2.7.1.138	A23187	calcium ionophore, 216% activation of ceramide kinase in A549 lung adenocarcinoma cells	640970	
2.7.1.138	Ca2+	1 mM, stimulatory effect in the absence of Mg2+	662592	
2.7.1.138	Calcium	-	691938	
2.7.1.138	Calmodulin	binding site is located at residues 422-435, which form a amphipathic helical wheel, motif 1-8-14, calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor	662431	
2.7.1.138	interleukin-1 beta	187% activation of ceramide kinase in A549 lung adenocarcinoma cells	640970	
2.7.1.138	Mg2+	3 mM, highly dependent on Mg2+	662592	
2.7.1.138	additional information	(2R)-isomers of (2S)-substrates are stimulatory	662592	
2.7.1.138	additional information	the enzyme is induced by the calcium triggers interleukin-1beta and IgE/Ag due to calcium mobilization	661860	
2.7.1.138	peroxisome proliferator-activated receptor beta	upregulation of CERK through activation of peroxisome proliferator-activated receptor beta (PPARbeta) results in decreased intracellular ceramide levels and increased cell survival with less cell death	692307	
2.7.1.138	Phorbol esters	e.g. PMA	661860