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) membrane conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase 16020 696380 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) membrane electron microscopy reveals the two-part structure of the complex consisting of a peripheral and a membrane arm. The peripheral arm contains all known cofactors and the NADH-binding site, whereas the membrane arm has to be involved in proton translocation 16020 696147 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) membrane subunit NuoA topology modeling, overview 16020 725005 7.1.1.2 NADH:ubiquinone reductase (H+-translocating) membrane the membrane-bound respiratory enzymes differs from the canonical NADH: dehydrogenase (complex I), because it is not involved in the vectorial transfer of protons across membranes 16020 700003 7.1.1.3 ubiquinol oxidase (H+-transporting) membrane - 16020 -, 714129, 714130, 714131, 714135, 714285, 715458, 716311, 723938, 741957, 741989, 742510 7.1.1.3 ubiquinol oxidase (H+-transporting) membrane bound 16020 725289 7.1.1.4 caldariellaquinol oxidase (H+-transporting) membrane - 16020 -, 718705, 718959, 719784, 720484, 720951, 722598, 741970 7.1.1.4 caldariellaquinol oxidase (H+-transporting) membrane grown under aerobic conditions 16020 719514 7.1.1.5 menaquinol oxidase (H+-transporting) membrane - 16020 -, 713980, 714287, 715344, 715416, 747686 7.1.1.6 plastoquinol-plastocyanin reductase membrane - 16020 712236, 724409 7.1.1.6 plastoquinol-plastocyanin reductase membrane the cytochrome b6f complex is located in the appressed granal membranes and nonappressed stroma thylakoids 16020 712948 7.1.1.7 quinol oxidase (electrogenic, proton-motive force generating) membrane - 16020 743604, 752197 7.1.1.7 quinol oxidase (electrogenic, proton-motive force generating) membrane subnit cydA has nine transmembrane helices with the O2 reactive site near the periplasmic surface. Residue His19, the ligand to the high spin heme b595 component of the oxidase, is located near the periplasmic surface of the protein 16020 727505 7.1.1.8 quinol-cytochrome-c reductase membrane - 16020 -, 396001, 439946, 439952, 439954, 439956, 439966, 439967, 439969, 439974, 439995, 439998, 440003, 440004, 440005, 440007, 440015, 440019, 440021, 440022, 440023, 440024, 440030, 440036, 657683, 659238, 659673, 724452, 725396, 741983, 742085 7.1.1.8 quinol-cytochrome-c reductase membrane analysis of the localization and orientation of the enzyme complex in the membrane bilayer 16020 657945 7.1.1.8 quinol-cytochrome-c reductase membrane inner membrane 16020 439946 7.1.1.8 quinol-cytochrome-c reductase membrane integral 16020 658009, 658161 7.1.1.8 quinol-cytochrome-c reductase membrane integral multisubunit membrane protein 16020 440021 7.1.1.8 quinol-cytochrome-c reductase membrane membrane localization and organization of enzyme complex domains, overview 16020 725875 7.1.1.8 quinol-cytochrome-c reductase membrane membrane-bound 16020 -, 439999, 440023 7.1.1.8 quinol-cytochrome-c reductase membrane plasma membrane 16020 439995 7.1.1.9 cytochrome-c oxidase membrane - 16020 -, 396115, 396129, 396136, 690895, 691023, 691404, 692102, 725571, 741883, 741886, 742785, 755271 7.1.1.9 cytochrome-c oxidase membrane protoplast membrane vesicles 16020 396113 7.1.1.9 cytochrome-c oxidase membrane solubilized with Triton X-100 16020 -, 664918 7.1.1.9 cytochrome-c oxidase membrane the near N-terminus ca. 2/3 of the MCOX2e region contains an interspecifically variable number of predicted transmembrane helices 16020 691491 7.1.1.9 cytochrome-c oxidase membrane the near N-terminus ca.2/3 of the MCOX2e region contains an interspecifically variable number of predicted transmembrane helices 16020 691491 7.1.2.1 P-type H+-exporting transporter membrane - 16020 710718 7.1.2.1 P-type H+-exporting transporter membrane a-subunit 16020 720989 7.1.2.1 P-type H+-exporting transporter membrane goblet cell apical membrane 16020 721122 7.1.2.2 H+-transporting two-sector ATPase membrane - 16020 -, 210231, 210238, 210242, 210247, 210253, 669124, 672320, 672662, 680590, 680591, 685315, 695945, 696385, 696773, 698308, 698678, 700972, 711096, 711145, 711178, 711184, 711250, 711288, 711528, 711693, 712011, 712369, 712371, 712379, 712383, 712416, 713098, 718793, 718963, 749178 7.1.2.2 H+-transporting two-sector ATPase membrane bound 16020 685326 7.1.2.2 H+-transporting two-sector