2.5.1.21	cytoplasm	combined in silico prediction and subcellular localization, experiments in tobacco indicate that squalene synthase is probably in the cytoplasm or on the cytoskeleton. The squalene synthase protein has two transmembrane regions in the C-terminal	5737	746683	
2.5.1.21	endoplasmic reticulum	-	5783	697143, 703278, 722759	
2.5.1.21	endoplasmic reticulum	associated enzyme with C-terminus anchored in the endoplasmic reticulum membrane and the N-terminus including active site is exposed in the cytosol	5783	739037	
2.5.1.21	endoplasmic reticulum	localization depends on the protein's N-terminal hydrophobic transmembrane domain	5783	689567	
2.5.1.21	endoplasmic reticulum	squalene synthase TkSQS1 and squalene epoxidase TkSQE1 proteins colocalize in the endoplasmic reticulum membrane	5783	759950	
2.5.1.21	endoplasmic reticulum membrane	CrSQS protein has two putative transmembrane domains at the C-terminus, Phe398-Glu420 and Gln436-Leu458	5789	739406	
2.5.1.21	endoplasmic reticulum membrane	squalene synthase consists of both an N-terminal catalytic domain and a C-terminal domain tethering the enzyme to the endoplasmic reticulum membrane	5789	737775	
2.5.1.21	endoplasmic reticulum membrane	squalene synthase consists of both an N-terminal catalytic domain and a C-terminal domain which consists of a hinge region and a membrane spanning helix responsible for tethering the enzyme to the cytosolic face of the endoplasmic reticulum	5789	737775	
2.5.1.21	membrane	-	16020	-, 489835, 489845, 489859, 739582, 739589	
2.5.1.21	membrane	a membrane associated enzyme	16020	739290	
2.5.1.21	membrane	bound	16020	738718, 738856, 741903	
2.5.1.21	membrane	bound, the membrane-binding domains of the human enzyme are 30 residues of the N-terminus and 47 residues of the C-terminus	16020	738718	
2.5.1.21	membrane	membrane-bound	16020	759271	
2.5.1.21	membrane	model of the secondary structure and its possible membrane orientation	16020	489834	
2.5.1.21	membrane	the enzyme has two transmembrane domains at its C-terminus	16020	758957	
2.5.1.21	microsome	-	-	-, 489826, 489828, 489836, 489837, 489842, 489845, 489846, 721801, 721802, 739290, 739589, 759144	
2.5.1.21	microsome	integral membrane protein	-	489841	
2.5.1.21	microsome	membranes	-	489835	
2.5.1.21	peroxisome	-	5777	489840, 697143	
2.5.1.21	soluble	-	-	706375