1.3.1.48 13,14-dihydro-15-prostaglandin E2 competitive product inhibition 42975 1.3.1.48 15-keto prostaglandin F2alpha 43.06% residual activity at 0.1 mM 68883 1.3.1.48 5-(2-chloro-3-((4-methylcyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224555 1.3.1.48 5-(2-chloro-3-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224566 1.3.1.48 5-(2-chloro-3-(1-cyclopropylethoxy)benzylidene)-1,3- thiazolidine-2,4-dione - 224563 1.3.1.48 5-(2-chloro-3-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224557 1.3.1.48 5-(2-chloro-3-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224560 1.3.1.48 5-(2-chloro-3-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224556 1.3.1.48 5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 217193 1.3.1.48 5-(2-chloro-3-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione - 224574 1.3.1.48 5-(2-chloro-3-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224558 1.3.1.48 5-(2-chloro-3-(3-cyclohexylpropoxy)benzylidene)thiazolidine-2,4-dione - 224575 1.3.1.48 5-(2-chloro-3-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224565 1.3.1.48 5-(2-chloro-3-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione the compound significantly increases the level of PGE2 in skin defects 224570 1.3.1.48 5-(2-chloro-3-(4-cyclohexylbutoxy)benzylidene)thiazolidine-2,4-dione - 224576 1.3.1.48 5-(2-chloro-3-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione - 224559 1.3.1.48 5-(2-chloro-3-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione - 224571 1.3.1.48 5-(2-chloro-3-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224561 1.3.1.48 5-(2-chloro-3-(cyclohexylmethoxy)benzylidene)thiazolidine-2,4-dione - 224573 1.3.1.48 5-(2-chloro-3-(cyclohexyloxy)benzylidene)thiazolidine-2,4-dione - 224572 1.3.1.48 5-(2-chloro-3-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224562 1.3.1.48 5-(2-chloro-3-(cyclopentyloxy)benzylidene)-1,3-thiazolidine-2,4-dione - 224567 1.3.1.48 5-(2-chloro-3-phenethoxybenzylidene)thiazolidine-2,4-dione - 224569 1.3.1.48 5-(3-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione - 224568 1.3.1.48 5-(3-(bicyclo[2.2.1]hept-2-ylmethoxy)-2-chlorobenzylidene)-1,3-thiazolidine-2,4-dione - 224564 1.3.1.48 benzylidene acetophenone 21.09% residual activity at 0.5 mM 68884 1.3.1.48 Cibacron blue 3 G-A competitive inhibition vs. NADH, noncompetitive vs. 15-keto-prostaglandin E2 43928 1.3.1.48 Cibacron blue 3 G-A - 43928 1.3.1.48 ciglitazone - 17605 1.3.1.48 dicoumarol 0.1 mM, 86% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 754 1.3.1.48 dicoumarol 0.1 mM, complete inhibition 754 1.3.1.48 dicoumarol 11.45% residual activity at 0.1 mM 754 1.3.1.48 Disulfiram 0.1 mM, 61% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 986 1.3.1.48 indomethacin 0.1 mM, 97% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 546 1.3.1.48 indomethacin 0.1 mM, 95% inhibition 546 1.3.1.48 indomethacin - 546 1.3.1.48 indomethacin 14.22% residual activity at 0.1 mM 546 1.3.1.48 additional information finasteride has no inhibitory effect 2 1.3.1.48 additional information evaluation of non-steroidal anti-inflammatory drugs (NSAIDs) as enzyme potential inhibitors 2 1.3.1.48 additional information thiazolidinediones as enzyme inhibitors. No inhibition by 5-(2-chloro-3-(1-cyclopropylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione 2 1.3.1.48 NADH uncompetitive inhibition at high concentrations 8 1.3.1.48 NADP+ - 10 1.3.1.48 NADPH competitive inhibition vs. NADH, noncompetitive vs. 15-keto-prostaglandin E2 5 1.3.1.48 NADPH - 5 1.3.1.48 p-chloromercuribenzoate - 43 1.3.1.48 p-chloromercuribenzoate 0.0001 mM, 85% inhibition 43 1.3.1.48 p-chloromercuribenzoate 0.1 mM, complete inhibition 43 1.3.1.48 p-chloromercuribenzoate 0.1 mM, 97% inhibition 43 1.3.1.48 quercitrin 0.1 mM, 76% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 1936 1.3.1.48 quercitrin 95% inhibition 1936 1.3.1.48 quercitrin 13.14% residual activity at 0.1 mM 1936 1.3.1.48 thiazolidinedione - 18785