ATPase membrane exclusively internal location 16020 210238 7.1.2.2 H+-transporting two-sector ATPase membrane the transmembrane domain of subunit b of F1F0 ATP synthase is sufficient for H+-translocating activity together with subunits a and c 16020 655485 7.1.3.1 H+-exporting diphosphatase membrane - 16020 654880, 655751, 718788 7.1.3.1 H+-exporting diphosphatase membrane bound 16020 654878, 669165 7.1.3.1 H+-exporting diphosphatase membrane located within or near the membrane 16020 654844 7.1.3.1 H+-exporting diphosphatase membrane no plasma membane 16020 -, 669292 7.1.3.1 H+-exporting diphosphatase membrane type II 16020 -, 655882 7.1.3.1 H+-exporting diphosphatase membrane type II enzyme, proton translocating form 16020 655459 7.1.3.2 Na+-exporting diphosphatase membrane - 16020 -, 747060, 761174, 761446 7.2.1.1 NADH:ubiquinone reductase (Na+-transporting) membrane - 16020 -, 392695, 392716, 672135, 674274, 674705, 710746, 711991, 711992, 711994, 711996, 712274, 712407, 724251, 725402, 725433, 725538, 725539, 742842 7.2.1.1 NADH:ubiquinone reductase (Na+-transporting) membrane associated to 16020 392715 7.2.1.1 NADH:ubiquinone reductase (Na+-transporting) membrane bound to 16020 699385 7.2.1.1 NADH:ubiquinone reductase (Na+-transporting) membrane membrane-embedded 16020 725448 7.2.1.2 ferredoxin-NAD+ oxidoreductase (Na+-transporting) membrane - 16020 -, 733377, 733825, 741690, 745340, 760762, 760905 7.2.1.2 ferredoxin-NAD+ oxidoreductase (Na+-transporting) membrane bound to 16020 732808 7.2.1.2 ferredoxin-NAD+ oxidoreductase (Na+-transporting) membrane membrane-bound enzyme 16020 -, 733098 7.2.1.2 ferredoxin-NAD+ oxidoreductase (Na+-transporting) membrane recombinant subunit RnfG, the C-terminal domain containing FMN is located on the outer aspect of the cytoplasmic membrane 16020 -, 762254 7.2.1.2 ferredoxin-NAD+ oxidoreductase (Na+-transporting) membrane tightly bound membrane-bound enzyme 16020 733098 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane - 16020 389973, 750349 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane a transmembrane enzyme, CYB561 proteins have six trans-membrane helices and two b-type hemes, one on each side of the membrane 16020 744757 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane a transmembrane enzyme, in the vacuolar (tonoplast) membrane. CYB561 proteins have six trans-membrane helices and two b-type hemes, one on each side of the membrane, transmembrane orientation, modeling 16020 744757 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane a transmembrane enzyme, in the vacuolar (tonoplast) membrane. CYB561 proteins have six transmembrane helices and two b-type hemes, one on each side of the membrane, transmembrane orientation, modeling 16020 744757 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane a transmembrane enzyme, localization of both the N- and C-termini of CGCytb in the cytoplasm. Native CGCytb is a trans-membrane electron transferring protein that has 6 transmembrane domains with two pairs of His residues, arranged on four consecutive transmembrane domains (the CYB561-core), for coordinating two b-type hemes, one on each side of the membrane, transmembrane orientation, modeling 16020 744757 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane a transmembrane enzyme, localization of both the N- and C-termini of CGCytb in the cytoplasm. Native CGCytb is a transmembrane electron transferring protein that has 6 transmembrane domains with two pairs of His residues, arranged on four consecutive transmembrane domains (the CYB561-core), for coordinating two b-type hemes, one on each side of the membrane, transmembrane orientation, modeling 16020 744757 7.2.1.3 ascorbate ferrireductase (transmembrane) membrane trans-membrane protein 16020 715013 7.2.2.1 Na+-transporting two-sector ATPase membrane - 16020 210274, 210276, 210278, 684748, 722227, 730065, 747288 7.2.2.10 P-type Ca2+ transporter membrane - 16020 210473, 210480, 210486, 210487, 210491, 210497, 654747, 654846, 656229, 667604, 667825, 667995, 667996, 669345, 669646, 670493, 670669, 670677, 670757, 670793, 684657, 698885, 719980, 720644 7.2.2.10 P-type Ca2+ transporter membrane endomembrane 16020 720773 7.2.2.10 P-type Ca2+ transporter membrane in membranes isolated from sporulating bacteria but not from vegetative cells, the expression of enzyme is dependent on the sporulating time 16020 655189 