6.1.1.2 chuangxinmycin - 704281 6.1.1.2 glyceraldehyde 3-phosphate dehydrogenase the oxidized form of glyceraldehyde 3-phosphate dehydrogenase interacts with both full-length and mini tryptophanyl-tRNA synthetase and specifically stimulates the aminoacylation potential of mini, but not full-length tryptophanyl-tRNA synthetase. In contrast, reduced glyceraldehyde 3-phosphate dehydrogenase does not bind to tryptophanyl-tRNA synthetase and does not influence their aminoacylation activity 661186 6.1.1.2 heme - 703734 6.1.1.2 heme enhances activity 702375 6.1.1.2 heme R135H/E438A double mutant 703734 6.1.1.2 hemin heme can interact strongly with Zn2+-depleted full-length TrpRS, but not the Zn2+-bound enzyme, with a stoichiometric heme:protein ratio of 1:1 to enhance the aminoacylation activity significantly, involvement of heme in regulation of TrpRS aminoacylation activity, overview 672219 6.1.1.2 hygromycin - 704281 6.1.1.2 indolmycin - 704281 6.1.1.2 interferon gamma strong upregulation of the alternatively spliced truncated mini enzyme form 650116 6.1.1.2 interferon gamma strongly stimulates and regulates the expression of the enzyme isoforms via 2 specific interferon-gamma-sensitive promoters that are additionally regulated by the interferon regulatory factor 1 653395 6.1.1.2 interferon regulatory factor 1 stimulates and regulates the enzyme isoforms expression via 2 specific interferon-gamma-sensitive promoters that are additionally regulated by the interferon gamma 653395 6.1.1.2 interferons interferons alpha, beta, and gamma, induction of accumulation of the enzyme, organelle-specific, the highest content is observed in the cytoplasm, followd by the nucleolus and the nucleus, the latter with a low enzyme content 653176 6.1.1.2 additional information TrpRS is highly upregulated by interferon-gamma, IFN-gamma 672219 6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, overview 676170 6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, overview 676170 6.1.1.2 serine hydroxamate - 704281 6.1.1.2 Zn2+ - 703734 6.1.1.2 Zn2+ R135H/E438A double mutant 703734