3.4.24.87 cell surface - 9986 713561 3.4.24.87 cell surface ADAMTS13 binds to endothelial cells in a specific, reversible, and time-dependent manner with a Kd of 58 nM. Binding requires the COOH-terminal thrombospondin type 1 repeats of the protease. Binding is inhibited in the presence of heparin and by trypsin treatment of the cells 9986 712393 3.4.24.87 endoplasmic reticulum homogeneous distribution of wild-type ADAMTS13 in cis-Golgi and endoplasmic reticulum compartments. Reduction of ADAMTS13(Val88Met) in both compartments. ADAMTS13(Gly1239Val) fails to reach the cis-Golgi compartment and remains in the endoplasmic reticulum 5783 668882 3.4.24.87 extracellular - - 710732, 710826, 710827, 711560, 711561, 711563, 711564, 711565, 711567, 711569, 711571, 711574, 711575, 711576, 711578, 711579, 711809, 712070, 712115, 712127, 712195, 712203, 712393, 712568, 712569, 712899, 712900, 712901, 713079, 713347, 713381, 713400, 713531, 713532, 713534, 713536, 713560, 713561 3.4.24.87 extracellular ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule - 711570 3.4.24.87 extracellular plasma - 650102, 650709, 650710, 650712, 650714, 650715, 650717, 650725, 651439, 652191, 652431, 652481, 653678 3.4.24.87 extracellular secrete enzyme - 713533 3.4.24.87 extracellular secreted enzyme - 711562, 713116 3.4.24.87 extracellular the enzyme is secreted - 712099, 713189 3.4.24.87 Golgi apparatus homogeneous distribution of wild-type ADAMTS13 in cis-Golgi and endoplasmic reticulum compartments. Reduction of ADAMTS13(Val88Met) in both compartments. ADAMTS13(Gly1239Val) fails to reach the cis-Golgi compartment and remains in the endoplasmic reticulum 5794 668882 3.4.24.87 intracellular - 5622 713534