2.7.11.30	actividin	activates Smad2 phosphorylation via type I receptor kinases	663984	
2.7.11.30	actividin	binds and activates the type I receptor ALK7	664721	
2.7.11.30	actividin	TGF-beta receptor I and ALK7 possess an actividin receptor-binding domain	664282	
2.7.11.30	actividin A	required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site	665487	
2.7.11.30	actividin B	required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site	665487	
2.7.11.30	ALK5	is important for ALK1/TGF-beta signaling	666312	
2.7.11.30	growth differentiation factor-9	i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9	666359	
2.7.11.30	additional information	increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells	664721	
2.7.11.30	nodal	-	664282	
2.7.11.30	SARA protein	i.e. Smad anchor for receptor activation protein, binding site for co-modulator Smad4, modulates self-association of partially phosphorylated Smad2 preventing premature release of monophosphorylated substrate, interaction with Smad2 via the Smad2 MH2 domain	664036	
2.7.11.30	TGF-beta	-	664318, 664715, 665532	
2.7.11.30	TGF-beta	a potent regulator of cell proliferation, differentiation, motility, and apoptosis, binds to and activates serine/threonine receptors that phosphorylate Smad2 and Smad3	665554	
2.7.11.30	TGF-beta	activates the TGF-beta receptor by direct binding	666512	
2.7.11.30	TGF-beta	activates the TGF-beta type I receptor kinase by binding, affects BGN and GADDbeta45 expression in PANC-1 and M-63 cells via ALK5 and Smad phosphorylation/activation, overview	665640	
2.7.11.30	TGF-beta	activates the type II and type I membrane receptors, e.g. ALK1 and ALK5	666312	
2.7.11.30	TGF-beta	binds and activates the TGF-beta receptor kinase, promotes transforming growth in advanced carcinogenesis, influences transcription activity of cells	666443	
2.7.11.30	TGF-beta	binds and activates the TGF-beta receptor, treatment of cells with TGF-beta increaes the production of matrix proteins	665481	
2.7.11.30	TGF-beta	binds and activates the TGF-family receptor kinases of type I and type II, e.g. type I receptor ALK7	664721	
2.7.11.30	TGF-beta	binds to and activates TbetaRI receptor kinase that phosphorylates Smad2	664036	
2.7.11.30	TGF-beta	i.e. transforming growth factor-beta, interacts with and activates type I transforming growth factor-beta receptor	663984	
2.7.11.30	TGF-beta	interacts with and activates type I actividin receptor-like kinase 5, ALK5	666359	
2.7.11.30	TGF-beta 3	binds and activates ALK5	665699