1.11.1.27 additional information physiological mechanism for the glutathionylation of the oxidized cysteine in 1-cysPrx by its heterodimerization with glutathione-loaded glutathione S-transferase P (GST-pi) results in heterodimer formation, glutathionylation of the enzyme (1-cysPrx), and enzyme reactivation. Maximum activation of the enzyme (1-cysPrx) occurrs with a 1:1 molar ratio of glutathione-saturated glutathione S-transferase P and a 2:1 molar ratio of glutathione to enzyme (1-cysPrx) 755233