1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) cell surface - 9986 -, 668301, 690185, 697997 1.1.3.B4 glycerol oxidase cell surface - 9986 -, 738126 1.11.1.5 cytochrome-c peroxidase cell surface noncovalent association with cell surface, exposed to cell exterior 9986 673536 1.11.1.6 catalase cell surface high level of H2O2 tolerance of strain S-1T even in presence of 100 mM H2O2 is attributable to its cell surface catalase activity 9986 687862 1.14.11.4 procollagen-lysine 5-dioxygenase cell surface - 9986 745323 1.14.11.4 procollagen-lysine 5-dioxygenase cell surface LH3 found on the cell surface bypasses the Golgi complex 9986 722865 1.14.18.2 CMP-N-acetylneuraminate monooxygenase cell surface - 9986 745641, 746215 1.15.1.1 superoxide dismutase cell surface of tachyzoites 9986 659780 1.17.3.2 xanthine oxidase cell surface co-localization of the enzyme with Toll-like receptor-4 on the cell surface membrane, inhibited by heparin 9986 684329 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) cell surface - 9986 655720, 673986, 724415 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) cell surface GAPDH attaches to the cell wall at pH 5 but is released to the medium at pH 8 9986 -, 687380 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) cell surface in complex with the streptococcal plasmin receptor, Plr, and streptococcal surface dehydrogenase, SDH 9986 674559 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) cell surface - 9986 -, 724415 1.23.1.1 (+)-pinoresinol reductase cell surface - 9986 746162 1.23.1.2 (+)-lariciresinol reductase cell surface - 9986 746162 1.3.1.72 DELTA24-sterol reductase cell surface hepatocellular carcinoma cells, hepatoblastoma cell line, and cervical adenocarcinoma-derived cell line 9986 746181 1.4.3.21 primary-amine oxidase cell surface - 9986 703130 1.4.3.21 primary-amine oxidase cell surface of adipocytes 9986 705350 1.5.1.30 flavin reductase (NADPH) cell surface - 9986 765814 2.2.1.2 transaldolase cell surface - 9986 -, 718647 2.3.1.177 3,5-dihydroxybiphenyl synthase cell surface detection of enzyme in discrete globules and at the surface of cells treated with an suspension of Erwinia amylovora 9986 735410 2.3.1.26 sterol O-acyltransferase cell surface approximately 10-15% of the enzyme in freshly harvested, non-attached macrophages is exposed to the extracellular space 9986 486705 2.3.2.13 protein-glutamine gamma-glutamyltransferase cell surface - 9986 675883, 703983, 759712 2.3.2.2 gamma-glutamyltransferase cell surface - 9986 736144, 736220, 755785, 757548 2.3.2.2 gamma-glutamyltransferase cell surface the enzyme is a lipoprotein and is attached to the outer side of the cytoplasmic membrane 9986 -, 757270 2.3.2.3 lysyltransferase cell surface - 9986 757555 2.3.2.5 glutaminyl-peptide cyclotransferase cell surface - 9986 759031, 759839 2.4.1.129 peptidoglycan glycosyltransferase cell surface - 9986 -, 735922 2.4.1.16 chitin synthase cell surface - 9986 -, 673759, 686465 2.4.1.212 hyaluronan synthase cell surface - 9986 736064 2.4.1.221 peptide-O-fucosyltransferase cell surface cell surface accumulation of Notch in ofut1 mutant cells 9986 704718 2.4.1.221 peptide-O-fucosyltransferase cell surface OFUT1 associates with Notch at the cell surface and promotes the constitutive endocytosis of Notch receptors 9986 704343 2.4.1.221 peptide-O-fucosyltransferase cell surface OFUT1 may be a chaperone of Notch that is necessary for retaining Notch at the cell surface once it has traversed the secretory pathway 9986 703986 2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase cell surface - 9986 703661 2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase cell surface - 9986 690230, 690409, 693025, 695221 2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase cell surface - 9986 657750, 675952 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase cell surface fusion proteins PIR1-HA-FUT6 and PIR2-FLAG-FUT6 9986 661803 2.4.1.66 procollagen glucosyltransferase cell surface - 9986 722865 