2.3.1.B41	1-(5-((3-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydropyrrolo[1,2-a]quinoxalin-4-yl)naphthalen-2-ol	-	755787	
2.3.1.B41	2-(3-chloro-(4-benzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid	i.e. CL-5A	757236	
2.3.1.B41	2-(3-chloro-4-(2,4,6-trichloro-N-(2,4,6-trichlorobenzoyl)benzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid	i.e. CL5D, SIRT6 displays ordered binding and CL5D does not improve H3K9ac binding	757236	
2.3.1.B41	2-(3-chloro-4-(2,4-dichlorobenzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid	i.e. CL-4	757236	
2.3.1.B41	2-(3-chloro-4-(4-chlorobenzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid	i.e. CL-5B	757236	
2.3.1.B41	2-(4-benzamidophenyl)-1,3-dioxoisoindoline-5-carboxylic acid	i.e. CL-5	757236	
2.3.1.B41	2-fluoropalmitic acid	-	757236	
2.3.1.B41	4-(pyridin-2-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-(pyridin-2-yl)pyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-(pyridin-3-yl)-5-((3-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-(pyridin-3-yl)pyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-(pyridin-4-yl)pyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	4-phenylpyrrolo[1,2-a]quinoxaline	-	755787	
2.3.1.B41	arachidonic acid	-	757236	
2.3.1.B41	arotinoid acid	i.e. TTNPB	757236	
2.3.1.B41	eicosatrienoic acid	-	757236	
2.3.1.B41	L-NASPA	-	757236	
2.3.1.B41	linoleic acid	EC50 value of 0.089 mM	738060	
2.3.1.B41	luteolin	EC50 value of 0.27 mM	738060	
2.3.1.B41	lysophosphatidic acid	highly activating	757236	
2.3.1.B41	mead acid	-	757236	
2.3.1.B41	additional information	binding of free fatty acids to SIRT6 significantly enhances SIRT6's in vitro histone deacetylase activity	757931	
2.3.1.B41	additional information	binding of free fatty acids to SIRT6 significantly enhances SIRT6's in vitro histone deacetylase activity. Given Sirt6 critical roles in multiple molecular pathways, including DNA repair, telomere maintenance, glycolysis, gluconeogenesis, lipid metabolism, inflammation, and tumor suppression, it is clear that attempts to enhance the activity of SIRT6 could provide therapeutic benefits, development of SIRT6 activators, overview	757931	
2.3.1.B41	additional information	screening for SIRT6 activator small molecules, dose-response and Michaelis-Menten parameters of activation by the SIRT6 activators, overview. Structure-activity relationship analysis yields activators with improved potency and selectivity for SIRT6. Enzyme residue Arg65 is critical for activation by facilitating a conformational step that initiates chemical catalysis. Arg65 mediates a conformational change after substrate binding and that the rate of this change is enhanced by small-molecule activation of deacetylation and during demyristoylation	757236	
2.3.1.B41	additional information	structural basis of sirtuin 6 activation by synthetic small molecules, overview. Synthesis and screening of pyrrolo[1,2-a]quinoxaline derivatives, yielding synthetic Sirt6 activators performing direct, substrate-independent compound binding to the Sirt6 catalytic core and potent activation of Sirt6-dependent deacetylation of peptide substrates and complete nucleosomes. Crystal structures of Sirt6/activator complexes reveal that the compounds bind to a Sirt6-specific acyl channel pocket and identify key interactions. Weak and possibly non-specific activating effects are also reported for the plant metabolite fatty acids (Sirt6). Preparation of the 4-substituited-4,5-dihydropyrrolo[1,2-a]quinoxalines and 4-substituited-pyrrolo[1,2-a]quinoxalines. Sirt6 activator-binding site and mechanism, microscale thermophoresis binding experiments, overview	755787	
2.3.1.B41	additional information	the enzyme activity is not stimulated by N-stearoylethanolamine and N-arachidonoylethanolamine	738060	
2.3.1.B41	additional information	the enzyme is unaffected by the activators isonicotinamide and resveratrol	729665	
2.3.1.B41	N-(alpha-linolenoyl)ethanolamine	-	738060	
2.3.1.B41	N-(gama-linolenoyl)ethanolamine	-	738060	
2.3.1.B41	N-linoleoylethanolamine	-	738060	
2.3.1.B41	N-linoleoylglycine	-	757236	
2.3.1.B41	N-myristoylethanolamine	-	738060	
2.3.1.B41	N-myristoylethanolamine	EC50 value of 0.0075 mM	738060	
2.3.1.B41	N-oleoylethanolamine	strongest activator with EC50 value of 0.0031 mM	738060	
2.3.1.B41	N-palmitoleoylethanolamine	-	738060	
2.3.1.B41	N-palmitoylethanolamine	-	738060	
2.3.1.B41	oleic acid	EC50 value of 0.23 mM	738060	
2.3.1.B41	phenyl(4-phenylpyrrolo[1,2-a]quinoxalin-5(4H)-yl)methanone	-	755787	
2.3.1.B41	quercetin	EC50 value of 0.99 mM	738060