1.1.1.268	ethanesulfonate	1 mM, 5.6fold increase in ratio of turnover number to Km-value for 2-butanone as substrate	
1.1.1.268	ethanesulfonate	the addition of ethanesulfonate dramatically increases the enentiomeric excess of (S)-2-butanol produced by all forms of recombinant R-HPCDH except the R152A and R196A mutants. The effect of ethanesulfonate and other additives on (S)-butanol production is termed enantioselective modulation, and it is highly selective for sulfonate containing molecules. The interpretation is that the sulfonate of ethanesulfonate interacts with R152 and R196 in the CoM binding pocket alongside 2-butanone, in a way that discourages a si-face hydride addition to produce (R)-2-butanol	
1.1.1.268	methanesulfonate	1 mM, 5.6fold increase in ratio of turnover number to Km-value for 2-butanone as substrate	
1.1.1.268	propanesulfonate	1 mM, 1.7fold increase in ratio of turnover number to Km-value for 2-butanone as substrate