7.2.2.10 P-type Ca2+ transporter membrane integral 16020 669559 7.2.2.10 P-type Ca2+ transporter membrane integral membrane protein 16020 210478 7.2.2.10 P-type Ca2+ transporter membrane isozymes SPCA1 and SPCA2 16020 669312 7.2.2.10 P-type Ca2+ transporter membrane methods using bile salt detergents to reconstitute the purified Ca-ATPase into a variety of phospholipid bilayers and compare their ATP hydrolytic and Ca2+ pumping properties in these phospholipid membranes 16020 210493 7.2.2.12 P-type Zn2+ transporter membrane - 16020 246928, 684877, 685144, 685173, 685314, 685477, 687525, 718990 7.2.2.13 Na+/K+-exchanging ATPase membrane - 16020 246948, 246949, 246962, 246967, 655252, 655745, 656225, 656894, 671274, 672637, 672864, 673231, 674599, 675592, 675717, 675719, 675880, 677134, 687510, 690001, 695469, 701165, 701433, 710718, 711156, 711636, 711638, 711650, 711774, 711941, 712134, 712377, 712538, 712794, 712805, 712817, 713004, 720204, 734421, 750308 7.2.2.13 Na+/K+-exchanging ATPase membrane components of the sodium pump are membrane intercalated and protrude from the membrane surface 16020 246970 7.2.2.13 Na+/K+-exchanging ATPase membrane enzyme is distributed in a polarized manner in a restricted domain of the plasma membrane and polarity depends on interactions between the beta-subunits of Na+/K+-ATPases located on neighboring cells. These beta-subunits have sufficient proximity and affinity to permit a direct interaction, without requiring any additional extracellular molecules to span the distance. The beta-beta interaction is species-specific 16020 720411 7.2.2.13 Na+/K+-exchanging ATPase membrane lateral and basal membrane of secretory cells 16020 720120 7.2.2.13 Na+/K+-exchanging ATPase membrane light caveolar membranes contain 30-40% of alpha1 subunits and 80-90% of beta1 subunits. Subunits are associated with caveolin oligomers 16020 684330 7.2.2.14 P-type Mg2+ transporter membrane - 16020 -, 686901, 687696, 696596, 697187, 698035, 699744, 700652, 750401 7.2.2.14 P-type Mg2+ transporter membrane basolateral localization of both endogenous and ectopically expressed transporter CNNM4. Single knockdown of my1B, a cargo-recognition subunit of AP-1B, does not affect basolateral localization, but simultaneous knockdown of the my1A subunit of AP-1A abrogates localization 16020 733276 7.2.2.14 P-type Mg2+ transporter membrane inner mitochondrial membrane 16020 -, 719452 7.2.2.14 P-type Mg2+ transporter membrane the CorA monomer has a C-terminal membrane domain containing two transmembrane segments 16020 686274 7.2.2.14 P-type Mg2+ transporter membrane the transmembrane helices are connected by 5 loops, structure, overview 16020 689150 7.2.2.16 ABC-type ferric hydroxamate transporter membrane - 16020 750741 7.2.2.17 ABC-type ferric enterobactin transporter membrane - 16020 749466, 751949 7.2.2.19 H+/K+-exchanging ATPase membrane - 16020 246851, 246853, 671212, 674353, 685080, 685328, 685549, 685586, 688059, 688697, 688799, 689063, 690064, 695477, 695503, 697414, 697487, 698979, 699742, 711245, 711398, 712894, 713552, 734279 7.2.2.19 H+/K+-exchanging ATPase membrane apical membrane 16020 700593 7.2.2.19 H+/K+-exchanging ATPase membrane apical membrane, cytoplasmic tubular membranes in the resting state 16020 700593 7.2.2.19 H+/K+-exchanging ATPase membrane bound 16020 246850 7.2.2.19 H+/K+-exchanging ATPase membrane gastric vesicles are prepared from mucosa in the fundic region of hog stomaches 16020 686551 7.2.2.19 H+/K+-exchanging ATPase membrane healthy prostate tissue displays a membrane-bound ATP12A staining with focal accumulated pattern, whereas in the benign prostate hyperplasia and cancerous prostate tissue (tumor grade I-III) the protein appears to be displaced in the luminal cells of the glandular epithelium 16020 719250 7.2.2.19 H+/K+-exchanging ATPase membrane luminal region 16020 671168 7.2.2.19 H+/K+-exchanging ATPase membrane membrane localization and topology model of HKalpha2, overview 16020 690064 7.2.2.2 ABC-type Cd2+ transporter membrane - 16020 700809 7.2.2.20 ABC-type Zn2+ transporter membrane - 16020 752919 7.2.2.21 Cd2+-exporting ATPase membrane G970R mutation affects correct trafficking of the protein 16020 687681 7.2.2.22 P-type Mn2+ transporter membrane - 16020 -, 761447 7.2.2.3 P-type Na+ transporter membrane - 16020 -, 655753, 686551, 711004, 711011, 711013, 711296, 711297, 713191, 718694, 720830, 