2.1.1.67 2,3-Dithiopropanol - 15471 2.1.1.67 2,4-dithiopyrimidine - 50477 2.1.1.67 2,8-dihydroxy-6-mercaptopurine - 50478 2.1.1.67 2-amino-6-thiopurine - 29360 2.1.1.67 2-Hydroxy-6-mercaptopurine - 15494 2.1.1.67 2-mercaptoethanol - 63 2.1.1.67 2-methylthio-4-hydroxypyrimidine 1.8 mM, 45% inhibition 50494 2.1.1.67 2-Methylthiouracil - 43167 2.1.1.67 3,4,5-triiodobenzoic acid - 110163 2.1.1.67 3,4-dimethoxy-5-hydroxybenzoic acid - 13314 2.1.1.67 3,4-dimethoxybenzoic acid - 9612 2.1.1.67 3,5-dichlorobenzoic acid - 110169 2.1.1.67 3,5-dihydroxy-4-methoxybenzoic acid - 110170 2.1.1.67 3,5-dimethylbenzoic acid - 110171 2.1.1.67 3,5-dinitrobenzoic acid - 50505 2.1.1.67 3-bromo-5-hydroxy-4-methoxybenzoic acid - 110197 2.1.1.67 3-chloro-5-hydroxy-4-methoxybenzoic acid - 110198 2.1.1.67 3-hydroxy-4,5-dimethoxybenzoic acid - 110207 2.1.1.67 3-hydroxy-4-methoxy-5-(dimethylamino)benzoic acid - 110208 2.1.1.67 3-hydroxy-4-methoxy-5-nitrobenzoic acid - 110209 2.1.1.67 3-hydroxy-4-methoxybenzoic acid - 50510 2.1.1.67 3-hydroxy-5-iodo-4-methoxybenzoic acid - 110211 2.1.1.67 4-hydroxy-3-methoxybenzoic acid - 9611 2.1.1.67 5-amino-salicylic acid - 109764 2.1.1.67 5-Aminosalicylate - 3607 2.1.1.67 5-methyl-2,4-dithiopyrimidine - 50558 2.1.1.67 6-hydroxy-2-thiopurine - 50565 2.1.1.67 6-Mercaptopurine - 1345 2.1.1.67 6-Mercaptopurine TPMT activity and protein levels are diminished in cells incubated with 6-mercaptopurine 1345 2.1.1.67 6-methylmercaptopurine - 29633 2.1.1.67 6-methylthiopurine - 7134 2.1.1.67 6-thioguanine mixed inhibitor of 6-mercaptopurine methylation 1253 2.1.1.67 aspirin - 3100 2.1.1.67 Azathioprine IC50: 0.43-0.532 mM 4790 2.1.1.67 bendroflumethiazide - 50643 2.1.1.67 benzoic acid substituted benzoic acids, benzoic acid compounds, noncompetitive inhibition 498 2.1.1.67 benzoic acid benzoic acid derivatives 498 2.1.1.67 benzoic acid - 498 2.1.1.67 celecoxib - 1809 2.1.1.67 diclofenac - 1291 2.1.1.67 Disulfiram - 986 2.1.1.67 Ethacrynic acid - 1046 2.1.1.67 flurbiprofen - 3816 2.1.1.67 Furosemide - 1557 2.1.1.67 Furosemide IC50: 0.015-0.019 mM, has the potential to inhibit thiopurine S-methyltransferase in patients with chronic inflammatory bowel disease 1557 2.1.1.67 glutathione - 44 2.1.1.67 Ibuprofen - 1645 2.1.1.67 Ketoprofen - 3079 2.1.1.67 L-cysteine 1.8 mM, 50% inhibition 74 2.1.1.67 L-homocysteine - 305 2.1.1.67 L-homocysteine thiolactone - 15818 2.1.1.67 lornoxicam - 6300 2.1.1.67 Mefenamic acid - 2086 2.1.1.67 meloxicam - 5320 2.1.1.67 mesalazine - 36968 2.1.1.67 mesalazine thiopurine S-methyltransferase inhibition of multimatrix mesalazine is lower than that of time-dependent mesalazine 36968 2.1.1.67 additional information low levels of methionine can result in low S-adenosyl-L-methionine levels and consequently decreased TPMT activity 2 2.1.1.67 N-ethylmaleimide - 49 2.1.1.67 nabumetone - 18650 2.1.1.67 naproxen - 1792 2.1.1.67 olsalazine - 18662 2.1.1.67 paracetamol - 7459 2.1.1.67 piretanide IC50: 0.3-0.313 mM 56888 2.1.1.67 piroxicam - 4121 2.1.1.67 S-adenosyl-L-homocysteine - 36 2.1.1.67 S-adenosyl-L-methionine - 24 2.1.1.67 S-Methylglutathione - 3363 2.1.1.67 sulfasalazine - 4146 2.1.1.67 sulphasalazine - 20530 2.1.1.67 testosterone IC50: 0.03-0.072 mM 284 2.1.1.67 tolfenamic acid - 18661 2.1.1.67 trichlormethiazide - 50995 2.1.1.67 tropolone - 1033