2.7.4.9 (+/-)(Z)-5-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one - 89103 2.7.4.9 (+/-)(Z)-5-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one - 89104 2.7.4.9 (3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid - 28894 2.7.4.9 (3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid - 28895 2.7.4.9 (3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid comparison with inhibition of Mycobacterium tuberculosis enzyme 25619 2.7.4.9 (3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid comparison with inhibition of human enzyme 25619 2.7.4.9 (4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one i.e. [6]-shogaol, isolated from Zingiber officinale 212237 2.7.4.9 (E)-5-(2-bromovinyl)-deoxyuridine - 77912 2.7.4.9 (NH4)2SO4 0.35 M, 50% inhibition 399 2.7.4.9 (R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28891 2.7.4.9 (R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28889 2.7.4.9 (S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28890 2.7.4.9 (S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28887 2.7.4.9 (S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28884 2.7.4.9 (S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28885 2.7.4.9 (S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28886 2.7.4.9 (S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28883 2.7.4.9 (S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28882 2.7.4.9 (S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28888 2.7.4.9 (S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid - 42378 2.7.4.9 (S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid - 89162 2.7.4.9 (S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid - 42379 2.7.4.9 (S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione - 28881 2.7.4.9 (Z)-1-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[c,d]indol-2(1H)one - 69913 2.7.4.9 (Z)-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one - 89102 2.7.4.9 (Z)-2-(4-(5-bromouracil-1-yl)but-2-enyl)-1H-benzo[d,e] isoquinoline-1,3(2H)-dione - 69914 2.7.4.9 (Z)-2-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[d,e]isoquinoline-1,3(2H)-dione - 69915 2.7.4.9 (Z)-2-(4-(thymin-1-yl)but-2-enyl)-2,3-dihydro-1H-benzo-[d,e]isoquinolin-1-one - 69916 2.7.4.9 (Z)-2-(4-(thymin-1-yl)but-2-enyl)-2H-naphtho[1,8 cd]isothiazole-1,1-dioxide - 69917 2.7.4.9 (Z)-2-(4-(thymin-1-yl)but-2-enyl)-6-nitrobenzo[c,d]indol-2(1H)one - 69918 2.7.4.9 (Z)-8-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one - 89105 2.7.4.9 (Z)-8-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one - 89106 2.7.4.9 1,3-bis[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea - 154698 2.7.4.9 1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea - 36255 2.7.4.9 1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea - 89090 2.7.4.9 1-((2R,4S,5R)-4-hydroxy-5-(2-(methylsulfonyl)ethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 89076 2.7.4.9 1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione - 172197 2.7.4.9 1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 89079 2.7.4.9 1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28879 2.7.4.9 1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 28880 2.7.4.9 1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione i.e. shogaol with thymine head group 212238 2.7.4.9 1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 251716 2.7.4.9 1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 253191 2.7.4.9 1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - 253169 2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2R,3R,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea - 172202 2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 8820 2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of human enzyme 8820 2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea - 8820 2.7.4.9 1-(3,4-dichlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea comparison with inhibition of human enzyme 71214 2.7.4.9 1-(3-amino-3-deoxy-2-O,3-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine IC99: 500 microg/ml 62644 2.7.4.9 1-(3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine IC99: 100 microg/ml 62645 2.7.4.9 1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 25850 2.7.4.9 1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea comparison with inhibition of human enzyme 25850 2.7.4.9 1-(4-benzyloxyphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea comparison with inhibition of human enzyme 71215 2.7.4.9 1-(4-bromobenzyl)-5-methylpyrimidine-2,4(1H,3H)-dione comparison with inhibition of human enzyme 69947 2.7.4.9 1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 18800 2.7.4.9 