748229 7.2.2.3 P-type Na+ transporter membrane proteoliposome 16020 719166 7.2.2.3 P-type Na+ transporter membrane sequence contains ten membrane-spanning segments 16020 667799 7.2.2.3 P-type Na+ transporter membrane transmembrane protein 16020 747716, 749270 7.2.2.4 ABC-type Na+ transporter membrane - 16020 -, 747725, 748509, 748675 7.2.2.5 ABC-type Mn2+ transporter membrane encoded by scaB, transmembrane 16020 210342 7.2.2.5 ABC-type Mn2+ transporter membrane MntB 16020 210346 7.2.2.5 ABC-type Mn2+ transporter membrane PsaC 16020 210343 7.2.2.6 P-type K+ transporter membrane - 16020 -, 696156 7.2.2.6 P-type K+ transporter membrane bound 16020 655413 7.2.2.6 P-type K+ transporter membrane intramembrane enzyme 16020 685229 7.2.2.7 ABC-type Fe3+ transporter membrane protein YbtP and protein YbtQ both contain an amino-terminal membrane-spanning domain and a carboxy-terminal ATPase 16020 210303 7.2.2.7 ABC-type Fe3+ transporter membrane the ABC transporter system includes a periplasmic binding protein, YfeA, an ATP-binding protein YfeB and two integral membrane proteins YfeC and YfeD 16020 210309 7.2.2.7 ABC-type Fe3+ transporter membrane the ferrisiderophore permease complex includes the periplasmic component CbrA, the integral membrane proteins CbrB and CbrC, and the ATP-binding unit CbrD 16020 -, 210305 7.2.2.8 P-type Cu+ transporter membrane - 16020 -, 722821, 725389, 725999, 733703, 734282 7.2.2.8 P-type Cu+ transporter membrane an integral membrane protein of cytoplasmic membranes 16020 -, 720396 7.2.2.8 P-type Cu+ transporter membrane inner membrane 16020 750917 7.2.2.8 P-type Cu+ transporter membrane integral membrane protein 16020 723738 7.2.2.9 P-type Cu2+ transporter membrane - 16020 684963, 685935, 688411, 689075, 689738, 695478, 696595, 697073, 699709, 699977, 701335, 713537 7.2.2.9 P-type Cu2+ transporter membrane 2 week old mice, vicinity of the basolateral membrane 16020 684373 7.2.2.9 P-type Cu2+ transporter membrane at or proximal to basolateral plasma membrane of midgut cells 16020 687122 7.2.2.9 P-type Cu2+ transporter membrane ATP7A protein levels are increased in brush-border and basolateral membrane vesicles isolated from iron-defiocient rats 16020 669393 7.2.2.9 P-type Cu2+ transporter membrane ATP7B is a 165-kDa protein with eight transmembrane segments and most of the soluble parts exposed to the cytosol 16020 712486 7.2.2.9 P-type Cu2+ transporter membrane ATP7B is a transmembrane protein 16020 698990 7.2.2.9 P-type Cu2+ transporter membrane basolateral membrane 16020 684963 7.2.2.9 P-type Cu2+ transporter membrane basolateral membrane of both the midgut and the Malpighian tubules. The enzyme translocates towards the basolateral membrane when exposed to elevated copper 16020 719036 7.2.2.9 P-type Cu2+ transporter membrane basolateral membrane of mammary epithelial cells in lactating mice 16020 684927 7.2.2.9 P-type Cu2+ transporter membrane integral membrane protein 16020 719771 7.2.2.9 P-type Cu2+ transporter membrane mainly located in the thylakoid membrane 16020 -, 246913 7.2.2.9 P-type Cu2+ transporter membrane targeting to plasma membrane shown, wild-type and recombinant protein 16020 685370 7.2.2.9 P-type Cu2+ transporter membrane the enzyme continuously recycles between the Golgi and the plasma membrane, and elevated copper shifts the steady-state distribution from the Golgi to the plasma membrane 16020 246912 7.2.2.9 P-type Cu2+ transporter membrane trafficking in polarized cells 16020 684720 7.2.2.9 P-type Cu2+ transporter membrane trafficking in polarized cells summarized 16020 684720 7.2.4.1 carboxybiotin decarboxylase membrane - 16020 686491 7.2.4.1 carboxybiotin decarboxylase membrane membrane-bound beta-subunit of the oxaloacetate decarboxylase Na+ pump is responsible for the decarboxylation of carboxybiotin and the coupled translocation of Na+ ions across the membrane 16020 686379 7.2.4.2 oxaloacetate decarboxylase (Na+ extruding) membrane - 16020 4259, 4260, 4261, 4264, 4265, 4266, 4267 7.2.4.2 oxaloacetate decarboxylase (Na+ extruding) membrane alpha-subunit is peripheral membrane protein, beta- and gamma-subunits are integral membrane proteins, spatial model 16020 4262 7.2.4.2 oxaloacetate decarboxylase (Na+ extruding) membrane beta and gamma subunits are integral membrane proteins, alpha subunit is attached to the gamma subunit 16020 649873, 649957, 649974, 650112 7.2.4.2 oxaloacetate