1.1.1.100 (E)-1-(4-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one 80% residual activity 155193 1.1.1.100 (E)-2-nitrophenyl cinnamate - 77139 1.1.1.100 (E)-3-phenoxybenzyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate 61% residual activity 155191 1.1.1.100 (E)-4-cyanophenyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate - 77138 1.1.1.100 (E)-benzyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate 71% residual activity 155192 1.1.1.100 (E)-phenyl 3-(benzo[d][1,3]dioxol-5-yl)acrylate 69% residual activity 77137 1.1.1.100 1,2,3,4,6-penta-O-galloyl-beta-D-glucose mixed type of inhibition. IC50 value 0.9 microgramm per ml, Ki value 0.21 microgramm per ml 12736 1.1.1.100 1,2,3,4,6-penta-O-galloyl-beta-D-glucose minimal inhibitory concentration 0.125 mg/ml 12736 1.1.1.100 1,2,3,4,6-penta-O-galloyl-beta-D-glucose minimal inhibitory concentration 0.25 mg/ml 12736 1.1.1.100 1,2,3,4,6-penta-O-galloyl-beta-D-glucose compound is transported across cancer cell membrane to further down-regulate FAS and activate caspase-3 in MDA-MB-231 cells. Compared with other FAS inhibitors, including catechin gallate and morin, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose involves a higher reversible fast-binding inhibition with an irreversible slow-binding inhibition, i.e. saturation kinetics with a dissociation constant of 0.59 microM and a limiting rate constant of 0.16 per min. The major reacting site of PGG is on the beta-ketoacyl reduction domain of FAS. Compound exhibits different types of inhibitions against the three substrates in the FAS overall reaction 12736 1.1.1.100 3-hydroxybutyryl-CoA competitive product inhibition 2190 1.1.1.100 3-hydroxybutyryl-CoA noncompetitive product inhibition pattern 2190 1.1.1.100 4-acetoxyanthecotulide most active linear sesquiterpene lactone from Anthemis auriculata against FabG 37715 1.1.1.100 4-hydroxyanthecotulide linear sesquiterpene lactone from Anthemis auriculata 37714 1.1.1.100 Acyl carrier protein beta-ketobutyryl-CoA reductase activity of FabG1 is inhibited, activity of FabG2 is unaffected 8033 1.1.1.100 acyl-carrier protein inhibition of wild-type with increasing concentrations 1134 1.1.1.100 anthecotulide linear sesquiterpene lactone from Anthemis auriculata 25447 1.1.1.100 bithionol over 75% inhibition at 0.02 mM, IC50: 0.010 mM 2724 1.1.1.100 bromochlorophen an anthelmintic agent, over 75% inhibition at 0.02 mM, IC50: 0.0154 mM 60350 1.1.1.100 chlorogenic acid IC50: 0.881-0.948 mM 592 1.1.1.100 di-resorcinol sulfide over 75% inhibition at 0.02 mM, IC50: 0.0038 mM 60349 1.1.1.100 DL-3-hydroxybutyryl-CoA competitive product inhibition 9430 1.1.1.100 epigallocatechin gallate - 1234 1.1.1.100 grape skin extract inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 4.61 microg/ml and 20.3 microg/ml, respectively. Inhibits the overall reaction of FAS competitively with acetyl-CoA, noncompetitively with malonyl-CoA and in a mixed manner with NADPH 209722 1.1.1.100 Guanidinium chloride FabG is fully unfolded at 4 M, approximately 90% of the enzyme activity can be recovered on dialyzing the denaturant. In presence of NADPH, there is no stabilization of FabG in case of equilibrium unfolding with guanidinium chloride 2558 1.1.1.100 Hexachlorophene an anthelmintic and antimicrobial agent, over 75% inhibition at 0.02 mM, IC50: 0.002 mM 2082 1.1.1.100 kaempferol - 408 1.1.1.100 additional information not: N-ethylmaleimide, arsenite 2 1.1.1.100 additional information no inhibition by triclosan 2 1.1.1.100 additional information cinnamic acid derivatives can be accommodated in the substrate-binding region of the active site, above the nicotinamide moiety of the NADPH cofactor 2 1.1.1.100 additional information FabG is inhibited by extract of galangal (rhizome of Alpinia officinarum). Minimum inhibitory concentration is above 1.28 mM 2 1.1.1.100 additional information FabG is inhibited by extract of galangal (rhizome of Alpinia officinarum). Minimum inhibitory concentration is 0.32-0.64 mM 2 1.1.1.100 additional information FabG is inhibited by extract of galangal (rhizome of Alpinia officinarum). Minimum inhibitory concentration is 0.01-0.02 mM 2 1.1.1.100 additional information FabG is inhibited by extract of galangal (rhizome of Alpinia officinarum). Minimum inhibitory concentration is 0.025-0.05 mM 2 1.1.1.100 additional information FabG is inhibited by extract of galangal (rhizome of Alpinia officinarum), strongest inhibition with 40% ethanol extract of galangal. Inhibition is consisted of both reversible and irreversible inhibition. Inhibits FabG in a competitive pattern against NADPH, irreversible inhibition presents two phases (slow and fast one) 2 1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge 2 1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge; inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Leaf extracts of Acer saccharum and Acer truncatum Bunge display time-dependent irreversible inhibition of FabG, whereas leaf extracts of Acer platanoides, Acer campestre and Acer rubrum show reversible inhibition 2 1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge. Is inhibited by the leaf extracts from all five kinds of maples more effectively than are other Gram-negative bacteria strains 2 1.1.1.100 additional information inhibition by leaf extracts from Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge, except strain 04-5 2 1.1.1.100 N-(1,3-dioxoisoindolin-2-yl)-2-oxo-2H-chromene-3-carboxamide 69% residual activity 77140 1.1.1.100 NADP+ competitive product inhibition 10 1.1.1.100 NADP+ noncompetitive product inhibition pattern 10 1.1.1.100 p-chloromercuribenzoate - 43 1.1.1.100 Phenylglyoxal with NADPH 45% remaining activity, without total loss of activity 301 1.1.1.100 Phenylglyoxal - 301 1.1.1.100 quercetin - 137 1.1.1.100 resveratrol inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 11.1 microg/ml and 21.9 microg/ml, respectively. In 3 T3-L1 preadipocytes, resveratrol reduces lipid accumulation remarkably 799 1.1.1.100 RNAi suppresses KCR activity, which results in a reduction of cuticular wax load and affects very-long-chain fatty acid composition of sphingolipids, seed triacylglycerols, and root glycerolipids. RNAi-suppressed Arabidopsis KCR1 plants display fused vegetative and reproductive organs, an abnormal root morphology and have abnormal trichome and epidermal cell morphology 1580 1.1.1.100 tachyplesin - 259753 1.1.1.100 Tannic acid - 1019 1.1.1.100 Tannic acid strongest inhibition on FabG, shows time-dependent irreversible inhibition 1019 1.1.1.100 Tannic acid displays very strong inhibition 1019 1.1.1.100 Urea FabG is fully unfolded at 6 M, approximately 90% of the enzyme activity can be recovered on dialyzing the denaturant. Two states in the reversible unfolding process of FabG in presence of NADPH, one is an activity-enhanced state and the other, an inactive state in case of equilibrium unfolding with urea 116