1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of human enzyme 18800 2.7.4.9 1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea - 18800 2.7.4.9 1-(4-chlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea comparison with inhibition of human enzyme 71213 2.7.4.9 1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89114 2.7.4.9 1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89128 2.7.4.9 1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89115 2.7.4.9 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89112 2.7.4.9 1-[(1'R,4'S)-4'-((S)-2-fluoro-1-hydroxyethyl)cyclopent-2'-enyl]-1H-thymine - 213761 2.7.4.9 1-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 42375 2.7.4.9 1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 19068 2.7.4.9 1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 89075 2.7.4.9 1-[(1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 42377 2.7.4.9 1-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 42374 2.7.4.9 1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 42376 2.7.4.9 1-[(2E)-4-(5,6-dimethoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione inhibitor identified by 3D-QSAR pharmacophore generation 212246 2.7.4.9 1-[(2E)-4-[5,6-bis(hydroxymethyl)-2-oxobenzo[cd]indol-1(2H)-yl]but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione inhibitor identified by 3D-QSAR pharmacophore generation 212244 2.7.4.9 1-[(2S,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 154716 2.7.4.9 1-[(2S,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 154715 2.7.4.9 1-[(2Z)-(4-(5-bromouracil-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide - 89108 2.7.4.9 1-[(2Z)-4-(1,1-dioxido-2H-naphtho[1,8-cd][1,2]thiazol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 89110 2.7.4.9 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 24262 2.7.4.9 1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 14028 2.7.4.9 1-[(4aR,5S,7R,7aS)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 172201 2.7.4.9 1-[(Z)-(4-(thymin-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide - 89107 2.7.4.9 1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 251770 2.7.4.9 1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253189 2.7.4.9 1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253171 2.7.4.9 1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253170 2.7.4.9 1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253168 2.7.4.9 1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253192 2.7.4.9 1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253179 2.7.4.9 1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253180 2.7.4.9 1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253186 2.7.4.9 1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253187 2.7.4.9 1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253188 2.7.4.9 1-[2,5-dideoxy-5-[([4-[(2-fluorophenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253156 2.7.4.9 1-[2,5-dideoxy-5-[([4-[(2-methoxyphenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253157 2.7.4.9 1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]-N-[1-(4-hydroxyphenyl)-3-oxoniopropan-2-yl]prolinamide - 172189 2.7.4.9 1-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]-3-phenylthiourea - 154713 2.7.4.9 1-[3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl]thymine - 62643 2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]thiourea - 154714 2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 8821 2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea comparison with inhibition of human enzyme 8821 2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea - 8821 2.7.4.9 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]urea - 154711 2.7.4.9 1-[5-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2,5-dideoxy-a-D-erythro-pentofuranosyl]-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one - 89080 2.7.4.9 1-[5-[([4-[(2-chlorophenyl)methoxy]phenyl]carbamoyl)amino]-2,5-dideoxy-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione - 253155 2.7.4.9 1-[N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]pyrrolidine-2-carboxylate - 172187 2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methoxyphenyl)thiourea - 154700 2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methylphenyl)thiourea - 154701 2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea - 19065 2.7.4.9 1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-pyridin-3-ylthiourea - 154703 2.7.4.9 1-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]-3-phenylthiourea - 154699 2.7.4.9 2',3'-dideoxy-2',3'-didehydrothymidine poor inhibitor 146954 2.7.4.9 2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine - 89096 2.7.4.9 2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine - 89093 2.7.4.9 2',5'-difluoro-3'-azidomethylthymidine - 57782 2.7.4.9 2'-chlorothymidine 5'-monophosphate - 62655 2.7.4.9 2'-deoxy-5-(hydroxymethyl)uridine - 62646 2.7.4.9 2'-deoxy-5-(trifluoromethyl)uridine - 135616 2.7.4.9 2'-deoxy-5-ethyluridine - 62647 2.7.4.9 2'-deoxy-5-fluorouridine - 24238 2.7.4.9 2'-deoxy-5-hydroxyuridine - 36200 2.7.4.9 2'-deoxyuridine - 1705 2.7.4.9 2'-fluorothymidine 5'-monophosphate - 62654 2.7.4.9 2-((2R,3S,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-N-methylethanesulfonamide - 89077 2.7.4.9 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid - 89132 2.7.4.9 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid - 89133 2.7.4.9 2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid - 89139 2.7.4.9 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid - 89161 2.7.4.9 2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid - 28903 2.7.4.9 2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid - 28904 2.7.4.9 2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid - 28900 2.7.4.9 2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid - 28908 2.7.4.9 2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid 2 g/ml MIC against methicillin-resistant Staphylococcus aureus. The compound exhibits a striking inverted chiral preference for binding relative to earlier compounds and also has improved physical properties and pharmacokinetics 212242 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid - 28907 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid - 28892 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid - 28896 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid - 28906 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid - 28905 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid - 28901 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid - 28902 2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid - 28898 2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid - 28897 2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid - 28893 2.7.4.9 2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid - 28899 2.7.4.9 2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-(1H-indol-3-yl)propanoate - 172188 2.7.4.9 2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-(4-methylphenyl)propanoate - 172186 2.7.4.9 2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-hydroxypropanoate - 172192 2.7.4.9 2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)pentanedioate - 172182 2.7.4.9 2-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-3-(1H-indol-3-yl)propanoate - 172190 2.7.4.9 2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-(4-hydroxyphenyl)propanoate - 172185 2.7.4.9 2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-hydroxybutanoate - 172193 2.7.4.9 2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-hydroxypropanoate - 172191 2.7.4.9 2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-4-carboxybutanoate - 172181 2.7.4.9 2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)butanedioate - 172180 2.7.4.9 2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid - 89154 2.7.4.9 2-mercaptoethanol 0.4 mM 63 2.7.4.9 2-[(4aS,5R,7R,7aR)-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-2,2-dioxidooctahydrocyclopenta[c][1,2,6]thiadiazin-7-yl]-N-methylethanesulfonamide - 89081 2.7.4.9 2-[([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]methyl)amino]butanedioate - 89074 2.7.4.9 2-[([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]acetyl)amino]-3-hydroxybutanoate - 172194 2.7.4.9 2-[([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]acetyl)amino]-3-hydroxypropanoate - 172195 2.7.4.9 2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid - 89153 2.7.4.9 3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine - 89095 2.7.4.9 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine - 89083 2.7.4.9 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine - 89089 2.7.4.9 3'-(aminomethyl)-2'-chloro-3'-deoxythymidine - 57779 2.7.4.9 3'-(aminomethyl)-3'-deoxythymidine - 23531 2.7.4.9 3'-(azidomethyl)-2'-chloro-3'-deoxythymidine - 57780 2.7.4.9 3'-(azidomethyl)-3'-deoxy-2'-fluorothymidine - 57781 2.7.4.9 3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine - 61624 2.7.4.9 3'-(azidomethyl)-3'-deoxythymidine - 23530 2.7.4.9 3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine - 19059 2.7.4.9 3'-azido-2',3'-dideoxyuridine - 62649 2.7.4.9 3'-azido-3'-deoxy-4-thio-beta-D-thymidine - 89082 2.7.4.9 3'-azido-3'-deoxy-alpha-D-thymidine - 89088 2.7.4.9 3'-azido-3'-deoxy-thymidine-5'-monophosphate - 172199 2.7.4.9 3'-azido-3'-deoxythymidine - 1185 2.7.4.9 3'-azido-3'-deoxythymidine specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions 1185 2.7.4.9 3'-azido-3'-deoxythymidine 5'-monophosphate potent competitive inhibitor 4357 2.7.4.9 3'-azido-3'-deoxythymidine 5'-monophosphate - 4357 2.7.4.9 3'-azido-3'-deoxythymidine 5'-monophosphate potential inhibitor 4357 2.7.4.9 3'-azido-3'-deoxythymidine 5'-monophosphate potential inhibitor of the bacterial enzyme, not inhibitory in human 4357 2.7.4.9 3'-azido-3'-deoxythymidine 5'-phosphate - 21266 2.7.4.9 3'-azido-3'-deoxythymidine monophosphate - 16978 2.7.4.9 3'-azido-5-bromo-2',3'-dideoxyuridine - 62651 2.7.4.9 3'-azido-5-chloro-2',3'-dideoxyuridine - 62650 2.7.4.9 3'-azidothymidine poor inhibitor 33052 2.7.4.9 3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine - 19062 2.7.4.9 3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine - 19060 2.7.4.9 3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine - 19061 2.7.4.9 3'-Deoxythymidine - 8000 2.7.4.9 3'-deoxythymidine 5'-monophosphate - 127458 2.7.4.9 3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine - 19063 2.7.4.9 3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine - 89091 2.7.4.9 3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine - 19064 2.7.4.9 3-((2R,3S,5R)-3-hydroxy-5-(5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile - 172196 2.7.4.9 3-((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile - 89078 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide - 89121 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide - 89122 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile - 89118 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide - 89142 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide - 89155 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide - 89150 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide - 89140 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide - 89147 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide - 89145 2.7.4.9 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide - 89143 2.7.4.9 3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid - 89136 2.7.4.9 3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid - 89159 2.7.4.9 3-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-4-oxoniobutanoate - 172183 2.7.4.9 4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid - 42380 2.7.4.9 4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide - 89130 2.7.4.9 4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid - 89160 2.7.4.9 4-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-5-oxoniopentanoate - 172184 2.7.4.9 4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid compound shows showed cellular activity against Mycobacterium tuberculosis 212241 2.7.4.9 4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid compound shows showed cellular activity against Mycobacterium tuberculosis, MIC value above 32 microg/ml 212240 2.7.4.9 4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide not inhibitory up to 2 mM, inhibitory to Mycobacterium tuberculosis enzyme 38075 2.7.4.9 4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide comparison with inhibition of human enzyme 38075 2.7.4.9 4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid comparison with inhibition of Mycobacterium tuberculosis enzyme 25631 2.7.4.9 4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid comparison with inhibition of human enzyme 25631 2.7.4.9 4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide not inhibitory up to 2 mM, inhibitory to Mycobacterium tuberculosis enzyme 38076 2.7.4.9 4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide comparison with inhibition of human enzyme 38076 2.7.4.9 4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid comparison with inhibition of Mycobacterium tuberculosis enzyme 25632 2.7.4.9 4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid comparison with inhibition of human enzyme 25632 2.7.4.9 4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid comparison with inhibition of human enzyme 70172 2.7.4.9 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid - 253173 2.7.4.9 4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile - 253172 2.7.4.9 5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine - 89098 2.7.4.9 5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine - 89087 2.7.4.9 5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine - 89085 2.7.4.9 5'-([[4-chloro-3-(trifluoromethyl)benzyl]carbamothioyl]amino)-5'-deoxythymidine - 154707 2.7.4.9 5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine - 89092 2.7.4.9 5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine - 89094 2.7.4.9 5'-amino-5'-deoxythymidine - 8686 2.7.4.9 5'-aminodeoxythymidine - 52278 2.7.4.9 5'-azido-2',5'-dideoxy-3,4-dihydrothymidine - 89101 2.7.4.9 5'-azido-5'-deoxythymidine - 36434 2.7.4.9 5'-carboxyldeoxythymidine - 52279 2.7.4.9 5'-chlorodeoxythymidine - 52280 2.7.4.9 5'-deoxy-5'-(methylamino)thymidine - 62652 2.7.4.9 5'-deoxy-5'-([[2-(3,4-dichlorophenyl)ethyl]carbamothioyl]amino)thymidine - 154709 2.7.4.9 5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine - 19066 2.7.4.9 5'-deoxy-5'-[2-(methylsulfonyl)benzenesulfonylamido]thymidine 91% inhibition 146297 2.7.4.9 5'-deoxy-5'-[4-(4-fluorophenyl)-(1,2,3)triazol-1-yl]thymidine 87% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth 146298 2.7.4.9 5'-deoxy-5'-[4-(methylsulfonyl)benzenesulfonylamido]thymidine 94% inhibition 146299 2.7.4.9 5'-deoxy-5'-[[(2-phenylethyl)carbamothioyl]amino]thymidine - 154708 2.7.4.9 5'-deoxy-5'-[[(3,4-dichlorophenyl)carbamoyl]amino]thymidine - 154710 2.7.4.9 5'-deoxy-5'-[[(4-morpholin-4-ylphenyl)carbamothioyl]amino]thymidine - 154702 2.7.4.9 5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine - 19067 2.7.4.9 5'-deoxy-5'-[[(phenylcarbonyl)carbamothioyl]amino]thymidine - 154706 2.7.4.9 5'-deoxy-5'-[[2-(methylthio)anilinothiocarbonyl]amino]thymidine 84% inhibition 146295 2.7.4.9 5'-deoxy-5'-[[3-(methylthio)anilinothiocarbonyl]amino]thymidine 69% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth 146296 2.7.4.9 5'-Deoxythymidine - 7127 2.7.4.9 5'-iododeoxythymidine - 115029 2.7.4.9 5'-O-methylthymidine - 62653 2.7.4.9 5'-[(benzylcarbamothioyl)amino]-5'-deoxythymidine - 154705 2.7.4.9 5'-[([[9-(2-carboxyphenyl)-3-oxo-2,3-dihydro-1H-xanthen-6-yl]oxy]carbamothioyl)amino]-5'-deoxythymidine - 154704 2.7.4.9 5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine - 89097 2.7.4.9 5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine - 89100 2.7.4.9 5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine - 89099 2.7.4.9 5,5'-dithio-bis(2-nitrobenzoic acid) general thymidylate kinase inhibitor 2373 2.7.4.9 5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole - 89084 2.7.4.9 5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione i.e. shogaol with bromouracil head group 212239 2.7.4.9 5-bromo-2'-deoxyuridine - 5498 2.7.4.9 5-bromo-2'-deoxyuridine potential inhibitor with high selectivity between bacterial and human enzyme 5498 2.7.4.9 5-bromo-2'-deoxyuridine specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions 5498 2.7.4.9 5-bromo-deoxyuridine - 77909 2.7.4.9 5-chloro-2'-deoxyuridine - 11245 2.7.4.9 5-chloro-2'-deoxyuridine potential inhibitor with high selectivity between bacterial and human enzyme 11245 2.7.4.9 5-chloro-2'-deoxyuridine specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions 11245 2.7.4.9 5-chloro-deoxyuridine - 77910 2.7.4.9 5-fluoro-2'-deoxyuridine not inhibitory at 4 mM 3318 2.7.4.9 5-fluoro-2'-deoxyuridine potential inhibitor with high selectivity between bacterial and human enzyme 3318 2.7.4.9 5-fluoro-deoxyuridine - 77908 2.7.4.9 5-fluorodeoxyuridine poor inhibitor 3977 2.7.4.9 5-hydroxymethyl-dUMP - 32107 2.7.4.9 5-iodo-2'-deoxyuridine - 6124 2.7.4.9 5-iodo-2'-deoxyuridine potential inhibitor with high selectivity between bacterial and human enzyme 6124 2.7.4.9 5-iodo-2'-dUMP - 29596 2.7.4.9 5-iodo-5'-fluoro-2',5'-dideoxyuridine - 33323 2.7.4.9 5-iodo-deoxyuridine - 77911 2.7.4.9 5-iodo-dUMP 2.5 mM, 30% inhibition 20044 2.7.4.9 5-iodo-dUMP competitive versus both thymidylate and thymidine 20044 2.7.4.9 5-methoxy-2-[(2E)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-1H-isoindole-1,3(2H)-dione inhibitor identified by 3D-QSAR pharmacophore generation 212245 2.7.4.9 5-methyl iso-dCMP competitive 52288 2.7.4.9 5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione - 28877 2.7.4.9 5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione - 253174 2.7.4.9 5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione - 253165 2.7.4.9 5-methyl-1-[(2Z)-4-(2-oxobenzo[cd]indol-1(2H)-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione - 89109 2.7.4.9 5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione - 253159 2.7.4.9 5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 252231 2.7.4.9 5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 252232 2.7.4.9 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione - 15336 2.7.4.9 5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 252233 2.7.4.9 5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253166 2.7.4.9 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione - 253163 2.7.4.9 5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253160 2.7.4.9 5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253167 