decarboxylase (Na+ extruding) membrane reconstituted gamma-alpha-subunits or whole enzyme expressed in Escherichia coli 16020 4277 7.2.4.4 biotin-dependent malonate decarboxylase membrane enzyme system involving cytoplasmic and membrane components 16020 684744 7.2.4.5 glutaconyl-CoA decarboxylase membrane - 16020 -, 648354, 648355, 648358, 704548, 749751 7.2.4.5 glutaconyl-CoA decarboxylase membrane can be solubilized by 1% Trition X-100 16020 648362 7.2.4.5 glutaconyl-CoA decarboxylase membrane integral membrane protein 16020 648353 7.3.2.1 ABC-type phosphate transporter membrane - 16020 -, 667808, 668871, 669115, 669126, 670171, 670315, 686123, 689460, 720750 7.3.2.1 ABC-type phosphate transporter membrane apical membrane of proximal renal tubule, PiT-2 16020 668871 7.3.2.1 ABC-type phosphate transporter membrane pstC gene encodes an integral membrane protein, pstC gene encodes a peripheral membrane protein, which carries a putative nucleotide-binding site 16020 289157 7.3.2.3 ABC-type sulfate transporter membrane ATP-binding protein, associated to 16020 441607 7.3.2.4 ABC-type nitrate transporter membrane - 16020 684546, 687506, 711822, 734778 7.3.2.4 ABC-type nitrate transporter membrane accumulation of enzyme upon acid load or medium acidification 16020 689466 7.3.2.4 ABC-type nitrate transporter membrane part of a mobilizable respiratory island for nitrate respiration 16020 667562 7.3.2.4 ABC-type nitrate transporter membrane predominant localization 16020 689640 7.3.2.5 ABC-type molybdate transporter membrane - 16020 -, 210298, 734000, 734219, 734261, 751611 7.3.2.5 ABC-type molybdate transporter membrane ModB and ModC, ModB possesses six transmembrane domains 16020 719038 7.3.2.5 ABC-type molybdate transporter membrane ModB is a integral membrane, channel-forming protein 16020 210299, 210300 7.3.2.5 ABC-type molybdate transporter membrane ModB possesses six transmembrane domains 16020 719038 7.3.2.5 ABC-type molybdate transporter membrane ModB protein 16020 210298, 658591 7.3.2.5 ABC-type molybdate transporter membrane transmembrane domain structure, overview 16020 701226 7.3.2.6 ABC-type tungstate transporter membrane - 16020 -, 734000 7.3.2.7 arsenite-transporting ATPase membrane - 16020 696278, 699223, 715567 7.3.2.7 arsenite-transporting ATPase membrane ArsA protein is an extrinsic membrane protein, ArsB protein is an integral membrane protein 16020 210288 7.4.2.1 ABC-type polar-amino-acid transporter membrane - 16020 689051, 707658, 718559, 747169, 747962, 748336, 748922 7.4.2.1 ABC-type polar-amino-acid transporter membrane bound to 16020 246886, 246889, 246891 7.4.2.1 ABC-type polar-amino-acid transporter membrane mainly to a membrane-bound structure or invagination close to the kinetoplast, the latter corresponding to the flagellar pocket or associated structures, such as the cytostome or contractile vacuole 16020 718559 7.4.2.1 ABC-type polar-amino-acid transporter membrane the membrane-bound complex of the periplasmic histidine permease is composed of two integral membrane proteins, HisQ and HisM, and two copies of the ATP-binding subunit HisP 16020 246885 7.4.2.10 ABC-type glutathione transporter membrane - 16020 749485 7.4.2.10 ABC-type glutathione transporter membrane integral membrane protein 16020 749944 7.4.2.11 ABC-type methionine transporter membrane - 16020 750945, 751059, 752055 7.4.2.12 ABC-type cystine transporter membrane - 16020 -, 751594, 751917 7.4.2.13 ABC-type tyrosine transporter membrane integral membrane protein 16020 -, 750654 7.4.2.14 ABC-type antigen peptide transporter membrane 10 transmembrane (TM) helices for TAP1 and predicted 9-10 TMs for TAP2, membrane topology of TAP, overview 16020 760660 7.4.2.14 ABC-type antigen peptide transporter membrane 10 transmembrane helices for TAP1 and predicted 9-10 TMs for TAP2, membrane topology of TAP, overview 16020 760660 7.4.2.2 ABC-type nonpolar-amino-acid transporter membrane - 16020 689051, 747176 7.4.2.3 mitochondrial protein-transporting ATPase membrane matrix 16020 671931, 672993 7.4.2.5 bacterial ABC-type protein transporter membrane - 16020 -, 670687, 687663, 688391, 695878, 696550, 698596, 698615, 698635, 699554, 700101, 710640, 720060, 733679, 733710, 734330 7.4.2.5 bacterial ABC-type protein transporter membrane HylB C-terminal residues located in the cytoplasm 16020 210376 7.4.2.5 bacterial ABC-type protein transporter membrane inner