4.3.2.2 2'-deoxy-AMP - 12291 4.3.2.2 2'-deoxy-AMP competitive 12291 4.3.2.2 4-aminopyrazolo[3,4-d]pyrimidine ribose 5'-phosphate - 45195 4.3.2.2 5-aminoimidazole-4-carboxamide ribonucleoside 50% inhibition at 0.167 mM 6123 4.3.2.2 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate i.e. ZMP or AICAR, product inhibition, accumulation in the brain of Lesch-Nyhan disease patients induces inhibition of mitochondrial oxidative phosphorylation and adenylosuccinate lyase activity, followed by dowregulation of ATP levels and multifocal cell death in the cerebellum 147347 4.3.2.2 8-Aza-AMP - 29653 4.3.2.2 adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits negative cooperativity. Binding to enzyme mutants, overview 25953 4.3.2.2 adenosine phosphonobutyric acid, 2'(3'),5'-diphosphate i.e. APBADP, the non-cleavable substrate analogue acts as a competitive inhibitor with respect to either substrate. ASL binds up to 4 mol of APBADP per mole of enzyme tetramer, the enzyme exhibits positive cooperativity 25953 4.3.2.2 adenosine phosphonobutyric, 2'(3'), 5'-diposphate - 97740 4.3.2.2 adenyloethylphosphonate - 97739 4.3.2.2 adenylosuccinate 2',3'-acyclic (N,N-ethyl) diamine weak 96086 4.3.2.2 adenylosuccinate 2',3'-acyclic dialcohol - 45281 4.3.2.2 adenylosuccinate 2',3'-acyclic dialdehyde - 45282 4.3.2.2 ADP weak, competitive 13 4.3.2.2 ammonium salt of N6-malonyl adenosine 5'-phosphate noncompetitive inhibitor, irreversible 97781 4.3.2.2 AMP competitive 30 4.3.2.2 AMP - 30 4.3.2.2 AMP product inhibition competitive versus succinyladenosine monophosphate 30 4.3.2.2 arabinosyl-AMP - 29750 4.3.2.2 arabinosyl-AMP beta-D-arabinosyl-AMP, competitive 29750 4.3.2.2 ATP weak, competitive 4 4.3.2.2 CuSO4 complete inhibition at 0.05 mM 263 4.3.2.2 DL-3-phosphonoalanine - 96428 4.3.2.2 EDTA above 15 mM 21 4.3.2.2 erythro-beta-fluoro-4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide - 96481 4.3.2.2 erythro-beta-fluoroadenylosuccinate - 96482 4.3.2.2 erythro-beta-fluoroaspartate - 96483 4.3.2.2 fumarate noncompetitive 170 4.3.2.2 I- 100-200 mM 507 4.3.2.2 KBr presence of increasing concentrations of KBr of 0.1–2.5 M disrupt electrostatic interactions leading to ASL dissociation and loss of catalytic activity 2746 4.3.2.2 KCl stimulates up to maximum concentration of 80 mM, inhibition at higher concentration 79 4.3.2.2 L-Asp - 294 4.3.2.2 mercaptopurinosuccinate substrate inhibition 31046 4.3.2.2 Mg2+ concentration of Mg2+ approaching that of EDTA 6 4.3.2.2 MgCl2 - 196 4.3.2.2 additional information dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal 2 4.3.2.2 additional information as hydrophobic interactions are weakened at 8°C and 4°C, the catalytic activity of ASL decreases strikingly and the enzyme dissociates to a mixture of monomer-dimer-trimer, with small amounts of tetramer 2 4.3.2.2 N-(5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carbonyl)-L-threo-beta-methylaspartic acid 5'-phosphate - 98086 4.3.2.2 N6-(2-carboxyethyl)-AMP i.e. adenylopropionate 94431 4.3.2.2 N6-(D-1,2-dicarboxyethyl)-AMP i.e. D-adenylosuccinate 94433 4.3.2.2 N6-(DL-1,2-dicarboxy-threo-2-hydroxyethyl)-AMP i.e. adenylomalate 94434 4.3.2.2 N6-(DL-1-carboxy-2-phosphonoethyl)AMP i.e. adenylophosphonopropionate 94435 4.3.2.2 N6-(L-1,3-dicarboxyprop-1-yl)-AMP i.e. adenyloglutarate 98126 4.3.2.2 N6-(L-1-carboxy-2-cyanoethyl)-AMP i.e. adenylocyanopropionate 94436 4.3.2.2 N6-(L-1-carboxy-2-methylsulfoxyethyl)-AMP i.e. adenylomethylsulfoxypropionate 94437 4.3.2.2 N6-(L-1-carboxy-2-nitroethyl)-AMP competitive 94438 4.3.2.2 N6-(L-1-carboxy-2-sulfinoethyl)-AMP i.e. adenylosulfinopropionate 94440 4.3.2.2 N6-(L-1-carboxy-2-sulfoethyl)-AMP i.e. adenylosulfopropionate 96913 4.3.2.2 nitroacrylate 0.02 mM, 70% inactivation 98138 4.3.2.2 NO3- 100-200 mM 673 4.3.2.2 nonenal - 13208 4.3.2.2 phosphate competitive 16 4.3.2.2 phosphopropionoadenosine - 98190 4.3.2.2 PO43- activates at low concentration, inhibits at high concentrations above 25 mM 867 4.3.2.2 SO42- activates at low concentrations, inhibits at concentrations above 25 mM 245 4.3.2.2 threo-beta-4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide - 46403 4.3.2.2 threo-beta-fluoroadenylosuccinate - 45942 4.3.2.2 trans-4-hydroxy-2-nonenal 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex 23781 4.3.2.2 virazole 5'-phosphate - 97290