2.4.2.17	(4E)-4-[(4-chlorophenyl)(hydroxy)methylidene]-1-(pyridin-3-ylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione	binds to the cavity between the domains I and II. The terminal chlorobenzoyl group of 1 makes hydrophobic interactions with the amphiphilic pocket near the phosphoribosyl pyrophosphate binding site	76506	
2.4.2.17	1,2,4-Triazole-3-alanine	-	29236	
2.4.2.17	1-(5-phospho-alpha-D-ribosyl)-ATP	product inhibition, competitive to both substrates	51101	
2.4.2.17	1-(5-phospho-beta-D-ribosyl)-ATP	product inhibition	44706	
2.4.2.17	1-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-3-(1,3-thiazol-2-yl)propan-2-one	most potent inhibitor, spans the PR-ATP binding site, exhibits greater than 50% inhibition at 0.01 mM, 40% inhibition at 0.001 mM	39577	
2.4.2.17	2-([7-[(3-hydroxyphenyl)amino]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino)-5-nitrophenol	exhibits 46% inhibition	76537	
2.4.2.17	2-([7-[(3-hydroxyphenyl)amino]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino)-5-nitrophenol	has whole-cell activity at 0.012 mM	76537	
2.4.2.17	2-methyl-L-histidine	-	112427	
2.4.2.17	2-thiazol-DL-alanine	-	112455	
2.4.2.17	2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide	exhibits 71% inhibition	39582	
2.4.2.17	2-[(2-bromo-3,5-dinitrophenyl)carbonyl]-N-phenylhydrazinecarboxamide	has whole-cell activity at 0.025 mM	39582	
2.4.2.17	4-methoxybenzyl 2-methyl-5-oxo-4,7-dithiophen-2-yl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate	interacts with the phosphoribosyl diphosphate binding site but less strongly compared to compound 6 , exhibits greater than 50% inhibition at 0.01 mM	76644	
2.4.2.17	5-phospho-alpha-D-ribose 1-diphosphate	noncompetitive inhibitor with respect to both substrates in the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate	158	
2.4.2.17	adenine	competitive to ATP and 5-phospho-alpha-D-ribose 1-diphosphate	144	
2.4.2.17	ADP	competitive to ATP, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent	13	
2.4.2.17	ADP	-	13	
2.4.2.17	ADP	competitive to ATP	13	
2.4.2.17	ADP	orthosteric inhibition	13	
2.4.2.17	Ag+	-	75	
2.4.2.17	AMP	competitive inhibitor to 5-phospho-alpha-D-ribose 1-diphosphate, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent	30	
2.4.2.17	AMP	linear competitive inhibitor with respect to ATP, stabilizes the enzyme to thermal inactivation, protect the ordered enzymatic structure against thermodenaturation	30	
2.4.2.17	AMP	inhibits the enzyme complex together with histidine to the T-state	30	
2.4.2.17	AMP	binding structure and inhibition mode	30	
2.4.2.17	AMP	competitive	30	
2.4.2.17	AMP	competitive to ATP	30	
2.4.2.17	AMP	competitive inhibition	30	
2.4.2.17	AMP	-	30	
2.4.2.17	AMP	AMP is an inhibitor of subunit HisGS	30	
2.4.2.17	AMP	about 10% inhibition at 0.25 mM	30	
2.4.2.17	ATP	inhibits the reaction at high concentrations	4	
2.4.2.17	beta,gamma-methylene-ATP	competitive with respect to N-1-(5-phosphoribosyl)-ATP, noncompetitive with respect to diphosphate; inhibitor of the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate	3802	
2.4.2.17	beta-(2-thiazolyl)-DL-alanine	-	209516	
2.4.2.17	Ca2+	moderate inhibitory effect	15	
2.4.2.17	Cd2+	-	52	
2.4.2.17	Co2+	-	23	
2.4.2.17	Cu2+	-	19	
2.4.2.17	dicoumarol	competitive with respect to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	754	
2.4.2.17	dinitrophenol	diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	4519	
