1.14.15.6 1,2-di-(2'-hexyl-decanoyl)-sn-glycero-3-phosphocholine alpha-branched phosphatidylcholine, inclusion in vesicle-reconstituted system, partially in connection with the nonactivator lipids dimyristoyl-/dioleoyl-phosphatidylcholine, efficiency close to cardiolipin 285429 1.14.15.6 1,2-di-(2'-octyl-dodecanoyl)-sn-glycero-phosphocholine alpha-branched phosphatidylcholine, inclusion in vesicle-reconstituted system, partially in connection with the nonactivator lipids dimyristoyl-/dioleoyl-phosphatidylcholine, efficiency close to cardiolipin 285429 1.14.15.6 Brij 56, 76 and 96 285416 1.14.15.6 cardiolipin affinity of P-450scc for cholesterol is increased 285420 1.14.15.6 cardiolipin most potent and effective activator lipid, binds to enzyme and enhances the binding of cholesterol 285429 1.14.15.6 Emulgen 911 and 913 285416 1.14.15.6 fatty acid C18, natural detergents in DMPC vesicles, stimulation similar to octyl glucoside 285420 1.14.15.6 glycerol 5-20% concentration, 20-50% increase of enzyme activity 285418 1.14.15.6 Lipid from adrenal mitochondria accelerates activity 285418 1.14.15.6 additional information 4-nonylphenol induces enzyme expression by 150%, overview 673372 1.14.15.6 additional information activator of cholesterol side-chain cleavage isolated from the cytosol of bovine adrenal cortex 285426 1.14.15.6 additional information enzymatic activity is greatest at low ionic strength with a number of different ions 285427 1.14.15.6 additional information enzyme induction by gonadotropic stimuli, e.g. artificially by a salmon piuitary homogenate, in ovary 675689 1.14.15.6 additional information head and fatty acid groups have large effects on stimulation of activity, head group appears as major determinant of the lipid interaction with the P-450scc, 1-2 and 3-4 molecules of cardiolipin and the branched phosphatidylcholines, respectively, bind highly specific to P-450scc at an effector site distant from cholesterol binding site with a resultant stabilization of an optimal cholesterol-binding conformation of P-450scc 285429 1.14.15.6 additional information luteinizing hormone, progesterone, and prostaglandin E2 induce enzyme expression in luteal cells 676926 1.14.15.6 additional information P450scc induction by available nutrients and phytoplankton blooms 687991 1.14.15.6 additional information vitamin D3 and cholesterol are metabolized with comparable efficiencies in cyclodextrin, but the Km for both show a strong dependence on the cyclodextrin concentration, decreasing with decreasing cyclodextrin 704039 1.14.15.6 octyl glucoside high concentrations of this detergent cause 50% stimulation of cholesterol side-chain-cleavage in large unilamellar vesicles at low cholesterol concentration, 0.01 mM increase the proportion of P-450 bound by cholesterol 285420 1.14.15.6 Phospholipid cholesterol gains access to the cytochrome within micelles 285413 1.14.15.6 Phospholipid inclusion of P-450 into vesicles 285414 1.14.15.6 Phospholipid P-450scc reconstituted in vesicles, cholate-solubilized for small unilamellar dioleoylphosphatidylcholine vesicles, non-ionic detergent n-octyl glucoside used for large ones 285420 1.14.15.6 Runx2 activation of CYP11A1 by the osteogenic transcription factor Runx2 may contribute to attenuation of osteoblast growth. Runx2 binds to the CYP11A1 gene promoter, CYP11A1 is a direct target of Runx2 705739 1.14.15.6 Runx2 activation of CYP11A1 by the osteogenic transcription factor Runx2 may contribute to attenuation of osteoblast growth. Runx2 binds to the CYP11A1 gene promoter, CYP11A1 is a direct target of Runx2. Runx2 is rate limiting for CYP11A1 gene expression during differentation along the osteoblastic lineage 705739 1.14.15.6 Triton X-100 effect onto P-450 itself suggested 285416 1.14.15.6 Tween 20 - 285416 1.14.15.6 Tween 20 small stabilizing and binding activating effect on ternary complex of adrenodoxin-cholesterol-P-450scc 285413