2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase cell surface Fut8 partially localizes to the cell surface in an SH3-dependent manner 9986 757242 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase cell surface ART2 is attached to the cell surface by a glycosylphosphatidylinositol anchor in T-cells 9986 669719, 675027 2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase cell surface on epithelial cells lining human airways and cells, isozyme ART1 9986 674578 2.4.2.8 hypoxanthine phosphoribosyltransferase cell surface - 9986 759769 2.7.10.1 receptor protein-tyrosine kinase cell surface - 9986 692658, 693754 2.7.10.1 receptor protein-tyrosine kinase cell surface cell surface expression of ROR1 is uniform and constitutive, i.e., independent of anatomic niches, independent of biological and clinical heterogeneity of B-CLL, independent of B-cell activation, and at similar levels in all B-CLL samples tested 9986 691857 2.7.10.1 receptor protein-tyrosine kinase cell surface nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway 9986 693727 2.7.10.1 receptor protein-tyrosine kinase cell surface wild-type FLT3 receptor protein 9986 691724 2.7.2.3 phosphoglycerate kinase cell surface - 9986 -, 738273 2.8.2.11 galactosylceramide sulfotransferase cell surface minor part of recombinantly expressed enzyme 9986 672276 2.8.2.11 galactosylceramide sulfotransferase cell surface only a minor fraction of the enzyme 9986 672276 2.8.2.33 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cell surface the enzyme is principally Golgi associated, a small portion of the enzyme is located at the cell surface 9986 690891 3.1.1.3 triacylglycerol lipase cell surface - 9986 707500 3.1.1.3 triacylglycerol lipase cell surface bound 9986 709777 3.1.1.3 triacylglycerol lipase cell surface the cells show a fuzzy surface layer of recombinant surface-associated protein 9986 665175 3.1.1.34 lipoprotein lipase cell surface - 9986 690344 3.1.1.34 lipoprotein lipase cell surface bound 9986 -, 709009 3.1.1.5 lysophospholipase cell surface - 9986 729938 3.1.1.53 sialate O-acetylesterase cell surface isoform Lse, secreted from post-Golgi vesicle, limited lysosomal localisation 9986 699276 3.1.1.7 acetylcholinesterase cell surface - 9986 114162 3.1.1.7 acetylcholinesterase cell surface isoform AChE1 possesses glycosylphosphatidylinositol membrane anchors and are transported to the cell surface 9986 715174 3.1.1.7 acetylcholinesterase cell surface isoform AChE2 possesses glycosylphosphatidylinositol membrane anchors and is transported to the cell surface 9986 715174 3.1.13.1 exoribonuclease II cell surface RNase II is organized into cellular structures that appear to coil around the Escherichia coli cell periphery. The ability of RNase II to maintain cell viability in the absence of exoribonuclease polynucleotide phosphorylase is markedly diminished when the RNase II cellular structures are lost due to changes in the amphipathicity of the amino-terminal helix 9986 730030 3.1.2.20 acyl-CoA hydrolase cell surface exclusively associated with 9986 679739 3.1.3.1 alkaline phosphatase cell surface - 9986 729703, 730400 3.1.3.2 acid phosphatase cell surface - 9986 134709 3.1.3.26 4-phytase cell surface - 9986 -, 751972 3.1.3.48 protein-tyrosine-phosphatase cell surface receptor protein tyrosine phosphatases (PTPRs) are a family of cell surface receptor proteins 9986 749850 3.1.3.5 5'-nucleotidase cell surface - 9986 714927, 749534, 751905 3.1.3.5 5'-nucleotidase cell surface CD73 9986 716355 3.1.3.5 5'-nucleotidase cell surface plasma membrane-bound ecto-enzyme activity 9986 716985 3.1.3.6 3'-nucleotidase cell surface the 3'-nucleotidase activity is exclusively located on the Leishmania amazonensis external surface 9986 714930 3.1.3.60 phosphoenolpyruvate phosphatase cell surface - 9986 134800 3.1.3.8 3-phytase cell surface recombinant protein, localization to cell suface of Pichia pastoris with a glycosylphosphatidylinositiol anchoring system 9986 708522 3.1.31.1 micrococcal nuclease cell surface bound 9986 -, 135029 3.1.4.11 phosphoinositide phospholipase C cell surface isoform PLC2 9986 749956 3.1.4.12 sphingomyelin phosphodiesterase cell surface - 9986 751069 3.1.4.12 sphingomyelin phosphodiesterase cell surface neutral sphingomyelinase is concentrated at the endothelial cell surface in caveolae 9986 663586 3.1.4.4 phospholipase D cell surface expression of GFP-tagged PLD1 in COS-1 cells that are stimulated with mastoparan after cultivation in 20 micromol linoleic or linolenic acid for 4 days demonstrate that PLD1 dramatically alters its cellular distribution and is redistributed from intracellular vesicles to the cell surface 9986 691157 3.1.6.1 arylsulfatase (type I) cell surface - 9986 709806 3.1.6.8 cerebroside-sulfatase cell surface a large portion of the mammalian arylsulfatase A protein exists on the cell surface of vascular endothelial cells 9986 714779 3.2.1.14 chitinase cell surface - 9986 656704, 729441 3.2.1.166 heparanase cell surface - 9986 731867, 732546 3.2.1.166 heparanase cell surface HPSE can be trafficked to the cell surface or released into the extracellular matrix in order to effect breakdown of extracellular pools of heparan sulfate 9986 754873 3.2.1.166 heparanase cell surface the signal peptide sequence accounts for the chicken heparanase being readily secreted and localized in close proximity to the cell surface 9986 692954 3.2.1.18 exo-alpha-sialidase cell surface - 9986 -, 704674, 730414, 730792 3.2.1.21 beta-glucosidase cell surface - 9986 745701 3.2.1.22 alpha-galactosidase cell surface - 9986 739362 3.2.1.23 beta-galactosidase cell surface - 9986 698611 3.2.1.28 alpha,alpha-trehalase cell surface acid trehalase 9986 665006 3.2.1.28 alpha,alpha-trehalase cell surface apical, anchored by a glycosylphosphatidylinositol-anchor, isozyme type 2 9986 665197 3.2.1.28 alpha,alpha-trehalase cell surface Ath1 9986 708486 3.2.1.28 alpha,alpha-trehalase cell surface tightly packed 9986 664996 3.2.1.3 glucan 1,4-alpha-glucosidase cell surface the extracellular enzyme is attached to the cell wall 9986 682605 3.2.1.35 hyaluronoglucosaminidase cell surface Hyal2 is partly expressed at the cell surface 9986 704586 3.2.1.39 glucan endo-1,3-beta-D-glucosidase cell surface - 9986 -, 656726 3.2.1.4 cellulase cell surface - 9986 -, 654995 3.2.1.45 glucosylceramidase cell surface - 9986 680761 3.2.1.68 isoamylase cell surface TreX may be located at the cell surface due to the proline-rich region 9986 -, 717269 3.2.1.75 glucan endo-1,6-beta-glucosidase cell surface - 9986 -, 751089 3.2.1.8 endo-1,4-beta-xylanase cell surface Xyn5, binds to the cell surface via the SLH domain 9986 708936 3.2.1.97 endo-alpha-N-acetylgalactosaminidase cell surface - 9986 -, 665768 3.2.2.16 methylthioadenosine nucleosidase cell surface Bgp protein 9986 698517 3.2.2.5 NAD+ glycohydrolase cell surface - 9986 668457 3.2.2.5 NAD+ glycohydrolase cell surface NADase is a glycosylated, glycosylphosphatidylinositol-anchored cell surface protein 9986 -, 732135 3.2.2.9 adenosylhomocysteine nucleosidase cell surface Bgp protein 9986 698517 3.4.11.16 Xaa-Trp aminopeptidase cell surface cells expressing the enzyme intracellularly do not necessarily express it at the surface 9986 643873 3.4.11.2 membrane alanyl aminopeptidase cell surface - 9986 663873, 664466, 665146, 665231, 665710, 665955, 665958, 666240, 666997, 666998, 707961, 707970 3.4.11.2 membrane alanyl aminopeptidase cell surface CD13 9986 665112 3.4.11.2 membrane alanyl aminopeptidase cell surface ectoenzyme 9986 664688, 666148 3.4.11.2 membrane alanyl aminopeptidase cell surface ectoenzyme, the enzyme has an N-terminal membrane anchor 9986 663607 3.4.11.2 membrane alanyl aminopeptidase cell surface ectopeptidase 9986 663842 3.4.11.2 membrane alanyl aminopeptidase cell surface wild-type mature enzyme 9986 665708 3.4.11.3 cystinyl aminopeptidase cell surface the enzyme translocates to the cell surface within GLUT4 vesicles in response to insulin 9986 668760 3.4.11.3 cystinyl aminopeptidase cell surface TUG regulates IRAP cell