membrane 16020 720044 7.4.2.5 bacterial ABC-type protein transporter membrane inner membrane detected by immunoblotting, ExeA, cytoplasmic domain with ATP-binding site 16020 210378 7.4.2.5 bacterial ABC-type protein transporter membrane LcnC, N- and C-terminal parts located in the cytoplasm 16020 210371 7.4.2.5 bacterial ABC-type protein transporter membrane LctE and LctG transmembrane domains, Lctf ATP-binding domain 16020 210374 7.4.2.5 bacterial ABC-type protein transporter membrane SpaF, ATP-binding protein, membrane spanning domain located at C-terminus 16020 210370 7.4.2.5 bacterial ABC-type protein transporter membrane TAP1 and TAP2, hydrophobic N-terminus, C-terminal ABC domain 16020 210372 7.4.2.6 ABC-type oligopeptide transporter membrane - 16020 669083, 685829 7.4.2.6 ABC-type oligopeptide transporter membrane associated 16020 668920, 686956 7.4.2.6 ABC-type oligopeptide transporter membrane enzymes form membrane-spanning tunnels 16020 669847 7.4.2.6 ABC-type oligopeptide transporter membrane OppB and OppC are highly hydrophobic, integral membrane proteins. Each of these two proteins spans the membrane six times, with the N-terminus and the C-terminus both being located at the cytoplasmic face of the membrane 16020 246897 7.4.2.6 ABC-type oligopeptide transporter membrane OppB, OppC and OppD are membrane-associated proteins 16020 246895 7.4.2.6 ABC-type oligopeptide transporter membrane OppF, a component of the oligopeptide permease is a peripheral membrane protein located on the cytoplasmic side of the inner membrane 16020 246894 7.4.2.6 ABC-type oligopeptide transporter membrane the extracytoplasmic lipid-anchored substrate-binding protein, or receptor, OppA delivers peptides to an integral membrane complex OppBCDF, or translocator, where, on ATP binding and hydrolysis, translocation across the membrane takes place 16020 685623 7.4.2.7 ABC-type alpha-factor-pheromone transporter membrane - 16020 210419, 686462 7.4.2.7 ABC-type alpha-factor-pheromone transporter membrane integral membrane protein, at least a portion of the enzyme is exposed at the exocellular surface 16020 210417 7.4.2.7 ABC-type alpha-factor-pheromone transporter membrane newly synthesized enzyme first travels to the cell surface via the secretory pathway, endoplasmic reticulum, Golgi, secretory vesicles, resides in the plasma membrane transiently and subsequently undergoes endocytosis and degradation in the vacuole 16020 210413 7.4.2.7 ABC-type alpha-factor-pheromone transporter membrane ubiquitinated Ste6 is associated with. Ubiquitination of Ste6 or of a trafficing factor is required for Ste6 sorting into the multivesivular bodies pathway. Ste6 recycles between an internal compartment and the plasma membrane 16020 656755 7.4.2.8 protein-secreting ATPase membrane - 16020 -, 697956, 749849, 750966, 751074, 752130 7.4.2.8 protein-secreting ATPase membrane a peripheral membrane protein located at the cytoplasmic side 16020 733630 7.4.2.8 protein-secreting ATPase membrane associated 16020 698778 7.4.2.8 protein-secreting ATPase membrane EscC, outer membrane, EscV, inner membrane fraction, EscN, inner membrane fraction 16020 655719 7.4.2.8 protein-secreting ATPase membrane inner membrane 16020 670323 7.4.2.8 protein-secreting ATPase membrane membrane-bound 16020 687415 7.4.2.8 protein-secreting ATPase membrane peripheral membrane protein, associates with inner membrane 16020 656142 7.4.2.8 protein-secreting ATPase membrane peripherically associated to 16020 655875 7.4.2.8 protein-secreting ATPase membrane SsaN and its complex colocalize to the membrane fraction under type III secretion system T3SS-2 inducing conditions, SsaN, SsaK, and SsaQ co-localize to bacterial membranes after T3SS activation 16020 -, 735141 7.4.2.8 protein-secreting ATPase membrane stability of HrcN in depends on the conserved HrcL protein, which interacts with HrcN in vitro and in vivo, both HrcN and HrcL bind to the inner membrane protein HrcU and specifically localize to the bacterial membranes under T3S-permissive conditions, overview 16020 698605 7.4.2.8 protein-secreting ATPase membrane the T2S ATPase cycles between a cytoplasmic and a membrane-associated state in a secretion-related manner, T2S ATPase may directly associate with the membrane 16020 735088 7.4.2.9 ABC-type dipeptide transporter membrane - 16020 752025 7.5.2.1 ABC-type maltose transporter membrane - 16020 -, 654879, 