2.7.4.9 5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253162 2.7.4.9 5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253190 2.7.4.9 5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253181 2.7.4.9 5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253182 2.7.4.9 5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253175 2.7.4.9 5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253176 2.7.4.9 5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253177 2.7.4.9 5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253183 2.7.4.9 5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253184 2.7.4.9 5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253185 2.7.4.9 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione - 253164 2.7.4.9 5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione - 253161 2.7.4.9 5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione - 252250 2.7.4.9 5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione - 28878 2.7.4.9 5-[(E)-2-bromoethenyl]-2'-deoxyuridine - 62648 2.7.4.9 5-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid comparison with inhibition of human enzyme 70191 2.7.4.9 5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid comparison with inhibition of Mycobacterium tuberculosis enzyme 25640 2.7.4.9 5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid comparison with inhibition of human enzyme 25640 2.7.4.9 5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid - 253178 2.7.4.9 6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89119 2.7.4.9 6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one - 89120 2.7.4.9 6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89126 2.7.4.9 6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89117 2.7.4.9 6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89113 2.7.4.9 6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89116 2.7.4.9 6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89129 2.7.4.9 6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one - 89127 2.7.4.9 6-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide comparison with inhibition of human enzyme 70236 2.7.4.9 6-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide comparison with inhibition of human enzyme 70237 2.7.4.9 6-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide comparison with inhibition of human enzyme 70238 2.7.4.9 ADP 100 nM, 64% inhibition 13 2.7.4.9 ADP 0.5 mM, 33% inhibition 13 2.7.4.9 ADP 2.5 mM, 24% inhibition 13 2.7.4.9 ADP ADP*Mg2+ product inhibition, competitive versus MgATP2-, noncompetitive versus thymidylate 13 2.7.4.9 ADP - 13 2.7.4.9 ADP 25% inhibition 13 2.7.4.9 ADP ADP[beta-S] 13 2.7.4.9 albendazole - 3447 2.7.4.9 ATP - 4 2.7.4.9 azido-TMP - 127459 2.7.4.9 Ca2+ - 15 2.7.4.9 CH2ATP 100 nM, 23% inhibition 115459 2.7.4.9 Cu2+ - 19 2.7.4.9 D-2'-fluoroarabinosyl-5-methyldeoxyuridine poor inhibitor; strong 38236 2.7.4.9 dADP 100 nM, 57% inhibition 731 2.7.4.9 dADP 0.5 mM, 34% inhibition 731 2.7.4.9 dADP 2.5 mM, 23% inhibition 731 2.7.4.9 dADP - 731 2.7.4.9 dAMP 5 mM, about 15% inhibition 716 2.7.4.9 dATP 100 nM, 15% inhibition 140 2.7.4.9 dATP 0.4 mM, 12% inhibition, adult liver 140 2.7.4.9 dCTP - 179 2.7.4.9 deoxy-fluorothymidine - 89111 2.7.4.9 deoxythymidine - 3070 2.7.4.9 deoxythymidine potential inhibitor with high selectivity between bacterial and human enzyme 3070 2.7.4.9 deoxythymidine poor inhibitor 3070 2.7.4.9 deoxyuridine - 1060 2.7.4.9 dGDP 0.5 mM, 23% inhibition 1140 2.7.4.9 dGMP competitive 729 2.7.4.9 dGTP 100 nM, 12% inhibition 219 2.7.4.9 diethylcarbamazine - 51622 2.7.4.9 dTDP 100 nM, 39% inhibition 542 2.7.4.9 dTDP 0.5 mM, 91% inhibition 542 2.7.4.9 dTDP 2.5 mM, 75% inhibition 542 2.7.4.9 dTDP product inhibition, competitive versus MgATP2- 542 2.7.4.9 dTDP - 542 2.7.4.9 dTDP 0.4 mM, 48% inhibition 542 2.7.4.9 dTDP competitive with dTMP 542 2.7.4.9 dTMP - 635 2.7.4.9 dTTP 2.5 mM, 17% inhibition 145 2.7.4.9 dTTP competitive versus both thymidine and thymidylate 145 2.7.4.9 dTTP - 145 2.7.4.9 dTTP 0.4 mM, 43% inhibition 145 2.7.4.9 dTTP potent feedback inhibitor of dTMP 145 2.7.4.9 dUDP 0.5 mM, 42% inhibition 1787 2.7.4.9 dUDP 2.5 mM, 15% inhibition 1787 2.7.4.9 dUMP 2.5 mM, 19% inhibition 602 2.7.4.9 dUMP - 602 2.7.4.9 dUMP 5 mM, about 15% inhibition 602 2.7.4.9 EDTA 4 mM, 80% loss of activity 21 2.7.4.9 Fe2+ - 25 2.7.4.9 GDP 100 nM, 21% inhibition 53 2.7.4.9 guanidine hydrochloride guanidine hydrochloride-induced unfolding of thymidylate kinase is noncooperative and influences the functional properties of the enzyme much less than their Cm values. Complete inhibition at 0.4 M 1048 2.7.4.9 ivermectin - 213760 2.7.4.9 