surface targeting in 3T3-L1 adipocytes 9986 -, 754109 3.4.11.7 glutamyl aminopeptidase cell surface enzyme resides in the cytosol, but a subset of molecules are both bound to and secreted from the cell surface 9986 -, 732596 3.4.11.7 glutamyl aminopeptidase cell surface of COS cells, wild-type enzyme and mutant enzyme C43S 9986 654495 3.4.14.12 Xaa-Xaa-Pro tripeptidyl-peptidase cell surface - 9986 647188 3.4.14.5 dipeptidyl-peptidase IV cell surface - 9986 679975, 703039, 703300, 703678, 704968 3.4.15.1 peptidyl-dipeptidase A cell surface - 9986 667172 3.4.15.1 peptidyl-dipeptidase A cell surface both isoforms are shed from the cell surface via a sheddase-mediated cleavage, testis ACE is shed much more efficiently than somatic ACE 9986 678511 3.4.15.1 peptidyl-dipeptidase A cell surface membrane-bound on the surface of epithelial cells of epididymis and prostate 9986 755108 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase cell surface PBP3 is evenly distributed on both hemispheres but absent at the equator, the site of future division 9986 670303 3.4.16.5 carboxypeptidase C cell surface - 9986 702764 3.4.17.12 carboxypeptidase M cell surface - 9986 668817, 669830, 670291 3.4.17.21 Glutamate carboxypeptidase II cell surface - 9986 668154, 669506, 708256 3.4.17.21 Glutamate carboxypeptidase II cell surface of glia and nonmyelinating Schwann cells 9986 707124 3.4.17.21 Glutamate carboxypeptidase II cell surface PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer 9986 709648 3.4.17.23 angiotensin-converting enzyme 2 cell surface - 9986 707074 3.4.17.23 angiotensin-converting enzyme 2 cell surface cell-surface non-raft protein with the extracellular N-terminal and intracellular C-terminal domains. Binding to SARS-CoV-2 protein S induces the ACE2 internalization 9986 762787 3.4.18.1 cathepsin X cell surface - 9986 679023 3.4.18.1 cathepsin X cell surface cathepsin X is localized on the cell surface of primary osteoblasts 9986 708633 3.4.19.13 glutathione gamma-glutamate hydrolase cell surface - 9986 754112 3.4.21.105 rhomboid protease cell surface PbROM1 localizes to the surface of sporozoites after salivary gland invasion 9986 710398 3.4.21.105 rhomboid protease cell surface TgROM4 is localized to the cell surface 9986 -, 660387 3.4.21.105 rhomboid protease cell surface TgROM5 is localized to the cell surface, primarily at the posterior of the parasite 9986 -, 660387 3.4.21.106 hepsin cell surface - 9986 650510, 687522 3.4.21.107 peptidase Do cell surface - 9986 669100 3.4.21.109 matriptase cell surface - 9986 657796, 673572, 675024, 683145, 683364, 683489, 683493, 683494, 683514, 683674, 731663 3.4.21.109 matriptase cell surface acid-induced matriptase activation takes place both on the cell surface and inside the cells, likely due to the parallel intracellular acidification that activates intracellular matriptase 9986 709136 3.4.21.109 matriptase cell surface apical surface of epithelial cells 9986 732419 3.4.21.109 matriptase cell surface cell surface type II transmembrane protein 9986 731410 3.4.21.109 matriptase cell surface matriptase is activated when it reaches the cell surface 9986 708947 3.4.21.109 matriptase cell surface matriptase translocates to the cell surface and is activated within min after exposure of breast cancer cells to sphingosine-1-phosphate requiring actin cytoskeleton remodeling 9986 683893 3.4.21.109 matriptase cell surface the catalytic domain of matriptase is located in the extracellular space 9986 683343 3.4.21.109 matriptase cell surface the cytoplasmic domain of the enzyme contains an endocytosis motif that mediates the internalization of cell surface enzyme in a dynamin-dependent manner, Iron depletion does not affect the internalization of cell surface enzyme 9986 732181 3.4.21.110 C5a peptidase cell surface - 9986 651482, 673973 3.4.21.122 transmembrane protease serine 2 cell surface - 9986 754529 3.4.21.20 cathepsin G cell surface - 9986 718143, 753787 3.4.21.20 cathepsin G cell surface active enzyme 9986 683193 3.4.21.20 