1.8.4.11	3-carboxy 4-nitrobenzenethiol	binds specifically to the sulfenic acid reaction intermediate	23299	
1.8.4.11	dimedone	binds specifically to the sulfenic acid reaction intermediate	11197	
1.8.4.11	dimethyl sulfoxide	DMSO competitively inhibits the methionine-sulfoxide reduction ability of MsrA (12% residual activity at 0.1% (v/v) DMSO) and inhibits the antioxidant function of MsrA in yeast cells, resulting in higher sensitivity to oxidative stress	1217	
1.8.4.11	DMSO	-	896	
1.8.4.11	H2O2	1 mM, 85% deactivation. The active site of this enzyme is significantly altered after H2O2-mediated oxidation of L-methionine, L-tryptophan, and L-cysteine residues in its active site	22	
1.8.4.11	H2O2	the enzyme is only inactivated by high doses of H2O2, when treated with 0.5 mM H2O2 MsrA loses 20% of its activity and this inhibition reaches approximately 40% with 1 mM H2O2, MsrA is not significantly inhibited by lower concentrations of H2O2 (0.050 and 0.1 mM)	22	
1.8.4.11	H2O2	in the mouse enzyme, the sulfenic acid formed at the catalytic Cys residue is vulnerable to irreversible oxidation to cysteine sulfinic acid resulting in inactivation. Hyperoxidation is controlled by the presence or absence of residue Met229 in the carboxyl terminal domain. Mouse msrA becomes insensitive to hyperoxidation when the Met229 is mutated. Hyperoxidation occurs so long as the methionine is located within the 14 carboxyl terminal residues. Met229 may form a stable, non-covalent bond with Trp74 at the active site, preventing formation of a protective sulfenylamide with Cys72 sulfenic acid	22	
1.8.4.11	additional information	effects of high light, ozone, and paraquat on enzyme activity and photosynthetic activity in wild-type and transgenic plants, overview	2	
1.8.4.11	additional information	enzyme expression decreases during dehardening from 4°C to 22°C of cold-acclimated plants, effects of light and temperature on enzyme expression and activity, overview	2	
1.8.4.11	additional information	isozyme PMSRA5 expression is slightly suppressed by ozone	2