4.3.2.2 2'-deoxy-AMP - 12291 4.3.2.2 2'-deoxy-AMP competitive 12291 4.3.2.2 4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate - 45195 4.3.2.2 5-aminoimidazole-4-carboxamide ribonucleoside 50% inhibition at 0.167 mM 6123 4.3.2.2 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate i.e. ZMP or AICAR, product inhibition, accumulation in the brain of Lesch-Nyhan disease patients induces inhibition of mitochondrial oxidative phosphorylation and adenylosuccinate lyase activity, followed by dowregulation of ATP levels and multifocal cell death in the cerebellum 147347 4.3.2.2 8-Aza-AMP - 29653 4.3.2.2 adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits negative cooperativity. Binding to enzyme mutants, overview 25953 4.3.2.2 adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits positive cooperativity 25953 4.3.2.2 adenosine phosphonobutyric, 2'(3'), 5'-diposphate - 97740 4.3.2.2 adenyloethylphosphonate - 97739