cathepsin G cell surface expression at high levels on the surface of activated human neutrophils in catalytically active but inhibitor-resistant form 9986 683644 3.4.21.34 plasma kallikrein cell surface - 9986 667855 3.4.21.37 leukocyte elastase cell surface of activated neutrophils 9986 683644 3.4.21.37 leukocyte elastase cell surface of neutrophils 9986 683316 3.4.21.38 coagulation factor XIIa cell surface - 9986 696541 3.4.21.43 classical-complement-pathway C3/C5 convertase cell surface - 9986 732705, 81409 3.4.21.47 alternative-complement-pathway C3/C5 convertase cell surface - 9986 732705, 753082, 753422 3.4.21.5 thrombin cell surface - 9986 683292, 684005 3.4.21.50 lysyl endopeptidase cell surface - 9986 -, 732885 3.4.21.50 lysyl endopeptidase cell surface the enzyme is secreted by the type IX secretion system, T9SS, and anchored onto the cell surface by binding to A-LPS 9986 731826 3.4.21.59 Tryptase cell surface of degranulated mast cells 9986 670795 3.4.21.6 coagulation factor Xa cell surface - 9986 652731, 683259, 717234, 717253 3.4.21.62 Subtilisin cell surface - 9986 -, 707888 3.4.21.68 t-Plasminogen activator cell surface - 9986 701276 3.4.21.69 Protein C (activated) cell surface - 9986 717424 3.4.21.69 Protein C (activated) cell surface inactive enzyme 9986 731565 3.4.21.69 Protein C (activated) cell surface the activated protein C occurs at the cell surfaceof endothelial cells 9986 683624 3.4.21.7 plasmin cell surface plasminogen is a major surface-bound protein 9986 718277 3.4.21.72 IgA-specific serine endopeptidase cell surface - 9986 666398, 666834 3.4.21.73 u-Plasminogen activator cell surface - 9986 708679, 709067, 709091, 709570, 710553 3.4.21.73 u-Plasminogen activator cell surface on keratinocytes 9986 683220 3.4.21.73 u-Plasminogen activator cell surface the active form of uPA is bound to its high affinity receptor uPAR on the cell surface 9986 683550 3.4.21.75 Furin cell surface - 9986 669442, 693230, 708753, 710165, 717827 3.4.21.76 Myeloblastin cell surface - 9986 684453, 685785, 688708 3.4.21.76 Myeloblastin cell surface granulocytes and monocytes 9986 683193 3.4.21.76 Myeloblastin cell surface neutrophil 9986 709758 3.4.21.76 Myeloblastin cell surface strong correlation between PR3 and CD177 surface expression 9986 688215 3.4.21.B21 trepolisin cell surface - 9986 -, 732466 3.4.21.B25 PACE4 proprotein convertase cell surface - 9986 675881 3.4.21.B25 PACE4 proprotein convertase cell surface activated at the cell surface where it is tethered to heparan sulfate proteoglycans 9986 680190 3.4.21.B25 PACE4 proprotein convertase cell surface the enzyme is constitutively secreted into the extracellular media and localizes at the cell surface and in the extracellular matrix 9986 732179 3.4.21.B26 proprotein convertase 5 cell surface - 9986 731899 3.4.21.B27 proprotein convertase 7 cell surface only overexpressed PC7 activity reaches the cell surface, endosomes, and the trans-Golgi network 9986 753199 3.4.21.B28 fibroblast activation protein alpha subunit cell surface - 9986 650762, 707629, 717591, 731043, 752802 3.4.21.B6 prostasin cell surface - 9986 731623 3.4.21.B6 prostasin cell surface prostasin is glycosylphosphatidylinositol-anchored to the cell surface 9986 677453 3.4.21.B61 transmembrane protease serine 11D cell surface - 9986 754529 3.4.22.15 cathepsin L cell surface main localization. The 80-kDa precursor protein is noncovalently associated with the S-layer proteins, while the 47-kDa mature form is tightly associated with the underlying cell wall 9986 727753 3.4.22.26 cancer procoagulant cell surface loosely anchored on outside of cells 9986 30159 3.4.22.27 cathepsin S cell surface of vascular smooth muscle cells, by association with integrin alphanybeta3, surface distribution 9986 667140 3.4.22.35 Histolysain cell surface the enzyme is secreted and localized on the cell surface 9986 668769 3.4.22.36 caspase-1 cell surface - 9986 699419 3.4.22.37 gingipain R cell surface - 9986 697200 3.4.22.51 cruzipain cell surface the signaling