655437, 698632, 713028, 713059, 718597, 719904, 749274 7.5.2.1 ABC-type maltose transporter membrane associated 16020 656223 7.5.2.1 ABC-type maltose transporter membrane extracytoplasmic anchoring of the substrate binding protein 16020 698908 7.5.2.1 ABC-type maltose transporter membrane transmembrane protein complex 16020 721055 7.5.2.10 ABC-type D-xylose transporter membrane - 16020 -, 750370, 751468, 751596 7.5.2.11 ABC-type D-galactose transporter membrane - 16020 750461 7.5.2.13 ABC-type D-xylose/L-arabinose transporter membrane - 16020 -, 746846 7.5.2.3 ABC-type beta-glucan transporter membrane contains two transmembrane domains 16020 751123 7.5.2.5 ABC-type lipopolysaccharide transporter membrane - 16020 735227 7.5.2.6 ABC-type lipid A-core oligosaccharide transporter membrane - 16020 687605, 696114, 734250, 735225, 749842 7.5.2.6 ABC-type lipid A-core oligosaccharide transporter membrane orientation to the periplasmic side 16020 696222 7.5.2.7 ABC-type D-ribose transporter membrane - 16020 751054 7.5.2.7 ABC-type D-ribose transporter membrane RbsC is a membrane component of the ribose transporter, the protein transverses the membrane six times. The N and C termini are exposed to the cytoplasm 16020 289123 7.5.2.B7 ABC-type nodulation factor transporter membrane integral, NodJ 16020 210364, 210365 7.5.2.B7 ABC-type nodulation factor transporter membrane peripheral, ATP-binding protein, NodI 16020 210364, 210365 7.5.2.B8 ABC-type D-glucose transporter membrane bound to 16020 720226 7.6.2.1 P-type phospholipid transporter membrane - 16020 655136, 686022, 688907, 697213, 697594, 711144, 711622, 712395 7.6.2.1 P-type phospholipid transporter membrane endomembrane localization of class 2 and 6 P4-ATPases, overview. ATP9A is localized to the early/recycling endosomes but not late endosomes and to the trans-Golgi network rather than the cis-Golgi. Unlike ATP9A, ATP9B is localized exclusively to the perinuclear region but not on EEA1-positive early endosomes 16020 719979 7.6.2.1 P-type phospholipid transporter membrane of rod outer segment 16020 668454 7.6.2.1 P-type phospholipid transporter membrane trans-Golgi network membranes 16020 700100 7.6.2.1 P-type phospholipid transporter membrane transmembrane protein 16020 684674 7.6.2.10 ABC-type glycerol 3-phosphate transporter membrane probable an integral membrane protein 16020 -, 644088 7.6.2.10 ABC-type glycerol 3-phosphate transporter membrane the enzyme contains 12-transmembrane alpha-helical topologies with two six-helix halves connected by a long loop 16020 698679 7.6.2.10 ABC-type glycerol 3-phosphate transporter membrane the enzyme contains 12-transmembrane alpha-helices which form two domains, each of six transmembrane helices, surrounding a central lingand-binding cavity 16020 700251 7.6.2.11 ABC-type polyamine transporter membrane - 16020 -, 751493, 751585 7.6.2.11 ABC-type polyamine transporter membrane PotB and PotC contain six putative transmembrane segments linked by hydrophobic segments of variable length 16020 210316 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane integral, KpsM and KpsT 16020 210356 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane integral, VexB 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane intergral, BexB 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane intergral, CtrC 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane intergral, KpsM 16020 210355, 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane KpsT also appears in the outer membrane, detected by immunoblotting 16020 210358 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane KpsT, ATP-binding component 16020 210356, 210357, 210358, 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane membrane spanning, RfbA, as concluded from nucleotide sequence 16020 210359 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane peripheral inner membrane protein KpsT detected by immunoblotting 16020 210358 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane peripheral, ATP-binding protein BexA 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane peripheral, ATP-binding protein, CtrD 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane peripheral, ATP-binding protein, VexC 16020 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane peripheral, KpsT 16020 210357, 210358, 210363 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane