2.7.7.18 cytoplasm - 5737 703814, 739510 2.7.7.18 Golgi apparatus isoform NMNAT2 localizes to the cis-Golgi and endoplasmic reticulum-Golgi intermediate compartment. It is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface 5794 722676 2.7.7.18 mitochondrion - 5739 703814 2.7.7.18 mitochondrion isoform NMNAT3 is targeted to mitochondria by its N-terminus 5739 722676 2.7.7.18 additional information the three human isoforms NMNAT1-3 are localized to the nucleus, the Golgi complex, and mitochondria. Their genes contain unique exons that encode isoform-specific domains to mediate subcellular targeting and post-translational modifications. These domains are dispensable for catalytic activity - 722676 2.7.7.18 nucleus - 5634 703814 2.7.7.18 nucleus sequence of isoform NMNAT1 contains a predicted nuclear localization signal 5634 722676