factor NF-kB P65 colocalizes with cruzain on the cell surface of intracellular wild-type parasites 9986 718307 3.4.22.B28 calpain 8 cell surface mucous cells 9986 665705 3.4.22.B5 CPB protease cell surface attached to membrane domains via glycosylphophatidylinositol anchor 9986 697814 3.4.23.24 Candidapepsin cell surface - 9986 -, 754172 3.4.23.24 Candidapepsin cell surface Sap2 9986 707937 3.4.23.25 saccharopepsin cell surface - 9986 -, 754333, 755660 3.4.23.46 memapsin 2 cell surface - 9986 638909 3.4.23.46 memapsin 2 cell surface beta-secretase is a type 1 transmembrane protein present at the cell surface 9986 700482 3.4.23.46 memapsin 2 cell surface close interaction between BACE and low density lipoprotein receptor-related protein on the cell surface 9986 669331 3.4.24.11 neprilysin cell surface - 9986 709805 3.4.24.13 IgA-specific metalloendopeptidase cell surface - 9986 755335 3.4.24.13 IgA-specific metalloendopeptidase cell surface associated via an N-terminal membrane anchor, release upon proteolytic cleavage 9986 666834 3.4.24.13 IgA-specific metalloendopeptidase cell surface surface distribution of IgA1 protease on SS2 strain ZYS, overview 9986 -, 754643 3.4.24.15 thimet oligopeptidase cell surface - 9986 -, 752926 3.4.24.15 thimet oligopeptidase cell surface secretion to the medium 9986 683813 3.4.24.16 neurolysin cell surface - 9986 683087 3.4.24.18 meprin A cell surface - 9986 650462, 652104 3.4.24.23 matrilysin cell surface - 9986 755514 3.4.24.23 matrilysin cell surface extracellular MMP-7 binds to cell-surface cholesterol sulfate (CS) and acts as a membrane-associated protease 9986 754150 3.4.24.23 matrilysin cell surface syndecan-2 functions as a cell surface docking receptor for pro-MMP-7, overview 9986 709073 3.4.24.23 matrilysin cell surface the enzyme is secreted 9986 717801 3.4.24.23 matrilysin cell surface the MMP-7 Asp137 genetic variant is preferentially localized to the cell surface plasma membrane 9986 708642 3.4.24.24 gelatinase A cell surface besides MT-MMPs, which efficiently bind proMMP-2 to induce its activation, a limited number of cell-surface molecules have been shown to contribute to enhance proteolytic activity at the migrating front of invasive cells by clustering active MMP-2 at the cell membrane. Among them the heat shock protein HSP90a expressed at the surface of tumor cells promotes MMP-2 activity and tumor invasion by binding to the Hpx-like domain of MMP-2. The alphanybeta3 integrin is first identified as a binding site for the C-terminal Hpx-like domain of MMP-2 in studies investigating in vivo and in vitro interactions between angiogenic blood vessels and melanoma cells 9986 752865 3.4.24.24 gelatinase A cell surface complex formed by MT1-MMP, TIMP-2 9986 683846 3.4.24.34 neutrophil collagenase cell surface binding of MMP-8 to the surface of polymorphonuclear cells promotes stability 9986 669709 3.4.24.35 gelatinase B cell surface - 9986 -, 708445 3.4.24.36 leishmanolysin cell surface - 9986 -, 683079, 683418, 683897 3.4.24.36 leishmanolysin cell surface about two-thirds of newly synthesized enzyme becomes surface localized, the rest of enzyme does not reach the cell surface. Surface-localized enzyme is released at different rates from logarithmic and stationary phase virulent promastigotes. Major mechanism regulating enzyme abundance is the rate of loss of surface-localized enzyme from promastigote surface 9986 670182 3.4.24.36 leishmanolysin cell surface GP63 is able to act on its substrate proteins within the nucleus of its host cell 9986 718304 3.4.24.36 leishmanolysin cell surface major surface protein 9986 -, 31226 3.4.24.36 leishmanolysin cell surface surface molecules are glycosylphosphatidylinositol-anchored 9986 710519 3.4.24.36 leishmanolysin cell surface two-third of MSPs in promastigotes is orientated along the cell surface, whereas most MSPs in amastigotes are localized in the flagellar pocket 9986 -, 683857 3.4.24.56 insulysin cell surface - 9986 683342, 710682 3.4.24.63 meprin B cell surface - 9986 -, 650462, 652104, 752709, 753172, 753218, 753321, 753536, 753697, 754028, 754236, 754779, 755294, 755466 3.4.24.71 endothelin-converting enzyme 1 cell surface ECE-1 shedding from the surface of endothelial cells 9986 683474 3.4.24.71 endothelin-converting enzyme 1 cell surface isozyme ECE-1c 9986 683435 3.4.24.79 pappalysin-1 cell surface - 9986 735323 3.4.24.79 pappalysin-1 cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor, mechanism, overview, the PAPP-A-proMBP complex is unable to bind to the cell surface 9986 683645 3.4.24.79 pappalysin-1 cell surface surface association of PAPP-A accounts for its colocalization with activated macrophages in human atherosclerotic plaque, immunohistochemic analysis, overview 9986 683050 3.4.24.80 membrane-type matrix metalloproteinase-1 cell surface - 9986 638809, 638810, 678111, 679042, 680921, 683787, 709058, 709415, 734409, 753242, 753773, 754158, 754175, 755435 3.4.24.80 membrane-type matrix metalloproteinase-1 cell surface MT1-MMP forms a homophilic complex required for activity 9986 717536 3.4.24.80 membrane-type matrix metalloproteinase-1 cell surface MT1-MMP on cell surface rapidly turns over by auto-degradation or clathrin-dependent internalization. MT1-MMP inactivated by TIMP-2 avoids auto-degradation, and accumulates on the cell surface, overview 9986 707998 3.4.24.81 ADAM10 endopeptidase cell surface - 9986 667528, 668181, 668305, 668372, 668407 3.4.24.82 ADAMTS-4 endopeptidase cell surface - 9986 669205, 697804 3.4.24.86 ADAM 17 endopeptidase cell surface - 9986 638989, 638994, 638995, 639003, 639006 3.4.24.86 ADAM 17 endopeptidase cell surface most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface 9986 755446 3.4.24.87 ADAMTS13 endopeptidase cell surface - 9986 713561 3.4.24.87 ADAMTS13 endopeptidase cell surface ADAMTS13 binds to endothelial cells in a specific, reversible, and time-dependent manner with a Kd of 58 nM. Binding requires the COOH-terminal thrombospondin type 1 repeats of the protease. Binding is inhibited in the presence of heparin and by trypsin treatment of the cells 9986 712393 3.4.24.89 Pro-Pro endopeptidase cell surface - 9986 -, 754764 3.4.24.B10 ADAM12 endopeptidase cell surface - 9986 668997, 755025 3.4.24.B11 ADAMTS1 endopeptidase cell surface - 9986 697804 3.4.24.B12 ADAMTS5 endopeptidase cell surface - 9986 679600, 697804 3.4.24.B14 neprilysin-2 cell surface human neprilysin-2-beta is either localized to the extracellular surface or secreted 9986 733906 3.4.24.B28 ADAM15 cell surface - 9986 735237 3.4.24.B9 ADAM9 endopeptidase cell surface - 9986 754597 3.5.1.19 nicotinamidase cell surface surface location 9986 246587 3.5.1.2 glutaminase cell surface - 9986 -, 656204, 719119 3.5.1.2 glutaminase cell surface of neutrophils, isozyme LGA 9986 670391 3.5.1.24 choloylglycine hydrolase cell surface - 9986 -, 752522 3.5.1.28 N-acetylmuramoyl-L-alanine amidase cell surface LytA is a surface-exposed enzyme 9986 656504 3.5.1.28 N-acetylmuramoyl-L-alanine amidase cell surface recombinant PGRP-L shows primarily intracellular and cell surface location 9986 656179 3.5.1.41 chitin deacetylase cell surface at early parasite life cycle 9986 668662 3.5.1.92 pantetheine hydrolase cell surface - 9986 -, 734537 3.5.1.92 pantetheine hydrolase cell surface a glycosylphosphatidylinositol (GPI)-anchored ectoenzyme 9986 733009 3.5.1.92 pantetheine hydrolase cell surface pantetheinase is an ectoenzyme that is attached to the outer plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. GPI anchors consist of three domains: a phosphoethanolamine linker that attaches to the C terminal end of the target protein, a conserved glycan core and a phospholipid tail for anchoring to the lipid membrane 9986 -, 756537 3.5.2.6 beta-lactamase cell surface the class A beta-lactamase BlaC is a cell surface expressed serine hydrolase 9986 -, 756194 3.5.3.15 protein-arginine deiminase cell surface 90% of enzyme activity is cell surface associated 9986 -, 733075 3.6.1.15 nucleoside-triphosphate phosphatase cell