Wzm, integral 16020 210362 7.6.2.12 ABC-type capsular-polysaccharide transporter membrane Wzt, peripheral 16020 210362 7.6.2.13 ABC-type autoinducer-2 transporter membrane - 16020 -, 751590 7.6.2.16 ABC-type putrescine transporter membrane - 16020 -, 754044 7.6.2.2 ABC-type xenobiotic transporter membrane - 16020 -, 210383, 210384, 210385, 210386, 210387, 210388, 657552, 659277, 659373, 660546, 684938, 687189, 696129, 696248, 696343, 696432, 696714, 697106, 697110, 697202, 697583, 697585, 697586, 697587, 697712, 697760, 697766, 699450, 699752, 700297, 700300, 701069, 701356, 701435, 733305, 733332, 733756, 734280, 734772, 734833, 735307, 747044 7.6.2.2 ABC-type xenobiotic transporter membrane a transmembrane enzyme with 12 transmembrane segments 16020 755956 7.6.2.2 ABC-type xenobiotic transporter membrane a transmembrane protein 16020 697006 7.6.2.2 ABC-type xenobiotic transporter membrane canalicular membrane 16020 210396 7.6.2.2 ABC-type xenobiotic transporter membrane contains an additional third NH2-proximal membrane-spanning domain, not found in previously characterized ABC transporters. This domain, whose NH2-terminus is extracytolsolic, is essential for MRP-mediated transport activity 16020 210383 7.6.2.2 ABC-type xenobiotic transporter membrane hepatocanalicular membrane 16020 210385 7.6.2.2 ABC-type xenobiotic transporter membrane lateral and canalicular plasma membrane 16020 -, 210393 7.6.2.2 ABC-type xenobiotic transporter membrane MRP1 possesses three transmembrane domains, TMD0, TMD1, and TMD2 16020 698233 7.6.2.2 ABC-type xenobiotic transporter membrane MRP4 shows a dual membrane localisation in polarised cell types 16020 701356 7.6.2.2 ABC-type xenobiotic transporter membrane P-gp possesses a linker region of about 75 amino acids that connects two homologous halves, each of which contain a transmembrane domain followed by a nucleotide-binding domain 16020 711970 7.6.2.2 ABC-type xenobiotic transporter membrane recombinant YvcC is highly enriched in membrane vesicles and embedded in the membrane in a fully functional conformation 16020 658168 7.6.2.2 ABC-type xenobiotic transporter membrane the enzyme is a transmembrane protein 16020 210395 7.6.2.2 ABC-type xenobiotic transporter membrane the homodimeric protein consists of 12 transmembrane helices, and integral membrane protein 16020 -, 751692 7.6.2.2 ABC-type xenobiotic transporter membrane transmembrane protein 16020 210399, 210400, 696431 7.6.2.3 ABC-type glutathione-S-conjugate transporter membrane - 16020 748156, 748166 7.6.2.5 ABC-type heme transporter membrane - 16020 289160, 289166 7.6.2.5 ABC-type heme transporter membrane CcsA protein has six transmembrane regions with many conserved residues in both cytoplasmic and periplasmic domains 16020 289160 7.6.2.7 ABC-type taurine transporter membrane TauB, membrane bound, cytoplasmatic side 16020 210348 7.6.2.7 ABC-type taurine transporter membrane TauC, integral 16020 210348 7.6.2.8 ABC-type vitamin B12 transporter membrane - 16020 734003, 734820, 751661, 752215 7.6.2.8 ABC-type vitamin B12 transporter membrane integral membrane enzyme 16020 -, 750412 7.6.2.8 ABC-type vitamin B12 transporter membrane periplasmic and cytosolic orientation 16020 697950 7.6.2.8 ABC-type vitamin B12 transporter membrane periplasmic orientation 16020 696776 7.6.2.8 ABC-type vitamin B12 transporter membrane transmembrane enzyme 16020 -, 749978 7.6.2.9 ABC-type quaternary amine transporter membrane - 16020 -, 210323, 655328, 655339, 656531, 656670, 656842, 673631, 674658, 675375, 734090, 734234, 751296, 751583 7.6.2.9 ABC-type quaternary amine transporter membrane the amphipathic alpha-helix fused to the core of the transmembrane domain of the OpuABC subunit is located close to the membrane surface, where its hydrophobic face interacts with the transport protein rather than the membrane lipids. The amphipathic alpha-helix of OpuA is necessary for high activity of OpuA but is not critical for the biogenesis of the protein or the ionic regulation of transport 16020 718937 7.6.2.9 ABC-type quaternary amine transporter membrane the solute ABC transporter has a substrate-binding protein fused to the transmembrane domain 16020 749673 7.6.2.9 ABC-type quaternary amine transporter membrane transmembrane domain 16020 675495 7.6.2.9 ABC-type quaternary amine transporter membrane transmembrane domain fused to the substrate-binding domain 16020 675495