3.5.4.13 phosphate - 16 3.5.4.13 Cu2+ - 19 3.5.4.13 EDTA - 21 3.5.4.13 Hg2+ - 33 3.5.4.13 Ni2+ - 38 3.5.4.13 p-chloromercuribenzoate - 43 3.5.4.13 CTP - 60 3.5.4.13 p-hydroxymercuribenzoate - 98 3.5.4.13 dATP - 140 3.5.4.13 dTTP - 145 3.5.4.13 dTTP inhibition of deamination reaction 145 3.5.4.13 dTTP inhibits by increasing the kcat several fold, mutants S111T and E138D are less sensitive to dTTP, overview 145 3.5.4.13 dTTP inhibits the enzyme in a nonallosterical way, cooperative kinetics are imposed by a dTTP-dependent lag of product formation observed in presteady-state kinetics, the lag may be derived from a slow equilibration between an inactive and an active conformation of dCTP deaminase represented by the dTTP complex and the dUTP/dCTP complex, respectively, steady-state kinetic analysis of dTTP inhibition, overview 145 3.5.4.13 dTTP the inhibitor has a regukatory function for the bifunctional enzyme, mechanism of regulation by conformational changes, overview 145 3.5.4.13 dTTP inhibits dCMP deamination, feedback inhibition 145 3.5.4.13 CDP - 212 3.5.4.13 dUTP - 435 3.5.4.13 dUTP inhibition of deamination reaction 435 3.5.4.13 dTDP - 542 3.5.4.13 dTMP - 635 3.5.4.13 PDRP inhibits both dCTP and dCMP deaminase activities 69257 3.5.4.13 H4dUMP inhibits both dCTP and dCMP deaminase activities 69258