surface - 9986 -, 756676, 758530 3.6.1.22 NAD+ diphosphatase cell surface - 9986 656433 3.6.1.5 apyrase cell surface - 9986 -, 699181, 719597, 758530 3.6.1.5 apyrase cell surface NTPDase8 is a cell surface ectonucleotidase with a large extracellular domain containing the active site and is anchored to the membrane by two transmembrane domains at the N- and C-termini 9986 718863 3.6.1.5 apyrase cell surface the enzyme contains two transmembrane domains and five apyrase conserved regions, ACRs. ACR1 is located near the N-terminal transmembrane domain, whereas ACR5 is located near the C-terminal transmembrane domain 9986 695854 3.6.1.9 nucleotide diphosphatase cell surface - 9986 711034, 720186 3.6.5.2 small monomeric GTPase cell surface - 9986 756101 3.6.5.5 dynamin GTPase cell surface dynamin-1 9986 669580 3.6.5.5 dynamin GTPase cell surface dynamin-2 9986 669580 4.1.2.13 fructose-bisphosphate aldolase cell surface - 9986 -, 727893, 747043, 747971, 748619 4.1.2.13 fructose-bisphosphate aldolase cell surface surface-exposed enzyme 9986 748619 4.2.1.1 carbonic anhydrase cell surface - 9986 666801 4.2.1.1 carbonic anhydrase cell surface murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis 9986 -, 716685 4.2.1.11 phosphopyruvate hydratase cell surface - 9986 -, 651496, 666252, 696424, 698247, 704073, 704963, 705569, 706933, 715161, 730857 4.2.1.11 phosphopyruvate hydratase cell surface associated to the external surface of the parasite 9986 714875 4.2.1.11 phosphopyruvate hydratase cell surface putative ENOA translocation mechanism, overview 9986 714970 4.2.1.11 phosphopyruvate hydratase cell surface secreted enzyme associated to the external surface of the parasite 9986 714875 4.2.2.1 hyaluronate lyase cell surface - 9986 664708, 666077, 680874 4.4.1.3 dimethylpropiothetin dethiomethylase cell surface extracellular 9986 -, 34604 5.2.1.8 peptidylprolyl isomerase cell surface - 9986 680130 5.2.1.8 peptidylprolyl isomerase cell surface enzymes EF0685 and EF1534 9986 727618 5.3.1.1 triose-phosphate isomerase cell surface - 9986 -, 705563, 747934 5.3.4.1 protein disulfide-isomerase cell surface - 9986 679122, 679424, 679678, 706459, 727573, 728220, 747835, 747836 5.6.1.6 channel-conductance-controlling ATPase cell surface - 9986 734398 6.1.1.17 glutamate-tRNA ligase cell surface - 9986 675229 6.1.1.2 tryptophan-tRNA ligase cell surface - 9986 745941 6.1.1.6 lysine-tRNA ligase cell surface the enzyme is exposed on the surface of stressed cells, on which it co-localized with calreticulin in lipid rafts 9986 714671 7.1.2.2 H+-transporting two-sector ATPase cell surface - 9986 686272, 695945, 711983 7.1.2.2 H+-transporting two-sector ATPase cell surface the ectopic expression of ATP synthase is a consequence of translocation from the mitochondria 9986 718469 7.2.2.12 P-type Zn2+ transporter cell surface lipoprotein, detected by antibodies 9986 210345 7.2.2.19 H+/K+-exchanging ATPase cell surface - 9986 687724 7.4.2.1 ABC-type polar-amino-acid transporter cell surface - 9986 718559 7.4.2.14 ABC-type antigen peptide transporter cell surface - 9986 761023 7.4.2.6 ABC-type oligopeptide transporter cell surface - 9986 734416 7.4.2.6 ABC-type oligopeptide transporter cell surface more than 80% of the surface-localised ATPase activity of Mycoplasma hominis is derived from OppA, implicating that OppA is the main ATPase on the surface of mycoplasma cells 9986 685829 7.4.2.6 ABC-type oligopeptide transporter cell surface substrate binding protein OppA of the permease complex 9986 655869 7.4.2.7 ABC-type alpha-factor-pheromone transporter cell surface enzyme variant with a deletion in the linker region 9986 670202 7.6.2.1 P-type phospholipid transporter cell surface AP-1 is required, and GGA proteins, Golgi localized, gamma-ear containing, Arf-binding proteins acting as chlatrin adaptos, are dispensable, for efficient exclusion of Drs2p from exocytic vesicles targeted to the plasma membrane 9986 688911 7.6.2.2 ABC-type xenobiotic transporter cell surface of tumor cells 9986 696241