2.4.2.17	diphosphate	non competitive to both substrates	17	
2.4.2.17	EDTA	-	21	
2.4.2.17	EDTA	moderate inhibitory effect	21	
2.4.2.17	ethyl [(6-nitro-1,3-benzothiazol-2-yl)amino](oxo)acetate	exhibits 39% inhibition	154924	
2.4.2.17	Fe2+	-	25	
2.4.2.17	Fe3+	-	70	
2.4.2.17	Guanosine 5'-diphosphate-3'-diphosphate	in presence of partially inhibiting concentrations of histidine guanosine 5'-diphosphate-3'-diphosphate becomes a potent inhibitor of the residual activity of ATP phosphoribosyltransferase, no inhibition in absence of histidine, inhibition is slowly reversible	44202	
2.4.2.17	Hg2+	-	33	
2.4.2.17	Hg2+	moderate inhibitory effect	33	
2.4.2.17	histidine	feedback inhibition, inhibits the enzyme complex together with ATP to the T-state, no inhibition of mutants E130A and Y268F/Y269F	1063	
2.4.2.17	histidine	noncompetitive feedback inhibition	1063	
2.4.2.17	histidine	noncompetitive	1063	
2.4.2.17	L-histidine	feed-back inhibition; reversed by Hg2+, p-hydroxymercuribenzoate, methylmercuric bromide, Ni2+; the L-configuration is essential, substitution of alpha-amino group appreciably reduces inhibition, non competitive inhibitor with respect to both substrates	349	
2.4.2.17	L-histidine	feed-back inhibition; stabilizes the enzyme to thermal inactivation, protects the ordered enzymatic structure against thermodenaturation, no interaction with binding sites	349	
2.4.2.17	L-histidine	feed-back inhibition	349	
2.4.2.17	L-histidine	feed-back inhibition; inhibits reverse reaction cooperatively and completely	349	
2.4.2.17	L-histidine	feed-back inhibition; feed-back inhibition	349	
2.4.2.17	L-histidine	allosteric inhibition, synergistically favored by AMP; feed-back inhibition	349	
2.4.2.17	L-histidine	allosteric inhibitor, inhibition dependent on pH, uncompetitive versus ATP, noncompetitive versus 5-phospho-alpha-D-ribosyl diphosphate	349	
2.4.2.17	L-histidine	noncompetitive, alkaline pH decreases the inhibitory effect	349	
2.4.2.17	L-histidine	-	349	
2.4.2.17	L-histidine	allosterical inhibition	349	
2.4.2.17	L-histidine	complete inhibition at 0.1 mM	349	
2.4.2.17	L-histidine	in the presence of histidine, subunit HisZ mediates allosteric inhibition of the enzyme	349	
2.4.2.17	L-histidine	complete inhibition at 1 mM, about 10% inhibition at 0.25 mM	349	
2.4.2.17	L-histidine	noncompetitive inhibition, subunit HisZ activates subunit HisGS and mediates allosteric inhibition by histidine	349	
2.4.2.17	L-histidine	histidine allosterically inhibits the enzyme in a negative feedback control mechanism	349	
2.4.2.17	Methylmercuric bromide	-	30185	
2.4.2.17	Mg2+	at high concentrations, Ki = 23 mM	6	
2.4.2.17	Mn2+	moderate inhibitory effect	11	
2.4.2.17	additional information	carbonylcyanide m-chlorophenylhydrazone, which is a potent inhibitor of several enzymes with adenine-containing substrates or coenzymes has no effect	2	
2.4.2.17	N-ethylmaleimide	-	49	
2.4.2.17	N-[3-[(6-nitro-1,3-benzothiazol-2-yl)amino]-3-oxo-1-phenylpropyl]benzamide	occupies only the phosphoribosyl diphosphate binding site, exhibits greater than 50% inhibition at 0.01 mM, 35% inhibition at 0.001 mM	39628	
2.4.2.17	Ni2+	-	38	
2.4.2.17	p-hydroxymercuribenzoate	-	98	
2.4.2.17	Pentachlorophenol	competitive to ATP, inhibitor in both directions, diminishes yield of phosphoribosyladenosine triphosphate by acting as parasite substrate	1077	
2.4.2.17	Zn2+	-	14	
2.4.2.17	Zn2+	moderate inhibitory effect	14