3.4.24.60 (24-28)ANF pentapeptide i.e. Asn-Ser-Phe-Arg-Tyr, weak, substance P as substrate, inhibits cleavage of Gly9-Leu10 and Phe7-Phe8 bonds 90245 3.4.24.60 (25-28)ANF tetrapeptide i.e. Ser-Phe-Arg-Tyr, weak, substance P as substrate, inhibits cleavage of Gly9-Leu10 and Phe7-Phe8 bonds 90249 3.4.24.60 (Leu5)-enkephalin inhibitor of dactylysin towards substance P 132615 3.4.24.60 (Met5)-enkephalin inhibitor of dactylysin towards substance P 132616 3.4.24.60 1,10-phenanthroline metalloendopeptidase character 62 3.4.24.60 1,10-phenanthroline 0.01 or 0.05 mM Zn2+, Ca2+ or Mn2+ fully restores; metalloendopeptidase character 62 3.4.24.60 1,10-phenanthroline strongly inhibits 62 3.4.24.60 Acetorphan less efficient than phosphoramidon 29667 3.4.24.60 benzamidine weak 579 3.4.24.60 benzamidine not 579 3.4.24.60 beta(25-35)Amyloid peptide i.e. Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met 92705 3.4.24.60 beta(31-35)Amyloid pentapeptide i.e. Ile-Ile-Gly-Leu-Met 92706 3.4.24.60 beta(31-35)Amyloid-NH2 i.e. Ile-Ile-Gly-Leu-Met-NH2 92707 3.4.24.60 CP-96345 non-peptide agonist of substance P, substance P as substrate, inhibits cleavage of Gly9-Leu10 bond 92969 3.4.24.60 DTT - 177 3.4.24.60 EDTA metalloendopeptidase character 21 3.4.24.60 EDTA strongly inhibits 21 3.4.24.60 EGTA metalloendopeptidase character 173 3.4.24.60 EGTA strongly inhibits 173 3.4.24.60 Kelatorphan less efficient than phosphoramidon 10684 3.4.24.60 additional information no inhibition by N-tosyl-L-Phe chloromethyl ketone (i.e. TPCK); pepstatin, guanidylethylmercaptosuccinic acid (i.e. GEMSA), captopril, aprotinin, soybean trypsin inhibitor (i.e. STI), PMSF, IAA 2 3.4.24.60 additional information pepstatin, guanidylethylmercaptosuccinic acid (i.e. GEMSA), captopril, aprotinin, soybean trypsin inhibitor (i.e. STI), PMSF, IAA; retrothiorphan 2 3.4.24.60 additional information TIMPS (tissue inhibitor) 2 3.4.24.60 additional information not inhibited by TIMPs and 1mM captopril 2 3.4.24.60 N-ethylmaleimide - 49 3.4.24.60 N-ethylmaleimide not 49 3.4.24.60 p-chloromercuriphenylsulfonic acid - 1416 3.4.24.60 p-chloromercuriphenylsulfonic acid not 1416 3.4.24.60 Pentapeptides reproducing or mimicking the COOH-terminal sequence of ANF 24-28 ANF as substrate 99558 3.4.24.60 phosphoramidon not 645 3.4.24.60 phosphoramidon only at high concentrations, above 0.001 mM 645 3.4.24.60 phosphoramidon - 645 3.4.24.60 RP 67580 non-peptide agonist of substance P, substance P as substrate, inhibits cleavage of Gly9-Leu10 bond 94923 3.4.24.60 thiorphan not 1128 3.4.24.60 thiorphan i.e. 3-mercapto-2-benzyl-propanoylglycine, only at high concentrations, above 0.001 mM 1128 3.4.24.60 tosyl-Arg methyl ester i.e. TAME, weak 2098 3.4.24.60 tosyl-Arg methyl ester not 2098 3.4.24.60 [Ala26]-(21-28)ANF weak 90355 3.4.24.60 [Leu5]enkephalin i.e. Tyr-Gly-Gly-Phe-Leu, ANF as substrate 19839 3.4.24.60 [Leu5]enkephalin - 19839 3.4.24.60 [Leu5]enkephalinamide ANF as substrate 29228 3.4.24.60 [Leu5]enkephalinamide - 29228 3.4.24.60 [Val26]-(21-28)ANF weak 90362