KCl 0.5 M, 10% inhibition 79 2.7.4.9 levamisole - 3477 2.7.4.9 methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate - 89156 2.7.4.9 MgADP- - 795 2.7.4.9 Mn2+ slight inhibition 11 2.7.4.9 additional information several different TMP analogues tested and found to be inhibitory 2 2.7.4.9 additional information 3’-azido-3’-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents 2 2.7.4.9 additional information 3'-(aminomethyl)-3'-deoxy-2'-fluorothymidine is not inhibitory at 1 mM; 3’-azido-3’-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents 2 2.7.4.9 additional information acyclic nucleoside analogues (Z)-2-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[d,e]isoquinoline-1,3(2H)-dione and (Z)-2-(4-(thymin-1-yl)but-2-enyl)-2,3-dihydro-1H-benzo-[d,e]isoquinolin-1-one are not inhibitory up to 0.02 mM 2 2.7.4.9 additional information not inhibitory: 2-mercaptoethanol up to 5 mM, AMP, CMP, dCMP, GMP and dGMP and 2 2.7.4.9 additional information not inhibited by N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-phenylthiourea 2 2.7.4.9 additional information not inhibited by 3-((2R,3S,5R)-3-hydroxy-5-(5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile and 1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione 2 2.7.4.9 N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide - 89124 2.7.4.9 N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89146 2.7.4.9 N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89144 2.7.4.9 N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89135 2.7.4.9 N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89131 2.7.4.9 N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide - 89138 2.7.4.9 N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide - 89137 2.7.4.9 N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea comparison with inhibition of Mycobacterium tuberculosis enzyme 25661 2.7.4.9 N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea comparison with inhibition of human enzyme 25661 2.7.4.9 N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide - 89125 2.7.4.9 N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89151 2.7.4.9 N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89149 2.7.4.9 N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89158 2.7.4.9 N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89157 2.7.4.9 N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89148 2.7.4.9 N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide - 89152 2.7.4.9 N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea - 89086 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 25662 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea comparison with inhibition of human enzyme 25662 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea comparison with inhibition of Mycobacterium tuberculosis enzyme 25663 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea comparison with inhibition of human enzyme 25663 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea comparison with inhibition of Mycobacterium tuberculosis enzyme 25664 2.7.4.9 N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea comparison with inhibition of human enzyme 25664 2.7.4.9 N-(5'-deoxy-alpha-thymidin-5'-yl)-N'-[4-(2-chlorobenzyloxy)phenyl]urea - 253158 2.7.4.9 N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide - 89134 2.7.4.9 N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide - 89141 2.7.4.9 N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide - 89123 2.7.4.9 N-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]benzamide - 154712 2.7.4.9 NaCl 0.1 M, 25% inhibition 42 2.7.4.9 NH4Cl 0.4 M, 75% inhibition 329 2.7.4.9 P1,P5-di(adenosine-5')pentaphosphate potential inhibitor 2151 2.7.4.9 P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate - 172198 2.7.4.9 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate - 33273 2.7.4.9 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate - 33274 2.7.4.9 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate - 30319 2.7.4.9 suramin - 704 2.7.4.9 TDP - 694 2.7.4.9 thiourea-alpha-TM - 172200 2.7.4.9 thymidine 2.5 mM, 40% inhibition 166 2.7.4.9 thymidine 0.77 mM, 27% inhibition 166 2.7.4.9 thymidine - 166 2.7.4.9 TK-666 i.e. 2-(3-bromophenoxy)-4-((R)-3,3-dimethyl-1-((S)-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid 28876 2.7.4.9 UMP 5 mM, about 15% inhibition 133 2.7.4.9 Urea urea-induced unfolding of thymidylate kinase is noncooperative and influences the functional properties of the enzyme much less than their Cm values. Complete inhibition at 1.0 M 116 2.7.4.9 Zn2+ - 14 2.7.4.9 [(1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl]methyl acetate - 42373